CN-115554577-B - Drug-coated balloon catheter capable of recovering drug

CN115554577BCN 115554577 BCN115554577 BCN 115554577BCN-115554577-B

Abstract

The invention discloses a drug-coated balloon catheter capable of recovering drugs, which comprises a catheter and a balloon unit, wherein the balloon unit comprises a first balloon and a fifth balloon, the first balloon is sleeved at the distal end of the catheter and is used for carrying the drugs, the second balloon and the third balloon are sleeved at the proximal end and the distal end of the first balloon respectively, the fourth balloon and the fifth balloon are sleeved at the proximal end and the distal end of the second balloon and the third balloon respectively, when the drug-coated balloon catheter is in a collapsed state, the first balloon and the fifth balloon are in a contracted state, when the drug-coated balloon catheter is in a drug-released state, the second balloon and the third balloon are expanded and are attached to the wall of a blood vessel to form a working area, so that the drug released by the expanded first balloon is blocked in the working area and cannot be lost to other places along with blood flow, and when the drug is in a drug recovery state, the first balloon and the third balloon are in a collapsed state, the fourth balloon and the fifth balloon are in an expanded state so as to adhere the drugs, thrombus or plaque and the like in the blood vessel, thereby guaranteeing the quality of vascular intervention and reducing the risk of blockage.

Inventors

LIU CHAOSHENG
GUO XINYU
ZHOU YOUMING
ZHANG ZHIXUAN
WEI ZHENGJUN
LIN HAO
LI QINFANG

Assignees

广东博迈医疗科技股份有限公司

Dates

Publication Date: 20260505
Application Date: 20220927

Claims (11)

1. A drug-coated balloon catheter for drug recovery, comprising: the catheter is internally provided with a first cavity, a second cavity, a third cavity and a fourth cavity which are isolated from each other, and the first cavity is positioned at the center of the catheter to form a guide wire cavity; The balloon unit comprises a first balloon, a second balloon, a third balloon, a fourth balloon and a fifth balloon, wherein the first balloon is sleeved at the far end of the catheter and is communicated with the second cavity, the second balloon and the third balloon are sleeved at the near end and the far end of the first balloon respectively and are communicated with the third cavity, and the fourth balloon and the fifth balloon are sleeved at the near end and the far end of the second balloon and the third balloon respectively and are communicated with the fourth cavity, and the first balloon is used for carrying medicines; The drug-coated balloon catheter is provided with a folding state, a drug release state and a drug recovery state, wherein in the folding state, the first balloon to the fifth balloon are in a shrinkage state, in the drug release state, the first balloon to the third balloon are in an expansion state, the fourth balloon and the fifth balloon are in a shrinkage state, in the drug recovery state, the first balloon to the third balloon are in a folding state, and the fourth balloon and the fifth balloon are in an expansion state; The surfaces of the fourth balloon and the fifth balloon are respectively provided with an oleophylic coating, and the outer diameters of the fourth balloon and the fifth balloon in an expanded state are smaller than the outer diameters of the second balloon and the third balloon in an expanded state.
2. The drug-coated balloon catheter for drug recovery according to claim 1, wherein the surface of the first balloon is provided with a plurality of grooves, wherein the grooves are filled with liposomes, and the liposomes contain the drug.
3. The drug-coated balloon catheter of claim 2, wherein the groove is covered with a cover film having cut lines that break when squeezed or stretched to release the drug in the groove from the first balloon.
4. A drug-coated balloon catheter for drug recovery according to claim 2 or 3, wherein the drug on the surface of the first balloon is wrapped when the first balloon is in a contracted state, and wherein the drug on the surface of the first balloon is exposed and can contact a blood vessel when the first balloon is in an expanded state.
5. The drug-coated balloon catheter of claim 1, wherein the oleophilic coating is for adhering to both thrombus and drug.
6. The drug-coated balloon catheter of claim 1 or 5, wherein the fourth balloon and the fifth balloon are arcuate in cross-section when in an expanded state, and wherein the arcuate surfaces of the fourth balloon and the fifth balloon each face the first balloon, and wherein the arcuate back surfaces of both are remote from the first balloon.
7. The drug-coated balloon catheter of claim 6, wherein the bowstring surfaces of the fourth balloon and the fifth balloon are each provided with a support rib, wherein the support ribs are folded when the fourth balloon and the fifth balloon are in a contracted state, and wherein the support ribs are unfolded and radial when the fourth balloon and the fifth balloon are in an expanded state.
8. A drug-coated balloon catheter according to any of claims 1-3 and also comprising a plurality of metal rings disposed on said catheter and within said first balloon, said metal rings being adapted to reflect ultrasonic waves emitted by an extracorporeal ultrasound probe so that thrombus from the inner wall of a blood vessel is formed into small pieces under cavitation of the ultrasonic waves and falls into the blood vessel.
9. The drug-coated balloon catheter of claim 8, wherein the metal ring has a plurality of micro-holes thereon that reflect the ultrasonic waves multiple times to amplify cavitation of the ultrasonic waves.
10. A drug-coated balloon catheter for drug recovery according to any of claims 1-3, further comprising: a tip connected to a distal end of the catheter and in communication with the first lumen; The needle stand is connected to the proximal end of the catheter and is provided with a first interface, a second interface, a third interface and a fourth interface, the first interface is communicated with the first cavity, the second interface is communicated with the second cavity and is used for pressurizing and depressurizing the first balloon, the third interface is communicated with the third cavity and is used for pressurizing and depressurizing the second balloon and the third balloon, and the fourth interface is communicated with the fourth cavity and is used for pressurizing and depressurizing the fourth balloon and the fifth balloon.
11. The drug-coated balloon catheter of claim 10, wherein the tip is a conical head and the distal diameter of the tip is smaller than the proximal diameter thereof.

Description

Drug-coated balloon catheter capable of recovering drug Technical Field The invention relates to the technical field of medical appliances, in particular to a drug coating balloon catheter capable of recycling drugs. Background The balloon catheter with the drug coating is a balloon catheter with the drug coating loaded on the surface of a common bare balloon, after the balloon loaded with the drug is conveyed to a lesion site, the balloon expands to restore the vascular wall of the lesion site to be smooth, and the drug coating is eluted from the surface of the balloon and released to the vascular wall, so that proliferation of smooth muscle cells can be further inhibited, and vascular restenosis is prevented. Therefore, the drug-coated balloon catheter not only can be expanded into blood circulation to establish a channel through the balloon, but also can avoid the defects of restenosis, thrombus and the like in the stent after the stent implantation operation. Prior art drug coated balloon catheters generally use a balloon catheter having a balloon portion to which a drug coating is applied on the outer surface thereof, and then the drug-carrying balloon is delivered to the lesion and then expanded according to the characteristics of the lesion. However, in the process of conveying the medicine coating balloon catheter in blood vessels, the medicine loss rate is up to more than 50 percent due to the high-speed flowing blood flushing, so that the medicine amount of the medicine coating balloon releasable at a lesion part is reduced, the effectiveness of an instrument is influenced, and meanwhile, the medicine flushed by the blood can block a far-end blood vessel after falling off, the metabolic burden of an organism is increased, and the safety of the instrument is reduced. Accordingly, there is a need for a drug-coated balloon catheter that reduces the loss of drug in the blood circulation and allows recovery of drug particles floating in the blood, to solve the above-mentioned problems. Disclosure of Invention The invention aims to provide a drug-coated balloon catheter capable of reducing the loss of a drug in blood circulation and enabling recovery of drug particles floating in blood. The technical scheme includes that the balloon catheter with the drug coating comprises a catheter and a balloon unit, wherein a first cavity, a second cavity, a third cavity and a fourth cavity which are isolated from each other are arranged in the catheter, the first cavity is positioned at the center of the catheter to form a wire guide cavity, the balloon unit comprises a first balloon, a second balloon, a third balloon, a fourth balloon and a fifth balloon, the first balloon is sleeved at the far end of the catheter and is communicated with the second cavity, the second balloon and the third balloon are sleeved at the near end and the far end of the first balloon respectively, the second balloon and the fifth balloon are sleeved at the near end and the far end of the second balloon respectively, the fourth balloon and the fifth balloon are communicated with the fourth balloon, the first balloon, the second balloon, the third balloon and the fourth balloon are sleeved at the near end and the far end of the third balloon respectively, the first balloon and the fourth balloon are sleeved at the far end of the balloon, the first balloon and the fourth balloon are sleeved at the expanding state, the fourth balloon is in the expanding state, and the fourth balloon is in the expanding state, and the recovering state. Preferably, the surface of first sacculus is equipped with a plurality of recesses, the intussuseption of recess is filled with the liposome, the liposome contains the medicine, utilizes the liposome to increase medicine carrying efficiency to can improve the stability of medicine, in order to reduce the influence of blood washout to the medicine in the transportation, effectively prevent the drop of medicine, reduce the medicine loss. Preferably, the groove is covered with a cover film, the cover film is provided with a cutting line, the cutting line is broken when being extruded or stretched, so that the medicine in the groove is separated from the first balloon, the cover film can protect the medicine from falling off in the process of passing through a blood vessel, the cutting line on the cover film is broken when being stressed, the medicine can be released, and the cover film cannot fall off in blood. Preferably, the medicine on the surface of the first balloon is wrapped when the first balloon is in a contracted state, so that the scouring of blood to the medicine can be effectively avoided and the medicine loss can be reduced in the conveying process, and the medicine on the surface of the first balloon is exposed and can contact with blood vessels when the first balloon is in an expanded state. Preferably, the surfaces of the fourth balloon and the fifth balloon are respectively provided with an oleo