CN-116081105-B - Cryogenic storage device

CN116081105BCN 116081105 BCN116081105 BCN 116081105BCN-116081105-B

Abstract

The invention relates to biological sample storage, in particular to low-temperature storage equipment, and aims to solve the problem that the size of a freezing storage frame in the existing low-temperature storage equipment cannot be adjusted in the length dimension, so that the lifting space occupied by a lifting mechanism for lifting the whole freezing storage frame is large, and the inventory capacity is small indirectly. For this purpose, the cryogenic storage device of the invention comprises a freezer compartment, a first transfer mechanism and a lifting and separating mechanism, the freezer compartment comprising at least two separate compartments which can be combined together or separated, the lifting and separating mechanism comprising a first rotator, a second rotator, a clamping mechanism and at least two lifting mechanisms. The freezing storage rack designed by the invention realizes the function of adjusting the length and the size of the freezing storage rack, reduces the space occupation, enables the clamping mechanism to rotate under the action of the second rotator, enables the clamping mechanism to rotate to the end part when the freezing storage rack at one end of the inner warehouse far away from the discharge port is lifted, has small occupied space, and reduces the whole occupied space of the low-temperature storage equipment.

Inventors

WANG JIE
LIU ZHANJIE
ZHAO HONGBIN
ZHANG SHOUBING
REN WENGUANG
XIE YUGANG

Assignees

青岛海尔生物医疗科技有限公司
青岛海尔生物医疗股份有限公司

Dates

Publication Date: 20260508
Application Date: 20230215

Claims (13)

1. The low-temperature storage device is characterized by comprising a freezing warehouse, a first transfer mechanism and a lifting separation mechanism, wherein a freezing region is arranged in the freezing warehouse, a freezing frame is placed in the freezing region, the freezing frame comprises at least two split frames capable of being combined together or split, a plurality of freezing boxes are placed in the split frames, the first transfer mechanism is arranged in the freezing warehouse outside the freezing region, the first transfer mechanism is arranged to be capable of driving the lifting separation mechanism to move so as to lift the freezing frames in different positions, the lifting separation mechanism comprises a first rotator, a second rotator, a clamping mechanism and at least two lifting mechanisms, the first rotator and the second rotator are all arranged on the first transfer mechanism, the lifting mechanisms are connected with the first rotator, the clamping mechanism is connected with the second rotator, the first rotator is arranged to be capable of driving the lifting mechanisms to rotate, the second rotator is arranged to be capable of driving the clamping mechanisms to rotate, the first rotator and the second rotator are arranged to be capable of being matched with each other, and the first rotator and the second rotator are arranged to be capable of combining with the lifting frames, the first rotator and the second rotator are arranged to be capable of combining with the lifting frames; the number of the lifting mechanisms is the same as that of the split frame bodies, the lifting mechanisms are distributed on the first rotator in a circumferential arrangement mode, and the second rotator is positioned below the first rotator so that the clamping mechanisms are positioned below the lifting mechanisms; the opening of the freezing storage rack placed at one end of the freezing storage area far away from the discharge hole faces opposite to the opening of the freezing storage rack placed at other parts.
2. The cryogenic storage device of claim 1, further comprising a second transfer mechanism configured to enable removal of a cryopreserved cassette on the split shelf and transfer to a discharge port of the cryopreservation site or transfer of a cryopreserved cassette from a discharge port location of the cryopreservation site into the cryopreservation site and onto the split shelf.
3. The cryogenic storage device of claim 2, wherein the first and second rotators are each disposed on a strut, the struts being fixed to the first transfer mechanism, the first and second rotators being identical in structure, the first rotator comprising a turntable, a rotary drive, the turntable being nested on and rotatably connected to the struts, the rotary drive being mounted on the struts and being capable of driving the turntable to rotate, the lifting mechanisms being distributed in a circumferential arrangement on the turntable of the first rotator, the clamping mechanisms being disposed on the turntable of the second rotator.
4. The cryogenic storage apparatus of claim 1, wherein the clamping mechanism comprises a support plate, a clamping driver and two clamping bars, the support plate being connected to the second rotator such that the second rotator drives the support plate to rotate, the clamping driver being disposed on the support plate, the two clamping bars being slidably connected to the support plate, the clamping driver driving the two clamping bars toward or away from each other to clamp or unclamp the split frame.
5. The cryogenic storage device of claim 1, wherein the lifting mechanism comprises a lifter mounted on the first rotator and a gripper arranged to be able to drive the gripper to move up and down, the gripper being arranged to be able to grip the split frame.
6. The cryogenic storage device of claim 5, wherein the gripper comprises a gripping plate, a gripping groove is formed in the bottom end of the gripping plate, the gripping groove is of a T-shaped structure, and first scrap edges which are recessed downwards are formed in two side edge portions in the gripping groove respectively.
7. The low-temperature storage device according to claim 6, wherein an extraction hook is fixed at the top end of the split frame body, an extraction groove is fixed at the bottom end of the split frame body, and the extraction hook and the extraction groove can be hooked or separated from each other so as to realize that two adjacent split frame bodies are combined together or separated in an up-down arrangement mode.
8. The low-temperature storage device according to claim 7, wherein the extraction groove is a T-shaped chute, two side edge portions in the T-shaped chute are respectively provided with a second lapping groove recessed downward, the extraction hook is a T-shaped slider, the T-shaped slider can be inserted into the T-shaped chute to realize detachable connection of two adjacent split frames, the edge of the T-shaped slider can be sunk into the second lapping groove, the T-shaped slider can be inserted into the grabbing groove, and the edge of the T-shaped slider can be sunk into the first lapping groove to enable the grabber to grab the split frames.
9. The cryogenic storage device of claim 3, wherein the freezing store comprises an outer store and an inner store, the inner store is disposed in the outer store, a top end of the inner store is covered with a cover plate, the discharge port is disposed on a side wall of the outer store, a refrigeration system is installed in the inner store, and an inner cavity of the inner store forms the freezing zone.
10. The cryogenic storage device of claim 9, wherein the first transfer mechanism comprises a bracket, a first linear drive and a second linear drive, the second linear drive being mounted on top of the inner reservoir, the bracket being positioned above the inner reservoir and connected to the second linear drive, the second linear drive driving the bracket to move laterally, the first linear drive being disposed on the bracket, the post being connected to the first linear drive, the first linear drive driving the lifting mechanism, the clamping mechanism, the second rotator and the first rotator to move longitudinally together.
11. The cryogenic storage device of claim 9, wherein the second transfer mechanism comprises a travel drive assembly, a first support plate, a first lifting assembly, an angle rotation assembly and a box taking assembly, wherein the travel drive assembly is arranged on the inner warehouse, the first support plate is arranged above the inner warehouse and is connected with the travel drive assembly, the travel drive assembly is arranged to drive the first support plate to move transversely and longitudinally, the first lifting assembly is arranged on the first support plate, the first lifting assembly is connected with the angle rotation assembly to enable the angle rotation assembly to move up and down, the angle rotation assembly is connected with the box taking assembly to enable the angle rotation assembly to rotate, and the box taking assembly is arranged to enable a frozen box in the frozen storage rack to be lifted or carried in.
12. The cryogenic storage device of claim 11, wherein the box-taking assembly comprises a second support plate, a tray and a telescopic device, the second support plate is connected with the angle-rotating assembly, the tray is connected to the second support plate in a sliding manner, the telescopic device is mounted on the second support plate, the telescopic device is connected with the tray to drive the tray to extend or retract, and the tray can lift the freezing box.
13. The cryogenic storage device of claim 10, further comprising an uncapping mechanism disposed on the rack, the uncapping mechanism configured to grasp the cover plate for upward movement to open the inner bin.

Description

Cryogenic storage device Technical Field The invention relates to biological sample storage, in particular to low-temperature storage equipment. Background The development of life science research and the progress of disease analysis detection and treatment and health care technologies in the clinical medical field have promoted the increasingly wide demand for biological samples, and have also put higher demands on the storage technology and equipment of biological samples, including demands on the safety, reliability and stability of stored samples, and the accuracy, efficiency and scientificity of sample access processes and procedures. Long-term storage of biological samples generally requires the use of as low a temperature as possible to reduce the biochemical reactions within the sample and to increase the stability of the various components within the sample. The development and use of automated cryogenic or ultra-cryogenic biological sample access devices is a necessary development in order to achieve long-term, stable, reliable storage and sampling of large volumes of biological samples. But among the prior art, the cryopreservation frame in the low temperature storage equipment is single-section structure, promptly can't adjust in length direction, leads to when taking the cryopreservation box of cryopreservation frame bottom to need hoist mechanism to mention whole cryopreservation frame and arouse the very big problem of occupation lifting space to indirectly lead to inventory capacity little, and low temperature storage equipment is bulky, occupation space is big. Accordingly, the present invention needs to provide a new low-temperature storage device to solve the above-mentioned technical problems. Disclosure of Invention The invention aims to solve the technical problems that in the prior art, the freezing storage rack in the low-temperature storage equipment is of a single-section structure, namely, the size cannot be adjusted in the length dimension, so that the lifting space occupied by a lifting mechanism for lifting the whole freezing storage rack is large when a freezing storage box at the bottom of the freezing storage rack is taken, and the problems of small inventory capacity and large whole occupied space are indirectly caused. For this purpose, the invention provides a cryogenic storage device, which comprises a freezing chamber, a first transfer mechanism and a lifting separation mechanism, wherein the freezing chamber is internally provided with a freezing region, a freezing frame is placed in the freezing region, the freezing frame comprises at least two split frame bodies which can be combined together or split, a plurality of freezing boxes are placed in the split frame bodies, the first transfer mechanism is arranged in the freezing chamber outside the freezing region, the first transfer mechanism is arranged to drive the lifting separation mechanism to move so as to lift the freezing frames in different positions, the lifting separation mechanism comprises a first rotator, a second rotator, a clamping mechanism and at least two lifting mechanisms, the first rotator and the second rotator are all arranged on the first transfer mechanism, the lifting mechanisms are connected with the first rotator, the clamping mechanism is connected with the second rotator, the first rotator is arranged to drive the lifting mechanisms to rotate, the second rotator is arranged to drive the lifting mechanisms to rotate, the first rotator and the second rotator can be matched with the first rotator and the second rotator, the first rotator and the second rotator are arranged to split the first rotator and the second rotator, the first rotator and the second rotator are arranged to be matched with the first rotator and the second rotator, the first rotator and the second rotator are arranged to be matched with the first rotator and the second rotator. Under the condition that the technical scheme is adopted, the freezing frame is formed by combining at least two split frame bodies, the length and the size of the freezing frame can be adjusted, the freezing frame can be split under the mutual cooperation of the lifting mechanism, the clamping mechanism, the first rotator and the second rotator, and the split frame bodies can also be combined, so that in the process of lifting the freezing frame to the outer side of the freezing region, the split frame bodies positioned at the outer side of the freezing region can be separated from the freezing frame and then the rest split frame bodies can be lifted to the outer side of the freezing region, the vertical space occupied by the whole lifting and taking up the outer side of the freezing region is reduced, the storage capacity is improved compared with that of a single-section freezing frame under the same space, in addition, at least two lifting mechanisms are integrated on the first rotator, the first rotator drives the lifting mechanism to rotate s