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BR-112016013498-B1 - Oral care composition, method for reducing bad breath and use of said composition.

BR112016013498B1BR 112016013498 B1BR112016013498 B1BR 112016013498B1BR-112016013498-B1

Abstract

ANTI-BAD ODOR ORAL CARE COMPOSITION. An oral care composition comprising: arginine in salt or free form; and zinc ions, wherein the zinc ions are present in the composition at a concentration of 0.0001 mol/100g to 0.0150 mol/100g, based on the total weight of the composition.

Inventors

  • Joe Vazquez
  • HARSH M. TRIVEDI
  • LaTonya Kilpatrick-Liverman
  • Stacey Lavender

Assignees

  • COLGATE-PALMOLIVE COMPANY

Dates

Publication Date
20260317
Application Date
20131219

Claims (13)

  1. 1. Oral care composition, CHARACTERIZED by comprising: a. arginine in free form or salt; and b. zinc ions, wherein the zinc ions are present in the composition at a concentration of 0.00052 mol/100g to 0.00062 mol/100g, based on the total weight of the composition.
  2. 2. Oral care composition, according to claim 1, CHARACTERIZED in that arginine is present in the composition at a concentration of 0.1% by weight to 1% by weight, based on the total weight of the composition.
  3. 3. Oral care composition, according to claim 1 or 2, CHARACTERIZED in that arginine is present in the composition at a concentration of 0.5% by weight to 0.8% by weight, based on the total weight of the composition.
  4. 4. Oral care composition, according to any one of claims 1 to 3, CHARACTERIZED in that the zinc ions are provided by at least one zinc compound chosen from zinc oxide, zinc lactate, zinc chloride, zinc citrate, zinc acetate, zinc borate, zinc butyrate, zinc carbonate, zinc formate, zinc gluconate, zinc glycerate, zinc glycolate, zinc phosphate, zinc picolinate, zinc propionate, zinc salicylate, zinc silicate, zinc stearate, zinc tartrate, zinc undecylenate, zinc phosphate, zinc ricinoleate, zinc nitrate, and zinc sulfate.
  5. 5. Oral care composition, according to any one of claims 1 to 4, CHARACTERIZED in that the zinc ions are supplied by a zinc compound selected from the group consisting of zinc oxide, zinc lactate, zinc chloride and zinc citrate.
  6. 6. Oral care composition, according to any one of claims 1 to 5, CHARACTERIZED in that arginine is present as free arginine.
  7. 7. Oral care composition, according to any one of claims 1 to 6, CHARACTERIZED in that arginine is present as an arginine salt selected from the group consisting of arginine bicarbonate, arginine hydroxide, arginine carbonate, arginine phosphate and mixtures thereof.
  8. 8. Oral care composition, according to any one of claims 1 to 7, CHARACTERIZED in that the composition further comprises an orally acceptable vehicle.
  9. 9. Oral care composition, according to any one of claims 1 to 8, CHARACTERIZED in that the composition is a toothpaste, a gel, a mouthwash, a mouth rinse, a lozenge, a spray, a gum, a tablet or a film.
  10. 10. Oral care composition, according to any one of claims 1 to 9, CHARACTERIZED in that the composition is a mouthwash.
  11. 11. Oral care composition, according to any one of claims 1 to 10, CHARACTERIZED in that the composition is a toothpaste.
  12. 12. A method for reducing bad breath in the oral cavity of a subject, CHARACTERIZED in that the method comprises applying the oral care composition, as defined in any one of claims 1 to 11, to the oral cavity.
  13. 13. Use of the oral care composition, as defined in any of claims 1 to 11, CHARACTERIZED by being for making a cosmetic personal hygiene composition to reduce bad breath.

Description

FUNDAMENTALS [001] One of the biggest contributors to bad breath in the oral cavity is the bacteria present in the soft and hard oral tissues. Manual brushing and rinsing help to remove the bacteria, but they eventually repopulate over a period of time. [002] Zinc ions act as a bacteriostatic agent by binding with bacteria and slowing the growth phase, leading to slower cell division and repopulation. Zinc salts in oral care products are known to react with sulfur compounds found in bad breath. For example, the reaction of zinc oxide with hydrogen sulfide produces odorless zinc sulfide. [003] However, there is still a need in the art for oral care compositions that are even more effective in reducing bad breath than previous zinc ion-containing compositions. BRIEF SUMMARY [004] A first aspect of the present invention provides an oral care composition comprising: arginine in free form or salt; and zinc ions, wherein the zinc ions are present in the composition at a concentration of 0.0001 mol/100g to 0.015 mol/100g, based on the total weight of the composition. [005] Optionally, zinc ions are present in the composition at a concentration of 0.00025 mol/100g to 0.005 mol/100g, based on the total weight of the composition. [006] Optionally, zinc ions are present in the composition at a concentration of 0.0004 mol/100g to 0.0015 mol/100g, based on the total weight of the composition. [007] Optionally, zinc ions are present in the composition at a concentration of 0.00050 mol/100g to 0.001 mol/100g, based on the total weight of the composition. [008] Optionally, zinc ions are present in the composition at a concentration of 0.00052 mol/100g to 0.00062 mol/100g, based on the total weight of the composition. [009] Optionally, arginine is present in the composition at a concentration of 0.1% by weight to 1% by weight, based on the total weight of the composition. [010] Optionally, arginine is present in the composition at a concentration of 0.5% by weight to 0.8% by weight, based on the total weight of the composition. [011] Optionally, zinc ions are supplied, but not limited to, zinc oxide, zinc lactate, zinc chloride, zinc citrate, zinc acetate, zinc borate, zinc butyrate, zinc carbonate, zinc formate, zinc gluconate, zinc glycerate, zinc glycolate, zinc phosphate, zinc picolinate, zinc propionate, zinc salicylate, zinc silicate, zinc stearate, zinc tartrate, zinc undecylenate, zinc ricinoleate, zinc nitrate, zinc sulfate, or mixtures thereof. [012] Optionally, zinc ions are supplied by zinc oxide. [013] Optionally, zinc ions are supplied by zinc lactate. [014] Optionally, zinc ions are supplied by zinc chloride. [015] Optionally, zinc ions are supplied by zinc citrate. [016] Optionally, arginine is present as free arginine. [017] Optionally, arginine is present as arginine bicarbonate. [018] Optionally, arginine is present as a peptide having 2-4 amino acid units, at least one of which is arginine. [019] Optionally, the composition further comprises one or more selected abrasives, diluents, additional bicarbonate salts, pH modifying agents, surfactants, foam modulators, thickening agents, humectants, sweeteners, flavorings, pigments, antibacterial agents, anti-caries agents, anti-calculus or tartar control agents, bleaching agents, and mixtures thereof. [020] Optionally, the composition is a toothpaste, a gel, a mouthwash, a mouth rinse, a lozenge, a spray, a gum, a tablet, or a film. [021] Optionally, the composition is a mouthwash. [022] Optionally, the composition is a toothpaste. [023] In a second aspect, the present invention provides a method for reducing bad breath in a subject's oral cavity, the method comprising applying an oral care composition of the present invention to the oral cavity. [024] In a third aspect, the present invention provides use, in an oral care composition, of a combination of: arginine in free form or as a salt; and zinc ions, wherein the zinc ions are present in the composition at a concentration of 0.0001 mol/l00g to 0.015 mol/l00g based on the total weight of the composition, to reduce bad breath. DETAILED DESCRIPTION OF THE INVENTION [025] The following description of preferred embodiments is merely exemplary in nature and is in no way intended to limit the invention, its application or uses. [026] As used herein, ranges are used as shorthand to describe each and every value that is within the range. Any value within the range may be selected as the end of the range. All references cited herein are incorporated herein by reference in their entirety. In the event of a conflict between a definition in this disclosure and that of a cited reference, this disclosure prevails. [027] As stated herein, all compositional percentages are by weight of the total composition unless otherwise indicated. As stated herein, "ppm" (parts per million) refers to ppm by weight unless otherwise indicated. As stated herein, all ratios refer to ratios by weight unless otherwise indicated. [028] The pr