BR-102024018089-A2 - Formulation based on extract of the aerial parts of Stachys byzantina K. Koch (peixinho-da-horta)

BR102024018089A2BR 102024018089 A2BR102024018089 A2BR 102024018089A2BR-102024018089-A2

Abstract

This invention relates to a cosmetic formulation incorporating the ethanolic extract of Stachys byzantina with multifunctional anti-aging action, free of petroleum derivatives, parabens and allergenic agents, eco-friendly and with a natural surfactant. The technology offers the benefit of mitigating cellular senescence and skin aging through antioxidant and anti-glycation action and ultraviolet protection.

Inventors

NÍCOLAS DE CASTRO CAMPOS PINTO
VICTOR CAMPANA LEITE
MARIA FERNANDA FERNANDES

Assignees

UNIVERSIDADE FEDERAL DE JUIZ DE FORA - UFJF

Dates

Publication Date: 20260317
Application Date: 20240902

Claims (2)

1. FORMULATION BASED ON EXTRACT OF THE AERIAL PARTS OF Stachys byzantina K. KOCH (PEIXINHO-DA-HORTA), characterized by comprising: a) Glycerin (5%-20%); b) Sepiplus (2.5% - 15%); c) Simulgel (2.5% - 15%); d) Olivem 1000 (2% - 12%); e) Caprylic/Caproic Acid Triglycerides (3% - 20%); f) Vitamin E (1%-10%); g) Optfen (1% -15%); h) Ethanolic extract of the aerial parts of S. byzantina (1% - 30%); i) Water qsp.
2. Formulation based on extract of the aerial parts of Stachys byzantina K. Koch (peixinho-da-horta), according to claim 1, characterized by its antioxidant, antiglycation and ultraviolet protection properties.

Description

TECHNICAL FIELD [001] The present invention relates to a cosmetic formulation incorporating the ethanolic extract of Stachys byzantina, contemplated in the pharmaceutical sector. The technology offers the benefit of mitigating cellular senescence and skin aging through antioxidant, anti-glycation action and ultraviolet protection. STATE OF THE ART [002] The use of medicinal plants for the treatment, cure, and prevention of diseases stands out as one of the oldest forms of medicinal practice known to humankind. Nature represents an important source of bioactive compounds with therapeutic potential originating from microbial, plant, or other living organisms. The pharmacological activities of these metabolites can contribute to the cure and/or treatment of illnesses, and therefore, these products are of paramount importance for the development of new drugs (HUANG et al., 2021; NEWMAN; CRAGG, 2020). [003] Brazil is the country with the greatest biodiversity in the world, comprising more than 15% of all living species on the planet and, therefore, can play a prominent role in the development of new therapeutic technologies based on natural products (ELLWANGER et al., 2023; VALLI et al., 2018). [004] The genus Stachys belongs to the Lamiaceae family and comprises 300 species spread throughout the world (TUNDIS et al., 2014). The Lamiaceae family occupies a prominent position as one of the largest and most widespread families of flowering plants. Within this family there are more than 7,200 species and 240 genera, among which the following stand out: Salvia (900 species), Scutellaria (360 species), Stachys (300 species), Plectranthus (300 species), Hyptis (280 species), Teucrium (250 species), Vitex (250 species), Thymus (220 species) and Nepeta (200 species) (KUKIC-MARKOVIC, 2013). The species Stachys byzantina originates from Turkey, Asia and the Caucasus, but can also be found in regions with mild climates, where temperatures vary between 5 and 30 °C, such as in the South, Southeast and Midwest regions of Brazil. It is popularly known as peixinho-da-horta, orelha-de-lebre, lambari-de-folha or pulmonária (KINUPP; LORENZI, 2015; BRASIL, 2010). [005] In folk medicine, the aerial parts of the Stachys byzantina plant are used to treat various comorbidities such as infections, wounds, asthma, dysentery, epilepsy, digestive disorders, colds, rheumatic disorders, and neuropathy (LASHGARGAHI; SHAFAGHAT, 2017; ASNAASHARI et al., 2010). The leaves also have a notable amount of protein, making them highly viable as a protein source in diets that exclude animal products, such as strict vegetarian diets (SILVA et al., 2018). [006] Very preliminary studies on the properties of this plant have already demonstrated antioxidant, antibacterial, anti-inflammatory, antitumor and anticancer potential. In addition, S. byzantina has shown potential anti-obesity, antidiabetic and anti-hyperpigmentation effects. Sedative and diuretic effects are also reported in the treatment of digestive disorders, wounds, asthma, rheumatic disorders, dysentery, epilepsy, colds and neuropathy in folk medicine (BAHADORI et al., 2020a; BAHADORI et al. 2020b; DEMIRTAS et al. 2013; MANAFI et al. 2010; ASNAASHARI et al. 2010). [007] Several classes of natural compounds responsible for its biological activities have been isolated from different parts of the genus Stachys. Phytochemical investigations have shown the occurrence of iridoids, flavonoids, diterpenoids, saponins, and phenolic acids as secondary metabolites of Stachys (SAFARKAR et al. 2017; PIOZZI; BRUNO, 2011; KHANAVI M et al., 2005). The enzyme inhibition action present in Stachys is also reported in the literature, for enzymes such as cholinesterase, α-amylase, α-glucosidase, and tyrosinase, and is directly associated with the presence of catechins, p-hydroxybenzoic acid, chlorogenic acid, caffeic acid, ferulic acid, apigenin, and other compounds reported in these plant extracts (SARIKURKCU et al., 2015). [008] Parallel to the development of natural products, the incidence of various types of epithelial diseases and disorders is growing, and already affects a large part of the world's population. It is estimated that approximately one third of the world's population is affected by at least one skin condition, making dermatological diseases the fourth most common cause of all human diseases. (FLOHR; HAY, 2021; DESSIE et al., 2022). Hyperpigmentation and skin aging are among the main alterations that affect the personal characteristics and aesthetic appearance of the world's population (PIRES et al., 2022; VASCONCELOS, 2022). [009] Skin aging is a complex process involving structural, cellular, and extracellular matrix changes. It can be divided into intrinsic aging, which is determined by genetic factors and therefore represents a major challenge for the cosmetic industry, as it cannot be completely controlled, and extrinsic aging, which is influenced by environmental factors and the skin care p