BR-102019024166-B1 - Photoprotective compositions, formulations including photoprotective compositions and their uses.

Abstract

PHOTOPROTECTIVE COMPOSITIONS, PHOTOPROTECTIVE FORMULATIONS INCLUDING PHOTOPROTECTIVE COMPOSITIONS, PREPARATION METHODS AND THEIR USES. The present invention relates to compositions based on clays, oils and/or plant extracts with photoprotective and/or antioxidant activity and inorganic sunscreens; formulations including photoprotective compositions; their preparation methods and their uses. Problem to be solved: to provide hybrid compositions between organic and inorganic photoprotective ingredients, which do not require the use of nanoparticulate or synthetic chemical sunscreens, which provide adjustable degrees of SPF and UVA protection, and which make it possible to obtain photoprotective formulations in different pharmaceutical or cosmetic forms. Solution to the problem: Photoprotective compositions are disclosed that contain at least one clay, at least one oil and/or plant extract with photoprotective and/or antioxidant activity, and at least one inorganic sunscreen; wherein said clay is present in the composition at a concentration of 0.1 to 85% by weight; wherein said oil and/or plant extract is present in the composition at a concentration of 0.2 to 80% by weight; and wherein said inorganic sunscreen is present in the composition at a concentration of 0.5 to 75% by weight. Furthermore, a photoprotective formulation is disclosed, as well as its method of preparation – including said photoprotective composition.

Inventors

• Soraia Gomes Zonta
• BIANCA RAMOS PEZZINI
• MARINA GOMES
• THIAGO CAON

Assignees

• UNIVERSIDADE FEDERAL DE SANTA CATARINA
• BIOART BIOCOSMÉTICOS LTDA - ME

Dates

Publication Date

20260317

Application Date

20191115

Claims (15)

1. 1. Photoprotective composition CHARACTERIZED by the fact that it contains synergistically effective quantities of clays, oils and/or plant extracts with photoprotective and/or antioxidant activity, and sunscreens, wherein: said sunscreens are exclusively of the inorganic type, present in a concentration of 0.5% to 75% by weight of the composition; said clays are of the Kaolin type, making up a total clay concentration of, at most, 24.99% by weight, based on the total weight of the composition; said oils and/or plant extracts with photoprotective and/or antioxidant activity are present in a concentration greater than 5% and less than 80% by weight in the composition.
2. 2. Photoprotective composition, according to claim 1, CHARACTERIZED in that: said inorganic sunscreens are of the non-nanoparticulate type.
3. 3. Photoprotective composition, according to claim 1, CHARACTERIZED in that said vegetable oils and/or extracts are selected from the following group: green tea extract, green coffee extract, calendula extract, yerba mate extract, ginger extract, rosemary essential oil, lemongrass essential oil, grapefruit essential oil, sweet orange essential oil, lavender essential oil, pitanga essential oil, verbena essential oil, açaí vegetable oil, karanja vegetable oil, rosehip vegetable oil.
4. 4. Photoprotective composition, according to claim 1, CHARACTERIZED in that said inorganic sunscreens are hydroxyapatite.
5. 5. Photoprotective formulation CHARACTERIZED by including a photoprotective composition, according to claim 1.
6. 6. Photoprotective formulation, according to claim 5, CHARACTERIZED by being in the form of an emulsion, dispersion, paste, powder or stick.
7. 7. Multifunctional formulation CHARACTERIZED by including a photoprotective composition, according to claim 1.
8. 8. Multifunctional formulation, according to claim 7, CHARACTERIZED by being in the form of an emulsion, dispersion, paste, powder or stick.
9. 9. Photoprotective formulation, according to claim 5, CHARACTERIZED in that it contains: Zinc oxide (and) Simmondsia chinensis (jojoba) seed oil (and) polyhydroxystearic acid (and) jojoba esters in a concentration of 9 to 21% by weight of the composition; Euterpe oleracea fruit oil (and) tocopherol in a concentration of 4 to 8% by weight of the composition; Titanium dioxide (and) ethyl macadamiate (and) silica (and) alumina (and) stearic acid (and) polyhydroxystearic acid in a concentration of 3 to 7% by weight of the composition; Heptyl undecylenate in a concentration of 2 to 4% by weight of the composition; Ethylhexyl olivate in a concentration of 1 to 3% by weight of the composition; A first type of Kaolin in a concentration of 0.5 to 5% by weight of the composition; A second type of Kaolin in a concentration of 0.5 5% by weight of the composition; Tapioca starch at a concentration of 0.5 to 3% by weight of the composition; Propanediol at a concentration of 4 to 8% by weight of the composition; Cetearyl olivate (and) sorbitan olivate at a concentration of 3 to 7% by weight of the composition; Cetyl palmitate (and) sorbitan palmitate (and) sorbitan olivate at a concentration of 1 to 5% by weight of the composition; Olive oil peg-7 esters at a concentration of 1 to 3% by weight of the composition; Glyceryl caprylate at a concentration of 0.5 to 1.5% by weight of the composition; Cymbopogon citratus flower water at a concentration of 18 to 22% by weight of the composition; Camellia sinensis leaf extract at a concentration of 0.5 to 1.5% by weight of the composition; Water in a concentration sufficient to make up 100% by weight of the composition.
10. 10. Photoprotective formulation, according to claim 5, CHARACTERIZED in that it contains: Tapioca starch in a concentration of 0.5 to 3% by weight of the composition; Polyglyceryl-2-stearate, glyceryl stearate, stearyl alcohol in a concentration of 6 to 12% by weight of the composition; Propanediol in 4 to 8% by weight of the composition; Olive oil peg-7 esters in a concentration of 1 to 3% by weight of the composition; Glyceryl caprylate in a concentration of 0.5 to 2% by weight of the composition; Euterpe oleracea fruit oil (and) tocopherol in a concentration of 3 to 7% by weight of the composition; Heptyl undecylenate in a concentration of 2 to 4% by weight of the composition; Ethylhexyl olivate in a concentration of 1 to 3% by weight of the composition; Cymbopogon citratus flower water in a concentration of 8 to 16% by weight of the composition; a first type of Kaolin in a concentration of 0.5 to 5% by weight of the composition; a second type of Kaolin in a concentration of 0.5 to 5% by weight of the composition; Water (Aqua) (And) Calendula officinalis Flower Extract (And) Phospholipids (From Soybean Lecithin) (And) Tocopheryl Acetate in a concentration of 1 to 5% by weight of the composition; Camellia sinensis leaf extract at a concentration of 0.5 to 3% by weight of the composition; Zinc Oxide (and) Simmondsia Chinensis (Jojoba) Seed Oil (and) Polyhydroxystearic Acid (and) Jojoba Esters at a concentration of 5 to 30% by weight of the composition; Titanium dioxide (and) ethyl macadamiate (and) silica (and) alumina (and) stearic acid (and) polyhydroxystearic acid at a concentration of 2 to 10% by weight of the composition; Aqua in a concentration sufficient to make up 100% by weight of the composition.
11. 11. Photoprotective formulation, according to claim 5, CHARACTERIZED in that it contains: Tapioca starch at a concentration of 2% by weight of the composition; Polyglyceryl-2-stearate, glyceryl stearate, stearyl alcohol at a concentration of 9% by weight of the composition; Propanediol at 6% by weight of the composition; Olive oil peg-7 esters at a concentration of 2% by weight of the composition; Glyceryl caprylate at a concentration of 1% by weight of the composition; Euterpe oleracea fruit oil (and) tocopherol at a concentration of 5% by weight of the composition; Heptyl undecylenate at a concentration of 3% by weight of the composition; Ethylhexyl olivate at a concentration of 2% by weight of the composition; Cymbopogon citratus flower water at a concentration of 10% by weight of the composition; A first type of Kaolin at a concentration of 2% by weight of the composition; A second type of Kaolin Water (Aqua) (And) Calendula officinalis Flower Extract (And) Phospholipids (From Soybean Lecithin) (And) Tocopheryl Acetate at a concentration of 3% by weight of the composition; Camellia sinensis leaf extract at a concentration of 1% by weight of the composition; Zinc Oxide (And) Simmondsia Chinensis (Jojoba) Seed Oil (And) Polyhydroxystearic Acid (And) Jojoba Esters at a concentration of 11% by weight of the composition; Titanium dioxide (and) ethyl macadamiate (and) silica (and) alumina (and) stearic acid (and) polyhydroxystearic acid at a concentration of 5% by weight of the composition; Aqua at a concentration of 37% by weight of the composition.
12. 12. Use of a photoprotective composition as claimed in claim 1, CHARACTERIZED by protecting against ultraviolet radiation and/or combating photoaging.
13. 13. Use of a photoprotective formulation as claimed in claim 5, CHARACTERIZED by protecting against ultraviolet radiation and/or combating photoaging.
14. 14. Use of a multifunctional formulation as per claim 7, CHARACTERIZED by protecting against ultraviolet radiation and/or combating photoaging.
15. 15. Use of a multifunctional formulation as claimed in claim 7, CHARACTERIZED by containing other additives to serve as makeup, and may be in the form of an emulsion, dispersion, paste, powder or stick.

Description

Field of Invention [0001] The present invention relates to: photoprotective compositions based on clays, oils and/or plant extracts with photoprotective and/or antioxidant activity and inorganic sunscreens; photoprotective formulations including photoprotective compositions; their preparation methods and their uses. Said compositions and formulations are suitable for pharmaceutical and cosmetic use, and can be used in products such as sunscreen and/or makeup, for example. Fundamentals of the Invention [0002] As is common knowledge, photoprotection of the skin is necessary to avoid sunburn, delay photoaging, reduce the chances of developing skin cancer, among other damage caused by ultraviolet (UV) radiation. [0003] Research reveals that exposure to UVA radiation can lead to effects as undesirable as those from UVB radiation. In this sense, sun protection products should protect against both UVA and UVB in a single formulation and have adequate SPF (Sun Protection Factor), UVA Protection Factor, and critical wavelength (nm) values. [0004] There are basically two types of sunscreens used to provide photoprotection, namely, inorganic (physical) UV filters and organic (chemical) UV filters. In addition, many sunscreens absorb or reflect radiation only in a part of the UV spectrum, generally making it necessary to combine sunscreens to obtain a broad-spectrum UVA/UVB photoprotective effect. [0005] Synthetic chemical sunscreens have a limited UV absorption spectrum; low photostability, which can result in toxic degradation products; in addition to the risk of photoallergic reaction and systemic absorption, which can cause endocrine disorders. [0006] On the other hand, physical sunscreens are safer, exhibit high photostability, and do not cause contact dermatitis or photoallergic reactions. The particle size of inorganic filters can be reduced, increasing the level of photoprotection by forming more uniform films on the skin and increasing the ability to reflect radiation. However, nanoparticulate sunscreens can permeate the skin, be cytotoxic, cause oxidative stress, DNA damage, nervous system damage, and cancer. [0007] Thus, in order to balance the advantages and disadvantages of inorganic and organic sunscreens, hybrid compositions, that is, those comprising both organic photoprotective agents and inorganic photoprotective agents, have emerged, each with its own particularity, such as those revealed in documents WO2015189630 and WO2015193644. [0008] In addition, other examples of solutions that in some way approximate the present invention and that, therefore, should be cited in this document are described in documents US20160303019 and US20120107253. [0009] By way of example, it is highlighted that document US20120107253 describes sunscreen formulations whose composition is specifically based on natural ocean clay, as well as known inorganic and/or organic sunscreens, in order to synergistically reinforce protection against UV radiation. According to the inventors, other clays were tested and caused agglomeration problems, reducing SPF and UVA protection values, and did not present the synergistic effect with sunscreens observed for natural ocean clay. [0010] To maintain the transparency of the formulation after application to the skin, many commercial formulations are prepared by combining nano-particulate titanium dioxide and zinc oxide. However, nanoscale compounds induce the formation of free radicals after exposure to solar radiation, leading to cell damage (photomutagenicity). To circumvent this problem, US20120107253 provides non-nanoparticulate zinc oxide as an inorganic sunscreen. [0011] Many sunscreens, coating and dispersing agents used in sun protection products can be irritating, toxic and photosensitizing. In addition, high amounts of oil may be used in the formulation, possibly making it comedogenic and giving the product unpleasant sensory attributes. [0012] Therefore, and despite the fact that the solutions described above are functional for the purposes for which they were developed, there is still a gap in the state of the art regarding the provision of hybrid compositions between organic and inorganic photoprotective ingredients that do not require the use of nanoparticulate or synthetic chemical sunscreens, that provide adjustable SPF and UVA protection, and that make it possible to obtain photoprotective formulations in different pharmaceutical or cosmetic forms with the following advantages: suitable for all skin phototypes; with a pleasant odor, dry touch, adequate spreadability on the skin; without an oily appearance and without intense whitening of the skin; non-sticky, non-irritating and non-allergenic; with antioxidant action, also allowing the addition of active ingredients effective in the treatment of various skin conditions, for example, acne, inflammation and photoaging, conferring additional benefits to the final products. [0013] It is based on this scenario that the invention