CN-116270732-B - Silicon ion preparation for treating chronic pancreatitis and preparation method and application thereof

CN116270732BCN 116270732 BCN116270732 BCN 116270732BCN-116270732-B

Abstract

The application belongs to the technical field of biological medicines, and particularly relates to a silicon ion preparation for treating chronic pancreatitis, and a preparation method and application thereof. The silicon ion preparation has excellent effect of promoting regeneration of pancreatic acinar cells, can inhibit inflammation and fibrosis of pancreatic tissues, and can be used for treating chronic pancreatitis and preventing fibrosis, and has great application prospect. The silicon ion preparation provided in this example can treat chronic pancreatitis and prevent fibrosis, and the active material can remarkably treat the activity of pancreatitis cells so as to form healthy pancreatic tissue. The silicon ion preparation comprises the concentration of silicon ions in the silicon ion preparation being 5ppm to 800ppm, and the silicon ion preparation is prepared by releasing silicon ions from a silicon ore preparation.

Inventors

CHANG JIANG
XU YUZE
HUANG HAOJIE
YIN HUA
Zhang Zhaowenbin
YANG CHEN

Assignees

国科温州研究院(温州生物材料与工程研究所)

Dates

Publication Date: 20260508
Application Date: 20230321

Claims (2)

1. Use of a silicon ion preparation in the preparation of a preparation for treating chronic pancreatitis, wherein the concentration of silicon ions in the silicon ion preparation is 5ppm to 800ppm, the silicon ion preparation is prepared by releasing silicon ions from calcium silicate, and the preparation method of the silicon ion preparation comprises the following steps: the calcium silicate powder was added to serum-free DMEM medium or PBS at a solid/liquid ratio of 200 mg/mL at 37 ℃ for 24 hours, and then the mixture was centrifuged at 4000 rpm for 5 minutes, and the supernatant was collected and sterilized by filtration membrane to obtain a calcium silicate ion solution.
2. The use of claim 1, wherein the chronic pancreatitis comprises one or more of chronic calcified pancreatitis, chronic obstructive pancreatitis, and chronic inflammatory pancreatitis.

Description

Silicon ion preparation for treating chronic pancreatitis and preparation method and application thereof Technical Field The application belongs to the technical field of biological medicines, and particularly relates to a silicon ion preparation for treating chronic pancreatitis, and a preparation method and application thereof. Background Pancreatitis is a syndrome of fibrositis caused by a variety of factors. Its main pathological features include atrophy, destruction of pancreatic acini and interstitial fibrosis. Clinically, recurrent epigastric pain, insufficient secretion of internal and external pancreas, pancreatic duct stones, etc., eventually leading to reduced quality of life and life expectancy of the patient, and chronic pancreatitis increases the risk of pancreatic cancer in the patient. At present, diagnosis and treatment preparations adopted for chronic pancreatitis comprise stem cells or chemical small molecular medicines, however, the treatment methods of the stem cell treatment or the injection of the chemical small molecular medicines mainly treat symptoms, relieve symptoms and limit clinical application due to toxicology factors. Disclosure of Invention In view of the above, the embodiment of the application provides a silicon ion preparation for treating chronic pancreatitis, and a preparation method and application thereof, so as to solve the problems in the prior art. According to a first aspect of an embodiment of the present application, there is provided a silicon ion preparation for use in the treatment of chronic pancreatitis, comprising the concentration of silicon ions in the silicon ion preparation being 5ppm to 800ppm, the silicon ion preparation being prepared by releasing silicon ions from a silicon ore preparation. With reference to the first aspect, in a first possible implementation manner of the first aspect, the siliceous ore preparation includes a silicate-based bioceramic. With reference to the first possible implementation manner of the first aspect, in a second possible implementation manner of the first aspect, the silicate-based bioceramics include one or more of calcium silicate, zinc silicate, akenite, and 45S5 bioactive glass. With reference to the first aspect, in a third possible implementation manner of the first aspect, the concentration of silicon ions in the silicon ion preparation is 60ppm. A second aspect of an embodiment of the present application provides a method for preparing a silicon ion preparation according to the first aspect, the method comprising obtaining one or more silicon ore preparations; and (3) fully mixing the silicon ore preparation with PBS or a culture medium according to the preset concentration of silicon ions in the silicon ion preparation to obtain a mixed solution, and obtaining a supernatant of the mixed solution to obtain the silicon ion preparation meeting the requirement of the preset concentration. A third aspect of embodiments of the present application provides the use of a silicon ion formulation as described in the first aspect in the preparation of a formulation for the treatment of chronic pancreatitis. With reference to the third aspect, in a first possible implementation manner of the third aspect, the chronic pancreatitis includes one or more of chronic calcified pancreatitis, chronic obstructive pancreatitis, and chronic inflammatory pancreatitis. Compared with the prior art, the embodiment of the application has the beneficial effects that: The embodiment of the application provides a silicon ion preparation for treating chronic pancreatitis, and a preparation method and application thereof. The silicon ion preparation comprises the concentration of silicon ions in the silicon ion preparation being 5ppm to 800ppm, and the silicon ion preparation is prepared by releasing silicon ions from a silicon ore preparation. In the embodiment, the silicon ion preparation with the silicon ion Si concentration in the range of 5ppm-800ppm has excellent effect of promoting regeneration of pancreatic acinar cells, can inhibit inflammation and fibrosis of pancreatic tissues, and can be used for treating chronic pancreatitis and preventing fibrosis, and has great application prospect. Drawings In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments or the description of the prior art will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art. FIG. 1 is a schematic representation of the effect of using Calcium Silicate (CS) ion solutions of varying concentrations on pancreatic acinar cells according to an embodiment of the present application; FIG. 2 is a schematic diagram showing the effect of using Calcium Silicate