CA-3070633-C - USE OF SOPHOROLIPIDS AS FEED ADDITIVE

Abstract

The invention relates to methods for modulation of the gut flora and/or for supporting immune system function in animals comprising administration of one or more sophorolipids to an animal in need thereof. Animal feed compositions comprising sophorolipids are also provided.

Inventors

• Christopher Michael BUTT
• Pietro CELI
• Norman Salem

Assignees

• DSM IP ASSETS B.V.

Dates

Publication Date

20260505

Application Date

20180723

Priority Date

20170725

Claims (4)

1. 85912416 CLAIMS: 1. 34 One or more sophorolipids for use in the alleviation or treatment of coccidiosis and of diseases caused by clostridium sp.in an animal in need thereof, wherein the one or more sophorolipids is selected from the group consisting of ethyl-17-L-[2′-0-β-D glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6″—acetate; ethyl-17-L [(2′-0-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6′—acetate; ethyl-17-L-[2′-0-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9-octadecenoate-6′ 6″—diacetate; butyl-17-L-[2′-0-β-D-glucopyranosyl-β-D-glucopyranosyl)-oxy]-cis-9 octadecenoate-6″—acetate; butyl-17-L-[2′-0-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-cis-9-octadecenoate-6′—acetate; and butyl-17-L-[2′-0-β-D-glucopyranosyl-β-D glucopyranosyl)-oxy]-cis-9-octadecenoate-6′-6″—diacetate.
2. 2. The one or more sophorolipids for use of claim 1, wherein the animal is a poultry animal selected from the group consisting of chicken, broiler, layer, pullet and chick.
3. 3. The one or more sophorolipids for use of claim 1, wherein the one or more sophorolipids is for administration to the animal in the form of a feed additive or feed premix composition.
4. 4. The one or more sophorolipids for use of claim 3, wherein the one or more sophorolipids is for administration to the animal in the form of a feed premix composition which further comprises one or more components selected from the group consisting of: a) one or more carriers; b) one or more enzymes; c) one or more microbes; d) one or more vitamins; e) one or more minerals; f) one or more amino acids; and g) one of more organic acids.

Description

USE OF SOPHOROLIPIDS AS FEED ADDITIVE BACKGROUND [0001] The present invention relates to feed additive compositions containing one or more sophorolipids and a method for the modulation of the gut flora and/or for supporting immune system function in animals comprising administration of one or more sophorolipids to an animal in need thereof. More particular, the present invention relates to a method for treating or preventing coccidiosis and diseases caused by clostridium sp. with one of more sophorolipids. The invention also relates to feed additive or feed premix compositions comprising at least one sophorolipids. [0002] The term feed or feed composition means any compound, preparation, mixture or composition suitable for or intended for intake by an animal. [0003] The term animal includes all animals. Examples of animals are nonruminants, and ruminants. Ruminant animals include, for example, animals such as sheep, goat, and cattle, e.g. cow such as beef cattle and dairy cows. In a particular embodiment, the animal is a non-ruminant animal. Non-ruminant animals include pet animals, e.g. horses, cats and dogs; mono-gastric animals, e.g. pig or swine (including, but not limited to, piglets, growing pigs, and sows); poultry such as turkeys, ducks and chickens (including but not limited to broiler chicks, layers); fish (including but not limited to salmon, trout, tilapia, catfish and carp); and crustaceans (including but not limited to shrimp and prawn). [0004] Sophorolipids are surface-active glycolipid compounds that can by synthesized by a select number of non-pathogenic yeast species. Sophorolipids consist of a hydrophobic fatty acid tail of 16 or 18 carbon atoms and a hydrophilic carbohydrate head, sophorose. Sophorose is a glucose di-saccharide with an unusual 13-1,2 bond and can by acetylated on the 6'- and/or 6"-positions. One terminal or sub-terminal hydroxylated fatty acid is 13-glycosidically linked to the sophorose molecule. The carboxylic end of this fatty acid is either free (acidic or open form) or internally esterified at the 4"- or in some cases at the 6'- or 6"-position (lactonic form). The hydroxyl fatty acid itself counts in general 16 or 18 carbon atoms and can have one of more unsaturated bonds. 85912416 2 [0005] Due to their biodegradability and low eco-toxicity, the use of sophorolipids as bio-surfactants in industrial applications has been increasingly explored. [0006] The present inventors now surprisingly found that sophorolipids have a great potential for use in animal feed. In particular it has been found that a composition comprising at least one sophorolipid specified hereinbelow may be used for the alleviation, cure or prevention of coccidiosis and of diseases caused by clostridium sp. [0007] The solution to this technical problem is provided by the embodiments characterized herein. [0008] BRIEF SUMMARY [0009] The present invention relates to sophorolipids as components of animal feed or feed additives, as well as to compositions, feed additives and feed containing them. In a preferred embodiment, the one or more sophorolipids are administered orally. The one or more sophorolipids may be in the form of a feed additive composition. In another embodiment, the one or more sophorolipids are added to a feed premix product. [001 0] Therefore the present invention provides the use of said compounds as components of animal feed or feed additives. [0011] The invention further provides the use of these compounds thereof for the preparation of compositions improving the performance of animals, especially having activity as modulators of the gastrointestinal microflora and which are applicable via animal feed. [0012] The present invention further relates to the use of sophorolipids as hereinabove defined in the manufacture of animal feed or animal feed additive for the alleviation, cure or prevention of coccidiosis and diseases caused by clostridium sp - particularly clostridium perfringens - in animals, such as poultry. [0013] Finally, the present invention provides animal feed additives on the basis of a sophorolipid compound according to the invention. [0014] The term "gut" as used herein designates the gastrointestinal or digestive tract (also referred to as the alimentary canal) and it refers to the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and expels the remaining waste. 3 [0015] The term gut "microflora" as used herein refers to the natural microbial cultures residing in the gut and maintaining health by aiding in proper digestion and/or supporting immune system function. [0016] The term "modulate" as used herein in connection with the gut microflora generally means to change, manipulate, alter, or adjust the function or status thereof in a healthy and normally functioning animal, i.e. a non-therapeutic use. [0017] Coccidia is a generic name given to single cell protozoan organisms that are intestinal parasites that