CN-115925807-B - New use of functional polypeptide

Abstract

The invention discloses a new application of a functional polypeptide, wherein the functional polypeptide is eucheuma peptide EZY-1, can be used for preparing an anti-aging medicament, or can be used for preparing the anti-aging medicament in combination with a chemotherapeutic medicament, or can be used as an active ingredient of the anti-aging medicament, or can be used for preparing an anti-aging medicament precursor for modification, or can be used for preparing an mTOR activity inhibitor, and the new application of the functional polypeptide can be used for obviously targeting mTOR activating protein Rictor, interfering mTOR complex assembly, inhibiting mTOR activation and delaying aging formation, and has obvious anti-aging function.

Inventors

• ZHANG HAITAO
• YU HUAJUN
• WU JUN

Assignees

• 广东医科大学

Dates

Publication Date

20260512

Application Date

20220728

Claims (2)

1. 1. Application of eucheuma peptide EZY-1 in preparing anti-aging medicine is provided, wherein the amino acid sequence of eucheuma peptide EZY-1 is SEQ ID NO. 1.
2. 2. Application of eucheuma peptide EZY-1 in preparing effective component of antiaging medicine, wherein the amino acid sequence of eucheuma peptide EZY-1 is SEQ ID NO 1.

Description

New use of functional polypeptide Technical Field The invention relates to the technical field of biological medicine. In particular to a novel application of functional polypeptide. Background Aging is a primary risk factor for many chronic diseases, and is mainly represented by the decline of hormone regulation level, gradual decline of functions of various organs of an organism, and gradual occurrence of degenerative diseases of various organs, wherein aging cell accumulation is a key factor for driving aging and aging-related diseases and the basis of aging of the organism. The inhibition of senescent cell phenotype generation becomes a new strategy for delaying population aging and preventing and treating senile diseases, and no effective anti-aging medicament is available at present. The polypeptide is used as the most basic substance for maintaining cell activity and supplying cell energy, is one of the most obvious ways of regulating immune function, and can delay the aging of specific immune organs and immune cells, delay the aging of nonspecific immune tissues and immune cells, repair damaged specific immune organs and immune cells and activate the immune function of human body. At present, the representative theory about aging mechanism is free radical theory, mitochondrial DNA damage theory and the like, the aging process of human beings is always accompanied with the disorder of immune functions, so that the improvement of the immune functions is one of the most effective methods for resisting aging, the aging is the primary risk factor for causing a plurality of chronic diseases and mainly represented by the decline of hormone regulation level, the gradual decline of the functions of each organ of an organism and the gradual occurrence of degenerative diseases of each organ, wherein the accumulation of aging cells is the key factor for driving the aging and the development of the aging-related diseases and the basis of the aging of the organism, the inhibition of the phenotype of the aging cells becomes a new strategy for delaying the aging of population and preventing and curing the aging diseases, no effective anti-aging drug is available at present, and the polypeptide is taken as the most basic substance for maintaining the cell activity and supplying the cell energy, is the most obvious way for regulating the immune functions, and can delay the aging of specific immune organs and immune cells, delay the aging of nonspecific immune tissues and immune cells, repair the specific immune organs and immune cells of the damage can be repaired and activate the immune functions of human body. Eucheuma (Eucheuma), also called chicken foot and chicken gum, belongs to algae, has rich algae body, is cylindrical, flat or flat, radiates or branches at two sides, has about 20 species, has about 5 species in China, is tropical algae, has high medicinal value, has obvious function of delaying senescence, has no report on the function of delaying senescence by Eucheuma source polypeptide at present, and has no report on the use of Eucheuma source polypeptide as a medicament for delaying senescence at home and abroad. The model animal caenorhabditis elegans (Caenorhabditis elegans) not only has the advantages of short life cycle, simple experimental operation and the like, but also has the key signal path with high homology with human beings, so that the model animal caenorhabditis elegans is an ideal animal model for researching the activities of natural products and traditional Chinese medicines, the aging state of human beings can be simulated through an experiment for prolonging the life of the animal caenorhabditis elegans, the mTOR signal path is closely related to cell aging, the activation of the path can promote the cell aging, the activity of the mTOR can be inhibited to slow down the aging process, the targeted inhibition of the mTOR path is a strategy for screening anti-aging medicines, the mTOR complex is assembled by a plurality of proteins by taking mTOR proteins as cores, and the existing mTOR complex inhibitors are mainly targeted inhibition of core proteins mTOR, but the inhibitors show strong toxic and side effects. Disclosure of Invention Therefore, the technical problem to be solved by the invention is to provide a new application of the functional polypeptide, and experiments prove that the independently developed functional polypeptide (patent number: 201711141671X) can obviously target and bind to mTOR activator protein Rictor, interfere mTOR complex assembly, inhibit mTOR activation and delay aging formation, has obvious aging-delaying function, and can be used for preparing an aging-delaying medicament or an active ingredient or a prodrug of the medicament. In order to solve the technical problems, the invention provides the following technical scheme: a functional polypeptide is separated and purified from eucheuma and named as eucheuma peptide EZY-1, wherein the eucheuma peptide E