CN-114768125-B - Low-frequency focusing electric stimulation device and method

CN114768125BCN 114768125 BCN114768125 BCN 114768125BCN-114768125-B

Abstract

The embodiment of the invention discloses a low-frequency focusing electric stimulation device and a method, wherein the device comprises an ultrasonic wave transmitting module, a static magnetic field generating module and a static magnetic field generating module, wherein the ultrasonic wave transmitting module is used for transmitting three ultrasonic waves to a target position, the three ultrasonic waves are perpendicular to each other and focused on the target position of a sample to be stimulated, the center frequencies of the three ultrasonic waves are in an arithmetic progression, the signal frequency difference value of two ultrasonic waves with adjacent frequencies is equal to a preset interference frequency, and the static magnetic field generating module is used for generating a constant static magnetic field at the target position so that the constant static magnetic field and the three ultrasonic waves generate target low-frequency alternating current signals at the target position, and the magnetic field direction of the constant static magnetic field is perpendicular to the combining direction of the three ultrasonic waves transmitted by the ultrasonic wave transmitting module. By the technical scheme of the embodiment of the invention, the effect of providing a low-frequency induction electric field and current with spatial symmetry and high resolution to induce the electrical activity of the neuron is realized.

Inventors

YIN TAO
WANG RURU
LIU ZHIPENG
ZHOU XIAOQING
WANG XIN
LIU RUIXU

Assignees

中国医学科学院生物医学工程研究所

Dates

Publication Date: 20260508
Application Date: 20220418

Claims (9)

1. A low frequency focused electrical stimulation apparatus comprising: The ultrasonic wave transmitting module is used for transmitting three ultrasonic waves to a target position, wherein the three ultrasonic waves are perpendicular to each other and are focused on the target position of a sample to be stimulated, the center frequencies of the three ultrasonic waves form an arithmetic progression, and the signal frequency difference value of two ultrasonic waves with adjacent frequencies is equal to a preset interference frequency; And the static magnetic field generating module is used for generating a steady static magnetic field at a target position so that the steady static magnetic field and the three ultrasonic waves generate target low-frequency alternating current signals at the target position, wherein the magnetic field direction of the steady static magnetic field is perpendicular to the combining direction of the three ultrasonic waves emitted by the ultrasonic wave emitting module.
2. The apparatus of claim 1, wherein the ultrasonic wave transmitting module comprises: the pulse ultrasonic excitation source is used for providing an ultrasonic excitation signal; The first ultrasonic transducer is connected with the pulse ultrasonic excitation source and is used for converting an ultrasonic excitation signal corresponding to the first ultrasonic transducer in the ultrasonic excitation source into first ultrasonic waves; the second ultrasonic transducer is connected with the pulse ultrasonic excitation source and is used for converting an ultrasonic excitation signal corresponding to the second ultrasonic transducer in the ultrasonic excitation source into second ultrasonic waves; The third ultrasonic transducer is connected with the pulse ultrasonic excitation source and is used for converting an ultrasonic excitation signal corresponding to the third ultrasonic transducer in the ultrasonic excitation source into third ultrasonic waves; the first ultrasonic wave, the second ultrasonic wave and the third ultrasonic wave are perpendicular to each other.
3. The apparatus of claim 2, wherein the pulsed ultrasonic excitation source is a three-channel pulsed ultrasonic excitation source, and the first, second, and third ultrasonic transducers are single-element focused ultrasonic transducers.
4. The apparatus as recited in claim 2, further comprising: the fixing module is used for fixing the first ultrasonic transducer, the second ultrasonic transducer and the third ultrasonic transducer and adjusting the positions and angles of the first ultrasonic transducer, the second ultrasonic transducer and the third ultrasonic transducer.
5. The apparatus as recited in claim 4, further comprising: The fixing module comprises three nonferromagnetic universal cantilever supports, wherein the first ultrasonic transducer, the second ultrasonic transducer and the third ultrasonic transducer are respectively fixed on the nonferromagnetic universal cantilever supports, and the height and the angle of the nonferromagnetic universal cantilever supports can be adjusted.
6. The apparatus of claim 1, wherein the center frequencies of the three ultrasonic waves satisfy the following condition: Wherein, the For the highest frequency among the center frequencies of the three ultrasonic waves, For the middle frequency among the center frequencies of the three ultrasonic waves, For the lowest frequency of the center frequencies of the three ultrasonic waves, And for the preset interference frequency, the preset interference frequency is the difference value between the highest frequency and the middle frequency, and the preset interference frequency is also the difference value between the middle frequency and the lowest frequency.
7. The apparatus of claim 1, wherein the static magnetic field generation module comprises: And at least two groups of permanent magnets, wherein each group of permanent magnets comprises two permanent magnets with the same size and matched magnetic induction intensity, and the N pole of the first permanent magnet and the S pole of the second permanent magnet in each group of permanent magnets are oppositely arranged.
8. The apparatus of claim 1, wherein the target low frequency ac electrical signal is determined from a combined ultrasonic signal of ultrasonic signals corresponding to the three ultrasonic beams; wherein, the ultrasonic signals corresponding to the three ultrasonic waves are respectively: The combined ultrasonic signal is: Wherein, the For coupling with the steady static magnetic field to generate the ultrasonic signal of the target alternating current signal, 、 And For the ultrasonic signals corresponding to the three ultrasonic waves, 、 And For the corresponding amplitude values of the three ultrasonic waves, 、 And For the angular frequency corresponding to the three ultrasonic waves, 、 And For the phase corresponding to the three ultrasonic waves, Is time.
9. The apparatus of claim 1, wherein the induced current density of the target low frequency ac signal at the target location is: Wherein, the For the induced current density of the target low frequency alternating current signal at the target location, For the conductivity of the sample to be stimulated, For the tissue density of the sample to be stimulated, For the propagation speed of ultrasound in the sample to be stimulated, For the ultrasonic sound pressure at the target location, For the magnetic field strength of the steady static magnetic field, As a time function of the time variation of the combined ultrasonic signal amplitude of the ultrasonic signals corresponding to the three ultrasonic waves, For the angular frequency of the amplitude of the resultant ultrasonic signal over time, Also the angular frequency of the target low frequency ac electrical signal, Is time.

Description

Low-frequency focusing electric stimulation device and method Technical Field The embodiment of the invention relates to an electrical stimulation technology, in particular to a low-frequency focusing electrical stimulation device and a method. Background The existing magneto-acoustic coupling stimulation device mainly uses a single ultrasonic transducer to inject high-frequency (MHz-level) ultrasonic waves into conductive tissues to be stimulated, simultaneously applies a static magnetic field perpendicular to the ultrasonic propagation direction, generates a high-frequency (MHz-level) induced electric field and current with the frequency equivalent to the ultrasonic frequency based on magneto-acoustic coupling effect, and is suitable for researching the effect of high-frequency (MHz-level) electrical stimulation on neurons. However, neurons have low-pass filtering characteristics, and thus, the magnetoacoustic coupling stimulation produced by existing magnetoacoustic coupling stimulation devices cannot produce low-frequency currents that are more likely to trigger the neuron response. Also, the use of a single ultrasonic transducer causes a problem that the focus of the ultrasonic beam is well focused only in the direction perpendicular to the propagation direction and poorly focused in other directions. Disclosure of Invention The embodiment of the invention provides a low-frequency focusing electric stimulation device and a method thereof, which are used for realizing the effect of providing a low-frequency induction electric field and current with spatial symmetry and high resolution so as to induce neuron electric activity. In a first aspect, an embodiment of the present invention provides a low frequency focused electrical stimulation apparatus, the apparatus comprising: The ultrasonic wave transmitting module is used for transmitting three ultrasonic waves to a target position, wherein the three ultrasonic waves are perpendicular to each other and are focused on the target position of a sample to be stimulated, the center frequencies of the three ultrasonic waves form an arithmetic progression, and the signal frequency difference value of two ultrasonic waves with adjacent frequencies is equal to a preset interference frequency; And the static magnetic field generating module is used for generating a steady static magnetic field at a target position so that the steady static magnetic field and the three ultrasonic waves generate target low-frequency alternating current signals at the target position, wherein the magnetic field direction of the steady static magnetic field is perpendicular to the combining direction of the three ultrasonic waves emitted by the ultrasonic wave emitting module. In a second aspect, an embodiment of the present invention further provides a low-frequency focusing electrical stimulation method, where the method includes: Based on an ultrasonic wave transmitting module, three ultrasonic waves are transmitted to a target position, wherein the three ultrasonic waves are perpendicular to each other and are focused on the target position of a sample to be stimulated, the center frequencies of the three ultrasonic waves form an arithmetic progression, and the signal frequency difference value of two ultrasonic waves with adjacent frequencies is equal to a preset interference frequency; And generating a steady static magnetic field at a target position based on a static magnetic field generating module, so that the steady static magnetic field and the three ultrasonic waves generate target low-frequency alternating current signals at the target position, wherein the magnetic field direction of the steady static magnetic field is perpendicular to the combining direction of the three ultrasonic waves emitted by the ultrasonic wave emitting module. According to the technical scheme, three ultrasonic waves are emitted to a target position through an ultrasonic emission module, wherein the three ultrasonic waves are perpendicular to each other and are focused on the target position of a sample to be stimulated, the center frequencies of the three ultrasonic waves are in an equi-differential array, the signal frequency difference value of two adjacent ultrasonic waves is equal to a preset interference frequency, a static magnetic field is generated at the target position through a static magnetic field generation module, so that a target low-frequency alternating current electric signal is generated by the static magnetic field and the three ultrasonic waves at the target position, the magnetic field direction of the static magnetic field is perpendicular to the combining direction of the three ultrasonic waves emitted by the ultrasonic emission module, the problems that the electric signal frequency is too high and the focusing performance is poor when the neuron electric activity is induced are solved, and the effect of providing a low-frequency induction electric field and current w