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BR-102024017925-A2 - PROCESS FOR OBTAINING NANOFIBERS FROM POLYMER SOLUTION, NANOFIBERS AND THEIR USES

BR102024017925A2BR 102024017925 A2BR102024017925 A2BR 102024017925A2BR-102024017925-A2

Abstract

The present invention relates to a process for obtaining nanofibers from a polymeric solution and essential oil, with deodorant and sweat-absorbing action. The nanofibers obtained are used as a polymeric matrix for deodorants and antiperspirants, as well as facial masks, foot and hand masks, anti-acne fiber or dressings, containing antibacterial or healing actives.

Inventors

  • VALÉRIA DE SOUZA SANTOS HOLSBACK
  • GISLAINE RICCI LEONARDI
  • RAFAEL CHELALA MOREIRA
  • JULIANO LEMOS BICAS
  • LONETÁ LAURO LIMA

Assignees

  • UNIVERSIDADE ESTADUAL DE CAMPINAS

Dates

Publication Date
20260317
Application Date
20240830

Claims (10)

  1. 1. Process for obtaining nanofibers characterized by comprising the following steps: (a) Preparation of the polymer solution; (b) Addition of active ingredients, mainly essential oil, extract and antibacterial active ingredient; preferably essential oil; and (c) Electrospinning of the polymer solution containing essential oil; (d) wherein the polymer solution comprises 8% to 10%, preferably 10% Ethylcellulose (EC) + Polyvinylpyrrolidone (PVP) in an 8:2 ratio solubilized in absolute ethanol; and (e) wherein the active ingredient comprises plant extracts, mainly essential oil of lemongrass, tea tree, sage, lavender, citronella, mint and/or plant extract of propolis, ginger, sage, aloe vera, witch hazel, peppermint, preferably comprising lemongrass essential oil, and optionally tea tree essential oil, at concentrations of 1% and 5%, preferably 1%.
  2. 2. Process, according to claim 1, characterized in that lemongrass essential oil has a minimum inhibitory concentration of 1.25 μL/mL and a minimum bactericidal concentration of 5.00 μL/mL against S. hominis.
  3. 3. Process, according to claim 1, characterized in that the electrospinning is carried out in conventional or portable electrospinning equipment, using a flow rate of 1 to 2 mL/hour, a voltage of 9kV, and attraction of the polymer solution by electrical potential difference to a collector at a distance of 7 to 12 cm from the needle, the polymer in the form of nanofibers being collected on a metal plate or directly on the skin.
  4. 4. Nanofibers characterized by being obtained according to the process described in claims 1 to 3 and comprising an 8% to 10% polymeric solution, preferably 10% Ethylcellulose (EC) + Polyvinylpyrrolidone (PVP) in an 8:2 ratio solubilized in absolute ethanol and preferably 1% lemongrass essential oil.
  5. 5. Nanofibers, according to claim 4, characterized in that they have an average diameter between 263 and 433 nm, preferably 348 nm.
  6. 6. Nanofibers, according to claim 4, characterized in that they exhibit degradation stages between 32°C and 430°C.
  7. 7. Nanofibers, according to claim 4, characterized in that they have the ability to absorb synthetic sweat, where the following physiological conditions are considered: temperature between 35 and 39 °C, preferably 37 °C, at pH between 4 and 7, preferably 5.5.
  8. 8. Nanofibers, according to claim 4, characterized in that they exhibit 0 to 20%, preferably 10-15%, more preferably 13% mass loss using synthetic sweat, wherein the following physiological conditions are considered: temperature between 35 and 39 °C, preferably 37 °C, at pH between 4 and 7, preferably 5.5.
  9. 9. Use of nanofibers according to claims 4 to 8, characterized by being used as a polymeric matrix for deodorants and antiperspirants.
  10. 10. Use, according to claim 9, characterized by the fact that it is also suitable for facial masks, foot and hand masks, anti-acne fiber or dressings, containing antibacterial or healing active ingredients.

Description

Field of invention [001] The present invention relates to a process for obtaining nanofibers from a polymeric solution and essential oil, with deodorizing and sweat-absorbing action. [002] The field of application of the present invention is Cosmetics and Personal Hygiene, more precisely in the area of developing new materials for controlling body odor and perspiration. Fundamentals of the invention [003] Deodorants and antiperspirants represent a category of personal hygiene products widely used for controlling body odor and reducing perspiration. While deodorants primarily aim to neutralize odor associated with bacterial activity on the skin, antiperspirants aim primarily to reduce the amount of sweat released by temporarily obstructing the sweat duct. Both products are frequently formulated with active ingredients, which may be antimicrobial agents, fragrances, and antiperspirant agents, aiming to provide protection against odor and/or sweat throughout the day (OLIVEIRA, E.C.V.; SALVADOR, D.S.; HOLSBACK, V.S.S. et al. Deodorants and antiperspirants: identification of new strategies and perspectives to prevent and control malodor and sweat of the body. International Journal of Dermatology. v.60(5), pp.613-619, 2021; KANLAYAVATTANAKUL, M; LOURITH, N. Body malodours and their topical treatment agents. International Journal of Cosmetic Science, v.33, p.298-311, 2011). [004] Consumer demand for more effective, safe, and sustainable products has been increasing significantly in recent years. The growing popularity of natural deodorants is noteworthy; they avoid the use of controversial ingredients such as parabens, triclosan, and aluminum, in favor of naturally derived ingredients like essential oils and plant extracts (OLIVEIRA, E.C.V.; SALVADOR, D.S.; HOLSBACK, V.S.S. et al. Deodorants and antiperspirants: identification of new strategies and perspectives to prevent and control malodor and sweat of the body. International Journal of Dermatology. v.60(5), pp.613-619, 2021). The use of essential oils in deodorants is a field of interest due to the potential antimicrobial and aromatic properties they offer. Monoterpene compounds, such as limonene, carvacrol, linalool, among others, are related to antibacterial activity, and many essential oils have been investigated for their ability to inhibit the growth of bacteria present on the skin (TEERASUMRAN, P.; VELLIOU, E.; BAI, S.; CAI, Q. Deodorants and antiperspirants: New trends in their active agents and testing methods. International Journal of Cosmetic Science. v.45, pp.426-443, 2023; KANLAYAVATTANAKUL, M; LOURITH, N. Body malodors and their topical treatment agents. International Journal of Cosmetic Science, v.33, p.298-311, 2011). [005] There is a growing demand for cosmetic and dermatological products that offer superior performance and safety, which drives the development and presentation of new ingredients, technologies and/or new ways of delivering active ingredients. In this context, electrospinning proves to be an interesting technique because it is capable of producing fibers with different properties, transporting actives and sustaining their release, as well as protecting them from degradation (RAHMATI, M.; MILLS, D.K.; URBANSKA, A.M.; et al. Electrospinning for tissue engineering applications. Progress in Materials Science, v.117, 2021). [006] Electrospinning is a technique that allows the production of fibers on a nanometric scale from an electrically charged polymer solution. Nanofibers are a differentiated material because they have a large surface area, flexibility, high mechanical performance (e.g., stiffness and tensile strength), porosity, and the ability to transport active ingredients within their structure, allowing for increased availability of the active agent to the target site. Such properties make polymeric nanofiber a potential candidate for many applications (LURAGHI, A.; PERI, F.; MORONI, L. Electrospinning for drug delivery applications: A review. Journal of Controlled Release, V.334, p. 463-484, 2021; RAHMATI, M.; MILLS, D.K.; URBANSKA, A.M.; et al. Electrospinning for tissue engineering applications. Progress in Materials Science, v.117, 2021; [007] Among the current applications derived from these materials, there are examples such as filtration membranes with high selectivity, coating of medical prostheses, and development of dressings and scaffolds for tissue recovery, such as skin, cartilage, and bone. With regard to drug delivery applications, nanofibers offer opportunities as an encapsulation and release system for different active compounds, such as antibiotics, antitumor agents, proteins, and antimicrobial agents (LURAGHI, A.; PERI, F.; MORONI, L. Electrospinning for drug delivery applications: A review. Journal of Controlled Release, V.334, p. 463-484, 2021; RAHMATI, M.; MILLS, D.K.; URBANSKA, A.M.; et al. Electrospinning for tissue engineering applications. Progress in Materials Science, v.117, 2021; [008] The typical