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CA-3171180-C - FLUID HANDLING CASSETTE FOR AN INFUSION SYSTEM

CA3171180CCA 3171180 CCA3171180 CCA 3171180CCA-3171180-C

Abstract

A fluid handling cassette for a medical infusion fluid handling system, such as an APD system, in which the cassette has a planar body with two pump chambers defined by depressions on a first side of the body and a flexible membrane attached on the first side of the body. The pump chambers are connected via valve wells to cassette ports on the first end and second end of the body. The cassette ports on the first end include a port to the drain line, the patient line and the heater bag line. The cassette ports on the second end are connected to solution lines. A first group of valves connect the pump chambers to channels on the second side of the body. A second group of valves connect the channels to the cassette ports.

Inventors

  • David W. McGill
  • Jacob W. Scarpaci
  • James D. Dale
  • Simon C. Helmore
  • Jason A. Demers

Assignees

  • DEKA PRODUCTS LIMITED PARTNERSHIP

Dates

Publication Date
20260505
Application Date
20090123
Priority Date
20080123

Claims (19)

  1. 104 What is claimed is: 1. A fluid handling cassette for use in a medical infusion system, the cassette comprising: a generally planar body having first and second pump chambers each formed as a depression in a first side of the body, each pump chamber having a first port and a second port connecting the respective pump chamber to a second side of the body; a plurality of valve wells on the first side of the body including first and second groups of valve wells, valve wells in the first group of valve wells each comprising a valve port and an opening connecting a respective valve well to the second side of the body; valve wells in the second group of valve wells each comprising a valve port connecting a respective valve well to the second side of the body, each of the valve wells of the second group of valve wells being connected to the second side of the body only by the respective valve port; a plurality of cassette ports located on a first end of the body, each of the plurality of cassette ports being directly connected to a respective valve well of the second group of valve wells; and a first and second fluid flowpath on the second side of the body, each fluid flowpath connected to the first or second port of a respective pump chamber via at least one valve well of the first group of valve wells; wherein the first and second fluid flowpaths are each connected to at least one of the plurality of cassette ports via a respective valve well of the second group of valve wells.
  2. 2. The fluid handling cassette of claim 1, wherein the second fluid flowpath is connected to a patient line cassette port of the plurality of cassette ports, the patient line cassette port configured for connection to a patient line.
  3. 3. The fluid handling cassette of claim 1, wherein the first fluid flowpath is connected to a drain line cassette port and a heater line cassette port of the plurality of cassette ports, the drain line cassette port configured for connection to a drain line, and the heater line 105 cassette port configured for connection to a heater bag line.
  4. 4. The fluid handling cassette of claim 1, further comprising a third group of valve wells , each valve well comprising a valve port connecting the respective valve well to the second side of the body, and each valve well of the third group of valve wells configured for fluid communication with a solution line located at a second end of the body.
  5. 5. The fluid handling cassette of claim 4, wherein each valve well of the third group of valve wells is connected to a lumen of a solution line spike on the second end of the body.
  6. 6. The fluid handling cassette of claim 4, wherein the second fluid flowpath is connected to the third group of valve wells via the respective valve ports of the third group of valve wells.
  7. 7. The fluid handling cassette of claim 1 or 4, wherein the cassette comprises a first flexible membrane attached to the first side of the body over the pump chambers and the plurality of valve wells, wherein the first flexible membrane over the pump chambers is configured for moving fluid in the pump chambers, and the first flexible membrane over the plurality of valve wells is configured for selectively occluding the valve ports of the respective valve wells.
  8. 8. The fluid handling cassette of claim 1 or 4, wherein the first and second fluid flowpaths comprise walls on the second side of the body, and wherein the cassette comprises a rigid or flexible sheet attached to the second side of the body, wherein the sheet is configured to make sealing contact with the walls to form the first and second fluid flowpaths. 106
  9. 9. An automated peritoneal dialysis system comprising a cycler including a cycler housing and a door arranged to enclose a cassette when the door is in a closed position; the door hingedly connected to the housing so that a mounting location on an inner side of the door is exposed when the door is lowered into an open position; the mounting location having a shape arranged to match a shape of a base member of the cassette to ensure proper orientation of the cassette when mounted in the mounting location; characterized in that the peritoneal dialysis system is configured to allow a user to place the cassette horizontally into the mounting location of the door when the door is in the open position, so that closing the door properly places the cassette into an interactive position with the cycler.
  10. 10. The peritoneal dialysis system of claim 9, wherein the inner side of the door includes a channel arranged to route patient, drain and heater bag lines attached to the cassette before closure of the door.
  11. 11. The peritoneal dialysis system of claim 10, wherein the channel comprises guides to hold the patient, drain and heater bag lines in a position opposite an occluder when the door is in a closed position.
  12. 12. The peritoneal dialysis system of claim 11, wherein the guides position the patient, drain and heater bag lines against an occluder stop of the door, so that actuation of the occluder when the door is in a closed position occludes one or more of said lines against the occluder stop.
  13. 13. The peritoneal dialysis system of claim 9, wherein the shape of the mounting location ensures that a pump chamber side of the cassette and a flexible membrane of the cassette faces a pump control surface of the peritoneal dialysis system when the door is in a closed position. 107
  14. 14. The peritoneal dialysis system of claim 13, wherein the door includes an air bladder behind the mounting location, so that actuation of the air bladder when the door is closed squeezes the cassette between the mounting location and the pump control surface.
  15. 15. The peritoneal dialysis system of claim 14, wherein said actuation of the air bladder presses the flexible membrane into contact with walls of the base member of the cassette, isolating channels and other flow paths of the cassette.
  16. 16. The peritoneal dialysis system of claim 13, wherein the control surface comprises a flexible gasket configured to selectively move portions of the flexible membrane of an installed cassette to cause pumping action in one or more pump chambers of the cassette.
  17. 17. The peritoneal dialysis system of claim 16, wherein the flexible gasket is configured to selectively move portions of the flexible membrane of the installed cassette to open or close valve ports of the cassette.
  18. 18. The peritoneal dialysis system of claim 9, wherein one or more solution lines to supply the cassette may be installed in a carriage of the door.
  19. 19. The peritoneal dialysis system of claim 9, wherein the cassette is placed in the mounting location with a membrane and a pump chamber side of the cassette facing upwardly, allowing the portions of the membrane associated with a pump chamber and valve ports of the cassette to interact with a control surface of the cycler when the door is closed.

Description

FLUID HANDLING CASSETTE FOR AN INFUSION SYSTEM DACK'.91tQIJNJl,: Peritonm Dialysis (PD) btvotves tfoiperfoijic infusion ofsterUe ,aqgeous.1£)lutio~ (called petit~<:'al. cli~ysJ$ .,i;QJJtfoμ, or dialysa~,) iln.to ~. peritane~ cavity . ,pf a pa(ie~t- l))iffiision aur.t :('lsm;Q,ts ~ch:aos~.,. take place/between .th• solttt,ip.n Mil:f;he Jllopdstteam iapt0$stbt ®ti.mil: lmd, . membrmies. These e~ehanges framfe:r waste products ,to tbe dialysate that the kidneys nprm:atJy ·~~ret,.i fh•wute .. pmd.UC1$ ~picall,~ ~.--i~t'Qf.,$1¢lltlte1t (~.,i:,d,itr01 ud :¢~on.de 1¢1J1J;, .• d ~th~· ppmp.punas .nprm~lly ex.c,retell; ~0Uih•th1'.·ld~ney•s1Ute urea,., ~rea,tibin,e, ·and \Vllef, 'f.he, dit1bsio)l nf water Mr0$s #he pedton~al membran.e <luring :aia~ysi, is called qitrafi1tratio:w. 1 i~pVo-~o.~.,pe:dtb~~l,.dialy~bf:so:luti(.)at iot,;ludo d!i«.~C in"conte.ntmf,iuns· su:mct,ent ·14: genemte the lieocssarf 01mofk: ptessure to rcm9ve waU,r ·trom the pauent througbultrafilttatiob. Continuous. Anlbμlatory Perit<?11eal oi,t,y~i,f (CABD~ a pP~nla1; {~. cf PD.,, A pa~ient ·Petfennt :OAPf) mpu,oly ·a~outfoμt ti~s :!l,dlY ~ ~S ,~/AtaiDlill.,Jn,'.<iU;ed~/~urr ¢APO~ ,ttte• patjent toitiall;y drains spent petitonea1 dfalysi.s solution fn:u:n hulber peo:tom,al cavity, ·and then 'infi.$es'~b :peljrQtie-1, dial.)\sbt .soJutjt)n. into'. hi$~tper:it~ea) Qavitf. This drah1arid' ,t}U :p~otedilr¢· us;p:aUy •tak~s •~out :r, ihont,. l\111,tomat¢d Peritoneal Diatyi,is {APO) is another ,P~hn: form of PD. APO uses a •;r :,t~hi~~.•e,Ue<l '& cyeJ~1\. to, trutoawf,icflllyii.n~,I· ,dweiU~ ,MXd d;rai~ :peritD1)E!61' dm:J.ys.i~ 1olUtlQ:n ~· and .fro.m.tb,e,,pdtient/$ pe:,ri:to,neal, icavi(y . .APO· is pa,t:ticnJ'.r;l.rJy. at~tive·tQ· a J?l) '~a,tient!, .l:,ecau,str it ,;an be perfo~ :at llight wJ:iU~ the pati:e:t)t if l.$le~ti This fr~s d,le patie.nt 1rom the d~y.:lq-da)t h " / • f, 1 ; Ii' Ii "/ I I 'I d~l'MI/Jd1'9f Cit~PO d~,nJ bl$/het~inJ and' ,WPikfutbquri~. The A:PI.l seqμellC'.e .typically lasts for .:•~veral hours. It ~it begins with an initial dram pl\~ to ~pty, fbe.:per,iro:n~al cavity, of:Sp~t.dial,rsat~ .. ThcAPD. $equ•u:e then ,pro.¢eeds, duo,ugh a: SQQ¢1t$$i:O# Qf :fUt, .d;Well, 'add 4rafo. pblses, 0ia:t ·fuHow one ·rsfteir theitlfhor, Bech fiUldwelUdrain .~uerrce is·r.:atled :a cycle. During the fill phase,. tb.f>~jrcle:t tran!!ftl:S,a .t:Jred~e~ioed .,9:lum.e. oftreslt~ wi:ti,ned: di,alYtllh> into th¢ peritone:,i·ca\'.'..ity <;:tf the pati~tr· Jllt dj:al,$1$a?e, retmlitl$ (O.t 1',;fwellt'') w;ithi~ ~e peritoneal eav.fW' for a period of Jim,; .. Tois is. muled the dwell phase, .Owing the drain pl\1iSe, the .cycler r~mQ~S: t;h:e,,!:it"nt diat:,1•·•from th" p~tone~ tJvityi 1 Date Re9ue/Date Received 2024-02-23 ··r»e numw:1:1 ipf ,fi(I.Vd~llldt~.n cyc;~~thAt ate :il/>qui~4>dudns. ••s:iv,11 APO ,St,$.,iQU, depends •upon. ·tlie total; volUPJ(' •O:f' tiialy1•te prescrtbed: foithe. pclittient's APD•t~g:l~lln,···a.Qd bt ~ftber .epteted ~lf pad;of the. treatQtent prescription or ca.leidated: ·by the cycler. t ' .A'.()I) :tan· 1bt ,and. is. px:aetioed in 4i~t, Wafs.·· 1Co1>tirn.10us Cycling Peritone1.d Dlalisis tcCPD) ls qn.e CQn:uttQuly used APP modality. - ' ~, - - ' , ' - ::ounn-,.each. fiUldwe,lJ/'1ra1p. phase .o(,(::.OJJO:, the ~yc~t infu$er.a pftsc1;!'.b.ed volumt 9fdlalYJ1;1te. ', After ,a'p~cp:~t~ diw~l:I. ~e~jQd,j 1tbe 1C)ltl~r 9amp,h,t~JrdraJnl ~If' Jtquiitf 'Molume: from the, pat,i,nt~ leaving the pt;:dtoneal cavity.empty; orftdry .. " T,ypicitlJy, CCPD ~mploys 4.:~ t}JildwelVdtain *t~le$ tQ ,Jcbi~e a,pres~f~ tber•PY voll)'.me1 \ 1, , " ' "' ',, , A.iler:·1tb,e' i111t J'~!i1Crlbed fillldwel'.Udr~D :cyel~ ,in ccm~ die ~yclei: infuses •a fibal'flU I v()lw:nc. The futal :fil!'.volume dwells bl tit¢ .pii.tlent lot liPJ:' .~Jed periocl: of tiroe, ll is x:kajoed:, : 1ei~r at th!! cftlet •Qf'thei 1t1e:lft·cpPD .~ssJ.~Di in:~ ,ef1,11:bt$:, or dunns; a,mid•,:la:y ~obaligj.,. "~e B.nal tilt voltirn,e can tont'aiu a different eon:oeii:tmtion ofdeitros:crthan the fill vahnne .of.tne• • ~~,i:ve CCPD flllld'!.V:elJldrain :fiU eyelets . the cy¢1¢r p,rovid¢i;~ lntemd:ttent '~ritb'1ea:l :PialyJit/{IPO) it 1MQ.th,r AzPO modal.it;y. lf1tJ 111 t)'~ic~111 used in· a~ate situations~ -w:hietta patient sndde,nly, enters dialysis therapy,. IPD can also be used when a :rmiietit r,quires: po,,. but t,1:g1not ~nderutko the :n;sp,o:,ns'i:bilitie,i J>f CAl:D ~r ,e:~el'\i\(st ,do i~ ·at 1ht?me. Like ce PD t lPD involves a set,te$ O·flllVdWellf drain cy~Jes:. tJnlike CCPPY !.PO <.toes fiQt 1.nobule,!'ac~nal··Ju ~-e,, :it· lPD,.die· p1ati~ll:$ p~rit~llCtdi t,"ity• is 1,t\ .frflll; -of:,Jially,ate (or ··d~n}, · in· beiwetn APO ther~py s~Jions. Tidal Peritoneal 'Dialysi.!11 .{TPD) iJanotber APD ntodal.ity.· ~i,k~ CCPO., TPD inctt;J.Cfe:s a . ,strieJ of fill(~we11/dl1iill· cycles~ tfnlike CCPD, :TeD ,tJ.Ql!s not: trmi,lr!.t~Jy, ,Qrain d1aty1a;te,:tf()n1 ~e· , pedilineat cavity dut(ng e~h i:!rain phase. ln$,tead, 'f PD estab1ishe; a base voh.im:e dtiriug the fi,st ,fin pb1