BR-102019017936-B1 - Cosmetic Composition and its Use, Dermocosmetic Formulation

Abstract

COSMETIC COMPOSITION AND ITS USE, DERMOCOSMETIC FORMULATION. The present invention relates to dermocosmetic formulations for use in combating skin aging, especially photoaging. The present invention promotes increased synthesis of collagen, elastin and glycosaminoglycans (GAGs), as well as significantly increasing the activity of the enzyme superoxide dismutase (SOD) and cell proliferation.

Inventors

• Erine Cardoso de Lima
• TALITHA FARINA BEZERRA
• Luiz Felipe de Oliveira Stehling
• Silvana Masiero

Assignees

• LUXBIOTECH FARMACÊUTICA LTDA

Dates

Publication Date

20260317

Application Date

20190828

Claims (20)

1. 1. Cosmetic composition characterized by comprising a combination of Sodium PCA, Sodium Lactate, Arginine, Aspartic Acid, PCA, Glycine, Alanine, Serine, Valine, Proline, Threonine, Isoleucine, Histidine, Phenylalanine, Olea europaea (olive) Leaf Extract, Butylene Glycol, Prunus mume Fruit Extract, Silanetriol, Rhamnose, Medicago sativa (Alfalfa) Extract, Ethylhexylglycerin, Glycerin, Microcitrus australasica Fruit Extract, Biosaccharide gum-1, Biosaccharide gum-2, Physalis angulata Extract, Caprylic Triglyceride and Capric Triglyceride.
2. 2. Cosmetic composition according to claim 1, characterized in that said composition further comprises moisturizing agents, chelating agents and cosmetically acceptable excipients, wherein the cosmetically acceptable excipients comprise surfactants, solvents, pH adjusting agents, skin protection agents, antioxidants, tonics, preservatives, opacifiers, antistatic agents, emollients, antiseborrheic agents, photoprotectors, emulsifiers and vehicles.
3. 3. Cosmetic composition according to claim 2, characterized in that the concentration range of the pH adjusting agents varies between 0.0150 to 0.5000% (w/w).
4. 4. Cosmetic composition according to claim 2, characterized in that the concentration range of the moisturizing agents varies between 0.0002 to 5.0000% (w/w).
5. 5. Cosmetic composition according to claim 2, characterized in that the concentration range of the preservatives varies between 0.0150 and 2.5000% (w/w).
6. 6. Cosmetic composition according to claim 2, characterized in that the concentration range of the emollients varies between 0.0002 to 5.0000% (w/w).
7. 7. Cosmetic composition according to claim 2, characterized in that the concentration range of the chelating agents varies between 0.1000 to 2.0000% (w/w).
8. 8. Cosmetic composition according to claim 2, characterized in that the concentration range of the protective agents varies between 0.0100 to 5.0000% (w/w).
9. 9. Cosmetic composition according to claim 2, characterized in that the concentration range of the antiseborrheic agents varies between 0.0002 to 5.0000% (w/w).
10. 10. Cosmetic composition according to claim 2, characterized in that the concentration range of the surfactants varies between 0.1000 to 12.5000% (w/w).
11. 11. Cosmetic composition according to claim 2, characterized in that the concentration range of the tonics varies between 0.1900% and 3.5000% (w/w).
12. 12. Cosmetic composition according to claim 2 characterized in that the concentration range of the vehicles varies between 0.0088 and 80.0000% (w/w).
13. 13. Cosmetic composition according to claim 2, characterized in that the pH adjusting agents are sodium hydroxide or citric acid.
14. 14. Cosmetic composition according to claim 2, characterized in that the chelating agents are selected from the group consisting of: disodium EDTA, pentasodium DTPA (pentasodium diethylenetriaminepentaacetate) and tetrasodium EDTA.
15. 15. Cosmetic composition according to claim 2, characterized in that the preservatives are selected from the group consisting of: Phenoxyethanol, Methylisothiazolinone, Methylchloroisothiazolinone, Methylparaben and Propylparaben.
16. 16. Cosmetic composition according to claim 2, characterized in that the emollients are selected from the group consisting of: Fucus Vesiculosus extract, Avena sativa kernel extract, Undecane and Zea mays wheat germ oil.
17. 17. Cosmetic composition according to claim 2, characterized in that the antiseborrheic agents are selected from the group consisting of: Coriandrum sativum Fruit/Leaf Extract, biotin, Camellia sinensis flower water and Phloretin.
18. 18. Cosmetic composition according to claim 2, characterized in that the surfactants are selected from the group consisting of: PEG-40 hydrogenated castor oil, ethoxylated sorbitan monooleate (polysorbate 80) and sorbitan monolaurate (Span 20).
19. 19. Cosmetic composition according to claim 2, characterized in that the tonics are selected from the group consisting of: Medicago sativa extract, Achillea millefolium extract, Aesculus chinensis extract and Angelica archangelica leaf extract.
20. 20. Cosmetic composition according to claim 2, characterized in that the vehicles are selected from the group consisting of: water, esters in general, mineral oil and vegetable oils and mixtures thereof, when in an emulsified system.

Description

FIELD OF THE INVENTION [0001] The present invention is directed towards the development of a dermocosmetic formulation for use in combating skin aging, especially photoaging. The present invention acts by increasing the synthesis of collagen, elastin and glycosaminoglycans (GAGs), in addition to significantly increasing the activity of the enzyme superoxide dismutase (SOD) and cell proliferation. FUNDAMENTALS OF THE INVENTION [0002] Skin aging can be classified in two ways: A. Intrinsic aging - or, as it is also known, chronological aging, is dependent on the genetics of each individual and, as the name suggests, is caused by time. B. Extrinsic aging - is that which results from factors external to the individual, that is, it can be caused by exposure of the skin to agents such as pollution, inadequate diet, but mainly, sun exposure. [0003] When aging is caused by sun exposure, it is called photoaging. This type of aging causes the appearance of spots on the skin, among other effects on the appearance of the skin. [0004] The search for substances that can slow down or reverse the skin aging process is a constant tool of research and development in the dermocosmetic field. Given these circumstances, the evaluation of the efficacy of compounds with antioxidant, immunomodulatory, protective, and skin homeostasis-regulating activities has been contributing to mitigating the aesthetic manifestations resulting from the accelerated aging process, especially photoaging. [0005] The severe appearance of the aging process is due, among other things, to drastic histological changes represented mainly by profound atrophy of the dermal architecture and destruction of important protein structures of the extracellular matrix (ECM) - especially collagen, elastin and glycosaminoglycans (GAGs) -, resulting in alterations that are often malignant or irreversible. [0006] Collagen and elastin form a three-dimensional network that constitutes the basic architecture of the dermis, in which other substances and various cell types are dispersed. Collagen is the most abundant macromolecule in connective tissue, and its main functions are to ensure the mechanical properties and structural integrity of tissues. Elastin is characterized by providing physical resistance to the skin, and its structure is especially involved in flexibility and plasticity. The polyanionic structure of GAG confers hydration retention power and is also responsible for interactions between the ECM and dermal cells, influencing cell signaling, differentiation, and proliferation processes. GAG molecules surround collagen, elastin, and dermal cells, especially fibroblasts, binding to water molecules and providing hydration to skin proteins. [0007] Furthermore, free radicals such as superoxides and hydroxyl radicals are formed by the oxidative phosphorylation process and cause damage to cellular constituents such as lipids, proteins, and especially nucleic acids. To try to reverse the damaging oxidative process, a mechanism called redox homeostasis is used by cells as an endogenous defense, and consists of a balance between the production of free radicals and their elimination by various antioxidant compounds and enzymes. This mechanism includes the enzymes superoxide dismutase (SOD), glutathione peroxidase, and catalase, as well as non-enzymatic reducing agents. [0008] In order to solve the problem of combating photoaging, several non-therapeutic techniques and forms of treatment are suggested in the literature and by another important segment, the cosmetic industry, which promotes treatments that use active ingredients incorporated into creams, cosmetic compositions, gels, elixirs, among others. [0009] For example, document BR 11 2012 007598 5 discloses a topical composition intended for the treatment of photoaging. However, in the aforementioned document, there are no teachings or data suggesting that the dermocosmetic composition of the present invention acts to increase the synthesis of collagen, elastin and glycosaminoglycans (GAG), in addition to significantly increasing the activity of the enzyme superoxide dismutase (SOD) and, mainly, cell proliferation. [0010] Thus, the development of a dermocosmetic formulation that acts as an antioxidant and is immunomodulatory, protective, and regulator of cutaneous homeostasis is urgently needed, so that it can be verified as an effect of combating photoaging, increasing the synthesis of collagen, elastin, and glycosaminoglycans (GAGs), in addition to a significant increase in the activity of the enzyme superoxide dismutase (SOD) and cell proliferation, measurable via quantification of the compound bromodeoxyuridine (BrdU). Quantification via BrdU is performed in tests on human fibroblasts, which are responsible for the production of collagen, elastin, and epithelial growth factors, minimizing the effect of photoaging significantly and superiorly to what is currently known in the state of the art. SUMMARY OF THE INVE