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CN-115671541-B - System for introducing flexible deep brain nerve electrode

CN115671541BCN 115671541 BCN115671541 BCN 115671541BCN-115671541-B

Abstract

The invention relates to a system for introducing a flexible deep brain nerve electrode, which is divided into an outer sheath, a pushing piece and an electrode. The distal end of the flexible array electrode is provided with a degradable bending anchor, after the introducing system is implanted into a specific position, the inner pushing member is pushed to drive the flexible array electrode to move in the outer sheath, and after the bending anchor of the flexible array electrode is released to be fixed, the inner pushing member and the outer sheath are sequentially withdrawn. The system is introduced, and the flexible polymer probe can be rapidly sent into the brain. By conveying the degradable bending anchoring piece, the micro-movement influence of the electrode caused by human breathing and movement after the flexible electrode is implanted can be effectively reduced, and the working time of the electrode is effectively prolonged. While the curved anchors slowly degrade over time, minimizing damage to brain tissue as the electrode is removed.

Inventors

  • LIANG CHUNYONG
  • CHEN LU
  • LIU NING
  • ZOU XIANRUI
  • WANG HONGSHUI

Assignees

  • 河北工业大学

Dates

Publication Date
20260512
Application Date
20221021

Claims (9)

  1. 1. A system for introducing a flexible deep brain nerve electrode, comprising: an electrode (130) having a first end and a second end (1301), the first end being connected to an electrical stimulation generator unit; An outer sheath (110), the outer sheath (110) having a cavity with a first opening and a second opening (1101), the electrode (130) entering the cavity from the first opening and exiting the cavity from the second opening (1101); the anchor piece (131) is an elastomer and is provided with a fixed end (1312) and a movable end (1311), the fixed end (1312) is fixedly connected with the second end (1301) of the electrode (130), the movable end (1311) moves along with the electrode (130), the anchor piece (131) has two states, the first state is that the anchor piece moves in the containing cavity, and the second state is that the anchor piece is connected with brain tissue outside the containing cavity; -a pushing member (120), the pushing member (120) being movable, the pushing member (120) pushing the electrode (130) through the anchor member (131) out of the cavity from the second opening (1101); the cavity is provided with a first wall surface (1105), the first wall surface (1105) is provided with a guide groove (1106), the guide groove (1106) is provided with a distal end and a proximal end, the distal end is provided with a second opening (1101) of the cavity, the proximal end is provided with a first opening of the cavity, and the movable end (1311) of the anchor piece (131) moves in the guide groove (1106).
  2. 2. The system of claim 1, wherein the pusher (120) is disposed between a first wall (1105) of the cavity and the electrode (130).
  3. 3. The system of claim 2, wherein the pusher (120) has an interface (1201), the interface (1201) interfacing with the anchor (131).
  4. 4. A system according to claim 3, wherein the second opening (1101) of the outer sheath (110) has a first tangential plane (1102) and a second tangential plane (1103), and the angle (1104) between the first tangential plane (1102) and the second tangential plane (1103) is 45-60 degrees.
  5. 5. The system of claim 4, wherein the guide slot (1106) has a protrusion (112) at a distal end.
  6. 6. The system of claim 5, wherein the electrode (130) is a flexible multichannel array electrode.
  7. 7. The system of claim 6, wherein the pushing member (120) material is one or a combination of two or more of a polymer, a noble metal, a stainless steel, a titanium alloy.
  8. 8. The system of claim 7, wherein the electrode (130) base material is a flexible insulating material.
  9. 9. The system of claim 8, wherein the material of the anchor (131) is polyglycolic acid, polylactic acid-glycolic acid copolymer, polycaprolactone, polyurethane, or polyethylene glycol.

Description

System for introducing flexible deep brain nerve electrode Technical Field The invention belongs to the field of implantable medical devices, and particularly relates to a system for introducing a flexible deep brain nerve electrode. Background The brain-computer interface is used for establishing a brand-new channel independent of communication and control of peripheral nerves and muscles between the brain and the external environment, so that direct interaction between the brain and external equipment is realized. The technology can establish communication between the brain of a human (or other animals) and the external environment so as to achieve the purpose of controlling equipment, and further plays roles of monitoring, replacing, improving/recovering, enhancing and supplementing. Currently, there are two main categories, non-invasive and invasive, non-invasive methods can record millions of neurons through the skull, but this signal is distorted and non-specific. Invasive methods are also classified into invasive electrodes on the surface of the cerebral cortex and deep in the brain, depending on the implantation site. Invasive electrodes implanted in the surface of the cortex can record signals more clearly than non-invasive electrodes, but can only record the activities of neurons on the surface of the cortex, and can not record signals deep in the brain, so that the use of the electrodes is greatly limited. While the deep brain electrodes are mostly electrodes made of hard metals or semiconductors. Although rigid metal array electrodes help penetrate the brain, mismatch in size, young's modulus, and bending stiffness between the rigid probe and brain tissue can lead to immune responses, limiting the function and lifetime of these devices. Another approach is to use thin, flexible multi-electrode polymer probes. The small size and increased flexibility of these probes should provide greater biocompatibility. However, one disadvantage of this approach is that the thin polymer probes are not stiff enough to be inserted directly into the brain, and their insertion must be facilitated by a stiffener, infusion or other method, so these methods are slow. In order to meet the functional requirements of high bandwidth brain-computer interfaces, while taking advantage of the characteristics of thin film devices, it is important to develop a device that efficiently and independently inserts a large number of fine, flexible polymer probes into multiple regions of the brain. Disclosure of Invention The invention aims to overcome the defects of the prior art and provides a system for introducing a flexible deep brain nerve electrode, which can rapidly send a flexible polymer probe into the brain. The technical scheme for realizing the purpose of the invention is as follows: a system for introducing a flexible deep brain nerve electrode, comprising: An electrode having a first end and a second end, the first end being connected to an electrical stimulation generator unit; The outer sheath is provided with a containing cavity, the containing cavity is provided with a first opening and a second opening, the electrode enters the containing cavity from the first opening, and passes out of the containing cavity from the second opening; The anchoring piece is an elastomer and is provided with a fixed end and a movable end, and the fixed end is fixedly connected with the second end of the electrode; the movable end moves along with the electrode and has two states, wherein the first state is moving in the cavity, and the second state is anchoring connection with brain tissue outside the cavity; And the pushing piece is movable and pushes the electrode through the anchoring piece to penetrate out of the accommodating cavity from the second opening. Further, the accommodating cavity is provided with a first wall surface, the first wall surface is provided with a guide groove, the guide groove is provided with a distal end and a proximal end, the distal end is arranged at the second opening of the accommodating cavity, the proximal end is arranged at the first opening of the accommodating cavity, the movable end of the anchoring piece moves in the guide groove, and the guide groove limits the track of the pushing electrode of the pushing piece. Further, the pushing piece is arranged between the first wall surface of the containing cavity and the electrode. Further, the pusher terminal has an interface that interfaces with the anchor. Further, the second opening of the outer sheath is provided with a first tangent plane and a second tangent plane, and the included angle between the first tangent plane and the second tangent plane is 45-60 degrees. The implantation position is calculated based on the length of the pusher in combination with brain CT to allow free movement of the pusher flexible array electrode between the protection position and the testing position. In the protecting position, the electrode is accommodated