CN-113939332-B - Methods, systems, and apparatus for managing transducer array placement

Abstract

A method is described that includes generating a three-dimensional (3D) model of a portion of a subject's body, determining a plurality of transducer array maps based on the 3D model and a plurality of simulated electric field distributions, determining one or more sets of transducer array maps from the plurality of transducer array maps, wherein each set of transducer array maps represents at least two transducer array maps having non-overlapping positions of a plurality of pairs of positions for transducer array placement, wherein the at least two transducer array maps satisfy a criterion, and causing the one or more sets of transducer array maps to be displayed.

Inventors

• H. S. hershkovich
• Z. Bomsong
• G. Jigman
• S. Luke sieberman
• O. Kook
• O. B.z. Bacaro

Assignees

• 诺沃库勒有限责任公司

Dates

Publication Date

20260508

Application Date

20200505

Priority Date

20200504

Claims (20)

1. 1. A method for managing transducer array placement, comprising: Generating a three-dimensional (3D) model of a portion of a subject's body; Determining a plurality of transducer array layouts based on the 3D model and the plurality of simulated electric field distributions, each transducer array layout comprising: a first pair of locations for placement of the first transducer array and the second transducer array, and A second pair of locations for placement of the third transducer array and the fourth transducer array; determining one or more sets of transducer array layouts from a plurality of transducer array layouts, wherein each set of transducer array layouts represents at least two transducer array layouts meeting a criterion, wherein the first and second pairs of positions of any one transducer array layout in the set are not at the same position on the 3D model as the first and second pairs of positions of any other transducer array layout in the set, and Causing a display of the set of one or more transducer array layouts.
2. 2. The method of claim 1, wherein the criteria comprises an amplitude of a simulated electric field distribution of a plurality of simulated electric field distributions within a region of interest (ROI) associated with the 3D model, a power density associated with the simulated electric field distribution of the plurality of simulated electric field distributions within the ROI, and an estimate of skin toxicity associated with the subject body part.
3. 3. The method of claim 1, further comprising receiving a selection of a set of transducer array maps of the one or more sets of transducer array maps.
4. 4. The method of claim 3, further comprising generating composite data based on the selected set of transducer array maps.
5. 5. The method of claim 4, wherein the composite data includes information associated with the selected transducer array layout atlas and a simulated electric field distribution of a plurality of simulated electric field distributions associated with the selected transducer array layout atlas.
6. 6. The method of claim 4, further comprising transmitting the composite data to a user device.
7. 7. The method of claim 1, wherein generating a 3D model comprises: Causing one or more user devices to display a plurality of images of a body part of a subject; Receiving a selection of one or more of the plurality of images based on a region of interest (ROI), and A 3D model is generated based on the one or more images.
8. 8. The method of claim 7, further comprising receiving information associated with an ROI from a first user device of the one or more user devices, and wherein receiving a selection of the one or more images comprises receiving a selection of the one or more images from a second user device of the one or more user devices.
9. 9. The method of claim 1, wherein determining a plurality of transducer array maps comprises: Determining a plurality of pairs of locations for transducer array placement based on the 3D model; determining a simulated electric field distribution of the plurality of simulated electric field distributions for each of the plurality of pairs of positions, and A plurality of transducer array layouts is determined based on the plurality of simulated electric field distributions.
10. 10. The method of claim 9, wherein determining the simulated electric field distribution for each of the plurality of pairs of locations comprises: simulating a first electric field generated by a first transducer array at a first location of the pair of locations; Simulating a second electric field generated by a second transducer array at a second location of the pair of locations, wherein the second location is opposite the first location, and A simulated electric field distribution is determined based on the first electric field and the second electric field.
11. 11. An apparatus for managing transducer array placement, comprising: one or more processors, and A memory storing processor-executable instructions that, when executed by one or more processors, cause an apparatus to: Generating a three-dimensional (3D) model of a portion of a subject's body; Determining a plurality of transducer array layouts based on the 3D model and the plurality of simulated electric field distributions, each transducer array layout comprising: a first pair of locations for placement of the first transducer array and the second transducer array, and A second pair of locations for placement of the third transducer array and the fourth transducer array; determining one or more sets of transducer array layouts from a plurality of transducer array layouts, wherein each set of transducer array layouts represents at least two transducer array layouts meeting a criterion, wherein the first and second pairs of positions of any one transducer array layout in the set are not at the same position on the 3D model as the first and second pairs of positions of any other transducer array layout in the set, and Causing a display of the set of one or more transducer array layouts.
12. 12. The apparatus of claim 11, wherein the criteria comprises an amplitude of a simulated electric field distribution of a plurality of simulated electric field distributions within a region of interest (ROI) associated with the 3D model, a power density associated with the simulated electric field distribution of the plurality of simulated electric field distributions within the ROI, and an estimate of skin toxicity associated with the subject body part.
13. 13. The apparatus of claim 11, wherein the processor-executable instructions, when executed by the one or more processors, further cause the apparatus to receive a selection of a set of transducer array maps of the one or more sets of transducer array maps.
14. 14. The apparatus of claim 13, wherein the processor-executable instructions, when executed by the one or more processors, further cause the apparatus to generate composite data based on the selected set of transducer array layouts.
15. 15. The apparatus of claim 14, wherein the composite data includes information associated with the selected transducer array layout atlas and a simulated electric field distribution of a plurality of simulated electric field distributions associated with the selected transducer array layout atlas.
16. 16. The apparatus of claim 14, wherein the processor-executable instructions, when executed by the one or more processors, further cause the apparatus to transmit composite data to a user device.
17. 17. The apparatus of claim 11, wherein the processor-executable instructions, when executed by the one or more processors, cause the apparatus to generate a 3D model, further cause the apparatus to: Causing one or more user devices to display a plurality of images of a body part of a subject; Receiving a selection of one or more of the plurality of images based on a region of interest (ROI), and A 3D model is generated based on the one or more images.
18. 18. The apparatus of claim 17, wherein the processor-executable instructions, when executed by the one or more processors, further cause the apparatus to receive information associated with an ROI from a first user device of the one or more user devices, and wherein receiving a selection of the one or more images comprises receiving a selection of the one or more images from a second user device of the one or more user devices.
19. 19. The apparatus of claim 11, wherein the processor-executable instructions, when executed by the one or more processors, cause the apparatus to determine a plurality of transducer array maps, further cause the apparatus to: Determining a plurality of pairs of locations for transducer array placement based on the 3D model; determining a simulated electric field distribution of the plurality of simulated electric field distributions for each of the plurality of pairs of positions, and A plurality of transducer array layouts is determined based on the plurality of simulated electric field distributions.
20. 20. The apparatus of claim 19, wherein the processor-executable instructions, when executed by the one or more processors, cause the apparatus to determine a simulated electric field distribution for each of a plurality of pairs of locations, further cause the apparatus to: simulating a first electric field generated by a first transducer array at a first location of the pair of locations; Simulating a second electric field generated by a second transducer array at a second location of the pair of locations, wherein the second location is opposite the first location, and A simulated electric field distribution is determined based on the first electric field and the second electric field.

Description

Methods, systems, and apparatus for managing transducer array placement Cross-reference to related patent applications The present application claims priority from U.S. provisional application Ser. No. 62/842,674, filed on 5/3 of 2019, and U.S. application Ser. No. 16/866,417, filed on 5/4 of 2020, both of which are incorporated herein by reference in their entireties. Background The tumor treatment field or TTFields is a low-intensity (e.g., 1-3V/cm) alternating electric field in the mid-frequency range (100-300 kHz). Such non-invasive treatment is targeted to solid tumors and is described in U.S. patent No. 7,565,205, which is incorporated herein by reference in its entirety. TTFields disrupt cell division during mitosis by physical interactions with key molecules. TTFields therapy is an approved monotherapy for recurrent glioblastoma and is an approved chemotherapy combination therapy for newly diagnosed patients. These electric fields are non-invasively induced by a transducer array (i.e., an electrode array) placed directly on the scalp of the patient. TTFields also appear to be beneficial in treating tumors in other parts of the body. As the electric field strength increases, the efficacy of TTFields therapy increases. Changing the positioning of the transducer array on the scalp (and/or other parts of the body) of the patient affects the electric field strength in the target area. Determining how the positioning of the transducer array can be changed while maintaining the target strength of the electric field in the target area is a difficult, labor-intensive and time-consuming process. Disclosure of Invention A method is described that includes generating a three-dimensional (3D) model of a portion of a subject's body, determining a plurality of transducer array maps based on the 3D model and a plurality of simulated electric field distributions, determining one or more sets of transducer array maps from the plurality of transducer array maps, wherein each set of transducer array maps represents at least two transducer array maps having non-overlapping positions of a plurality of pairs of positions for transducer array placement, wherein the at least two transducer array maps satisfy a criterion, and causing the one or more sets of transducer array maps to be displayed. Also described are methods including generating a three-dimensional (3D) model of a portion of a subject's body, determining a plurality of transducer array maps based on the 3D model and a plurality of simulated electric field distributions, receiving a selection of a first transducer array map of the plurality of transducer array maps, wherein the first transducer array map satisfies a criterion, determining one or more associated transducer array maps from the plurality of transducer array maps, wherein each associated transducer array map includes a location for transducer array placement that does not overlap with a location for transducer array placement of the first transducer array map, wherein each associated transducer array map satisfies the criterion, receiving a selection of a second transducer array map from the plurality of associated transducer array maps, and causing the first transducer array map and the second transducer array map to be displayed. Also described are methods including generating a three-dimensional (3D) model of a portion of a subject's body, determining a plurality of transducer array maps based on the 3D model and a plurality of simulated electric field distributions, receiving a selection of a first transducer array map and a second transducer array map of the plurality of transducer array maps, determining an overlap condition based on the first transducer array map and the second transducer array map, and causing the overlap condition to be displayed. Additional advantages will be set forth in part in the description which follows, or may be learned by practice. The advantages will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims. It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive. Drawings For ease of discussion to identify any particular element or act, the most significant digit(s) in the reference number refer to the figure number in which that element is first introduced. Fig. 1 illustrates an example apparatus for electrotherapy treatment. FIG. 2 illustrates an example transducer array. Fig. 3A and 3B illustrate an example application of the device for electrotherapy treatment. Fig. 4A shows a transducer array placed on a patient's head. Fig. 4B shows the transducer array placed on the abdomen of a patient. Figure 5A, transducer array placed on the torso of a patient. Fig. 5B shows the transducer array placed on the pelvis of a patient. Fig. 6 is a block diagram of a system for managing transducer array placemen