CN-115149836-B - Multi-pulse output transcranial magnetic stimulation circuit

CN115149836BCN 115149836 BCN115149836 BCN 115149836BCN-115149836-B

Abstract

The invention discloses a multi-pulse output transcranial magnetic stimulation circuit, which comprises an input module, a combined circuit module and an output module which are sequentially connected, wherein the combined circuit module comprises a combined discharge loop, a voltage control unit, a trigger control unit and a microcontroller, one input end of the combined discharge loop is connected with the input module, one output end of the combined discharge loop is connected with the output module, the voltage control unit and the trigger control unit are respectively in communication connection with the microcontroller, the voltage control unit and the trigger control unit are connected with the input module, and the trigger control unit is connected with the output module. The number of input modules and output modules of the present invention can be adjusted according to the user. Based on the triggering control unit, the on-off of the input modules and the output modules with corresponding numbers is controlled, so that the combined use of a plurality of stimulation devices is realized, the output form of multiple frequencies and multiple pulses is realized, the limitation of the existing stimulation frequency is broken, the special devices and the special systems are not required to be additionally selected, and the use cost is reduced.

Inventors

LONG JINGYAN
LIU XING
WANG ZHIBO

Assignees

深圳英智科技有限公司

Dates

Publication Date: 20260508
Application Date: 20220801

Claims (4)

1. The transcranial magnetic stimulation circuit with multi-pulse output is characterized by comprising an input module, a combined circuit module and an output module which are connected in sequence; The input modules are connected in parallel and connected with the combined circuit, and the output modules are connected in parallel and connected with the combined circuit; The combined circuit module comprises a combined discharging loop, a voltage control unit, a trigger control unit and a microcontroller, wherein one input end of the combined discharging loop is connected with the input module, one output end of the combined discharging loop is connected with the output module, and the voltage control unit and the trigger control unit are respectively in communication connection with the microcontroller; The voltage control unit and the trigger control unit are connected with the input module, and the trigger control unit is connected with the output module; The input module comprises a first triode, a capacitor and two first thyristors, wherein the capacitor is used for storing electric energy, the two first thyristors form a first thyristor discharge loop, and the capacitor and the first thyristor discharge loop are connected in parallel with an emitter of the first triode; the base electrode of the first triode is connected with the voltage control unit, and the control stage of each first thyristor is connected with the trigger control unit; The combined circuit module further comprises two second thyristors, the two second thyristors form a second thyristor discharge loop, and a control stage of each second thyristor is connected with the trigger control unit; the combined discharging loop is connected with the second thyristor discharging loop and the output module in series in sequence; The second thyristor discharge loops are in one-to-one correspondence with the output modules.
2. The multi-pulse output transcranial magnetic stimulation circuit according to claim 1, wherein the combined discharge circuit comprises a second triode and a resistor, wherein a base electrode of the second triode is connected with the trigger control unit, and an emitter electrode of the second triode is connected with the resistor.
3. The transcranial magnetic stimulation circuit with multiple pulse outputs according to claim 1, wherein the output module is a stimulation coil.
4. The multi-pulse output transcranial magnetic stimulation circuit according to claim 1, wherein the input module comprises a switching power supply, a capacitor and two third thyristors, wherein the capacitor is used for storing electric energy, the two third thyristors form a third thyristor discharge loop, and the capacitor and the third thyristor discharge loop are connected in parallel with one end of the switching power supply; The switching power supply is connected with the voltage control unit, and the control stage of each third thyristor is connected with the trigger control unit.

Description

Multi-pulse output transcranial magnetic stimulation circuit Technical Field The invention relates to the field of transcranial magnetic stimulation equipment, in particular to a multi-pulse output transcranial magnetic stimulation circuit. Background The Transcranial Magnetic Stimulation (TMS) is a painless and noninvasive physical nerve regulation and control technology, and the main technical principle is to apply a transient pulse magnetic field to cerebral cortex by utilizing Faraday electromagnetic induction principle, so that cortical neurons depolarize to generate action potentials, thereby affecting cerebral cortex electric activity and achieving the effect of nerve regulation and control. The transcranial magnetic stimulation technology has become a common diagnosis and treatment means for psychiatry and neurology so far, and a great deal of researches show that the transcranial magnetic stimulation technology has good treatment effects on diseases such as parkinsonism, epilepsy and related dyskinesia, depression and mood disorder, cerebral apoplexy, schizophrenia, chronic pain and the like. In addition, transcranial magnetic stimulation can also be used for objective and direct motor nervous system or sensory nervous system function examination, and diagnosis and evaluation of nervous system diseases such as evaluation of conductivity of a corticospinal cord bundle, evaluation of excitability of motor cortex, function of central nervous system damage, prognosis evaluation and the like can be performed. The first real transcranial magnetic stimulation instrument was developed in the United kingdom by Barker et al in 1985, which can generate single magnetic stimulation pulses and act on motor nerves to trigger the motion potential of hands, after which the technology developed gradually, the repeated transcranial magnetic stimulation instrument was developed, which can generate repeated transcranial magnetic pulses with the repetition frequency up to 100Hz, and through thirty years of development of transcranial magnetic stimulation technology, various output modes such as single-pulse transcranial magnetic stimulation, repeated transcranial magnetic stimulation, explosive transcranial magnetic stimulation, double-pulse paired transcranial magnetic stimulation, four-pulse or multi-pulse have been proposed. In the aspect of the marketization of transcranial magnetic stimulation instruments, various transcranial magnetic stimulation instruments with mature technology and excellent design are already proposed at home and abroad, but most transcranial magnetic stimulation proposed in the current market only supports output modes of single pulse, repeated pulse and explosive pulse, the repetition frequency only reaches 100Hz at most, the time interval between the two pulses only can reach 10ms at least, and the stimulation frequency of 100Hz is insufficient for some research applications. While the dual-pulse paired stimulation mode requires a minimum time interval of 1ms or even 0.5ms, the dual-pulse paired stimulation mode only has a specific transcranial magnetic stimulator which supports dual pulses by individual factories, but the device is a system which is independently customized, is high in price due to binding with the device, and is difficult to be widely popularized in clinical application. Disclosure of Invention The invention provides a multi-pulse output transcranial magnetic stimulation circuit, which aims to solve the problems of insufficient frequency and high manufacturing cost in the existing transcranial magnetic equipment. According to the embodiment of the application, a multi-pulse output transcranial magnetic stimulation circuit is provided, which comprises an input module, a combination circuit module and an output module which are sequentially connected, wherein a plurality of input modules are connected with the combination circuit in parallel, a plurality of output modules are connected with the combination circuit in parallel, the combination circuit module comprises a combination discharge loop, a voltage control unit, a trigger control unit and a microcontroller, one input end of the combination discharge loop is connected with the input module, one output end of the combination discharge loop is connected with the output module, the voltage control unit and the trigger control unit are respectively connected with the microcontroller in a communication way, the voltage control unit and the trigger control unit are connected with the input module, and the trigger control unit is connected with the output module. Preferably, the input module comprises a first triode, a capacitor and two first thyristors, wherein the capacitor is used for storing electric energy, the two first thyristors form a first thyristor discharge loop, the capacitor and the first thyristor discharge loop are connected with an emitting electrode of the first triode in parallel, a base electrode of the