CN-115844812-B - W/O/W gel type emulsifiable paste and preparation method thereof

Abstract

The invention relates to a W/O/W gel type emulsifiable paste and a preparation method thereof, belonging to the technical field of medicines and cosmetics, wherein the W/O/W gel type emulsifiable paste comprises nonionic surfactant, an emulsifying agent, a gel matrix material, an oil-soluble matrix, a water-soluble matrix, a pH regulator and water, and the pH regulator regulates the pH value of the W/O/W gel type emulsifiable paste to be 2.8-5.0. The cream has good stability, does not delaminate after being placed for 2 months at 4 ℃, and does not delaminate after being centrifuged (4000 r/min) for 30 min. In addition, the invention is convenient to use, has pH of 3.5-4.5, is suitable for the acidic internal environment in the human body, has lubricating effect, and is suitable for long-term daily use.

Inventors

• ZOU WEI
• GONG HUI
• ZHOU QI
• WU YINGLAN
• ZHANG BIKUI

Assignees

• 邹威
• 吴颖岚

Dates

Publication Date

20260505

Application Date

20221215

Claims (5)

1. 1. The W/O/W gel type cream is characterized by comprising a nonionic surfactant, an emulsifier, a gel matrix material, an oil-soluble matrix, a water-soluble matrix, a pH regulator, a preservative and water, wherein the pH regulator regulates the pH value of the W/O/W gel type cream to be 2.8-5.0, the nonionic surfactant is at least one of span 60 and span 40, the nonionic surfactant accounts for 1.5-3% of the total weight of the cream, the gel matrix material is carbomer, the gel matrix material accounts for 1.0-4.0% of the total weight of the cream, the oil-soluble matrix is at least one of paraffin and simethicone, the oil-soluble matrix accounts for 5.0-10.0% of the total weight of the cream, the emulsifier is mixed fatty glyceride, the emulsifier accounts for 0.5-1% of the total weight of the cream, the water-soluble matrix is glycerol, the at least one of the water-soluble matrix accounts for at least one of glycerol and the water-soluble matrix accounts for 0.07-0.0% of the total weight of the cream.
2. 2. The W/O/W gel-type cream according to claim 1, wherein the liquid paraffin is light liquid paraffin.
3. 3. The W/O/W gel type cream according to claim 1 or 2, wherein the pH regulator comprises at least one of sodium hydroxide and triethanolamine.
4. 4. The W/O/W gel-type cream according to claim 1 or 2, characterized in that the preservative is sorbic acid.
5. 5. The method for preparing the W/O/W gel cream as claimed in any one of claims 1 to 4, comprising the steps of: (1) Weighing raw materials including the nonionic surfactant, an emulsifier, a gel matrix material, an oil-soluble matrix, a water-soluble matrix, a pH regulator, a preservative and water; (2) Uniformly mixing the oil-soluble matrix, the nonionic surfactant and the emulsifier at 70-80 ℃, then adding the water-soluble matrix at 70-80 ℃ and water, and stirring for 25-45 minutes at the speed of 300-400 r/min to obtain W/O type colostrum; (3) Adding the gel matrix material into water, stirring for 35-55 min at the speed of 500-600 r/min to obtain an external water phase, adding the W/O colostrum obtained in the step (2) into the external water phase at room temperature, adding the pH regulator and the preservative, and stirring for 20-30 min at the speed of 400-500 r/min to obtain the W/O/W gel-type emulsifiable paste.

Description

W/O/W gel type emulsifiable paste and preparation method thereof Technical Field The invention relates to a preparation method of a W/O/W gel type emulsifiable paste with acidic pH, bioadhesion and moisturizing and sliding functions, belonging to the technical field of medicines and cosmetics. Background The W/O/W emulsifiable paste is a complex emulsifiable paste system containing dispersed phase droplets and other smaller droplets, and sequentially comprises an inner water phase, an inner-water-oil interfacial film, an oil phase, an outer-oil-water interfacial film, and outer water from inside to outside, and belongs to a multiphase system. The W/O/W gel type emulsifiable paste with the gel matrix material as the continuous phase has large viscosity of the external water phase, so that the dispersion phase is stable, the tiny W/O type emulsifiable paste distributed in the gel is easier to be absorbed by human body, the proper gel matrix material is selected to enable the whole product to be acidic in pH and more suitable for the acidic environment (such as vagina) in the human body, the oil-soluble matrix in the system enables the product to have good lubrication effect, the oil-soluble matrix is wrapped outside the internal water phase, the external surface area of the oil-soluble matrix is increased, the lubricating but not greasy effect is achieved, the water-soluble matrix is added into the internal water phase, the water-locking effect is achieved, the moisturizing effect of the product is enhanced, and no related research report of related W/O/W gel type emulsifiable paste exists in the modern technology. Disclosure of Invention In view of the above, the present invention aims to provide a W/O/W gel-type cream and a method for preparing the same. In order to achieve the above purpose, the present invention provides the following technical solutions: The W/O/W gel type cream comprises a nonionic surfactant, an emulsifying agent, a gel matrix material, an oil-soluble matrix, a water-soluble matrix, a pH regulator and water, wherein the pH regulator regulates the pH value of the W/O/W gel type cream to be 2.8-5.0. Preferably, the nonionic surfactant comprises at least one of span 60 or span 40; Preferably, the emulsifier is a fatty acid glyceride type emulsifier, more preferably the emulsifier is a mixed fatty acid glyceride; The nonionic surfactant and the emulsifier form a water-in-oil type emulsifier; Preferably, the gel matrix material is carbomer; Preferably, the oil-soluble matrix comprises at least one of liquid paraffin and simethicone, more preferably, the liquid paraffin is light liquid paraffin; preferably, the water-soluble matrix comprises at least one of glycerol and propylene glycol; preferably, the pH regulator comprises at least one of sodium hydroxide and triethanolamine; preferably, the W/O/W gel-type cream further comprises a preservative, more preferably, the preservative is sorbic acid; preferably, the nonionic surfactant accounts for 1.5-3% of the total weight of the cream; Preferably, the emulsifier accounts for 0.5-1% of the total weight of the cream; More preferably, the water-in-oil emulsifier accounts for 2.0-4.0% of the total weight of the cream; Preferably, the gel matrix material accounts for 1.0-4.0% of the total weight of the cream; Preferably, the oil-soluble matrix accounts for 5.0-10.0% of the total weight of the cream; preferably, the water-soluble matrix accounts for 1.0-4.0% of the total weight of the cream; Preferably, the preservative accounts for 0.07-0.2% of the total weight of the cream; The invention also relates to a preparation method of the W/O/W gel type emulsifiable paste, which comprises the following steps: (1) Weighing raw materials including nonionic surfactant, emulsifier, gel matrix material, oil-soluble matrix, water-soluble matrix, pH regulator and water; (2) Uniformly mixing an oil-soluble matrix, a nonionic surfactant and an emulsifier at 70-80 ℃, then adding the water-soluble matrix at 70-80 ℃ and water, and stirring at a speed of 300-400 r/min for 25-45 minutes to obtain W/O type colostrum; (3) Adding the W/O colostrum obtained in the step (2) into the external water phase at room temperature, adding a pH regulator, and stirring at a speed of 400-500 r/min for 20-30 minutes to obtain W/O/W gel-type emulsifiable paste; in another embodiment, in said step (3), a pH adjustor is added simultaneously with a preservative. The W/O refers to water-in-oil type cream, the O/W refers to oil-in-water type cream, and the W/O/W refers to water-in-oil-water type cream. The invention provides a W/O/W gel-type emulsifiable paste and a preparation method thereof, wherein the gel-type emulsifiable paste is prepared by a two-step emulsification method, the type and the using amount of materials are reasonably selected in the preparation process, the HLB value, the viscosity and the pH value of the prepared emulsifiable paste can be finally controlled, so that t