Search

CA-3112997-C - PET FOOD COMPOSITIONS FOR WEIGHT MANAGEMENT IN PETS WITH ADVERSE FOOD REACTION

CA3112997CCA 3112997 CCA3112997 CCA 3112997CCA-3112997-C

Abstract

The presently disclosed subject matter provides a hypoallergenic palatable composition. The composition includes at least about 25% of at least partially hydrolysed proteins and at least about 10% of crude fibers by weight, based on the total weight of dry matter of the composition. The composition can be used to achieve weight loss and/or weight management of pet animals affected with adverse food reactions (AFR), particularly cutaneous adverse food reactions (CAFR).

Inventors

  • Benedicte Garzino
  • Marie-Anne Hours
  • Helene Charles
  • Matthieu Filippini

Assignees

  • MARS, INCORPORATED

Dates

Publication Date
20260505
Application Date
20191017
Priority Date
20181018

Claims (20)

  1. 32 What is claimed is: 1. A hypoallergenic palatable composition, comprising: at least 25% by weight of at least partially hydrolysed proteins; and at least 10% by weight of crude fibers, based on the total weight of dry matter of the composition, and from about 4% to about 12% moisture, wherein the at least partially hydrolysed proteins have a molecular weight ranging from about 1,000 Da to about 11,000 Da.
  2. 2. The composition of claim 1, wherein the at least partially hydrolysed proteins comprise at least 95% of hydrolysed proteins, based on a total weight of proteins in the composition.
  3. 3. The composition of claim 1, wherein the at least partially hydrolysed proteins comprise totally hydrolysed proteins.
  4. 4. The composition of claim 1, wherein the at least partially hydrolysed proteins comprise proteins from a vegetal origin.
  5. 5. The composition of claim 4, wherein the at least partially hydrolysed proteins are from at least one of corn, wheat, pea, soy or rice origin.
  6. 6. The composition of claim 1, further comprising about 15% or less by weight of fat, based on the total weight of dry matter of the composition.
  7. 7. The composition of claim 1, wherein the composition further comprises about 30% or less by weight of starch, based on the total weight of dry matter of the composition.
  8. 8. The composition of claim 1, wherein the composition further comprises at least one flavour. 33
  9. 9. The composition of claim 8, wherein the at least one flavour comprises at least one flavour of protein origin.
  10. 10. The composition of claim 1, wherein the composition has a Metabolizable Energy (ME) of about 3,200 kcal/kg or less.
  11. 11. The composition of claim 10, wherein the ME of the composition is measured according to the modified Atwater factorial equation of the National Research Council (NRC) 2006.
  12. 12. A hypoallergenic palatable composition comprising, by weight, based on the total weight of the composition, - from about 20% to about 38% of at least partially hydrolysed proteins; - from about 17.4% to about 23% of crude fibers; - from about 4% to about 13% of crude fat; and - from about 4% to about 12% moisture, wherein the at least partially hydrolysed proteins have a molecular weight ranging from about 1,000 Da to about 11,000 Da.
  13. 13. The hypoallergenic palatable composition of claim 12, wherein the at least partially hydrolysed proteins are from a vegetal origin and comprise at least 95% of hydrolysed proteins, by weight, based on the total weight of proteins in the hypoallergenic palatable composition.
  14. 14. The composition of claim 12 or 13, wherein the composition further comprises an amount of at most 30% by weight of starch, based on the total weight of dry matter of the hypoallergenic palatable composition.
  15. 15. The composition of claim 14, wherein the composition comprises an amount of at most 22% by weight of starch.
  16. 16. The composition of any one of claims 1 to 15, for use in achieving weight management for a pet animal affected with an adverse food reaction. 34
  17. 17. The composition for use according to claim 16, wherein the pet animal is a cat or a dog.
  18. 18. The composition for use according to 16 or 17, wherein the pet animal is overweight.
  19. 19. A use, for achieving weight management in a pet animal affected with adverse food reaction, of a composition according to any one of claims 1 to 15.
  20. 20. The use of claim 19, wherein the pet animal is a cat or a dog.

Description

PET FOOD COMPOSITIONS FOR WEIGHT MANAGEMENT IN PETS WITH ADVERSE FOOD REACTION CROSS-REFERENCE TO RELATED APPLICATIONS 5 The present application claims the benefit of priority to EP Application Serial No. 18201322.7 filed on October 18, 2018. 1. FIELD OF THE INVENTION The presently disclosed subject matter relates to pet food compositions for IO achieving weight loss and/or weight management in pets affected with adverse food reactions (AFR), in particular with cutaneous adverse food reactions (CAFR). Specifically, the food compositions of the present disclosure can include a high hydrolysed protein content, a low fat content, and a high dietary fiber content, in particular a high crude fiber content. 2. BACKGROUND Obesity is now recognized as the most prevalent medical disease in pets worldwide, and can significantly decrease their overall longevity. Prevalence of overweightness and obesity in various populations of dogs reportedly range up to 59%. 20 (Courcier et al., 2010; APOP 2016). Courcier et al. have observed that the environmental risk factors associated with obesity in dogs are multifactorial and include owner's personal income, owner's age, frequency of snacks/treats, and amount of exercise the dog receives. Drug-based strategies, involving either dirlotapide or mitratapide, have 25 provided encouraging results in weight loss, but were poorly accepted in clinical practice, and hence were withdrawn from the market. (see German, 2016). Alternative strategies for weight management, including weight loss programs, were developed involving dietary energy restriction and the use of a purpose-formulated diet. A low calorie, high protein, and high fiber diet has been shown to be an efficacious 30 strategy to promote weight loss while preserving lean body mass. (Weber et al., 2007; German et al., 2010). 1 Date Re9ue/Date Received 2023-10-13 However, current commercial diets for weight loss contain intact protein sources which can cause allergic flares in allergic pets. In particular, a high protein diet can provoke adverse food reactions (AFR), particularly cutaneous adverse food reactions (CAFR). 5 CAFR is a non-seasonal pruritic dermatitis caused by ingested allergens, which are essentially proteins and/or glycoproteins of a molecular weight from l 0 kDa to 70 kDa. (Hefle et al., 1996). This condition is commonly observed in dogs and reported to account for up to 40% of dogs presented with pruritus. (Olivry and Mueller, 2016). Hydrolysed protein-based diets are one of the recognized strategies for the diagnosis and management 10 of dogs with CAFR. (Verlinden et al., 2006). However, hydrolysed proteins are not known to be very palatable. In addition, Hand et al. (Small animal clinical nutrition; 5th Edition) reported that, for dog pets with CAFR, the excess of dietary proteins should be avoided, i.e., that the dietary proteins should not exceed 16% to 22% by weight, based on the total weight of dry matter of the food product. 15 Nevertheless, diet compositions generally have moderate protein contents, which is not in favor of maintaining lean body mass during weight loss and providing adequate essential amino acids intake when the daily ration is restricted. Hence, the current strategies to manage both weight loss and CAFR are conflicting with respect to the protein and fat content, since managing CAFR would 20 involve moderate level of proteins and moderate level of fats, whereas managing weight loss would require high level of proteins and low level of fats. Consequently, because CAFR and obesity both have a high prevalence in pets, such as in dogs and in cats, there is a need to provide a food composition formulated to manage both conditions, i.e., to achieve weight loss and/or maintenance of lean body mass 25 in pets with concurrent CAFR. In addition, the food composition should be palatable, well tolerated by the pet, and easily produced. The disclosed subject matter addresses these and other needs. 3. SUMMARY OF THE INVENTION The present disclosure provides food compositions, and more particularly pet food compositions including a low fat, high hydrolysed protein, and high fiber content. The food compositions of the present disclosure can be utilized to achieve weight loss 2 Date Re9ue/Date Received 2023-10-13 and/or weight management of pet animals affected with adverse food reactions (AFR), particularly cutaneous adverse food reactions (CAFR). The present disclosure provides a hypoallergenic palatable composition. The composition includes at least about 25% by weight of at least partially hydrolysed proteins 5 and at least about 10% by weight of crude fibers, based on the total weight of dry matter of the composition. In certain embodiments, the at least partially hydrolysed proteins can include at least about 95% of hydrolysed proteins, based on the total weight of proteins in the composition. In certain embodiments, the at least partially hydrolysed proteins can include 10 totally hydrolysed pr