BR-102024018249-A2 - Formulation based on mucilage from the leaves of Pereskia aculeata Miller

BR102024018249A2BR 102024018249 A2BR102024018249 A2BR 102024018249A2BR-102024018249-A2

Abstract

This invention relates to an innovative formulation developed from the leaf extract of Pereskia aculeata, characterized by its prebiotic and antioxidant potential. This technology aims to offer an alternative therapeutic approach for the treatment of various skin conditions associated with skin microbiota imbalance and oxidative stress. Among the conditions treated by this topical formulation are atopic dermatitis, hidradenitis suppurativa, dry skin, acne, seborrheic dermatitis, and psoriasis, among others. The application of this formulation is intended for the pharmaceutical and cosmetic sectors, providing an effective and natural treatment option to promote skin health, restore microbial balance, and combat oxidative damage.

Inventors

NAIARA NORBERTO TAVARES DE OLIVEIRA
MARTHA EUNICE DE BESSA
ELITA SCIO FONTES

Assignees

UNIVERSIDADE FEDERAL DE JUIZ DE FORA - UFJF

Dates

Publication Date: 20260317
Application Date: 20240904

Claims (2)

1. Formulation based on mucilage from Pereskia aculeata Miller leaves, characterized by comprising: a) Hydroxyethylcellulose (0.5% to 1.0%); b) Mucilaginous extract of Pereskia aculeata (EMP) (3%); c) Glycerin (5%); d) Potassium sorbate (0.2%); e) Citric acid (0.05%); f) Triethanolamine (q.s.p. neutralization); g) Distilled water (q.s.p. 100 mL).
2. Formulation based on mucilage from the leaves of Pereskia aculeata Miller, according to claim 1, characterized by its prebiotic and antioxidant properties.

Description

TECHNICAL FIELD [001] The present invention relates to an innovative formulation developed from the extract of Pereskia aculeata leaves, characterized by its prebiotic and antioxidant potential. This technology aims to offer an alternative therapeutic approach for the treatment of various skin conditions associated with skin microbiota imbalance and oxidative stress. Among the conditions treated by this topical formulation are atopic dermatitis, hidradenitis suppurativa, dry skin, acne, seborrheic dermatitis, and psoriasis, among others. The application of this formulation is intended for the pharmaceutical and cosmetic sectors, providing an effective and natural treatment option to promote skin health, restore microbial balance, and combat oxidative damage. STATE OF THE ART [002] Natural products represent an unparalleled source of bioactive compounds, constituting a valuable economic resource for the cosmetics, pharmaceutical, and food industries. In recent years, one of the growing areas is the use of plant extracts as prebiotics. These prebiotics are defined as non-digestible carbohydrates that promote the growth or activity of specific groups of beneficial bacteria in the colon (NATH et al, 2018). [003] These substances are characterized by their effectiveness at low dosages, absence of side effects, and persistence in the intestinal tract. The best-known prebiotics include fructans, such as inulin, oligosaccharides, sugar alcohols, and complex polysaccharides, such as cellulose and β-glucans (LOLOU, PANAYIOTIDIS, 2019). [004] In addition to their use for the gut microbiota, prebiotics also have applications in the skin microbiota. The skin, the largest organ in the human body, acts as a barrier against extrinsic factors, such as physical, chemical, and microbiological threats. There is a strong symbiosis between the microorganisms that make up the skin microbiota, which plays a fundamental role in supporting the immune system. This microbiota contributes to the production of antimicrobial substances, such as lactic acid, and participates in the activation of signaling cascades that modulate the inflammatory response. Furthermore, the presence of a healthy skin microbiota is closely linked to its hydration and the maintenance of the health of this organ (LOLOU, PANAYIOTIDIS, 2019, SUGAWARA, et al., 2012; THUESON, et al., 1998.). [005] Another area of study that is gaining prominence is that of natural active ingredients with antioxidant potential, due to the harmful effects of reactive oxygen species (ROS) on various parts of the human body. Oxidative stress plays a central role in inducing inflammatory reactions in the body, being closely associated with the development of chronic diseases such as cancer, diabetes mellitus, atherosclerosis, and neurodegenerative diseases related to aging (ZAGÓRSKA-DZIOK, et al., 2021). In addition, free radicals are strongly related to skin aging, whether through the natural aging process or extrinsic factors such as UV radiation. They also contribute to inflammatory processes in the skin and the appearance of tumors (CRISTIANA, ELENA, 2018). Thus, natural ingredients with antioxidant capacity represent great potential for the pharmaceutical and cosmetic industries, due to their ability to reduce the degradation of tissues and cells in the human body caused by free radicals (ZAGÓRSKA-DZIOK, et al., 2021). [006] In this context, it is known that since the dawn of time, substances of natural origin have been used to manufacture skin care products, whether these substances are derived from mineral, animal or vegetable sources. The use of these natural ingredients is a growing trend, due to the influence of the internet and social media. It is estimated that in recent years (2015 to 2019), the market for natural products grew by around 10 to 11% per year, representing an opportunity for the cosmetics industry, since consumers are willing to pay more for these products (FERREIRA, et al., 2021). [007] It is estimated that approximately one third of the ingredients listed in the INCI (International Nomenclature of Cosmetic Ingredients) system of the Personal Care Products Council are classified as botanical extracts. These ingredients include plant extracts, tinctures, waxes, vegetable oils, lipids, plant carbohydrates, essential oils, and isolated plant substances such as vitamins, antioxidants, and other active ingredients with recognized biological activity (FERREIRA, et al., 2021). [008] The leaves of Pereskia aculeata Miller, popularly known as ora-pro-nobis, are traditionally used as an emollient and in the treatment of skin wounds and inflammatory processes. In addition, it is consumed as a food supplement by the population, being considered a non-conventional food plant (PANC) (BESSA, 2020; PINTO, 2016). [009] A study conducted by Bessa (2020) demonstrated the prebiotic and antioxidant activity of a carbohydrate-rich extract from the species P. aculeata in relation t