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BR-112016022470-B1 - Flavored Nicotine Powder Inhaler

BR112016022470B1BR 112016022470 B1BR112016022470 B1BR 112016022470B1BR-112016022470-B1

Abstract

FLAVORED NICOTINE POWDER INHALER. This description refers to flavored nicotine powder inhalers, comprising a body, an airflow channel, a nicotine powder receptacle, and an aroma delivery element in fluid connection with the airflow channel, wherein the nicotine powder is delivered at airflow rates that mimic a smoking regime.

Inventors

  • IHAR NIKOLAEVICH ZINOVIK
  • Gérard Zuber

Assignees

  • PHILIP MORRIS PRODUCTS S.A

Dates

Publication Date
20260310
Application Date
20150423
Priority Date
20140428

Claims (5)

  1. 1. Nicotine powder inhaler (10) comprising: a body extending between a mouthpiece part (12) and a distal end part (14); an airflow channel (13, 15) extending between the mouthpiece part (12) and the distal end part (14); a nicotine powder receptacle (25, 30, 32, 33) disposed along the airflow channel (13, 15) and characterized in being configured to receive a capsule (20, 120) comprising a dose of nicotine powder comprising a nicotine salt and a flavoring; and a swirling element (50) configured to induce rotary motion in the airflow from the airflow channel (15); wherein the dose of nicotine powder can be inhaled into the lungs of a user at an inhalation rate of less than about 5 L/min.
  2. 2. Nicotine powder inhaler (10), according to claim 1, characterized in that the flavoring comprises a powdered flavoring.
  3. 3. Nicotine powder inhaler (10), according to any of the preceding claims, characterized in that the flavoring comprises a liquid flavoring.
  4. 4. Nicotine powder inhaler (10), according to any of the preceding claims, characterized in that the flavoring is a filament impregnated with menthol.
  5. 5. Nicotine powder inhaler (10), according to any of the preceding claims, characterized in that it further comprises a dose of a second active agent.

Description

[001] This description refers to flavored nicotine powder inhalers, in which the flavored nicotine powder is dispensed at low airflow rates. [002] Dry powder inhalers (DPIs) are known and used to treat respiratory diseases by delivering a dry powder containing a pharmaceutical agent, in aerosol form, through inhalation into the patient's airways. For deep distribution into the lungs, particles in the 1 to 5 micrometer range are required. In pharmaceutical dry powders, the active pharmaceutical ingredient (API) is agglomerated on the surface of larger carrier particles, for example, lactose, and DPIs therefore operate complex mechanisms to ensure that these agglomerates disperse, break down, or disintegrate before the API can be inhaled deep into the lungs. Pharmaceutical dry powders containing lactose as a carrier are typically in the 20 to 100 micrometer range. Existing DPIs, for example, first "grind" or deagglomerate the dry powder or compress the larger dry powder particles to result in the aforementioned particle size range. [003] DPIs rely on the force of the patient's inhalation to drag the powder from the device, subsequently breaking the powder into particles small enough to enter the lungs. Sufficiently high inhalation rates are required to determine the correct dosage and complete disintegration of the powder. Typically, a large amount of API remains bound to the carrier surface and is deposited in the upper airways due to incomplete powder disintegration. Existing DPI inhalation rates are generally in the range of 40-120 liters/min (L/min). Existing DPIs are therefore only suitable for delivering dry powder to users in a manner different from the inhalation rate associated with smoking devices. [004] It would be desirable to provide a flavored nicotine powder inhaler that can deliver flavored nicotine powder to a user during inhalation or airflow rates that are within the inhalation regimen for smoking or conventional airflow rates. It would be desirable to provide a flavored nicotine powder inhaler that has a size and configuration similar to that of a conventional cigarette. It would be desirable to provide a flavored nicotine powder inhaler that can deliver a measured dose of flavored nicotine and optional simultaneous delivery of a second active ingredient. [005] The flavored nicotine powder inhalers of the invention described in this document can be used to deliver flavored nicotine to a user during inhalation or at airflow rates that are close to or within the inhalation of the smoking regime or conventional airflow rates. The flavored nicotine powder inhalers can deliver a predictable and measured dose of flavored nicotine or other optional active ingredients. The flavored nicotine powder inhalers of the invention described in this document have a size and configuration similar to that of a conventional cigarette and have a simple configuration. [006] As described in this document, a flavored nicotine powder inhaler includes a body extending between a mouthpiece and a distal end portion and an airflow channel extending along the body of the inhaler. The nicotine powder receptacle, together with the airflow channel, holds a dose of nicotine powder. An aroma delivery element is in fluid communication with the airflow channel. The dose of nicotine powder can be inhaled into a user's lungs at an inhalation rate of less than about 5 L/min, or preferably less than about 2 L/min. Preferably, the dose of nicotine powder is a nicotine salt contained in a capsule that can be pierced by the inhaler. [007] Several aspects of the flavored nicotine powder inhalers described in this document may have one or more advantages over standard dry powder inhalers. For example, flavored nicotine powder inhalers deliver the dry powder nicotine and flavored particles during inhalation or at airflow rates that are within the inhalation regime of smoking or conventional airflow rates and inhalation methods. This allows even users with compromised or impaired respiratory conditions to successfully deliver the dry powder nicotine and flavoring. The flavored nicotine powder inhalers described in this document have a simplified configuration that allows the user to predetermine the measured dose of dry powder nicotine and flavoring. The dry powder nicotine may be in a series or parallel flow relationship with the flavor delivery element. The flavoring may be a dry powder or a liquid flavoring. The additional advantages of one or more aspects of the aroma delivery system described in this document will be evident to those skilled in the art after reading and understanding this description. [008] The term "nicotine" refers to nicotine and nicotine derivatives, such as nicotine salts. [009] The term "flavoring" or "aroma" refers to organoleptic compounds, compositions, or materials that alter the taste or aroma characteristics of nicotine during its consumption or inhalation. [0010] This description provides flavored nico