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CN-113274028-B - Equipment for detecting peristaltic waves of endometrium and application method

CN113274028BCN 113274028 BCN113274028 BCN 113274028BCN-113274028-B

Abstract

The invention discloses a device for detecting endometrial peristaltic waves and a use method thereof, comprising a trunk, a branch, an electrode array and a medicine slow-release array, the main body is provided with a branch, the main body and the branch are both provided with electrode arrays, and the main body is also provided with a medicine slow-release array. The invention belongs to the technical field of measuring equipment, and aims to solve the problem that the measurement of the peristaltic frequency of endometrium is inaccurate in the prior art. The device has the technical effects that the device realizes the measurement of the peristaltic wave of the endometrium and the treatment of the endometrium through the arrangement of the electrode array and the medicine slow-release array.

Inventors

  • LU SHILONG
  • HUANG XIN
  • WU JIANG

Assignees

  • 江苏英诺麦德科技有限公司

Dates

Publication Date
20260508
Application Date
20210506

Claims (8)

  1. 1. The equipment for detecting the peristaltic waves of the endometrium is characterized by comprising a main body (1), a branch (2), an electrode array (18) and a medicine slow-release array (7), wherein the branch (2) is arranged on the main body (1), the electrode array (18) is arranged on the main body (1) and the branch (2), and the medicine slow-release array (7) is also arranged on the main body (1); The power supply device is a battery or a wireless charging module and a charging coil, the power supply device and the main board are arranged in a main trunk, the electrode array, the switch and the power supply device are electrically connected with the main board, a circuit module is arranged on the main board, and comprises a multiplexer, a signal conditioning device, a filter, a variable gain amplifier, an analog-digital converter, a power management module, a wireless module, a central processing unit, a medicine slow-release driving unit, a medicine slow-release control module, a digital-analog converter, an output signal modulation conditioning module, an analog signal driving module and a multiplexing and state retainer; The electrode array (18) comprises a measuring electrode (3) and a reference electrode (6), wherein the branch stems (2) are arranged on two sides of the trunk (1), the measuring electrode (3) is arranged on two surfaces of the branch stems (2), and the reference electrode (6) is arranged at the end part of the trunk (1); The device can sense myoelectric parameter data of the endometrial peristaltic waves measured from each measuring electrode, a plane distribution map of the endometrial peristaltic waves in the uterus is obtained by placing each data into a data matrix according to the position relation of the electrodes, cells without the electrodes are filled by averaging adjacent cell data of the data matrix, a complete digital matrix is obtained, the data in different time are processed repeatedly to obtain a plurality of digital matrices, and finally the distribution change condition of the endometrial peristaltic waves is obtained by arranging the data in time sequence.
  2. 2. An endometrial peristaltic wave detection device according to claim 1, characterized in that the electrode array (18) further comprises treatment electrodes (4), both surfaces of the stem (1) and both surfaces of the stem (2) being provided with the treatment electrodes (4).
  3. 3. The device for endometrial peristaltic wave detection according to claim 1, wherein said drug sustained release array (7) comprises a plurality of sustained release units, a plurality of said sustained release units being disposed on the surface of said stem (1).
  4. 4. A device for endometrial peristaltic wave detection according to claim 3, characterized in that the slow release unit comprises a switch (11) and a drug storage unit (12), the switch (11) being electrically connected to the drug storage unit (12), the slow release unit and the switch (11) being both arranged on the surface of the backbone (1).
  5. 5. The device for endometrial peristaltic wave detection according to claim 1, further comprising a protrusion (5), wherein one end of the stem (1) is provided with the protrusion (5), and wherein the reference electrode (6) is arranged on the surface of the protrusion (5).
  6. 6. An endometrial peristaltic wave detection device according to claim 5, further comprising a collar (8), said collar (8) being provided at an end of said protrusion (5) facing away from said trunk (1).
  7. 7. An apparatus for endometrial peristaltic wave detection according to claim 6, further comprising a fiber (9), said fiber (9) being provided on said collar (8).
  8. 8. The device for detecting peristaltic waves of the endometrium according to claim 5, further comprising a pull string (15) and a sleeve (33), wherein the sleeve (33) is sleeved on the protruding portion (5), one end of the pull string (15) is connected with the stem (2), and the other end of the pull string (15) passes through the sleeve (33) and is slidable relative to the sleeve (33) with respect to the pull string (15).

Description

Equipment for detecting peristaltic waves of endometrium and application method Technical Field The invention relates to the technical field of measuring equipment, in particular to equipment for detecting endometrial peristaltic waves, and further relates to a using method of the equipment for detecting endometrial peristaltic waves. Background Uterus is one of the important reproductive organs of females, which is an important place for female reproductive fertility activities. The uterus is a hollow organ, located in the center of the pelvic cavity, and the cavity is covered with mucous membranes, called endometrium. From puberty to menopause, the endometrium is affected by ovarian hormones, and periodically thickens and falls off to form menses. The uterus has a myometrium layer composed of a large amount of smooth muscle bundles and a small amount of elastic fibers, and is mainly divided into an inner layer (annular arrangement of the muscle fibers), a middle layer (crossed arrangement of the muscle fibers) and an outer layer (longitudinal arrangement of the muscle fibers) 3 layers. Due to the structural features of the myometrium, the contraction takes two forms, one is a contraction involving local aggregation of the myometrium, which occurs sporadically, and can last for several minutes, primarily at the time of delivery to promote fetal delivery, or a relatively low-intensity contraction occurs at the time of menstruation to promote menstrual discharge, and the other is a fine, regular peristaltic contraction occurring from the myometrium adjacent to the endometrium, which induces endometrial peristalsis (Endometrial Peristalsis), otherwise known as uterine peristalsis. A regular wave-like movement similar to intestinal peristalsis, called endometrial peristalsis wave (Endometrial PERISTALSIS WAVE, EPW), can be observed by imaging. Endometrium peristalsis is very slight and is not perceived by the human body itself. Endometrial peristaltic waves play an important role in normal reproductive function regulation and embryo implantation, such as sperm transport, embryo implantation, and maintenance of pregnancy. Furthermore, in the current assisted reproductive technology, endometrial peristaltic waves affect endometrial receptivity and thus embryo implantation. Therefore, the analysis of the peristaltic wave of the endometrium and the intervention treatment of the abnormal condition of the peristaltic wave of the endometrium are of great significance for improving the clinical pregnancy rate. The occurrence of endometrial peristaltic waves may be associated with the modulation of the secretion of sympathetic/parasympathetic nerves, estrogens, progestins, prostaglandins, oxytocin and the like. The frequency, direction and amplitude of the peristaltic wave of the endometrium can show different characteristics in different periods along with the growth and ovulation of the follicle. The direction of the peristaltic wave of the endometrium is generally divided into 5 types, namely, a first wave from the cervix to the fundus, a second wave from the fundus to Gong Gengbo, a third wave which is emitted from the fundus and the cervix at the same time, a fourth random wave with an indefinite direction, and a fifth and no movement. For example, reverse movement (peristaltic wave from the uterine bottom to the uterine neck) is usually presented in menstrual period, so that the discharge of menstrual blood is facilitated, the frequency, the speed and the amplitude of forward movement (peristaltic wave from the uterine neck to the uterine bottom) are gradually increased along with the growth of the follicle, the rapid transportation of sperms in female genital tracts is facilitated, fertilization is facilitated, peak is reached before ovulation, the opposite movement of early luteal phase (at the same time, xiang Xiangbo from the uterine neck and the uterine bottom) occurs, the discharge of embryos from the uterine neck or oviduct is facilitated, and the implantation of embryos is facilitated. The movement mode can cause the flow of intrauterine liquid, provide necessary nutrition and oxygen for embryo before implantation, and provide quiet environment for embryo implantation due to less and less endometrium peristalsis in late luteal phase (late post-ovulation). There are various possible abnormal endometrial peristalsis, and no perfect theoretical system is established at present, and the specific mechanism is not clear at present. Abnormal endometrial peristalsis may also be caused by uterine lesions such as endometriosis, adenomyosis, uterine fibroids, congenital uterine deformities, and the like. Abnormal endometrial peristalsis may affect normal transport of sperm or embryo implantation, resulting in infertility. There are also studies showing that endometrial peristaltic waves have a significant effect on pregnancy outcome in a test tube infant during assisted reproductive procedures. For example, one of t