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CN-114901797-B - Bioreactor, end plate for a bioreactor and data transmission unit for an end plate

CN114901797BCN 114901797 BCN114901797 BCN 114901797BCN-114901797-B

Abstract

Bioreactor (1) having a container (13), an end plate (11), a stirrer, a drive unit (15), at least one field device (50, 50a,50 b) arranged in an interior space (14), the field device having field device electronics and a data transmission unit arranged on the end plate (11), the data transmission unit having a motor head (40) which can be coupled to the analysis unit signal technology and to the drive unit (15) energy technology and which comprises motor head electronics, and at least one communication unit which can be coupled to the motor head (40) signal technology, comprising an adapter part (20, 20a,20 b) having adapter electronics which is electrically connected to the field device electronics (50, 50a,50 b) of the field device, the adapter electronics and/or the communication electronics comprising a signal transducer, and a communication part (20, 20a,20 b) having communication electronics which is electrically connected to the adapter electronics and the motor head electronics, and at least one communication unit (20 a,20 b) being configured as separate parts which can be coupled to each other by means of the individual communication units (40, 20a, 40).

Inventors

  • G. Atel

Assignees

  • 艾本德欧洲股份公司
  • 艾本德欧洲股份公司

Dates

Publication Date
20260421
Application Date
20201210
Priority Date
20191218

Claims (19)

  1. 1. A bioreactor (1) for culturing microorganisms and/or cell cultures, having: -a container (13), An end plate (11) configured to close the container (13), -A stirrer having: o a stirring shaft (12) led through the end plate (11) into the inner space (14) of the container (13), and O a stirring element connected to the stirring shaft (12) in the interior (14) of the container (13), -A drive unit (15) arranged on the end plate (11), coupled with the stirring shaft (12), and At least one field device (50, 50a,50 b) arranged in the interior space (14) having field device electronics, Wherein the end plate (11) comprises: an inner side and an outer side opposite the inner side, A stirrer connection means configured to, O passing the stirring shaft (12) through the end plate (11), and O is connected to the drive unit (15), -At least one field device connection arrangement configured to connect the field device (50, 50a,50 b) on the inside, and -A data transmission unit arranged on the outside, having: -a motor head (40) which can be coupled signal-technically to the evaluation unit and which is coupled energy-technically to the drive unit (15) and which comprises motor head electronics, and O at least one communication unit in signal communication with the motor head (40), comprising: an adapter (20, 20a,20 b) having an adapter electronics, which is electrically connected to the field device electronics of the field device (50, 50a,50 b), and A communication section (30, 30a,30 b) having communication electronics electrically connected to the adaptation electronics and the motor head electronics, Wherein the adaptation electronics are designed to exchange signals between the field device electronics and the communication electronics, wherein the signals carry field device information as well as measurement information and/or control information, Wherein the communication electronics are designed to exchange signals between the adaptation electronics and the motor head electronics, Wherein the data transmission unit further comprises a signal converter configured as part of the adaptation electronics and/or as part of the communication electronics; Wherein the adapter part (20, 20a,20 b) and the communication part (30, 30a,30 b) are designed as separate, mutually couplable components, Wherein the motor head (40) is configured as a separate component that can be coupled to the communication unit.
  2. 2. An end plate (11) for closing a bioreactor (1), comprising An inner side and an outer side opposite the inner side, A stirrer connection means configured to, O guides a stirring shaft (12) through the end plate (11), and O a drive unit (15) which can be coupled to the stirring shaft (12), At least one field device connection means configured to connect a field device (50, 50a,50 b) on the inner side, -A data transmission unit arranged on the outside, having: o a motor head (40) which can be coupled in signal technology with an analysis unit and can be coupled in energy technology with a drive unit (15) arranged on an end plate (11) of the bioreactor (1) and comprises motor head electronics, and O at least one communication unit in signal communication with the motor head (40), comprising: An adapter (20, 20a,20 b) having an adapter electronics, which can be electrically connected to field device electronics of the field device (50, 50a,50 b), and A communication section (30, 30a,30 b) having communication electronics electrically connected to the adaptation electronics and the motor head electronics, Wherein the adaptation electronics are designed to exchange signals between the field device electronics and the communication electronics, wherein the signals carry field device information as well as measurement information and/or control information, Wherein the communication electronics are designed to exchange signals between the adaptation electronics and the motor head electronics, Wherein the data transmission unit further comprises a signal converter, which is configured as part of the adaptation electronics and/or as part of the communication electronics, Wherein the adapter part (20, 20a,20 b) and the communication part (30, 30a,30 b) are designed as separate, mutually couplable components, Wherein the motor head (40) is configured as a separate component that can be coupled to the communication unit.
  3. 3. A data transmission unit for an end plate (11) of a bioreactor (1), having: -a motor head (40) which can be coupled signal-technically with the analysis unit and can be coupled energy-technically with a drive unit (15) arranged on an end plate (11) of the bioreactor (1) and which comprises motor head electronics, and -At least one communication unit in signal technical connection with the motor head (40), respectively comprising: o an adapter (20, 20a,20 b) having adapter electronics which can be electrically connected to field device electronics of a field device (50, 50a,50 b), and O a communication section (30, 30a,30 b) having communication electronics electrically connected to the adaptation electronics and the motor head electronics, Wherein the adaptation electronics are designed to exchange signals between the field device electronics and the communication electronics, wherein the signals carry field device information as well as measurement information and/or control information, Wherein the communication electronics are designed to exchange signals between the adaptation electronics and the motor head electronics, Wherein the data transmission unit further comprises a signal converter, which is configured as part of the adaptation electronics and/or as part of the communication electronics, Wherein the adapter part (20, 20a,20 b) and the communication part (30, 30a,30 b) are designed as separate, mutually couplable components, Wherein the motor head (40) is configured as a separate component that can be coupled to the communication unit.
  4. 4. A data transmission unit according to at least claim 3, wherein, -The adaptation portion (20, 20a,20 b) comprises a field device interface and a communicator interface, wherein the adaptation electronics O is connected between the field device interface and the communicator interface, O can be electrically connected to the field device electronics via the field device interface, and O is electrically connected to the communication electronics via the communicator interface, and -The communication part (30, 30a,30 b) comprises an adapter interface and a motor head interface, wherein the communication electronics O is connected between the adapter interface and the motor head interface, O electrically connected to the adapter electrical device through the adapter interface, and O is electrically connected to the motor head electronics through the motor head interface.
  5. 5. The data transmission unit according to claim 3 or 4, comprising at least a first set of first adaptations and a second set of second adaptations, Wherein the adaptation electronics of the first adaptation part (20 a) are designed to exchange signals between the field device electronics of the first field device (50 a) and the communication electronics, Wherein the adaptation electronics of the second adaptation part (20 b) are configured to exchange signals between the field device electronics of the second field device (50 b) and the communication electronics, Wherein the adaptation portion (20, 20a,20 b) of each communication unit is selected from at least the first set of first adaptation portions (50 a) and the second set of second adaptation portions (50 b) depending on the field device (50, 50a,50 b) to be coupled.
  6. 6. The data transmission unit according to claim 3 or 4, wherein, -The adapter part (20, 20a,20 b) comprises a field device coupling configured to mechanically, detachably connect the field device (50, 50a,50 b) with the adapter part (20, 20a,20 b), and/or -The communication part (30, 30a,30 b) comprises an adapter coupler configured to mechanically, detachably connect the adaptation part (20, 20a,20 b) with the communication part (30, 30a,30 b).
  7. 7. The data transmission unit according to claim 3 or 4, Wherein the signal converter is an analog-to-digital converter, And/or -Wherein the adaptation electronics and/or the communication electronics and/or the signal converter are designed to receive an analog signal, to convert the received analog signal into a standardized analog signal and to convert the standardized analog signal into a digital signal and to transmit the digital signal, and/or vice versa.
  8. 8. A data transmission unit according to claim 3 or 4, wherein the communication electronics and/or the motor head electronics are designed to receive signals contactlessly or contactlessly, to convert signals into radio signals and to transmit them by radio or wire, and/or vice versa.
  9. 9. The data transmission unit of claim 8, wherein the communication electronics and/or the motor head electronics are designed to receive signals wiredly.
  10. 10. A data transmission unit according to claim 3 or 4, wherein the adaptation electronics are designed to receive signals contactlessly or contactlessly, to convert signals into radio signals and to transmit them by radio or wire, and/or vice versa.
  11. 11. The data transmission unit of claim 10, wherein the adaptation electronics are designed to receive signals wiredly.
  12. 12. The data transmission unit according to claim 4, wherein the field device interface and/or the communicator interface and/or the adapter interface and/or the motor head interface are configured as connectors on a cable.
  13. 13. The data transmission unit of claim 12, wherein the cable has a length of at most 50 cm.
  14. 14. The data transmission unit according to claim 3 or 4, wherein, -The motor head (40) is energetically coupled with the communication part (30, 30a,30 b), wherein the motor head electronics are designed to supply current to the communication electronics, and/or -The communication part (30, 30a,30 b) is coupled with the adaptation part (20, 20a,20 b) in an energy-technical manner, wherein the communication electronics are designed to supply current to the adaptation electronics, and/or The adapter (20, 20a,20 b) can be coupled to the field device (50, 50a,50 b) in an energy-saving manner, wherein the adapter electronics are designed to supply current to the field device electronics, Wherein the current is transmitted in contact and/or inductively.
  15. 15. The data transmission unit of claim 14, wherein the current is transmitted wiredly.
  16. 16. A data transmission unit according to claim 3 or 4, wherein the motor head (40) comprises: -a communication interface electrically connected with the communication electronics, and A feed interface to which a feed cable can be electrically connected, wherein the feed interface can be electrically connected to the analysis electronics of the analysis unit, Wherein the motor head electronics are connected between the communication interface and the feed interface, Wherein the motor head electronics are designed to exchange signals between communication electronics electrically connected to the communication interface and analysis electronics electrically connectable to the feed interface.
  17. 17. A data transmission unit according to claim 3 or 4, wherein the motor head electronics are designed to send signals based on a bus protocol to or receive signals from the communication electronics of the communication part (30, 30a,30 b) via one or more bus systems.
  18. 18. Use of a data transmission unit according to any one of claims 3 to 17 for an end plate (11) according to claim 2 and/or for a bioreactor (1) according to claim 1.
  19. 19. A method for providing a data transmission unit, comprising the steps of: -providing a motor head which is signally coupled with the analysis unit and which is energetically coupleable with a drive unit arranged on an end plate of the bioreactor and which comprises motor head electronics, and -Assembling at least one communication unit comprising the steps of: o selecting an adapter with adapter electronics according to the field device to be coupled to the adapter, O provides a communication section having communication electronics, O coupling the adaptation part with the communication part and electrically connecting the adaptation electronics with the communication electronics, -Electrically connecting the communication electronics with the motor head electronics.

Description

Bioreactor, end plate for a bioreactor and data transmission unit for an end plate Technical Field The present invention relates to a bioreactor, in particular for culturing microorganisms and/or cell cultures, an end plate for closing such a bioreactor, and a data transmission unit for the end plate. The invention also relates to a method for providing a data transmission unit. Background A bioreactor, also commonly referred to as a fermenter, is a container in which certain microorganisms, cells or plants are cultivated, preferably under as optimal, controllable and reproducible conditions as possible, in order to obtain the cells themselves or a part thereof or a metabolite thereof. For this purpose, the bioreactor encloses a reaction chamber in which a culture medium can be accommodated. The volume of the bioreactor can range from a few milliliters on a laboratory scale, particularly in a screening mode, to thousands of cubic meters on a production scale. On a laboratory scale, particularly for research and development purposes, bioreactors with volumes up to 10 liters are preferably used. Laboratory scale bioreactors differ from production scale bioreactors in terms of power input, mass transport, and materials used. Laboratory scale bioreactors are usually made of glass and/or metal, in particular stainless steel, since such bioreactors have to be sterilized between uses, preferably by hot steam in an autoclave. As an alternative to reusable bioreactors, disposable bioreactors may also be used. Disposable bioreactors are used to perform a single biological or biotechnological process and are subsequently disposed of. By providing each individual process with a new, preferably in-process sterilized, disposable bioreactor, the risk of contamination can be reduced while also saving the costs of performing the cleaning and sterilization process. Most bioreactors have agitators, the agitator shaft of which can be rotated by a drive unit. This allows the stirring element, which is connected to the stirring shaft in a rotationally fixed manner, to be rotated as well, and allows the substances present in the reaction chamber, in particular the nutrient medium, to be mixed. In particular, two or more stirring elements, preferably axially spaced apart, may also be arranged on the stirring shaft and connected thereto. The stirring element or stirring elements can also be constructed in one piece with the stirring shaft. Furthermore, bioreactors typically have multiple interfaces, primary and secondary materials, and various instrumentation, such as sensors and/or actuators, that may be introduced into the reaction chamber. Fluid lines, in particular gas lines, such as for example inflation or deflation lines, can preferably also be connected via these connections. By means of the sensor and/or the actuator, an optimal product yield can be pursued. For this purpose, sensors are generally used to monitor the conditions in the reaction chamber, in particular the pH value, the redox potential (Redoxpotential), the O 2 content in the medium and possibly in the exhaust gas, the CO 2 content in the exhaust gas, the temperature, the optical density of the medium, the foam formation, the glucose content, the glycerol content and/or the lactic acid content. In addition, various actuators, such as peltier coolers and/or light bars, may be provided in order to create the best possible culture conditions. The sensors and the actuators (if present) are connected to the corresponding measuring module and/or analysis unit and/or control unit, respectively, by cables. These cables often have good shielding and special construction to ensure the integrity of the data, which may be severely disturbed by external influences such as electromagnetic fields. The number of cables in the case of multiple sensors and/or actuators may lead to a high degree of ambiguity. In addition, the number of cables also limits the operation of the bioreactor. In particular in the case of bioreactors with smaller scale (for example in the range of 300 ml), operational restrictions are particularly evident. Disclosure of Invention It is therefore an object of the present invention to provide an improved solution to at least one of the above problems. The object of the present invention is in particular to provide a solution which enables an improved operation of the bioreactor and at the same time enables a robust data transmission. According to a first aspect, the initially mentioned object is achieved by a bioreactor, in particular for culturing microorganisms and/or cell cultures, comprising a vessel, an end plate designed to close the vessel, a stirrer having a stirring shaft which is introduced through the end plate into the interior of the vessel and a stirring element which is connected to the stirring shaft in the interior of the vessel, a drive unit which is arranged on the end plate and is coupled to the stirring shaft, and at least one field