CN-112118855-B - Weight management composition

CN112118855BCN 112118855 BCN112118855 BCN 112118855BCN-112118855-B

Abstract

The present invention provides a method of promoting weight management in a mammal comprising administering to the mammal a composition comprising at least one weight loss agent and at least one mitochondrial enhancer. The weight-reducing agent may be selected from psyllium, guar gum, capsaicin, chitosan, caffeine, gamboge, red pine, capsaicin, yohimbine, butterfly inferior, glucomannan, african mango, guarana, pyruvic acid, carnitine, beta-glucan, fucoxanthin, raspberry ketone, white kidney beans, kola nuts, chromium, ginseng, psyllium, san johnsonii, dandelion, hydroxycitric acid, conjugated linoleic acid, green tea, black tea, coffee bean extract, forskolin, and bitter orange. The mitochondrial enhancer may be selected from beet root extract, nitrate, idebenone, nicotinamide riboside, enalapril, vitamin C, vitamin D, vitamin E, thiamine, riboflavin, magnesium, calcium, phosphate, phospholipid, creatine, pyruvic acid, coenzyme Q10, NADH, niacin, L-carnitine, dichloroacetate, curcumin, schisandrin, and resveratrol. Compositions for weight management are also provided.

Inventors

Mark tanoposky

Assignees

爱瑟金股份有限公司

Dates

Publication Date: 20260512
Application Date: 20190320
Priority Date: 20180320

Claims (8)

1. A weight management composition for a mammal, the weight management composition consisting of: i) A weight-reducing agent; ii) mitochondrial enhancer, and Iii) One or more physiologically acceptable excipients and/or one or more nutrient sources, or none of the additional ingredients of iii), Wherein the weight-reducing agent comprises 50-1000mg of green tea extract, 50-1000mg of green coffee bean extract and 15-100 mg of forskolin, and the mitochondrial enhancer comprises 50-5000mg of beet root extract, 50-900mg of coenzyme Q10, 50-900mg of alpha lipoic acid and 50-900mg of vitamin E, or Wherein the weight-reducing agent consists of 50-1000mg of green tea extract, 50-1000mg of green coffee bean extract, 15-100 mg of forskolin, 50-500mg of black tea extract and 500-3 g of conjugated linoleic acid, the mitochondria enhancer consists of 50-5000mg of beet root extract, 50-900mg of coenzyme Q10, 50-900mg of alpha lipoic acid, 50-900mg of vitamin E and 1-5g of creatine, And wherein the amount of each ingredient in the composition is selected to result in a reduction of fat mass in the mammal of at least 1% and substantially maintain lean mass.
2. The composition of claim 1, wherein the one or more nutrient sources are selected from the group consisting of proteins, carbohydrates, lipids, fibers, vitamins, and minerals.
3. The composition of claim 1, which is decaffeinated.
4. The composition of claim 1, formulated for oral administration.
5. The composition of claim 1, provided in two different dosage forms.
6. The composition of claim 1, wherein the weight-loss agent is provided in a first dosage form and the mitochondrial enhancer is provided in a second dosage form.
7. Use of the weight management composition of any one of claims 1 to 6 in the manufacture of a medicament for promoting weight management in a mammal.
8. A weight management composition for mammals, consisting of: i) A weight-reducing agent; ii) mitochondrial enhancer, and Iii) One or more physiologically acceptable excipients and/or one or more nutrient sources, or none of the additional ingredients of iii), Wherein the weight reducing agent comprises 5-50wt% of green tea extract and green coffee bean extract, and 0.05-50wt% of forskolin, and the mitochondria enhancer comprises 1-50wt% of beet root extract, coenzyme Q10 and vitamin E, and 5-50wt% of alpha lipoic acid, or Wherein the weight-reducing agent consists of 5-50 wt% of green tea extract and green coffee bean extract each, 0.05-50 wt% of forskolin, 20-70 wt% of conjugated linoleic acid and 5-50 wt% of black tea extract each, the mitochondrial reinforcing agent consists of 1-50 wt% of beet root extract, coenzyme Q10 and vitamin E each, 5-50 wt% of alpha lipoic acid and 20-70 wt% of creatine each, And wherein the amount of each ingredient in the composition is selected to result in a reduction of fat mass in the mammal of at least 1% and substantially maintain lean mass.

Description

Weight management composition Technical Field The present invention relates generally to compositions and methods for improving the health of an individual, and more particularly to compositions and methods for promoting weight management in an individual. Background The prevalence of overweight and obesity has become one of the most significant health problems faced worldwide. The incidence of obesity has increased almost twice over the past 30 years, about 40% of adults over 18 years of age are now overweight, and about 13% obese worldwide. It is well known that the presence of obesity is associated with the development of many other diseases, such as fatty liver disease, cardiovascular disease, type 2 diabetes, hypertension, dyslipidemia, gallbladder disease, osteoarthritis, sleep apnea, asthma, chronic kidney disease and depression. Obesity is caused by an imbalance between the total energy expenditure and the energy intake of an individual. Thus, these obesity-related complications can be prevented or treated by reducing body weight. One of the most effective strategies available for weight loss is to engage in a structural program of physical exercise, such as endurance or resistance exercise training. Research conducted over the past decades has repeatedly shown that sports or physical exercise increases energy consumption, thereby promoting weight loss and improving health, but most of the population in most countries does not reach recommended levels. The main reasons for individuals not participating in sports include inconvenience, expense, time-consuming, difficult to perform, boring, or unpleasant. Eating healthy, balanced foods without excessive amounts is a method of reducing energy intake to promote fat loss and maintain good health. However, like sports, eating healthy foods has many obstacles, such as lack of more expense and time needed to obtain food, prepare food, and in contrast, many healthy foods or diets are not palatable than unhealthy alternatives. Furthermore, even though weight loss is achieved by food and exercise, the reduction in fat is often insufficient to meet the overall weight loss required by an individual to maintain optimal health. Accordingly, it is desirable to provide improved weight management compositions and methods for improving the health of an individual. Disclosure of Invention Weight management compositions have now been developed which have been determined to promote weight loss in individuals. Accordingly, in a first aspect of the present invention there is provided a weight management composition comprising a weight loss agent and a mitochondrial enhancer. In one embodiment, a weight management composition is provided comprising a weight loss agent comprising green tea extract, green coffee bean extract, and forskolin, and a mitochondrial enhancer comprising beet root extract, coenzyme Q10, alpha lipoic acid, and vitamin E. In another aspect of the invention, a method for promoting weight management in a mammal is provided, the method comprising the step of administering to the mammal a weight management composition comprising a weight loss agent and a mitochondrial enhancer. In another aspect, a method of treating or ameliorating at least one of body weight, body fat, mitochondrial capacity, fatty liver disease, dyslipidemia, oxidative stress levels, brown adipose tissue activity, and systemic inflammatory levels in a mammal is provided, the method comprising administering to the mammal a composition comprising a weight loss agent and a mitochondrial enhancer. These and other aspects of the invention will become apparent from the following detailed description with reference to the accompanying drawings. Drawings Figure 1 illustrates the body weight of mice fed a weight management composition or control diet and assigned to sitting or exercise training conditions for 30 days. FIG. 2 illustrates A) relative fat mass and B) relative muscle mass (lean mass) of mice fed a weight management composition or control diet and assigned to sitting or exercise training conditions for 30 days. Figure 3 illustrates the relative weights of the following tissues, a) intra-abdominal fat pad, B) liver and C) tibialis anterior (TA; sum of both recorded) for mice fed a weight management composition or control diet and assigned to sitting or exercise training conditions for 30 days. Figure 4 illustrates the relative weights of the following tissues, a) quadriceps (Quad; sum of both), B) heart, C) pancreas, and D) inter-scapular Brown Adipose Tissue (BAT) in mice fed a weight management composition or control diet and assigned to sitting or exercise training conditions for 30 days. Figure 5 illustrates food intake at the endpoint timeline for mice when fed a weight management composition or control diet and assigned to sitting or exercise training conditions for 30 days. Figure 6 illustrates a) maximum exercise capacity and B) stick performance for mice fed weight management