BR-102013005581-B1 - Restorative Dental Composition and Its Uses

Abstract

DENTAL RESTORATIVE COMPOSITION AND ITS USES The present invention describes a dental restorative composition formed by a resin coupled to bioactive glass microparticles and functional monomers, capable of paralyzing carious lesions in enamel and actively remineralizing them. The lesion is not filled by resin and the surrounding tissues become resistant to subsequent cariogenic challenges. This composition can also be applied as an adhesive resin for direct and indirect restorations with restorative composite resin.

Inventors

• MÁRIO ALEXANDRE COELHO SINHORETI
• Victor Pinheiro Feitosa
• RAVANA ANGELINI SFALCIN
• TATIANY GABRIELLE FREIRE ARAÚJO
• AMÉRICO BORTOLAZZO CORRER
• SALVATORE SAURO
• TIMOTHY FREDERICK WATSON

Assignees

• KING'S COLLEGE LONDON
• UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP

Dates

Publication Date

20260317

Application Date

20130308

Claims (20)

1. 1. A restorative dental composition characterized by comprising a resin matrix based on selected di- and trimethacrylates of triethylene glycol dimethacrylate (TEGDMA) and trimethylpropane trimethacrylate (TMPTMA); selected phosphated functional acid monomers of 10-methacryloyl oxydecyl dihydrogen phosphate (MDP); and selected bioactive glass microparticles of SiO2-Na2O-CaO-P2O5.
2. 2. Composition according to claim 1, characterized in that the resin matrix is selected from acrylates, methacrylates, methacrylamides, acrylamides, siloranes, preferably di- and trimethacrylates, more preferably triethylene glycol dimethacrylate (TEGDMA) and trimethylpropanetrimethacrylate (TMPTMA).
3. 3. Composition according to claim 2, characterized in that triethylene glycol dimethacrylate (TEGDMA) is added in amounts between 50% and 90% by weight.
4. 4. Composition according to claim 2, characterized in that trimethylpropane trimethacrylate (TMPTMA) is added between 2% and 20% by weight.
5. 5. Composition according to claim 1, characterized in that the functional acid monomers are selected from 10-methacryloyl-oxy-decyl-dihydrogen-phosphate (MDP)
6. 6. Composition according to claim 5, characterized in that 10-methacryloyl-oxy-decyl-dihydrogen-phosphate (MDP) is added between 5% and 20% by weight.
7. 7. Composition according to claim 1, characterized by the selected bioactive glass microparticles being SiO2-Na2O-CaO-P2O5.
8. 8. Composition according to claim 7, characterized in that the bioactive glass microparticles are or are not modified by beta tricalcium phosphate and/or zinc oxide.
9. 9. Composition according to claim 7, characterized in that bioactive glass microparticles are added between 5% and 20% by weight.
10. 10. Composition according to claim 1, characterized by optionally comprising photoinitiators, co-initiators, polymerization reaction accelerators, spontaneous polymerization inhibitors, radiopacifiers and pigments.
11. 11. Composition according to claim 10, characterized in that the photoinitiators are selected from phenylpropadione, camphorquinone and phosphine oxides, such as BAPO and TPO, preferably camphorquinone.
12. 12. Composition according to claim 11, characterized in that the photoinitiators are added in amounts between 0.5% and 2% by weight.
13. 13. Composition according to claim 10, characterized in that the co-initiators are selected from aromatic or non-aromatic amines, preferably ethyl-dimethyl-amino-benzoate.
14. 14. Composition according to claim 13, characterized in that the co-initiators are added in amounts between 0.5% and 2% by weight.
15. 15. Composition according to claim 10, characterized in that the polymerization reaction accelerators are selected from among the onium salts, preferably diphenyl-iodonium-hexafluorophosphate.
16. 16. Composition according to claim 15, characterized in that the polymerization reaction accelerators are added in amounts between 0.5% and 2% by weight.
17. 17. Composition according to claim 10, characterized in that the spontaneous polymerization inhibitors are preferably di-tert-butyl methyl phenol or butylated hydroxytoluene (BHT).
18. 18. Composition according to claim 17, characterized in that spontaneous polymerization inhibitors are preferably added below 0.02% by weight.
19. 19. Composition according to claim 10, characterized in that the radiopacifiers are selected from lead oxides or other metals, preferably triphenylbismuth.
20. 20. Composition according to claim 19, characterized in that the radiopacifiers are added in amounts between 1% and 3% by weight.

Description

Field of Invention [001] The present invention relates to a restorative dental composition. More specifically, the present invention relates to a resin composition with functional acid monomers reinforced with bioactive glass microparticles. [002] The composition can be used as a restorative infiltrant for initial carious lesions in enamel, for sealing dentin and pits and fissures, and as an adhesive resin for direct and indirect restorations with restorative composite resin. Fundamentals of the Invention [003] Recently, a new type of dental material was created with the aim of infiltrating initial carious lesions in enamel. With the current mindset of minimally invasive dentistry, these infiltrants arrest carious lesions before they reach the dentin (Paris and Meyer-Lueckel 2010). As carious lesions progress and reach the dentin tissue, a cavity is formed that necessarily requires a more extensive restoration and greater loss of healthy dental tissue. Consequently, with the use of infiltrating resins, the preservation of healthy dental tissue is prioritized, and this innovative material plays an important role in conservative dentistry. However, carious lesions, when limited to the enamel, have a 50% chance of being remineralized with specific treatments. Such treatments were the preferred choice prior to the creation of infiltrants. With the application of an essentially resinous (infiltrating) material, the possibility of remineralization is drastically reduced, since the resin infiltrates and completely fills the pores of the lesion, and there is no component in the material's composition capable of actively remineralizing the surrounding dental tissue. [004] Several documents related to dental infiltrants are found in the literature, and the most relevant are cited below. US patents 7,485,673, 8,362,172, and 8,183,305 describe essentially resinous materials in which, in some cases, a functional acid monomer that can be phosphated has been added. With such materials, there is no possibility of enamel remineralization since all the tissue to be remineralized has been filled only with resin. Thus, disadvantageously, none of them describes the addition of bioactive glass to self-adhesive restorative dental resins, as described in the present invention, which allows the remineralization of the surrounding dental tissue in initial carious lesions in enamel. Furthermore, the present invention promotes greater durability of the restorative treatment and deposits minerals in the regions of the carious lesion that were not properly infiltrated with resin. [005] Patent application US2012/0058152, dated 10/02/2009, describes a commonly used composition for bone regeneration based on resin and bioactive glass. However, two basic differences can be cited. The first difference refers to the presence of phosphated acid monomers in the composition of the present invention, which advantageously allows a high chemical bond to calcium and bone and dental tissues. Most cements for bone regeneration do not contain such monomers. The second and main difference is in the composition of the resinous organic phase, because while the resin for bone regeneration must be biodegradable and composed of a polymer with low mechanical properties, the dental composition of the present patent application is a resinous restorative material with high mechanical strength and with components essentially different from usual bone cements. Dental resin must be non-biodegradable and resistant to various external stimuli such as water, exactly the opposite of biodegradable bioglass-reinforced resin, with application in bone tissue, described in the document cited above. [006] Other documents were found concerning self-adhesive resinous dental materials employing acidic functional monomers similar to those that can be used in the present invention, such as US application 2010/0240795, dated 09/07/2009, and US patent 6,869,984. The self-adhesive resins described even contain filler particles that release fluorides; however, none of the documents show the addition of bioactive glass particles without the use of silanes. Bioactive glass particles release ions such as calcium, zinc, and phosphates, as well as some minerals that actively remineralize the surrounding dental tissues. The main difference between the present invention and the materials found in the documents cited above is the use of simple or modified bioactive particles containing beta-tricalcium phosphate and zinc oxide, and their use in conjunction with an infiltrating resin and phosphated acid monomers. [007] The bioactive glass particles employed in the present invention do not require silane bonding agents, since upon contact with water they release ions and minerals and at the same time undergo slight expansion, becoming attached to the polymer network. However, disadvantageously, self-adhesive restorative resins with fluoride-releasing particles need to be silanized, as presented