CN-115087726-B - Hangover relieving agent containing glutathione and aldehyde dehydrogenase

Abstract

The present invention relates to a hangover alleviating composition comprising a dried powder, lysate or extract of an enzyme producing glutathione and aldehyde dehydrogenase. In particular, the present invention relates to a hangover alleviating composition containing dried powders, lysates or extracts of Saccharomyces cerevisiae (Saccharomyces cerevisiae) Kwon P-1 KCTC 13925BP and Saccharomyces cerevisiae Kwon P-2 KCTC14122BP and Saccharomyces cerevisiae Kwon P-3 KCTC14123BP yeast, which simultaneously produce glutathione and aldehyde dehydrogenase.

Inventors

• QUAN XINGZE

Assignees

• 匹克生物酶高科技有限公司

Dates

Publication Date

20260505

Application Date

20210217

Priority Date

20200218

Claims (2)

1. 1. Use of a composition comprising glutathione and an aldehyde dehydrogenase in the preparation of a hangover relief agent, wherein the composition comprises a lysate of a mutated Saccharomyces cerevisiae from which the glutathione and the aldehyde dehydrogenase are derived, or the use comprises extracting glutathione and the aldehyde dehydrogenase from the mutated Saccharomyces cerevisiae, and Wherein the mutant Saccharomyces cerevisiae is selected from the group consisting of Saccharomyces cerevisiae Kwon P-1 deposited with the accession number KCTC13925BP, saccharomyces cerevisiae Kwon P-2 deposited with the accession number KCTC14122BP, and Saccharomyces cerevisiae Kwon P-3 deposited with the accession number KCTC14123BP, or a mixture thereof.
2. 2. The use of claim 1, wherein the composition is characterized by further comprising added NAD.

Description

Hangover relieving agent containing glutathione and aldehyde dehydrogenase Technical Field The present invention relates to a hangover alleviating agent comprising Glutathione (GSH) and aldehyde dehydrogenase (hereinafter referred to as "ALDH"). Specifically, the present invention relates to an agent for relieving hangover, which contains glutathione and aldehyde dehydrogenase derived from Saccharomyces cerevisiae (Saccharomyces cerevisiae) Kwon P-1KCTC 13925BP and Saccharomyces cerevisiae Kwon P-2KCTC14122BP or Saccharomyces cerevisiae Kwon P-3KCTC14123BP yeast. Background Although it is a fun food accompanying the history of human beings, excessive drinking can reach a hangover state in which people feel uncomfortable with the body and spirit, causing nausea, vomiting, dizziness, thirst, impossibility, drowsiness, headache, causing abnormality of the cerebral nervous system (Alcohol Use Disorder, AUD) (Shao-CHENG WANG ETAL, 2020), and becoming a social problem causing serious severe symptoms (Alcohol Addiction) and mental panic disorder. (Choe Songsig 2013). After drinking, alcohol is absorbed 5% in the mouth, 10-15% in the stomach, 80% in the small intestine, and flows into the blood, and breaks down 2 to 4% in the lung, 2 to 4% in the kidneys, 2 to 6% by sweat, and 90% in the liver. In the liver, alcohol decomposition is converted to acetaldehyde (ACETALDEHYDE) by alcohol dehydrogenase (Alcohol dehydrogenase, ADH) and then to non-toxicity by aldehyde dehydrogenase (Aldehyde dehydrogenase, ALDH). However, it is reported that 15% to 50% of asians deficient in aldehyde dehydrogenase or having an oppositional gene for aldehyde dehydrogenase (ALDH 2x 2) are unable to decompose acetaldehyde produced during alcohol consumption, develop the phenomenon of reddish facial alcohol-red syndrome (Alcohol Flushing Syndrome) (Brooks, p.j.et al.2009), and have a high probability of developing alcoholism or liver disease due to accumulation of acetaldehyde (Larson, H.N et al, 2007). Acetaldehyde cannot be decomposed and remains in the human body, and causes death or disorder due to alcoholic liver disease (Alcohol hepatitis) or cirrhosis (liver cirrhosis). (Gilpin, N.W.et., 2008) In addition, excessive residual in-vivo aldehydes (Aldehyde) generated by alcohol intake have been reported to cause diseases due to oxidation such as cardiovascular diseases, diabetes, neurodegenerative diseases, upper digestive and respiratory cancers, radiation dermatitis, fanconi anemia, peripheral nerve injury, inflammation, osteoporosis and aging (Chen et al 2014). In addition, it is reported that in most countries, the scale of socioeconomic loss due to drinking is about 0.5 to 2.7% relative to GDP, and in korea, the socioeconomic loss due to drinking is estimated to reach 14 mega 9,352 million korea in one year of 2000, wherein the reduction in productivity and loss due to diseases, accidents, hangover are estimated to reach 6 mega 2,845 million korea (Jeog Wujinet al 2006). In order to solve such social problems, various studies and experiments on substances capable of reducing toxicity of ethanol or inhibiting expression of toxicity have been conducted, and as a result, various health-aid food-related products have been developed. Alcohol flowing into the body is absorbed in the stomach or small intestine and enters into blood vessels, and is transferred to the liver to be decomposed and detoxified. Alcohol dehydrogenase (ADH, alcohol Dehydrogenase) existing in the liver cells first oxidizes alcohol to acetaldehyde (ACETALDEHYDE), and then acetaldehyde is decomposed into acetic acid (Acetate) by ALdehyde dehydrogenase (ALDH, ALdehyde DeHydrogenase) existing in the liver cells and transferred to muscles or adipose tissue of the whole body, and finally decomposed into carbon dioxide and water. Acetaldehyde, which is the primary metabolite of ethanol, is very reactive, more toxic than ethanol, and is a major cause of hangover and alcoholic liver disease. The reported number of aldehyde dehydrogenases present in the human body is 19 (MARCHITTI ET al 2007, 2008), and among them, the aldehyde dehydrogenase2 (ACETALDEHYDE DEHYDROGENASE 2) mainly present in the mitochondria shows that acetaldehyde is the lowest Km value (0.2 μm) when analyzed by using acetaldehyde as a substrate for enzyme, and the acetaldehyde derived from alcohol is preferably oxidized and removed, compared with the case of using other types of aldehyde as a substrate. Acetaldehyde, which is a hangover-causing substance produced in ethanol metabolism in living bodies, is very important for human health by efficiently converting it into acetic acid to remove aldehyde (Eriksson et al 1977). In addition, aldehyde dehydrogenase 2 is used not only for acetaldehyde but also for metabolic processes of aldehydes such as aliphatic aldehydes, aromatic aldehydes, polycyclic aldehydes, etc., to remove toxic substances in vivo (Klyosovet al 1996). Representative examples are the effects