Search

CA-3013477-C - MOISTURIZING COMPOSITIONS AND USES THEREOF

CA3013477CCA 3013477 CCA3013477 CCA 3013477CCA-3013477-C

Abstract

Provided herein is an interpenetrating polymer network moisturizing composition comprising a crosslinked polypeptide or polysaccharide; a branched polymer with a hydrophobic modification; a linear polypeptide or polysaccharide; and a crosslinking agent, wherein the crosslinking agent is a mono-valent or di-valent ion, wherein the crosslinked polypeptide or polysaccharide entraps the interlaced branched polymer with a hydrophobic modification and the linear polypeptide or polysaccharide to form the interpenetrating polymer network. Also provided herein are drug or active ingredient delivery systems and uses thereof and methods of producing same.

Inventors

  • Kathy Ann FIELDS
  • Kathryn Pregerson RODAN
  • George Paul MAJEWSKI
  • Timothy John FALLA
  • Dzung Q. LE

Assignees

  • RODAN & FIELDS, LLC

Dates

Publication Date
20260505
Application Date
20170213
Priority Date
20160212

Claims (20)

  1. CLAIMS What is claimed: 1. An interpenetrating polymer network moisturizing composition comprising: crosslinked gellan gum; hydrophobically modified cetyl hydroxyethylcellulose; sodium hyaluronate; and a crosslinking agent, wherein the crosslinking agent is a mono-valent or divalent ion, wherein the cetyl hydroxyethylcellulose and the hyaluronate are interlaced, and wherein the crosslinked gellan gum entraps the interlaced cetyl hydroxyethylcellulose with a hydrophobic modification and the hyaluronate to form the interpenetrating polymer network.
  2. 2. A drug or active ingredient delivery system comprising: crosslinked gellan gum; hydrophobically modified cetyl hydroxyethylcellulose; sodium hyaluronate; a crosslinking agent, wherein the crosslinking agent is a mono-valent or divalent ion; and a drug or active ingredient, wherein the cetyl hydroxyethylcellulose and the hyaluronate are interlaced, and wherein the crosslinked gellan gum entraps the interlaced cetyl hydroxyethylcellulose and the hyaluronate to form the interpenetrating polymer network.
  3. 3. The moisturizing composition or delivery system of claim 1 or 2, wherein the mono-, or di-valent ion is selected from the group consisting of 2-Pyrrolidone-5-Carboxylic Acid (PCA) and related salts, sea salt, inorganic salts of citric acid, inorganic salts of lactic acid, calcium ascorbate, magnesium ascorbate, calcium oxide, calcium benzoate, calcium sorbate, calcium aspartate, magnesium carbonate, magnesium chloride, magnesium nitrate, and any combination thereof.
  4. 4. The moisturizing composition or delivery system of claim 3, wherein the PCA is calcium PCA, sodium PCA, zinc PCA, or magnesium PCA. 9231952 Date Rer;ue/Date Received 2024-03-07
  5. 5. The moisturizing composition or delivery system of claim 4, wherein the crosslinking agent is a combination of calcium PCA and magnesium PCA.
  6. 6. The moisturizing composition or delivery system of any one of claims 1 to 5, further comprising at least one humectant, wherein the at least one humectant is selected from the group consisting of glycerin, diglycerin, betaine, diols, propylene glycol, butylene glycol, pentylene glycol, propanediol, 1,2-hexanediol, D-ribose, glucose, sorbitol, dextrose, urea, 2- Pyrrolidone-5-Carboxylic Acid, sea salt, inorganic salts of citric acid, inorganic salts oflactic acid, ectoin, lactic acid, betaine, glycolic acid, lactobionic acid, and any combination thereof.
  7. 7. The moisturizing composition or delivery system of claim 6, wherein the humectant is at about 25% w/w to about 80% w/w.
  8. 8. The moisturizing composition or delivery system of any one of claims 1 to 7, wherein the crosslinked gellan gum is at about 0.01 % w/w to about 5% w/w.
  9. 9. The moisturizing composition or delivery system of any one of claims 1 to 8, wherein the cetyl hydroxyethylcellulose is at about 0.01% w/w to about 5% w/w.
  10. 10. The moisturizing composition or delivery system of any one of claims 1 to 9, wherein the sodium hyaluronate is at about 0.01 % w/w to about 5% w/w.
  11. 11. The moisturizing composition or delivery system of any one of claims 1 to 10, wherein the mono-, or di-valent ion is at about 0.01 % w/w to about 5% w/w.
  12. 12. The moisturizing composition or delivery system of any one of claims 1 to 11, wherein the moisturizing composition is selected from the group consisting of liquid, solution, emulsion, cream, suspension, triturate, jelly, foam, paste, ointment, shampoo, adhesive, serum, milk, lotion, salve, oil, butter, gel, and balm.
  13. 13. Use of the moisturizing composition or delivery system according to any one of claims 1-12 for treating dry and/or irritated skin.
  14. 14. A method of producing an interpenetrating polymer network moisturizing composition, the method comprising: dispersing non-crosslinked gellan gum in water to form a first phase; 9231952 Date Rer;ue/Date Received 2024-03-07 combining sodium hyaluronate and hydrophobically modified cetyl hydroxyethylcellulose with a humectant to form a second phase; combining the first and second phases to form a third phase of uncrosslinked interlaced polymers, polypeptides, or polysaccharides; and adding at least one crosslinking agent to the third phase to crosslink one or more polypeptide, polymer, or polysaccharide to form an interpenetrating polymer network moisturizing composition, wherein the at least one crosslinking agent is a mono-valent or di-valent ion.
  15. 15. The method of claim 14, wherein the at least one crosslinking agent is selected from the group consisting of 2-Pyrrolidone-5-Carboxylic Acid (PCA) and related salts, sea salt, inorganic salts of citric acid, inorganic salts of lactic acid, calcium ascorbate, magnesium ascorbate, calcium oxide, calcium benzoate, calcium sorbate, calcium aspartate, magnesium carbonate, magnesium chloride, magnesium nitrate, and any combination thereof.
  16. 16. The method of claim 15, wherein the PCA is calcium PCA, sodium PCA, zinc PCA, or magnesium PCA.
  17. 17. The method of any one of claims 14 to 16, wherein the crosslinked gellan gum is at about 0.01% w/w to about 5% w/w.
  18. 18. The method of any one of claims 14 to 17, wherein the cety 1 hydroxyethylcellulose is at about 0.01% w/w to about 5% w/w.
  19. 19. The method of any one of claims 14 to 18, wherein the sodium hyaluronate is at about 0.01 % w/w to about 5% w/w.
  20. 20. The method of any one of claims 14 to 19, wherein the mono-, or di-valent ion is at about 0.01% w/w to about 5% w/w.

Description

MOISTURIZING COMPOSITIONS AND USES THEREOF [0001] [blank] SUMMARY [0002] Embodiments herein are directed to moisturizing compositions comprising: an interpenetrating polymer network made up of a crosslinked polypeptide or polysaccharide; a. branched polymer with a hydrophobic modification; and a linear polypeptide or polysaccharide. In some embodiments. the composition is an interpenetrating polymer network comprising a crosslinked polypeptide or polysaccharide; a branched polymer with a hydrophobic modification; and a linear polypeptide or polysaccharide, wherein the crosslinked polypeptide or polysaccharide entraps the interlaced branched polymer with a hydrophobic modification and the linear polypeptide or polysaccharide to form the interpenetrating polymer network. [0003] Some embodiments are directed to methods of treating dry and/or irritated skin comprising administering a moisturizing composition comprising: an i11terpenetrating polymer netwotk made up of a crosslinked polypeptide or polysaccharide; a branched polymer with a hydrophobic modification; and a linear polypeptide or polysaccharide. [0004] Some embodiments are directed to a method of producing an interpenetrating polymer network moisturizing composition, the method comprising: dispersing a noncrosslinked polypeptide or polysaccharide capable of crosslinking i11 water to fonn a first phase; combining a linear polypeptide or polysaccharide and a branched polymer with a hydrophobic modification with a humectant to form a second phase; combining the first and second pbases to fonn a third phase of uncrosslinked interlaced polymers, polypeptides, or polysaccharides; adding a mono-valent ion, di-valent ion or a combination thereof to the third phase to crosslink one or more polypeptide, polymer, or polysaccharide to form an interpenetrating polymer network moisturizing composition. Date Rec;ue/Date Received 2023-07-07 WO 2017/139765 PCT/0S2017/017671 BRIEF DESCRIPTION OF THE FIGURES [0005] FIG. 1 depicts the DVS vveight versus time curve for fonnulation 1505-56. [0006] FIG. 2 depicts the DVS weight change versus percent relative humidity curve for formulation 1505-56. [0007] FIG. 3 depicts the DVS weight versus time curve for fonnulation 1505-57. [0008] FIG. 4 depicts the DVS weight change versus percent relative humidity curvt~ for formulation 1505-57. [0009] [0010] FIG. 5 depicts the DVS vveight versus time curve for fonnulation 1505-58. FIG. 6 depicts the DVS weight change versus percent relative humidity curve for formulation 1505-58. [OOH] FIG. 7 depicts the DVS vveight versus time curve for fonnulation 1505-59. [0012] FIG. 8 depicts the DVS weight change versus percent relative humidity curve for formulation 1505-59. [0013] FIG. 9 depicts improvements in clinical grading. A) Demonstrates improvement in radiance after 1 week. B) Demonstrates improvement in fine lines afler l week. [0014] FIG. 10 depicts the improvement in moisture as measured by capacitance using the Comeometer over the course of the study. [0015] FIG. 11 depicts 3 different subjects and the change in mean comeometer measurements over the course of the study. A) Subject #7 with baseline severe dry skin. B) Subject #16 with baseline moderate dry skin. C) Subject #14 with baseline mild dry skin. [0016] FIG. 12 depicts improvement in conductance moisture measurements using the SKICON test. [0017] Cutometer. FIG. 13 depicts the improvements in skin elasticity after l week measured by the WO 2017/139765 PCT/0S2017/017671 [00181 FIG. 14 depicts the improvement in the skin as subjectively reported by each individual. A) Improvement in radiance after 1 week. B) Rep01ted improvement in firmness. C) Improvement in plumpness after l week. [0019] FIG. 15 provides a photograph of severe dry skin prior to the application of a moisturizing composition and a photograph of skin 15 minutes after the application of formulation 1505-21. [0020] FIG. 16A depicts the linear, branched, and crosshnked polymers, polypeptides, and polysaccharides in embodiments described herein. FIG. 6B is a chemistry depiction of the 3D3P interpenetrating polymer network. [00211 FIG. 17 shows the percent sample weight change by sorption under 5% relative humidity (RH) and 5%---95% RH. [0022] FIG. 18 shows the mean corneometry scores fbr once daily use of3D3P-IPN and commercial hydration product. [0023] FIG. 19 shows VisioScan images for baseline and 8 weeks after treatment with fommlation 1505-42B. DETAILED DESCRIPTION [0024] Traditional methods of hydrating skin (especially facial skin) are not sufficient especially in dry weather conditions. Commonly formulated barrier forming occlusive agents (petrolatum, high MW silicone fluids, plant butters) work well for reducing trans epiden:nal water loss but these materials exhibit some undesired properties including the increa5ed potential of comedogenicity (dogging of pores). Occlusive materials also do not attract/accumulate water at the skin's surfa,ce which is limiti