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BR-102024018271-A2 - PROCESS FOR THE PRODUCTION OF ADDITIVATED FILLER CEMENT, ADDITIVATED FILLER CEMENT AND ITS USES

BR102024018271A2BR 102024018271 A2BR102024018271 A2BR 102024018271A2BR-102024018271-A2

Abstract

The present invention relates to processes for the production of additive-enhanced obturation cement, said additive-enhanced obturation cement, and related uses. The addition of plasticizers in the preparation of obturation cements improves the handling and plasticity characteristics of bioceramic cements. Furthermore, the additive-enhanced obturation cement described in this technology exhibits improved cell viability and physicochemical properties. The additive-enhanced cement of the present invention has applications in endodontics, for example, in root canal obturation procedures.

Inventors

  • MARINA ANGÉLICA MARCIANO DA SILVA
  • THIAGO BESSA MARCONATO ANTUNES
  • GABRIEL BISPO CARVALHO

Assignees

  • UNIVERSIDADE ESTADUAL DE CAMPINAS

Dates

Publication Date
20260317
Application Date
20240905

Claims (20)

  1. 1. Process for producing a dental composition characterized by comprising the mixing of a PVA-based plasticizer with a dental cement, wherein the dental composition is an additive-enhanced obturation cement.
  2. 2. Process for producing dental composition, according to claim 1, characterized by comprising the steps of: a) Preparation of the liquid phase (plasticizer); b) Preparation of the powder phase; and c) Spatulation of the cement.
  3. 3. Process for producing dental composition, according to claim 1 or 2, characterized by additionally comprising a step for measuring the viscosity of the liquid phase.
  4. 4. Process for producing dental composition, according to claims 1 to 3, characterized in that the liquid phase is prepared from dissolving powdered polyvinyl alcohol in distilled water, at a concentration in the range of 2% (w/v) to 6% (w/v), preferably at a concentration of 4% (w/v).
  5. 5. Process for producing dental composition according to claims 1 to 4, characterized in that the viscosity of the liquid phase is from 50 cP (0.05 Pa.s) to 70 cP (0.07 Pa.s), preferably in that the viscosity is from 55 cP (0.055 Pa.s) to 65 cP (0.065 Pa.s).
  6. 6. Process for producing dental composition, according to claims 1 to 5, characterized in that the powder phase is prepared from a mixture of 20% to 30% (w/w) of a radiopacifying agent and 70% to 80% (w/w) cement, based on the total weight of the powder phase.
  7. 7. Process for producing dental composition, according to claims 1 to 6, characterized in that the radiopacifying agent and the cement are preferably in a ratio of 25:75.
  8. 8. Process for producing dental composition, according to claims 1 to 7, characterized in that the radiopacifying agent is selected from the group comprising zinc oxide, bismuth oxide, barium oxide, calcium tungstate, barium sulfate, tantalum oxide, or combinations thereof, preferably in which the radiopacifier is zirconium oxide.
  9. 9. Process for producing dental composition, according to claims 1 to 8, characterized in that the cement is selected from the group comprising tricalcium and dicalcium silicates, preferably in that the cement is white Portland cement.
  10. 10. Process for producing dental composition, according to claims 1 to 9, characterized by the spatulation comprising mixing the powder phase with the liquid phase, in a ratio of 3:2 (w/v).
  11. 11. Dental composition, as obtained by the process defined in claims 1 to 10, characterized by comprising: a powder phase comprising 70% to 80% (w/w) of a cement and 20% to 30% (w/w) of a radiopacifying agent, based on the total weight of the powder phase; and a liquid phase comprising 2% to 6% (w/v) of polyvinyl alcohol (PVA), wherein the powder phase and the liquid phase are in a ratio of 3:2 (w/v).
  12. 12. Dental composition, according to claim 11, characterized in that the cement is selected from the group comprising tricalcium and dicalcium silicates, preferably in that the cement is white Portland cement.
  13. 13. Dental composition, according to claim 11 or 12, characterized in that the radiopacifying agent is selected from the group comprising zinc oxide, bismuth oxide, barium oxide, calcium tungstate, barium sulfate, tantalum oxide, or combinations thereof, preferably in which the radiopacifier is zirconium oxide.
  14. 14. Dental composition, according to claims 11 to 13, characterized in that the liquid phase is an aqueous solution comprising between 2% and 6% (w/v) of PVA, preferably, wherein the liquid phase is a 4% (w/v) PVA solution.
  15. 15. Dental composition, according to claims 11 to 14, characterized in that the dental composition is an additive-enhanced obturation cement.
  16. 16. Dental composition, according to claims 11 to 15, characterized by having an alkaline pH.
  17. 17. Dental composition, according to claims 11 to 16, characterized by having low solubility and solubility in the range of 0.01% to 3%, preferably in the range of 0.1% to 1%, more preferably still in which the solubility is 0.21%.
  18. 18. Dental composition, according to claims 11 to 17, characterized by having a setting time of less than 60 minutes, preferably less than 50 minutes, more preferably by having a setting time of 45 minutes.
  19. 19. Dental composition, according to claims 11 to 18, characterized by having a cell viability above 100%, preferably above 110%, preferably above 120%, preferably above 130%, and even more preferably above 140%.
  20. 20. Use of cement, radiopacifying agent and polyvinyl alcohol characterized by being in the manufacture of a dental composition, as defined in claims 11 to 19, for endodontic treatments.

Description

FIELD OF THE INVENTION: [001] The present invention falls within the field of endodontics, more precisely in the preparation of root canal obturation cement. [002] Thus, the present invention describes a process for producing additive-enhanced filling cement and said additive-enhanced filling cement which exhibits improved results for physicochemical properties and cell viability. BACKGROUND OF THE INVENTION: [003] Success in endodontic treatment depends on several factors, including both the technique used and the obturation material. Previously, calcium silicate-based cements were mixed with water to ensure setting (hardening). However, cements mixed with water have a sandy characteristic and therefore present problems regarding their handling and the plasticity of the resulting cements. For this reason, techniques employing the addition of plasticizers in the cement formulation have been studied. [004] Thus, the second generation of silicate-based cements, also called bioceramics, is characterized by the addition of plasticizers in order to improve the rheological characteristics of the cements. For example, the addition of polymers such as polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), polycarboxylate (PC) and propylene glycol (PPG) has been studied. For example, patent BR1020130213080B1 teaches a dental cement binder composition and its production process, in which propylene glycol, polyethylene glycol 400 and glycerin were used as plasticizers in the preparation of the cement. In turn, patent EP1727507B1 discloses a hybrid composite material of dental bioceramic cement and polymer derived from MTA combined with various polymers, such as polyvinylpyrrolidone, polyvinyl acetate, 2-hydroxyethyl methacrylate, sodium n-dodecyl sulfate, and phosphorylcholine, and the resulting composite material can be incorporated into an acceptable filling material, such as gutta-percha. [005] The state of the art also presents some investigations related to the use of polyvinyl alcohol (PVA) in dental compositions. For example, the studies by Yamamoto, M. et al. (2012), entitled “Newly developed mineral trioxide aggregate containing polyvinyl alcohol”, published in Dental Materials Journal, investigate the apatite-forming capacity and viscosity of an MTA-PVA paste for dental treatments. Similarly, the studies by Noh, Y.S., et al. (2015), entitled “Mechanical properties and microstructure analysis of mineral trioxide aggregate mixed with hydrophilic synthetic polymer”, published in Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology, investigate the application of a PVA-modified liquid to improve the handling properties of mineral trioxide aggregate (MTA). In turn, the studies by Yousefi, K., et al. (2020), entitled “Nanocement/poly(vinyl alcohol) composites for endodontic applications”, published in Materials Chemistry and Physics, investigate the effects of poly(vinyl alcohol) on the physical, mechanical and clinical properties of a Nano Fast Cement (NFC) for dental purposes. [006] However, although the addition of these polymers preliminarily solves the problems related to cement rheology, for the success of the operation, it is also important that the cement used in endodontic treatments also presents interesting characteristics, such as low solubility, favorable setting time (hardening), and alkaline pH. In addition, considering better recovery, it is important that the cements are also biocompatible and exhibit good cellular responses. [007] Thus, it is seen that the state of the art lacks alternatives for additive-enhanced obturating cement that has interesting results with high cell viability and low solubility like that of the present invention. [008] Therefore, the need to develop technologies capable of overcoming the problems related to the rheology of obturation cements, while maintaining low solubility and favoring cell viability, is undeniable. BRIEF DESCRIPTION OF THE INVENTION: [009] Initially, it should be noted that the following description is based on preferred embodiments of the invention, without being limited to them. The present invention describes a process for producing additive-enhanced sealing cement and said additive-enhanced sealing cement which exhibits improved results for physicochemical properties and cell viability. [0010] Thus, the present invention discloses processes for producing a dental composition comprising mixing a PVA-based plasticizer with a dental cement, wherein the dental composition is an additive-enhanced obturation cement. In one embodiment of the invention, the process for producing the dental composition comprises steps of preparing the liquid phase (plasticizer); preparing the powder phase; and spatulating the cement. In one embodiment of the present invention, the liquid phase is prepared by dissolving powdered polyvinyl alcohol in distilled water at a concentration in the range of about 2% (w/v) to about 6% (w/v). In a preferred embodiment of th