CN-115672148-B - Processing production line of ivermectin drug-loaded particles loaded by silica aerogel

Abstract

The invention belongs to the field of antiparasitic drugs, in particular to a processing production line of ivermectin drug-loaded particles loaded by silica aerogel, which aims at solving the problems that the existing process needs to transport the prepared drug-loaded solid, the operation is complicated, a plurality of power devices are needed to stir and mix the device, the cost is high, the discharging is incomplete, the operation is complicated, the invention provides a proposal that the production line comprises a first mixing box and a collecting box, the outer wall of the first mixing box is fixedly connected with three supporting rods, the collecting box is positioned under the first mixing box, the top of the first mixing box is fixedly communicated with a hollow round platform cylinder, in the invention, the stirring assembly is arranged to fully stir materials, and the first mixing box and the second mixing box utilize the power of a servo motor, so that the cost is greatly reduced, and the first supporting block and the second supporting block can be driven to lift through the lifting assembly, so that the feeding and discharging process is completed, meanwhile, the loading and transporting are not needed, and the workload is greatly reduced.

Inventors

• JI GENLONG

Assignees

• 江西省科达动物药业有限公司

Dates

Publication Date

20260508

Application Date

20221114

Claims (4)

1. 1. The utility model provides an ivermectin medicine granule processing production line that carries of silica aerogel load, includes first mixing box (3) and collecting box (1), the outer wall fixedly connected with three bracing piece (2) of first mixing box (3), a serial communication port, collecting box (1) are located under first mixing box (3), the fixed intercommunication in top of first mixing box (3) has hollow round platform section of thick bamboo (10), the fixed intercommunication in top of hollow round platform section of thick bamboo (10) has second mixing box (4), the top fixedly connected with of second mixing box (4) two curved plates (5) that set up symmetrically, two the top fixedly connected with same roof (6) of curved plate (5), the inner wall slip of roof (6) is run through and is had sliding sleeve (13), the inside of sliding sleeve (13) is provided with the stirring subassembly that is used for stirring material; One side of one arc-shaped plate (5) is fixedly connected with a fixed plate (17), and a lifting assembly for driving the sliding sleeve (13) to lift is arranged in the fixed plate (17); the stirring assembly comprises a first rotating shaft (9) which rotates to penetrate through a sliding sleeve (13), a plurality of stirring blades (11) are fixedly sleeved on the outer wall of the first rotating shaft (9), a first supporting block (14) and a second supporting block (15) are fixedly sleeved on the outer wall of the first rotating shaft (9), the second supporting block (15) is matched with the first mixing box (3), the first supporting block (14) is matched with the hollow round platform barrel (10), and a first spur gear (7) is fixedly connected to the top of the first rotating shaft (9); the lifting assembly comprises an electromagnetic clutch (23) fixedly sleeved in a fixed plate (17), two output shafts of the electromagnetic clutch (23) are respectively fixedly connected with a second rotating rod (29) and a first rotating rod (27), a fifth spur gear (28) is fixedly sleeved on the outer wall of the first rotating rod (27), a connecting plate (24) is fixedly connected to one side of the sliding sleeve (13), a rack (19) is fixedly connected to one side of the connecting plate (24), and the rack (19) is meshed with the fifth spur gear (28); The outer wall of the second rotating rod (29) is fixedly sleeved with a first bevel gear (18), the top of the top plate (6) is fixedly connected with a servo motor (16), an output shaft of the servo motor (16) rotates to penetrate through the top plate (6) and is fixedly sleeved with a fourth spur gear (21) and a second bevel gear (22), and the second bevel gear (22) is meshed with the first bevel gear (18); The inner wall of the top plate (6) rotates and penetrates through a second rotating shaft (12), a third spur gear (20) meshed with a fourth spur gear (21) is fixedly sleeved on the outer wall of the second rotating shaft (12), and a second spur gear (8) meshed with the first spur gear (7) is fixedly sleeved on the outer wall of the second rotating shaft (12).
2. 2. The silica aerogel supported ivermectin drug-loaded particle processing production line according to claim 1, wherein a sliding rod (25) is fixedly connected to the top of the rack (19), and the top of the sliding rod (25) penetrates through the top plate (6) in a sliding mode and is fixedly connected with a limiting block (26).
3. 3. The silica aerogel supported ivermectin drug-loaded particle processing line of claim 1, wherein the first spur gear (7) is thicker than the second spur gear (8).
4. 4. The silica aerogel supported ivermectin drug-loaded particle processing production line according to claim 1, wherein sealing rings are arranged on the outer walls of the first supporting block (14) and the second supporting block (15).

Description

Processing production line of ivermectin drug-loaded particles loaded by silica aerogel Technical Field The invention relates to the technical field of antiparasitic drugs, in particular to a processing production line of ivermectin drug-loaded particles loaded by silica aerogel. Background Animal parasitic diseases are common diseases of animal husbandry in China, are various and widely distributed, and cause great harm to the animal husbandry. Among antiparasitic drugs, ivermectin is a drug that can repel both endoparasites and ectoparasites, and has good repellency to nematodes in the body and arthropods in the body. The ivermectin is an avermectin derivative, belongs to macrolide antibiotics, has high fat solubility, is almost insoluble in water, has the characteristics of high efficiency, broad spectrum, low toxicity and no cross drug resistance, and has good prevention and treatment effects on the parasitic diseases in and out of the livestock and poultry. The invention belongs to the field of antiparasitic pharmaceutical preparations, and particularly relates to an ivermectin drug-loaded silica aerogel particle, which is prepared by the steps of (1) dissolving ivermectin in a low-boiling-point organic solvent to prepare a saturated ivermectin solution, (2) dispersing silica aerogel powder in the saturated ivermectin solution, stirring under heating reflux, and removing the solvent to obtain the ivermectin drug-loaded silica aerogel particle, wherein the low-boiling-point organic solvent is one or more of chloroform, ethyl acetate, methanol, acetone and ethanol. The ivermectin is loaded into the porous silica aerogel, the drug loading capacity is large, and the curve obtained by an in-vitro slow release test is gentle. When the method is used, two mixing devices are needed, and the following defects exist; 1. The manufactured medicine carrying solid is required to be transported, and the operation is complicated; 2. a plurality of power devices are needed for stirring and mixing the devices, so that the cost is high; 3. the discharging is incomplete, the operation is tedious, so we propose the silicon dioxide aerogel loaded ivermectin medicine carrying granule processing production line, in order to solve the above-mentioned problem. Disclosure of Invention The invention aims to solve the defects of the prior art that the manufactured medicine carrying solid is required to be transported, the operation is complex, a plurality of power devices are required to stir the device, the mixing cost is high, the discharging is incomplete, and the operation is complex, and provides a silica aerogel loaded ivermectin medicine carrying particle processing production line. In order to achieve the above purpose, the present invention adopts the following technical scheme: The production line for processing the ivermectin medicine carrying particles loaded by the silica aerogel comprises a first mixing box and a collecting box, wherein three supporting rods are fixedly connected to the outer wall of the first mixing box, the collecting box is positioned right below the first mixing box, a hollow round platform barrel is fixedly communicated with the top of the first mixing box, a second mixing box is fixedly communicated with the top of the hollow round platform barrel, two arc plates which are symmetrically arranged are fixedly connected to the top of the second mixing box, the top of each arc plate is fixedly connected with the same top plate, a sliding sleeve penetrates through the inner wall of the top plate in a sliding mode, and a stirring assembly for stirring materials is arranged inside the sliding sleeve; one side fixedly connected with fixed plate of arc, the inside of fixed plate is provided with the lifting unit who is used for driving the slip sleeve and goes up and down. Preferably, the stirring assembly comprises a first rotating shaft which rotates to penetrate through the sliding sleeve, a plurality of stirring blades are arranged on the outer wall of the first rotating shaft in a fixed mode, a first supporting block and a second supporting block are arranged on the outer wall of the first rotating shaft in a fixed mode in a sleeved mode, the second supporting block is matched with the first mixing box to be used, the first supporting block is matched with the hollow round platform barrel to be used, a first spur gear is fixedly connected to the top of the first rotating shaft and used for stirring materials, and working efficiency is improved. Preferably, the lifting assembly comprises an electromagnetic clutch fixedly sleeved inside the fixed plate, two output shafts of the electromagnetic clutch are fixedly connected with a second rotating rod and a first rotating rod respectively, a fifth spur gear is fixedly sleeved on the outer wall of the first rotating rod, a connecting plate is fixedly connected to one side of the sliding sleeve, a rack is fixedly connected to one side of the connecting pl