CN-115299988-B - Ultrasonic sequencing systems and methods

Abstract

A system includes a catheter configured for delivery to a body lumen defined by surrounding tissue, a plurality of ultrasound transducers connected to a distal end of the catheter, and an electronics module configured to selectively turn on/off each ultrasound transducer according to a predetermined activation sequence and process signals received from each ultrasound transducer to produce at least a 2D display of the surrounding tissue. The user may selectively calculate and display various aspects of cardiac activity. The user may display Dipole Density (DDM), charge Density (CDM) or voltage (V-V). The shape and position of the chamber (surface) and the potential recorded on the electrodes can be displayed. The system may also toggle between different display modes and may use post-processing tools to change the manner in which various types of information are displayed. Methods are also provided.

Inventors

• Derek R week
• GRAYDON E BEATTY
• Markus julian
• Timothy J Cole ties up
• J Christophe fliehr pedicle
• R Maxwell fliehr pedicle

Assignees

• 阿库图森医疗有限公司

Dates

Publication Date

20260505

Application Date

20160512

Priority Date

20150512

Claims (20)

1. 1. A method of performing a positioning and imaging process, comprising: Providing a cardiac catheter comprising a plurality of biopotential electrodes and a plurality of ultrasound transducers connected to a 3D array at a distal end of the catheter; Providing a positioning system comprising a plurality of surface electrodes for generating one or more positioning signals and determining the position of one or more of said biopotential electrodes with respect to a coordinate system by recording and analyzing data collected from the surface electrodes; there is provided an imaging system comprising an electronic module for: Selectively switching on/off each of the plurality of ultrasonic transducers according to a predetermined activation sequence that avoids sequential activation of two adjacent transducers within two or three mutually adjacent spaces, wherein the adjacent spaces are spaces on a single spline comprising a first transducer and a second transducer, spaces across the spline comprising a first transducer and a second transducer, and/or spaces diagonally across the spline comprising a first transducer and a second transducer, and Signals received from each ultrasound transducer are processed to produce a 3D display of surrounding tissue, wherein the surrounding tissue is positioned relative to the coordinate system by one or more of the biopotential electrodes.
2. 2. The method of claim 1, wherein the surrounding tissue is one or more walls of a ventricle.
3. 3. The method of claim 1, wherein the 3D display of surrounding tissue is presented on a user interface system having a display screen and user control means, the user interface system allowing graphical manipulation of the 3D display of surrounding tissue.
4. 4. The method of claim 1, wherein the 3D array is a basket array, a spiral array, a balloon, radially deployable arms, or other expandable and compressible structure.
5. 5. The method of claim 1, wherein the ultrasound transducer is disposed on a plurality of splines of the 3D array.
6. 6. The method of claim 5, wherein the 3D array comprises at least three splines.
7. 7. The method of claim 5, wherein at least two ultrasonic transducers are disposed on each spline.
8. 8. The method of claim 5, wherein the biopotential electrode is also disposed on a plurality of splines of the 3D array.
9. 9. The method of claim 8, wherein at least some of the biopotential electrodes and at least some of the ultrasonic transducers are disposed on the same spline.
10. 10. The method of claim 8, wherein one biopotential electrode and one ultrasound transducer are placed together to form a pair of electrodes/transducers, and the system comprises multiple pairs of electrodes/transducers.
11. 11. The method of claim 10, wherein the one or more splines comprise a plurality of pairs of electrodes/transducers.
12. 12. The method of claim 10, wherein the plurality of splines comprises at least one pair of electrodes/transducers.
13. 13. The method of claim 10, wherein each spline comprises a flexible PCB and each pair of electrodes/transducers is electrically connected to the flexible PCB.
14. 14. The method of claim 10, wherein each pair of electrodes/transducers share a common communication path.
15. 15. The method of claim 10, wherein all electrode/transducer pairs on the spline share a common communication path.
16. 16. The method of claim 10, wherein all electrode/transducer pairs on the spline share a common ground.
17. 17. The method of claim 1, further comprising the electronic module associating an electrical activity with one or more images generated using an imaging device.
18. 18. The method of claim 17, wherein the imaging device comprises an imaging device selected from the group consisting of a fluoroscope, an MRI, a CT scanner, an ultrasound imaging device, and combinations of two or more of these.
19. 19. The method of claim 1, wherein the activation sequence avoids sequential activation of two transducers from a single spline.
20. 20. The method of claim 1, the electronic module comprising one or more switches, the method comprising selectively opening and/or closing the one or more switches to activate the one or more switches to electrically connect the transducer to a signal generator.

Description

Ultrasonic sequencing systems and methods The application relates to a split application of a Chinese patent application with the application date of 2016, 05 and 12, the application number of 201680040709.1, the name of ultrasonic sequencing system and method and the stage date of 2018, 01 and 10 entering China. RELATED APPLICATIONS The present application is based on the priority of U.S. provisional patent application Ser. No. 62/160,529 entitled "Ultrasound Sequencing SYSTEM AND Method," filed 5/12/2015, by 35 USC 119 (e), the disclosure of which is incorporated herein by reference in its entirety. The present application, although not claiming priority thereto, may be related to U.S. patent application serial No. 14/865,435 filed on 25 th month 2015, entitled "Method and Device for Determining and Presenting Surface Charge and Dipole Densities on Cardiac Walls", to continuation of U.S. patent No. 9,167,982 (hereinafter referred to as the '982 patent) filed on 27 th month 2015, entitled "Method and Device for Determining and Presenting Surface Charge and Dipole Densities on Cardiac Walls", to continuation of U.S. patent No. 8,918,158 (hereinafter referred to as the' 158 patent) filed on 23 th month 2014, entitled "Method and Device for Determining and Presenting Surface Charge and Dipole Densities on Cardiac Walls", to continuation of U.S. patent No. 8,700,119 (hereinafter referred to as the '119 patent) filed on 15 th month 2014, entitled "Method and Device for Determining and Presenting Surface Charge and Dipole Densities on Cardiac Walls", to continuation of U.S. patent 8,417,313 (hereinafter referred to as the' 313 patent) filed on 9 th month 2013, entitled "Method and Device for Determining and Presenting Surface Charge and Dipole Densities on Cardiac Walls", to state 35371 of PCT application CH2007/000380, entitled "Method and Device for Determining and Presenting Surface Charge and Dipole Densities on Cardiac Walls", to be filed on 3 th month 2008/000380, and published by WO 2007/01406, each of which is incorporated herein by reference. The present application, although not claiming priority thereto, may be related to U.S. patent application serial No. 14/886,449 filed on 10 month 19 of 2015, entitled "Device and Method for the Geometric Determination of Electrical Dipole Densities on the Cardiac Wall", to the continuation-in-progress application of U.S. patent No. 9,192,318 (hereinafter referred to as the '318 patent) filed on 11 month 24 of 2015, entitled "Device and Method for the Geometric Determination of Electrical Dipole Densities on the Cardiac Wall", to the continuation-in-progress application of U.S. patent No. 8,512,255 (hereinafter referred to as the' 255 patent) filed on 8 month 20 of 2013, entitled "Device and Method for the Geometric Determination of Electrical Dipole Densities on the Cardiac Wall", of the '255 patent, published as US2010/0298690 (hereinafter referred to as the' 690 publication), which is a national phase 35usc 371 application of PCT application No. PCT/IB09/00071 filed on 16 of 2009, entitled "A Device and Method for the Geometric Determination of Electrical Dipole Densities on the Cardiac Wall", to WO 2009/547, claims priority application No. 00068/08 filed on 17 of 2008, each of which is incorporated herein by reference. The present application, although not claiming priority thereto, may be related to U.S. patent application serial No. 14/003,671 filed on 9/6 of 2013, entitled "Device and Method for the Geometric Determination of Electrical Dipole Densities on the Cardiac Wall",, which is a 35usc 371 state phase application published as WO2012/122517 (hereinafter' 517 publication), entitled "Device and Method for the Geometric Determination of Electrical Dipole Densities on the Cardiac Wall",, the disclosure of each of which is incorporated herein by reference, to U.S. patent application serial No. 61/451,357. The present application, although not requiring its priority, may be related to U.S. design application serial No. 29/475,273, filed on 12/2013, entitled "Catheter System and Methods of Medical Uses of Same,Including Diagnostic and Treatment Uses for the Heart",, which is a 35 USC 371 national stage application of PCT application No. PCT/US2013/057579 filed on 8/30/2013, entitled "Catheter System and Methods of Medical Uses of Same,Including Diagnostic and Treatment Uses for the Heart",, which requires priority of U.S. patent provisional application serial No. 61/695,535, filed on 8/31/2012, the disclosure of which is incorporated herein by reference. The present application, although not claiming priority thereto, may be related to U.S. patent application serial No. 14/762,944, filed on 7 months of 2015, entitled "Expandable Catheter Assembly with Flexible Printed Circuit Board (PCB) ELECTRICAL PATHWAYS", filed on 7 months of 2014, published as "Expandable Catheter Assembly with Flexible Printed Circuit Board (PCB) ELECTRICAL PATHWAYS", filed on 7 months