CN-114392479-B - Active implantable pulse generator system for generating bi-directional pulses and control method

CN114392479BCN 114392479 BCN114392479 BCN 114392479BCN-114392479-B

Abstract

The application relates to the technical field of implantable medical devices, in particular to an active implantable pulse generator system for generating bidirectional pulses and a control method, wherein the system comprises the following components: the device comprises a microcontroller, a bidirectional pulse generating circuit, a charge pump unit, a DA unit, an electrode wire and a sensing filtering amplifying unit, wherein the bidirectional pulse generating circuit comprises two charging capacitor units and a plurality of discharging loops. Under the control of a microcontroller, the system firstly charges the two charging capacitor units through the charge pump unit, then the bidirectional pulse generating circuit can send bidirectional pulses with preset groups to human tissues according to preset voltage values and preset pulse discharge time so as to achieve the purpose of treatment, and finally, the discharge electrodes are in short connection to balance the charges in the human tissues, so that the charge accumulation effect caused by unidirectional stimulation pulses is eliminated, and the problem that the charge accumulation effect damages the human tissues is avoided.

Inventors

ZHANG GUANGLEI
HE LICHUAN
HE JIFENG
JIN HUA
CHEN XIAOLONG
LIU WEI

Assignees

乐普医学电子仪器股份有限公司

Dates

Publication Date: 20260508
Application Date: 20220218

Claims (8)

1. An active implantable pulse generator system for generating bi-directional pulses, comprising: a microcontroller for controlling operation of the active implantable pulse generator; the bidirectional pulse generating circuit is connected with the microcontroller and is used for sending bidirectional pulses to human tissues through electrode wires; The charge pump unit is connected with the microcontroller and the bidirectional pulse generation circuit and is used for doubling the power supply voltage of the active implantable pulse generator and then supplying power to the bidirectional pulse generation circuit; The DA unit is connected with the microcontroller, the bidirectional pulse generating circuit and the charge pump unit and is used for converting a digital signal which is generated by the microcontroller and used for controlling the target amplitude of the bidirectional pulse into an analog signal and transmitting the analog signal to the bidirectional pulse generating circuit and the charge pump unit, so that the bidirectional pulse generating circuit generates bidirectional pulses with preset amplitude; An electrode wire connected to the bi-directional pulse generating circuit for applying the bi-directional pulse generated by the bi-directional pulse generating circuit to human tissue; The sensing filtering amplifying unit is connected with the microcontroller and the electrode lead, and is used for detecting weak signals of human tissues sensed by the electrode lead, filtering and amplifying the signals, converting the signals into analog quantities and transmitting the analog quantities to the microcontroller; the charge pump unit comprises a first charge pump and a second charge pump; the electrode lead comprises an electrode anode, an electrode cathode and an electrode anode common end; The bidirectional pulse generating circuit comprises a first charging capacitor unit, a second charging capacitor unit, a nineteenth on-off switch and a plurality of discharging loops; the first charge capacitor unit is connected with the first charge pump through an eleventh on-off switch, and the second charge capacitor unit is connected with the second charge pump through a twelfth on-off switch; one end of the discharging loop is connected with the fixed end of the first selection switch, and the other end of the discharging loop is connected with the fixed end of the second selection switch; one contact of the first selection switch is connected between the first charging capacitor unit and the eleventh on-off switch, and the other contact of the first selection switch is connected with the system ground; One contact of the second selection switch is connected between the second charging capacitor unit and the twelfth on-off switch, and the other contact of the second selection switch is connected with the system ground; the nineteenth on-off switch is connected in parallel with two ends of the discharge loop.
2. The bi-directional pulse generating active implantable pulse generator system of claim 1, wherein said discharge circuit comprises a first discharge on-off switch, a second discharge on-off switch, a third discharge on-off switch, a fourth discharge on-off switch; one end of the first discharge on-off switch is connected with the fixed end of the first selection switch, and the other end of the first discharge on-off switch is respectively connected with one end of the second discharge on-off switch and one end of the third discharge on-off switch; The other end of the second discharge on-off switch is connected with one end of the positive electrode, and the other end of the third discharge on-off switch is connected with one end of the common end of the positive electrode; the other end of the electrode positive electrode and the other end of the electrode positive electrode public end are both used for being connected with human tissues; One end of the fourth discharge on-off switch is connected with the fixed end of the second selection switch, and the other end of the fourth discharge on-off switch is connected with one end of the electrode negative electrode; The other end of the electrode negative electrode is used for being connected with the human tissue.
3. The bi-directional pulse generating active implantable pulse generator system of claim 1 or 2, wherein said first charge capacitor unit comprises a first set of charge capacitors and a first set of charge-discharge on-off switches corresponding to said first set of charge capacitors; One end of the first group of charging capacitors is grounded, and the other end of the first group of charging capacitors is connected with one end of the eleventh on-off switch and one contact of the first selection switch through the first group of charging-discharging on-off switches; the second charging capacitor unit comprises a second group of charging capacitors and a second group of charging and discharging on-off switches corresponding to the second group of charging capacitors; One end of the second group of charging capacitors is grounded, and the other end of the second group of charging capacitors is connected with one end of the twelfth on-off switch and one contact of the second selection switch through the second group of charging and discharging on-off switches.
4. The bi-directional pulse generating active implantable pulse generator system of claim 3, wherein said first set of charge capacitors comprises a first charge capacitor, a second charge capacitor, and a third charge capacitor, said first set of charge-discharge on-off switches comprising a thirteenth on-off switch, a fourteenth on-off switch, and a fifteenth on-off switch; one end of the first charging capacitor, one end of the second charging capacitor and one end of the third charging capacitor are all grounded, the other end of the first charging capacitor is connected with one end of the thirteenth on-off switch, the other end of the second charging capacitor is connected with one end of the fourteenth on-off switch, the other end of the third charging capacitor is connected with one end of the fifteenth on-off switch, and the other end of the thirteenth on-off switch, the other end of the fourteenth on-off switch and the other end of the fifteenth on-off switch are all connected with one end of the eleventh on-off switch and one contact of the first selection switch; The second group of charging capacitors comprises a fourth charging capacitor, a fifth charging capacitor and a sixth charging capacitor, and the second group of charging and discharging on-off switches comprises a sixteenth on-off switch, a seventeenth on-off switch and an eighteenth on-off switch; One end of the fourth charging capacitor, one end of the fifth charging capacitor and one end of the sixth charging capacitor are all grounded, the other end of the fourth charging capacitor is connected with one end of the sixteenth on-off switch, the other end of the fifth charging capacitor is connected with one end of the seventeenth on-off switch, the other end of the sixth charging capacitor is connected with one end of the eighteenth on-off switch, and the other end of the sixteenth on-off switch, the other end of the seventeenth on-off switch and the other end of the eighteenth on-off switch are all connected with one end of the twelfth on-off switch and one contact of the second selection switch.
5. A method of controlling an active implantable pulse generator system for generating bi-directional pulses, the method using the active implantable pulse generator system for generating bi-directional pulses of claim 1, the method comprising: The microcontroller controls the charge pump unit to charge the bidirectional pulse generating circuit; The microcontroller controls the bidirectional pulse generating circuit to generate and send a plurality of groups of bidirectional pulses; And shorting the discharge electrode to balance charges.
6. The method of claim 5, wherein the microcontroller controlling the charge pump unit to charge the bi-directional pulse generating circuit comprises: The microcontroller sends a charging switch closing instruction to close an eleventh on-off switch and respectively close a thirteenth on-off switch, a fourteenth on-off switch and a fifteenth on-off switch; The first charge pump detects the voltage value of a first charge capacitor, the voltage value of a second charge capacitor and the voltage value of a third charge capacitor respectively, and if the first charge pump detects that the voltage value of the first charge capacitor, the voltage value of the second charge capacitor and the voltage value of the third charge capacitor are consistent with preset voltage values indicated by the output of the DA unit, the microcontroller sends a charge switch off instruction to enable the eleventh on-off switch, the thirteenth on-off switch, the fourteenth on-off switch and the fifteenth on-off switch to be turned off; the microcontroller sends a charging switch closing instruction to close the twelfth on-off switch and respectively close the sixteenth on-off switch, the seventeenth on-off switch and the eighteenth on-off switch; The second charge pump detects the voltage value of the fourth charge capacitor, the voltage value of the fifth charge capacitor and the voltage value of the sixth charge capacitor respectively, and if the second charge pump detects that the voltage value of the fourth charge capacitor, the voltage value of the fifth charge capacitor and the voltage value of the sixth charge capacitor are consistent with the preset voltage value indicated by the output of the DA unit, the microcontroller sends a charge switch off instruction to enable the twelfth on-off switch, the sixteenth on-off switch, the seventeenth on-off switch and the eighteenth on-off switch to be turned off.
7. The method of claim 5, wherein the controlling the bi-directional pulse generating circuit by the microcontroller to generate and deliver sets of bi-directional pulses comprises: the microcontroller controlling the bi-directional pulse generating circuit to generate and issue a forward pulse discharge includes: The microcontroller sends a forward pulse discharge switch closing instruction: closing a thirteenth on-off switch and/or a fourteenth on-off switch and/or a fifteenth on-off switch; Closing the first discharge on-off switch, closing the second discharge on-off switch or the third discharge on-off switch, and closing the fourth discharge on-off switch; contacting the second selector switch with its system ground; After the preset pulse discharging time, the microcontroller sends a forward pulse discharging switch off instruction: Opening the thirteenth on-off switch and/or the fourteenth on-off switch and/or the fifteenth on-off switch; the first discharge on-off switch is disconnected, the second discharge on-off switch or the third discharge on-off switch is disconnected, and the fourth discharge on-off switch is disconnected; causing the second selector switch to close its other contact; The microcontroller controlling the bi-directional pulse generating circuit to generate and issue a negative going pulse discharge includes: the microcontroller sends a negative pulse discharge switch closing instruction: Closing the sixteenth on-off switch and/or the seventeenth on-off switch and/or the eighteenth on-off switch; Closing the fourth discharge on-off switch, closing the second discharge on-off switch or the third discharge on-off switch, and closing the first discharge on-off switch; contacting the first selector switch with its system ground; After the preset pulse discharging time, the microcontroller sends a negative pulse discharging switch off instruction: opening the sixteenth on-off switch and/or the seventeenth on-off switch and/or the eighteenth on-off switch; The fourth discharge on-off switch is disconnected, the second discharge on-off switch or the third discharge on-off switch is disconnected, and the first discharge on-off switch is disconnected; Causing the first selector switch to close its other contact; wherein a set of the bi-directional pulses includes a positive pulse discharge and a negative pulse discharge.
8. The method for controlling a bi-directional pulsed, active implantable pulse generator system of claim 5, the method is characterized in that the step of shorting the discharge electrode and performing charge balance comprises the following steps: The microcontroller sends a charge balance switch closing instruction to enable the first discharge on-off switch, the second discharge on-off switch, the third discharge on-off switch and the fourth discharge on-off switch in each discharge loop to be closed, and enables the nineteenth on-off switch to be closed; after the preset charge balance time, the microcontroller sends a charge balance switch off instruction to enable the first discharge on-off switch, the second discharge on-off switch, the third discharge on-off switch and the fourth discharge on-off switch in each discharge loop to be disconnected.

Description

Active implantable pulse generator system for generating bi-directional pulses and control method Technical Field The application relates to the technical field of implantable medical devices, in particular to an active implantable pulse generator system for generating bidirectional pulses and a control method. Background The implanted pulse generator is an active medical instrument which is implanted into human body for a long time, and comprises a cardiac pacemaker, various nerve stimulators, muscle stimulators and the like. The implanted pulse generator is generally composed of a circuit board, a titanium shell, a battery and epoxy resin, and the implanted electrode is used for sending pulse stimulation signals to a target treatment position of a human body so as to achieve the aim of treatment. The implantable pulse generator is usually provided with program-controlled equipment matched with the implantable pulse generator, and information is exchanged between the implantable pulse generator and the program-controlled equipment through two-way wireless communication. In the prior art, the implanted pulse generator generally sends unidirectional stimulation pulses with smaller energy, and although the unidirectional stimulation pulses have better action inducing effect, various researches prove that the charge accumulating effect of the unidirectional stimulation pulses can cause damage to stimulated nerves and human tissues. Disclosure of Invention The application provides an active implantable pulse generator system for generating bidirectional pulses and a control method thereof, which are used for solving the problem that the charge accumulation effect generated by the traditional implantable pulse generator damages stimulated nerves and human tissues. The technical scheme adopted by the application for solving the technical problems is as follows: in a first aspect, an active implantable pulse generator system for generating bi-directional pulses, comprising: a microcontroller for controlling operation of the active implantable pulse generator; the bidirectional pulse generating circuit is connected with the microcontroller and is used for sending bidirectional pulses to human tissues through electrode wires; The charge pump unit is connected with the microcontroller and the bidirectional pulse generation circuit and is used for doubling the power supply voltage of the active implantable pulse generator and then supplying power to the bidirectional pulse generation circuit; The DA unit is connected with the microcontroller, the bidirectional pulse generating circuit and the charge pump unit and is used for converting a digital signal which is generated by the microcontroller and used for controlling the target amplitude of the bidirectional pulse into an analog signal and transmitting the analog signal to the bidirectional pulse generating circuit and the charge pump unit, so that the bidirectional pulse generating circuit generates bidirectional pulses with preset amplitude; An electrode wire connected to the bi-directional pulse generating circuit for applying the bi-directional pulse generated by the bi-directional pulse generating circuit to human tissue; And the sensing filtering amplifying unit is connected with the microcontroller and the electrode lead, and is used for detecting weak signals of human tissues sensed by the electrode lead, filtering and amplifying the signals, converting the signals into analog quantities and transmitting the analog quantities to the microcontroller. Further, the charge pump unit comprises a first charge pump and a second charge pump; the electrode lead comprises an electrode positive electrode, an electrode negative electrode and an electrode positive electrode common end. Further, the bidirectional pulse generating circuit comprises a first charging capacitor unit, a second charging capacitor unit, a nineteenth on-off switch and a plurality of discharging loops; the first charge capacitor unit is connected with the first charge pump through an eleventh on-off switch, and the second charge capacitor unit is connected with the second charge pump through a twelfth on-off switch; one end of the discharging loop is connected with the movable end of the first selection switch, and the other end of the discharging loop is connected with the movable end of the second selection switch; one contact of the first selection switch is connected between the first charging capacitor unit and the eleventh on-off switch, and the other contact of the first selection switch is connected with the system ground; One contact of the second selection switch is connected between the second charging capacitor unit and the twelfth on-off switch, and the other contact of the second selection switch is connected with the system ground; the nineteenth on-off switch is connected in parallel with two ends of the discharge loop. Further, the discharge loop comprises a first discharge on-off