CN-116250943-B - Detachable parathyroid kit for gland blood supply detection

CN116250943BCN 116250943 BCN116250943 BCN 116250943BCN-116250943-B

Abstract

The invention belongs to the technical field of kits, and particularly relates to a detachable kit for parathyroid gland blood supply detection, which comprises a box body, wherein an openable box cover is arranged at the top of the box body, a developing solution injection mechanism, a liquid medicine injection mechanism and a three-way connection mechanism are arranged in the box body, a first end of the three-way connection mechanism is connected with the developing solution injection mechanism, a second end of the three-way connection mechanism is connected with the liquid medicine injection mechanism, a third end of the three-way connection mechanism is used for connecting a retention needle, and the three-way connection mechanism can be switched between a developing solution injection function and a reagent injection function. The kit structure designed by the invention is matched with indocyanine green water solution and other developing reagents for use, can guide a doctor to decide whether to reserve or transplant parathyroid glands or help the doctor to find the position of parathyroid glands to be resected in thyroid total resection and central area lymph node cleaning operation or parathyroid tumor resection operation, and the device can be repeatedly used, saves materials, is environment-friendly and has high mechanical injection efficiency.

Inventors

FAN JING
WANG TING
KONG JING
MENG HUIMIN
LI SONGPENG
WANG YIDI
LI MENGXUAN
DING JIAJUN

Assignees

中国人民解放军空军军医大学

Dates

Publication Date: 20260508
Application Date: 20230317

Claims (7)

1. The detachable parathyroid blood supply detection kit comprises a box body (1), wherein an openable box cover (2) is arranged at the top of the box body (1), and is characterized in that a developing solution injection mechanism (3), a liquid medicine injection mechanism (4) and a three-way connection mechanism (5) are arranged in the box body (1), a first end of the three-way connection mechanism (5) is connected with the developing solution injection mechanism (3), a second end of the three-way connection mechanism is connected with the liquid medicine injection mechanism (4), a third end of the three-way connection mechanism (5) is used for connecting a retention needle, the three-way connection mechanism (5) can be switched between a developing solution injection function and a reagent injection function, and the three-way connection mechanism (5) is not communicated with the developing solution injection mechanism (3) and the liquid medicine injection mechanism (4) simultaneously; the three-way connecting mechanism (5) comprises a liquid outlet (51), a developing solution inlet (52) and a medicament inlet (53), wherein the liquid outlet (51) is communicated with the developing solution inlet (52) or the liquid outlet (51) is communicated with the medicament inlet (53); The three-way connecting mechanism (5) further comprises an outer shell (50), the outer shell (50) is arranged in the box body (1), the outer shell (50) is provided with a liquid outlet (51), a developing solution inlet (52) and a reagent inlet (53), a three-way pipe (54) is arranged in the outer shell (50), a first end of the three-way pipe (54) is connected with the liquid outlet (51), a second end of the three-way pipe is connected with the developing solution inlet (52), a third end of the three-way pipe is connected with the reagent inlet (53), a cut-off device (55) is arranged at the junction of the three ends of the three-way pipe (54), and the cut-off device (55) is used for intercepting the second end or the third end of the three-way pipe (54) so that the reagent box is switched between a developing solution injection function and a reagent injection function; The shutoff device (55) comprises a rotating shaft (551) and a shutoff plate (552), the rotating shaft (551) is arranged at the junction of the three ends of the three-way pipe (54), the rotating shaft (551) is axially connected with the shutoff plate (552), the shutoff plate (552) is in contact with the inner wall of the three-way pipe (54), the shutoff plate can intercept one liquid flow passage of the developing liquid inlet (52) or the medicament inlet (53) together with the rotating shaft (551), and the rotating shaft (551) is provided with a driving device for controlling the rotation of the same.
2. The detachable parathyroid gland blood supply detection kit according to claim 1, wherein the top surface and one side surface of the box body (1) are in an open state, and a shielding surface (21) is arranged at the same side of the box cover (2) as the open side surface of the box body (1).
3. The detachable parathyroid gland blood supply detection kit according to claim 1, wherein the driving device is a handle, the rotating shaft (551) penetrates through the outer shell (50) and the tee pipe (54), a sealing device is arranged at the penetrating connection of the three parts, and the part of the rotating shaft (551) located outside the outer shell (50) is connected with the handle; or the driving device is a controller, and the shutoff device (55) further comprises a first floater (553) and a second floater; The first floater (553) is positioned on one side of the shutoff plate (552) close to the developer inlet (52), a first pressure sensor (5521) which can be in contact with the first floater (553) is arranged on the shutoff plate (552), a first elastic rope (5531) is arranged around the periphery of the first floater (553), a first circular arc frame (5532) is arranged around the periphery of the first elastic rope (5531), when no liquid flows, the first floater (553) is separated from the first pressure sensor (5521), the first floater (553) is in contact with the first pressure sensor (5521) under the impact force of the liquid, and the first pressure sensor (5531) generates a pressure signal; The second floater is located one side of closure plate (552) near medicament import (53), be equipped with on closure plate (552) can with second pressure sensor (5522) of second floater contact, be equipped with second elastic rope around the periphery of second floater, be equipped with the second circular arc frame around the periphery of second elastic rope, when there is not liquid flow, second floater with second pressure sensor (5522) separation, under the impact force of liquid, second floater with second pressure sensor (5522) contact, second pressure sensor (5522) produces pressure signal.
4. A detachable parathyroid gland blood supply detection kit according to claim 3, wherein the developing solution injection mechanism (3) comprises a first injection cylinder (31) and a first power device, a first connecting pipe (32) is arranged at the front end of the first injection cylinder (31), and the first connecting pipe (32) is detachably connected with the developing solution inlet (52); The liquid medicine injection mechanism (4) has the same structure as the developing liquid injection mechanism (3).
5. The removable parathyroid blood supply test kit of claim 4, wherein the first power device is a peristaltic pump; or the first power device is a telescopic motor (34), the front end of a push rod (33) is arranged inside the tail end of the first injection cylinder (31), the tail end of the push rod (33) is connected with the telescopic end of the telescopic motor (34), and the fixed end of the telescopic motor (34) is arranged on the side wall, opposite to the side surface opening, of the box body (1).
6. The detachable parathyroid blood supply detection kit according to claim 5, wherein a control panel is further arranged on the inner wall of the kit body (1), a plurality of working switches are arranged on the control panel, the working switches respectively control the first power device and the second power device correspondingly, and the controller is respectively and electrically connected with the first pressure sensor (5521), the second pressure sensor (5522), the first power device, the second power device, the power supply and the control panel.
7. The detachable parathyroid gland blood supply detection kit according to claim 1, wherein a supporting plate (11) is longitudinally arranged on one side, close to the side surface opening, of the box body (1), a first bayonet (111) and a second bayonet (112) are arranged on the supporting plate (11), the first bayonet (111) is connected with the developing solution injection mechanism (3), and the second bayonet (112) is connected with the liquid medicine injection mechanism (4); the three-way connecting mechanism (5) is positioned between the side opening of the box body (1) and the supporting plate (11).

Description

Detachable parathyroid kit for gland blood supply detection Technical Field The invention belongs to the technical field of kits, and particularly relates to a detachable kit for parathyroid blood supply detection. Background Parathyroid gland has small volume and diameter of about 3-5mm, is positioned near thyroid gland, and is round or elliptical. Parathyroid gland is one of the important endocrine glands of the human body. The parathyroid cells are divided into main cells and eosinophils, wherein the main cells form a substantial gland, can secrete parathyroid hormone, participate in metabolism of calcium and phosphorus in the body, can act on intestines, renal tubules and the like, and have functions very important for maintaining normal human health. Parathyroid glands branch primarily from the hypothyroid artery, but may also obtain blood supply from the anastomotic branch between the superior and inferior thyroid arteries or the inferior thyroid artery. Because the blood vessel of the normal parathyroid gland is very thin, the normal parathyroid gland is not easy to be identified by naked eyes. Therefore, when a lesion in the thyroid gland such as a thyroid cancer invading the parathyroid blood supply, or a parathyroid injury blood supply by surgical removal exists, the parathyroid blood supply is affected, thereby affecting the physiological function of the parathyroid gland and further impairing the health of the human body. Thus, detecting the state of the parathyroid blood supply and hormone secretion are very useful tests to determine parathyroid function. Second, when a parathyroid disorder (e.g., parathyroid tumor) requires surgical excision, a physician is required to visually identify the location. Thus, detecting the presence of parathyroid glands is also a very useful test. Various detection means for parathyroid health condition and judging position are disclosed in Chinese patent, for example, CN109847072A discloses a parathyroid blood supply detection kit which comprises indocyanine green water solution, the indocyanine green water solution is injected into human body through peripheral vein, then the parathyroid blood supply is observed to be normal through fluorescence, the kit can help doctors accurately judge whether parathyroid blood supply is damaged, and can guide doctors to decide whether to reserve or transplant in thyroid complete resection and central regional lymph node cleaning operation, thereby reducing the complication incidence rate of temporary and permanent parathyroid hypofunction after operation of patients and improving the safety of thyroid operation. For another example, CN108152273a discloses a parathyroid hormone kit for detecting peripheral blood, and a preparation method and application thereof, the kit comprises a parathyroid hormone immunochromatography detection card and a release agent, the parathyroid hormone immunochromatography detection card comprises a test strip, the test strip comprises a detection line and a quality control line, a mouse anti-human parathyroid hormone monoclonal antibody is coated on the detection line, and a sheep anti-rabbit polyclonal antibody is coated on the quality control line. The parathyroid hormone kit provided by the patent has the advantages of high sensitivity, strong stability, wide linear range and excellent accuracy and precision. There are also many kits for testing parathyroid function on the market, such as human parathyroid hormone-related protein (PTHrP) ELISA detection kit-Yuntai and the like. It can be seen from the above publications and products that the selection of a characteristic target substance or target tissue, followed by detection or treatment with specific reagents, is the main principle of parathyroid function detection kits, but these products do not consider the "mechanical mechanism" to aid in detection. Taking CN109847072a as an example, the patent only emphasizes that indocyanine green water solution is injected into a human body through peripheral vein, then the blood supply of parathyroid gland is observed to be normal through fluorescence, developer is generally stored in an injector, then is injected into vein through an indwelling needle, and has no injection mechanism matched with the parathyroid gland detection developing reagent, the medicine liquid needs to be sucked out of a reagent bottle of the kit manually, then is injected into the indwelling needle manually, finally flows into vein, the consumed medical equipment mainly comprises the injector and the indwelling needle, the indwelling needle can be used for injecting other medicine liquid, but the injector for injecting developer cannot be reused, so that great waste is caused, and the environment protection is not facilitated. Secondly, the number of parathyroid glands of the human body is more than 4, and the parathyroid glands are respectively positioned at different positions on the back side of the thyroid gland. In a thy