CN-112998649-B - Mobile wearable monitoring system

Abstract

Described herein are a series of inventions including one or more wearable devices (i.e., attached or applied to a limb, body, head, or other body area, as well as systems suitable for implantation or physiological attachment). These systems have a means for monitoring relevant parameters that enables diagnostic or prognostic monitoring and corresponding analytical determination and characterization for the occurrence or detection of events or health conditions of interest. One application involves sleep monitoring and associated EEG sensors.

Inventors

• DAVID BURTON

Assignees

• 大卫·伯顿

Dates

Publication Date

20260512

Application Date

20160106

Priority Date

20150106

Claims (4)

1. 1. A sensor system for a wearable application, comprising: A sensor for head or forehead application comprising one or more monitoring electrophysiological electrodes for monitoring and delivering a magnetic stimulation signal to a subject; The stimulation system is configured to generate the magnetic stimulation signal; the monitoring system comprises an electronic module configured to monitor at least one electrophysiological signal; in combination with the processing of the calculated source localization of the electrical stimulation to facilitate evaluation of brain stimulation sources or related spatiotemporal dynamic measurements, synchronizing the monitored response with the delivered magnetic stimulation signals.
2. 2. The system of claim 1, wherein the process is further configured to assess the responsiveness of the stimulated region of the brain in order to provide biofeedback between monitoring and processing of the stimulus and the generation or nature of the stimulus produced as a way of achieving a desired response effect.
3. 3. The system of claim 1, wherein the process is further configured to assess the responsiveness of the stimulated region of the brain and provide feedback between the monitored properties of the electrophysiological signal and the magnetic stimulation signal.
4. 4. A system according to any one of claims 1-3, further comprising one or more vascular measurement sensors.

Description

Mobile wearable monitoring system Technical Field The present disclosure relates to monitoring systems, and particularly to a portable wearable monitoring system. Background Human circadian rhythms are an endogenous (self-sustaining or "built-in") biological process with a convertible physiological oscillation (rhythm) of about 24 hours. A typical biological clock can be represented by the following 24 hour cycle sequence: 00:00 midnight-sleep onset 02:00-Deep sleep stage 04:30-Minimum body temperature 06:45-Blood pressure experienced the fastest pressure increase 07:30-Stop melatonin secretion 08:30-Possible defecation 08:30-Testosterone secretion is maximal 09:00-Possible defecation 10:00-Peak alertness 12:00 Noon 14:30-Coordinated surplus 15:30-Most sensitive to reaction time 17:00-Maximum intensity of cardiovascular efficacy 18:30-Peak blood pressure Peak 19:00-body temperature 21:00-Onset of melatonin secretion 22:30-Inhibited defecation 00:00 Midnight-sleep onset 02:00-Repeating the above typical diurnal cycle The biological clock cycle includes the following 3 aspects: 1. a free-running period of about 24 hours (known as tau or greek letter "τ"); 2. The switching characteristics (switching) can be reset or adapted by exposure to an external stimulus, such as light or a temperature change. An example of a transition or adjustment of a person's biological clock is when a person is subjected to unexpected or unexpected sleep impulses due to jet lag or other disruption of conventional sleep habits. For example, a person's body has not adjusted or synchronized the local time or current regular sleep/wake cycle of a biological clock (circadian clock or rhythm), which may occur after international travel, crossing different time zones, or adjustment during or after shifts, or stay up due to required learning or other events; The "temperature compensation" feature, i.e. the body maintains a certain circularity in the physiological temperature range despite dynamic changes (temperature and thermal energy of molecular processes in the cell are different) 1. Biological clocks have profound effects on metabolism, general health and sleep/wakefulness regulation The link between shift work and metabolic disease has been demonstrated 2; Studies have linked sleep time and circadian rhythm disorders to a variety of diseases, such as type 2 diabetes, cancer and gastrointestinal disorders 2; Post-holiday rework time difference (e.g., habit of changing sleep time on weekends is related to weight gain) 2; The biological clock regulates energy homeostasis and its destruction resembles a post-sham rework time difference, potentially resulting in a weight-related morbidity 2; The circadian rhythm factor plays an important role in sleep volume, i.e., the length of sleep does not depend on a steady state sleep factor, but on whether you sleep in accordance with their circadian sleep cycle (i.e., the circadian sleep cycle factor is more dominant than sleep homeostasis (sleep impulse) 2; Thus, from an actual or productivity perspective, understanding and guidance of the interactions and relationships between individual homeostasis and circadian processes may be an important aspect. Because a lot of time remains awake to achieve high quality sleep and both regular sleep and rise time are important to achieve a steady sleep cycle (i.e., more sleep time sleep or more sleep is not necessarily of better sleep quality, but sleep time can be most effectively used as opposed to your biological clock when working) 2. Based on previous wakefulness, the accumulation of homeostatic sleep factors, i.e., homeostatic factors (sleep impulses), increases the time you are awake. Thus, this factor is considered to be critical to sleep quality. For example, with an increase 2 in slow wave EEG activity, the longer you stay awake, the deeper the following sleep stages will be; In contrast, circadian rhythms play an important role in sleep volume. For example, the duration of sleep depends primarily on when you sleep. Importance of sleep Health, happiness, lifestyle, even in various aspects of life, high quality sleep is crucial The most detrimental effects of sleep deprivation result from sleep insufficiency. During deep sleep, the body repairs itself and resumes the energy of the previous day. What is important is the quality of the sleep time, not just the number of hours in bed. Sleep is composed of different stages, each stage of the sleep cycle providing different benefits. Deep sleep (N3 level) and REM sleep are the most important stages of sleep. For normal adults, about 50% of the total sleep time is used for stage 2 sleep, 20% of REM sleep, the remaining stages including deep sleep being 30%. Sleep deficiency is the difference between your amount of sleep and your needs. Sacrifice sleep increases your sleep deficit. Eventually, the sleep deficit must be "refunded" to rebate the "sleep account". The sleep deficiency contributes to sleep bre