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CN-114630697-B - Therapeutic device for painful inflammatory diseases and for neuro-muscular and neuromorphic posture adjustment

CN114630697BCN 114630697 BCN114630697 BCN 114630697BCN-114630697-B

Abstract

The treatment device of the invention consists of a support to be placed on the skin of a patient and is made of specific nanocrystals which, when suitably activated, produce electromagnetic emissions that have a beneficial effect on the inflammatory, painful diseases and neuromuscular and posture adjustment of the patient.

Inventors

  • FABIO FONTANA

Assignees

  • 法比奥·丰塔纳

Dates

Publication Date
20260505
Application Date
20201028
Priority Date
20191031

Claims (20)

  1. 1. Therapeutic device applied to the skin corresponding to the primary and secondary nerve endings of tendons, muscles, rawhide knots and nerve endings, which is advantageous for painful and inflammatory neuromuscular and posture readjustment, comprising at least one support (1), and a mixture (2) provided by a combination of at least two types of quantum dots, comprising the following: -graphene quantum dots with fluorescence corresponding, indicated, to λex 350 nm, λem 445 nm,FWHM 65 nm, quantum dots with quantum yield > 65%; Blue luminescent graphene quantum dots with fluorescence corresponding to λex 350nm, λem 445nm + -10 nm, FWM 75 nm, quantum yield not less than 20%; -cyan luminescent graphene quantum dots having fluorescence corresponding, indicated, to λem 475-495nm, fwhm70 nm, quantum yield > 17%; -water green luminescent graphene quantum dots having fluorescence indicative corresponding to λex 485nm, λem530nm ± 10nm, fwhm80 nm, quantum yield ∈485nm, > 17%; Perovskite quantum dots coated with oleic acid and oleylamine, with fluorescence corresponding, indirectionally, to quantum dots of λem 480 nm; -COOH functionalized CdTe core quantum dots, the fluorescence shown corresponds indirectionally to quantum dots with λem 710nm, quantum yield > 15%; Oleic acid functionalized CdS/ZnS core-shell quantum dots, the fluorescence shown corresponds indifferently to lambda max 385 nm, lambda em 400 nm ±10nm quantum dots with quantum yield > 50%; Oleic acid functionalized CdS/ZnS core-shell quantum dots, the fluorescence shown corresponds, indicated: maximum 405 nm, λem 425 nm + -10 nm quantum dots; Wherein the support (1) consists of a sheet-like element of transparent material at a reference wavelength and at the wavelength of the radiation emitted by the human body, the first side of the support (1) being suitable for direct contact with the skin of a person whose dysfunction or inflammatory disease is to be treated, and the mixture (2) having a concentration of 1 mg/cm 2 to 100 mg/cm 2 being placed on the opposite side of the first side of the support (1) or incorporated or dispersed into the sheet-like element itself, capable of emitting photons in the reference wavelength when stimulated by at least one of infrared, visible or ultraviolet electromagnetic radiation, having an intensity between 0.1 mW/cm 2 and 0.5mW/cm 2 , and wherein the reference wavelength is between 280 nm and 740 nm.
  2. 2. The therapeutic device of claim 1, wherein the intensity is between 0.2 mW/cm 2 and 0.4mW/cm 2 .
  3. 3. The therapeutic device of claim 1, wherein the reference wavelength is between 350 nm and 530 nm.
  4. 4. A treatment device according to any one of claims 1 to 3, characterized in that the support (1) is made of a material transparent to the electromagnetic radiation exciting the mixture (2).
  5. 5. A treatment device according to any one of claims 1 to 3, wherein the support consists of a plastic material which is able to connect to the epidermis of the patient and which is impermeable and inherently sweat relative to the skin.
  6. 6. A treatment device according to any one of claims 1 to 3, wherein the support is composed of a flexible material which can connect to the epidermis of the patient and follow its action and/or deformation without falling off.
  7. 7. The therapeutic device of claim 6, wherein the support has a thickness of between 0.05mm and 2 mm.
  8. 8. The therapeutic device of claim 7, wherein the support has a thickness of between 0.1 and 1 mm.
  9. 9. A treatment device according to any one of claims 1 to 3, characterized in that the mixture (2) is arranged in a distributed manner on the support (1), taking up a major part of the surface of the side on which it is arranged, exploiting the entire surface for a high transmission efficiency of the electromagnetic radiation, not blocked by the superposition of the quantum dots, with a thickness comprised between 0.001 and 1 mm.
  10. 10. A treatment device according to any one of claims 1 to 3, wherein the mixture (2) is arranged in discrete areas on the support (1), concentrating the radiant flux in a defined area so as to be received by the support, having a thickness of 0.005 to 1 mm.
  11. 11. A treatment device according to any one of claims 1 to 3, characterized in that the support (1) is coupled to a second sheet-like element (4, 5) for protection and confinement, which protects the mixture (2) from external agents or mechanical stresses that would damage the mixture (2).
  12. 12. The treatment device according to claim 11, characterized in that the second sheet element (4, 5) is made of a material transparent to infrared electromagnetic radiation, visible electromagnetic radiation or ultraviolet electromagnetic radiation, so that the electromagnetic radiation coming from the outside and passing through the second sheet element (4, 5) can excite the mixture (2) to emit a target frequency.
  13. 13. The treatment device according to claim 11, characterized in that the second sheet-like element (4, 5) has an extension comparable to that of the support (1), the surface of the side of the second sheet-like element facing the support (1) being coupled against the support (1), maintaining and hermetically restricting the sealing of the mixture (2).
  14. 14. The treatment device according to claim 11, characterized in that the second sheet element (4, 5) consists of a transparent protective ink or plastic film enabling to reduce the thickness of the treatment device and to make it easier to wear.
  15. 15. The treatment device according to claim 11, characterized in that the mixture (2) is diluted in ink to be printed on the side of the support (1) facing the second sheet element (4, 5) or on the side of the second sheet element (4, 5) facing the support (1).
  16. 16. The treatment device according to claim 15, wherein the ink is a transparent ink such that all emitted photon emissions and incoming radiation can reach the mixture (2) with minimal attenuation.
  17. 17. A treatment device according to any one of claims 1 to 3, wherein the total thickness of the treatment device is kept to a minimum to maintain a high level of elasticity and to be able to accommodate the surface stress of the skin without cracking, breaking or tearing.
  18. 18. The treatment device according to claim 11, characterized in that the interconnection between the skin and the support (1) and/or the interconnection between the support (1) and the second sheet element (4, 5) is obtained by means of a flexible double-sided adhesive (3).
  19. 19. A treatment device according to any one of claims 1 to 3, characterized in that it is mostly transparent and is adhesively attached to the skin, placed in the vicinity of primary and secondary endings, tendons, muscles, rawhide knots, nerve endings, to facilitate nerve-muscle and posture readjustment, so that any redness of the skin can be examined.
  20. 20. A therapeutic device according to any one of claims 1 to 3, characterized in that it exerts a greater activity of the mixture (2) in the case of an ink comprising 5% to 80% carbon nanotubes, a mixture of 20% to 95%, depending on the type of quantum dots used and the target frequency of the therapeutic radiation, managing the calibration, redefinition and dosing of the quantity of photons emitted by the therapeutic device according to the patient's needs and desired stimulation.

Description

Therapeutic device for painful inflammatory diseases and for neuro-muscular and neuromorphic posture adjustment Technical Field The present invention aims to relate to a device that lets you treat painful inflammatory diseases and also let you make neuromuscular and posture adjustments. Background The human body is known to be sensitive to electromagnetic radiation. One example of such sensitivity is represented by the fact that the human body is able to react to sunlight through the synthesis of specific molecules. For example, stimulation of the human body in sunlight promotes the synthesis of vitamin D, which has a significant impact on the immune system, on calcium fixation in bone (biostimulation to accelerate recalcification). Many of these biological phenomena are still being studied, and some are yet to be fully developed and understood. However, based on certain natural effects such as exposure of the human body to solar radiation, there have been attempts to subject the human body to very intense lasers for therapeutic purposes to obtain more important effects, or at least to be equivalent to those obtained by solar radiation. The current results are less than satisfactory, and treatments with lasers now use rather limited and low intensity lasers. However, exposure to these lasers is always short because the bulky machinery of the physiotherapy center needs to be made available to a large number of patients. Moreover, it has been seen that the frequency of the light emitted by these lasers is specific to therapeutic purposes. Thus, patients suffering from several diseases or patients with various treatment inefficiencies should be treated with different laser shots and with various treatment courses. They are also present in the field of electronic components that emit photons of a selected wavelength when stimulated by a particular wavelength. These components are used to create photovoltaic panels and to make nanocrystalline video displays. No one has thought that these components could be used in the therapeutic field, also because most of them have entirely different fields and methods of use, although they have frequencies very close to the target frequency. For a long time, infrared irradiation of human skin has been used for physical therapy applications, which use low infrared emission frequencies between 760-1500nm, develop heat generation effects and generate high emission power with 150-1500W infrared lamps. It has been found that such heating is often intolerable because it is too intense. Moreover, although such treatments are known as physical therapy applications, the purpose of such treatments is to treat only the superficial layers of the epidermis. It has been found in the past that patients can also more easily tolerate the use of lasers and/or nanocrystals for physical therapy applications in the low infrared emission frequency range of 1100-1400 nm. However, these applications require a near and constantly active emission source for stimulating nanocrystals, which can reach 50W. This need for such power ignition lamps makes the aforementioned devices dependent on a fixed power source and, therefore, they are not portable. Thus, treatment using such nanocrystals and/or laser-based devices is limited to time, limited to the application of infrared radiation only at the healthcare facility with the aforementioned apparatus. Further application of lasers or nanocrystals in medical treatment of the surface layer of skin has in fact been confirmed that wavelengths between 613 and 846nm can be effective in the treatment of skin lesions. However, these patches can only be effectively treated when they are exposed to external ambient light (light is directed at the outer surface of the patch). However, to have therapeutic effects, these patches raise the skin temperature and in fact the nanocrystal emission field is in the low infrared range and cannot tolerate prolonged exposure to the external environment, causing inflammation in the parts of the red and damaged sites underneath these patches. For this reason, the nanocrystals are dispersed from each other at a distance such that ambient light passes through the spaces between the nanocrystals. If they are applied to the patient's skin but hidden under clothing, which would prevent the patch from receiving ambient light on their outer surface, the nanocrystals would not emit radiation for treating skin wounds. In the context of the foregoing application of patches employing nanocrystals, there are also bandages or other devices that are effective for treating exposed and external portions of a person when applied to the skin of the patient. The external part of the strap or other device, with respect to the part placed on the person, must be hit by the radiation coming from the outside and scatter the therapeutic radiation towards the skin, however, these devices appear to be ineffective and in fact they require: -an outer region fo