CN-115581640-B - Microcoagulation bead system and preparation method thereof

CN115581640BCN 115581640 BCN115581640 BCN 115581640BCN-115581640-B

Abstract

The present disclosure provides a microbead system characterized by having microbeads configured in an aqueous phase, further comprising a first emollient, an emulsifier. The microcoagulation beads provided by the invention have good compatibility with a matrix, high centrifugal stability, good high-temperature and low-temperature stability and reduced process loss. The preparation method of the micro-condensation beads provided by the invention is particularly suitable for a formula system with higher viscosity to form the micro-condensation beads.

Inventors

WU QINGYUN
SHU PENG

Assignees

深圳市护家科技有限公司

Dates

Publication Date: 20260508
Application Date: 20221104

Claims (3)

1. A method for preparing a micro-gel bead system is characterized in that, Comprising the following steps: Mixing a thickening agent with deionized water, heating, mixing the thickening agent with the deionized water, and heating to 70-90 ℃ to obtain a water phase; Heating the mixture of the first emollient and the emulsifier and the second emollient respectively, heating the mixture of the first emollient and the emulsifier to 50-70 ℃, heating the second emollient to 60-80 ℃, and mixing the mixture of the first emollient and the emulsifier with the second emollient to obtain an oil phase; Mixing the water phase and the oil phase, homogenizing, cooling and stirring to obtain the micro-gel bead system; After the water phase and the oil phase are mixed and homogenized, carrying out heat preservation treatment for 10-20 min, and then cooling and stirring; The thickener is configured as at least one of xanthan gum, sodium carbomer, sodium polyacrylate grafted starch, carbomer, acrylic acid (ester) type/C10-30 alkanol acrylate cross-linked polymer, ammonium acryloyldimethyl taurate/behenate polyether-25 methacrylate cross-linked polymer and acrylic acid (ester) type copolymer sodium; The first emollient is configured as polydimethylsiloxane, cyclopentadimethicone, and at least one of trimethylpentaphenyl trisiloxanes; The emulsifier is configured as a combination of silicone elastomer emulsifier KSG-210 and silicone emulsifier KF-6038, or a combination of silicone elastomer emulsifier SSG-210SP and silicone emulsifier KF-6038; the second emollient is specifically configured as at least one of beeswax, stearic acid, palmitic acid, behenic alcohol, stearyl alcohol, and behenic acid; the weight percentage of the first emollient is configured to be 0.06-15 wt%, and the weight percentage of the emulsifier is configured to be 0.02-5 wt%; the weight percentage of the second emollient is configured to be 0.01-10wt%.
2. The method according to claim 1, wherein, The weight percentage of the thickener is configured to be 0.2-5wt%.
3. A micro-coagulation bead system is characterized in that, Which is configured to be prepared according to the preparation method of any one of claims 1 to 2.

Description

Microcoagulation bead system and preparation method thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a micro-gel bead system and a preparation method thereof. Background Conventional, uniform systems of active ingredients in skin-applied formulations are susceptible to loss of stability and inactivation by external environmental influences during use. One way to solve this problem is to build a product system with a controlled release function, which on the one hand enables stable storage of the active ingredient and on the other hand achieves a slow release effect, which is beneficial for absorption of the active ingredient by the skin. The patent application discloses a preparation method of a microbead product, a preparation method and application thereof, wherein the preparation method can lead to the formation of the microbead in the emulsification process and the natural precipitation of the microbead in the cooling process, so that the compatibility between the microbead and the matrix in the formula is good, the centrifugal stability is high, the high-temperature and low-temperature stability is good, and the process loss is reduced. However, the bead yield in the emulsification cooling process is still not high enough, and the microcoagulite cannot be formed stably. Disclosure of Invention The invention aims to solve the technical problems: how to improve the preparation method of the prior art micro-coagulation bead system to obtain satisfactory micro-coagulation bead yield. Technical means for solving the technical problems: The inventor finds that by improving the preparation process of the micro-gel beads, specifically, after mixing and homogenizing the water phase and the oil phase, preserving heat for a specific time, and then cooling and stirring, the emulsifying capacity of the emulsifying agent in the micro-gel bead system can be reduced, the range of emulsifiable components is reduced, the types of the coated objects are converged, the condition that components such as vegetable oil and fatty acid fatty alcohol are emulsified is reduced, and finally, the condition that the micro-gel beads with uniform size and large quantity are formed is presented. Compared with the prior art, the bead yield of the micro-condensation beads is obviously improved, and the size and the shape of the micro-condensation beads are better at one time. The invention provides a micro-coagulation bead system and a preparation method thereof, wherein the micro-coagulation bead system comprises the following aspects: In a first aspect of the invention, there is provided a microbead system having microbeads configured in an aqueous phase; a first emollient and an emulsifier; The first emollient is configured to comprise silicone oil or modified silicone oil, and the HLB value range of the emulsifier is configured to be 3-10. In some embodiments, the weight percent of the first emollient is configured to be 0.06 to 15wt% and the weight percent of the emulsifier is configured to be 0.02 to 5wt%. In some embodiments, the microbead system further comprises 0.2-5wt% of a thickener. In some embodiments, the composition further comprises 0.01-10wt% of a second emollient. In some embodiments, the first emollient is configured as at least one of polydimethylsiloxane, cyclopentadimethicone, trimethylpentaphenyl trisiloxane. In a second aspect of the present invention, there is provided a method of preparing a microbead system, comprising: Mixing a thickening agent with deionized water and heating to obtain a water phase; heating the mixture of the first emollient and the emulsifier and the second emollient respectively, mixing the mixture of the first emollient and the emulsifier with the second emollient to obtain an oil phase, mixing the water phase and the oil phase, homogenizing, cooling and stirring to obtain the micro-gel bead system, wherein after mixing the water phase and the oil phase, homogenizing, heat preservation is carried out for 10-20 min, and cooling and stirring are carried out. In some embodiments, the weight percent of thickener is configured to be 0.2 to 5wt%. And in the heating treatment, the thickener and deionized water are mixed and heated to 70-90 ℃. In some embodiments, the first emollient and emulsifier mixture is warmed to 50-70 ℃ during the warming treatment when the weight percent of the first emollient is configured to be 0.06-15 wt% and the weight percent of the emulsifier is configured to be 0.02-5 wt%. In some embodiments, the weight percent of the second emollient is configured to be 0.01 to 10wt%, and the temperature of the second emollient is raised to 60 to 80 ℃ during the temperature raising treatment. In a third aspect of the present invention, there is provided a microbead system obtained by carrying out the aforementioned method for preparing a microbead system. The beneficial effects are that: The inventor can form the condition of u