CN-114829903-B - Biological component measuring device

CN114829903BCN 114829903 BCN114829903 BCN 114829903BCN-114829903-B

Abstract

A living body component measuring device (1) is provided with an optical medium (10), an excitation light source (16), a detection light source (20), and an optical position detector (25). The optical medium (10) includes a sample mounting surface (surface 2 (12)). The excitation light source (16) emits excitation light (17) toward the sample (5) placed on the sample placement surface (the 2 nd surface (12)). The detection light source (20) emits detection light (21) that advances in the optical medium (10). The light position detector (25) detects the position of the probe light (21) emitted from the optical medium (10). The optical medium (10) is formed from a chalcogenide glass.

Inventors

LIN ZHOUZUO
AKIYAMA KOICHI
TSUDA YUSUKE

Assignees

三菱电机株式会社

Dates

Publication Date: 20260505
Application Date: 20200727
Priority Date: 20191223

Claims (9)

1. A biological component measuring apparatus for measuring a component by utilizing heat generation of a biological sample that absorbs excitation light, the biological component measuring apparatus comprising: An optical medium including a biological sample mounting surface on which the biological sample is mounted, the optical medium being transparent to the excitation light and the detection light and being formed of a chalcogenide glass having a thermal conductivity smaller than that of zinc sulfide, and having a refractive index that changes due to the heat generation of the biological sample that absorbs the excitation light; An excitation light source that emits excitation light that advances through the optical medium toward the biological sample mounting surface; a detection light source that emits the detection light advancing in the optical medium; An optical position detector for detecting a position of the probe light emitted from the optical medium, and A temperature sensor for measuring the temperature of the optical medium, The light position detector detects a1 st position of the detection light emitted from the optical medium transparent to the excitation light and the detection light in a case where the excitation light is not emitted from the excitation light source and a2 nd position of the detection light emitted from the optical medium generating a refractive index gradient region due to the heat generated by the excitation light advancing in the optical medium transparent to the excitation light and the detection light in a case where the excitation light is emitted from the excitation light source, Determining said composition from said 1 st position and said 2 nd position, The temperature sensor is attached to a portion of the biological sample mounting surface that is distant from the biological sample, the excitation light, and the detection light.
2. The biological component measuring apparatus according to claim 1, wherein, The wavelength of the detection light is 1300nm or more and 1700nm or less.
3. The biological component measuring apparatus according to claim 1, wherein, The living body component measuring device further comprises: A photointerrupter arranged in the optical path of the excitation light, and And a lock-in amplifier connected to the photointerrupter and the optical position detector.
4. The living body component measuring apparatus according to any one of claims 1 to 3, wherein, The living body component measuring device further comprises: A temperature regulator for regulating the temperature of the optical medium, and And a temperature controller that controls the temperature regulator according to a1 st signal related to the temperature of the optical medium output from the temperature sensor.
5. The living body component measuring apparatus according to any one of claims 1 to 3, wherein, The living body component measuring device further comprises: a pressing unit configured to press the biological sample against the biological sample mounting surface; A pressure sensor for measuring the pressure of the pressing part pressing the biological sample, and And a pressure controller for controlling the pressing portion according to a2 nd signal related to the pressure outputted from the pressure sensor.
6. The living body component measuring apparatus according to any one of claims 1 to 3, wherein, The living body component measuring device further includes a positioning member that specifies a position of the living body sample in a traveling direction of the probe light.
7. The living body component measuring apparatus according to any one of claims 1 to 3, wherein, The probe light is totally internally reflected on the biological sample mounting surface.
8. The living body component measuring apparatus according to any one of claims 1 to 3, wherein, The probe light does not totally internally reflect on the biological sample mounting surface, but advances along the biological sample mounting surface.
9. The living body component measuring apparatus according to any one of claims 1 to 3, wherein, The living body component measuring device further comprises a living body component acquisition unit connected to the optical position detector, The optical position detector outputs the 1 st position and the 2 nd position to the biological component obtaining unit, The biological component obtaining unit calculates a displacement amount of the probe light, which is a distance between the 1 st position and the 2 nd position, and obtains an amount or concentration of the component in the biological sample or on a surface of the biological sample from the displacement amount.

Description

Biological component measuring device Technical Field The present disclosure relates to a biological component measuring apparatus. Background Japanese patent application laid-open No. 2017-519214 (patent document 1) discloses a non-invasive analysis system (noninvasive ANALYSIS SYSTEM) comprising an optical medium, an infrared light source, a probe light source (probe light source) and a photodiode. Specifically, a biological sample is disposed on the surface of an optical medium. The infrared light source emits infrared light. The infrared light is irradiated to the biological sample through the optical medium. The infrared light is absorbed by the biological sample, which heats up. The extent to which a biological sample absorbs heat depends on the amount or concentration of a biological component in the sample or on the surface of the sample. The detection light source emits detection light as visible light toward the optical medium. The probe light is totally internally reflected at the interface between the optical medium and the biological sample, and is emitted from the optical medium. The absorption heat of the biological sample is transferred to the optical medium, and the refractive index of the optical medium is changed. The change in refractive index of the optical medium affects total internal reflection of the probe light at the interface between the optical medium and the biological sample, and changes the traveling direction of the probe light emitted from the optical medium. The photodiode detects a change in the traveling direction of the detection light. The amount or concentration of the living body component is measured based on the change in the traveling direction of the detection light detected by the photodiode. For example, when the sample is the skin of a patient, the blood glucose level of the patient is measured as a biological component. Prior art literature Patent document 1 Japanese patent application laid-open No. 2017-519214 Disclosure of Invention However, in the non-invasive analysis system disclosed in patent document 1, the optical medium is formed of zinc sulfide (ZnS). Zinc sulfide (ZnS) has a high thermal conductivity of 27.2W/(m·k). The absorbed heat of the biological sample is transferred to the optical medium, and rapidly diffuses in the optical medium. Therefore, the change in refractive index of the portion of the optical medium on the optical path of the probe light becomes small. The living body component cannot be measured with high accuracy. The present disclosure has been made in view of the above problems, and an object thereof is to provide a living body component measuring device capable of measuring a living body component with improved accuracy. The living body component measuring device according to the first aspect of the present disclosure includes an optical medium, an excitation light source, a detection light source, and an optical position detector. The optical medium includes a sample mounting surface. The excitation light source emits excitation light that advances in the optical medium toward the sample placed on the sample placement surface. The detection light source emits detection light that advances in the optical medium. The optical position detector detects the position of the probe light emitted from the optical medium. When the sample mounting surface is viewed in plan, the optical path of the probe light in the optical medium overlaps with the portion of the sample mounting surface irradiated with the excitation light. The optical medium is formed of chalcogenide glass. The living body component measuring device according to the second aspect of the present disclosure includes an optical medium, an excitation light source, a detection light source, and an optical position detector. The optical medium includes a sample mounting surface. The excitation light source emits excitation light that advances in the optical medium toward the sample placed on the sample placement surface. The detection light source emits detection light that advances in the optical medium. The optical position detector detects the position of the probe light emitted from the optical medium. When the sample mounting surface is viewed in plan, the optical path of the probe light in the optical medium overlaps with the portion of the sample mounting surface irradiated with the excitation light. The optical medium is formed of a material having a thermal conductivity of 15.0W/(mK) or less. In the living body component measuring device according to the first aspect of the present disclosure, the optical medium is formed of a chalcogenide glass. In the living body component measuring device according to the second aspect of the present disclosure, the optical medium is formed of a material having a thermal conductivity of 15.0W/(m·k) or less. In the living body component measuring apparatus according to the first and second aspects of the present disclosure, the th