CN-116327880-A - Nebulizable anti-fatigue pharmaceutical composition

CN116327880ACN 116327880 ACN116327880 ACN 116327880ACN-116327880-A

Abstract

The invention provides an atomized anti-fatigue pharmaceutical composition. An nebulizable anti-fatigue pharmaceutical composition comprising: the active extract comprises at least one of a beautiful millettia root extract, an astragalus extract, a sealwort extract, a ginseng extract, an American ginseng extract, a pilose asiabell root extract, a cistanche extract, a cordyceps sinensis extract, a dogwood extract, a eucommia ulmoides leaf extract, a angelica sinensis extract, a liquorice extract, a dried orange peel extract, a dried ginger extract, a cinnamon extract, a fragrant solomonseal rhizome extract and a kudzuvine root extract. Therefore, the anti-fatigue pharmaceutical composition provided by the invention can be atomized, can greatly improve the absorption of a human body to a medicine, has the advantages of quick absorption, quick effect and small dosage, further achieves better anti-fatigue effect, and is convenient to carry; moreover, the active extracts are all natural herbal extracts, so that the side effect on human bodies is small, and the efficacy is good.

Inventors

XU JING
LUO JUNJUN
Li Xinduo
CHEN FANG
SCHUETTE
WU ZEHONG
YANG XUEMIN
CHEN ZHEN

Assignees

SHENZHEN RELX TECH CO LTD

Dates

Publication Date: 20230627
Application Date: 20230308
Priority Date: 20230308

Claims (10)

1. An nebulizable anti-fatigue pharmaceutical composition, comprising: the active extract comprises at least one of a beautiful millettia root extract, an astragalus extract, a sealwort extract, a ginseng extract, an American ginseng extract, a pilose asiabell root extract, a cistanche extract, a cordyceps sinensis extract, a dogwood extract, a eucommia ulmoides leaf extract, a angelica sinensis extract, a liquorice extract, a dried orange peel extract, a dried ginger extract, a cinnamon extract, a fragrant solomonseal rhizome extract and a kudzuvine root extract.
2. The anti-fatigue pharmaceutical composition according to claim 1, comprising, based on the total weight of the anti-fatigue pharmaceutical composition: 0.1% -5% of the active extract; 0.01% -3% of sweetener; 0.1 to 5 percent of cooling agent; 0.01% -5% of essence; and The balance of solvent.
3. The anti-fatigue pharmaceutical composition according to claim 2, wherein the cooling agent is at least one selected from the group consisting of menthol, menthone, isomenthone, l-menthyl lactate, WS-23, WS-3, WS-5, WS-12, neomenthol, isopulegol, menthyl acetate, isopulegol acetate, menthyl isovalerate and menthone, the sweetener is at least one selected from sucralose, neotame, cyclamate, acesulfame, aspartame, stevioside neohesperidin dihydrochalcone and hesperidin dihydrochalcone, the essence is at least one selected from limonene, benzyl alcohol, ethyl butyrate, vanillin, citronellal, isoamyl alcohol, ethyl maltol, linalool, isobutyl acetate, isoamyl acetate, benzyl benzoate, leaf alcohol, ethyl propionate, citral, gamma-decalactone, decanal, ethyl acetate, ethyl 2-methylbutanoate, myrcene, ethyl caproate, peach aldehyde, ethyl isovalerate, leaf alcohol acetate, acetic acid, benzaldehyde and 2-methylbutanoate, the solvent is at least one selected from propylene glycol, glycerol, water and ethanol.
4. An anti-fatigue pharmaceutical composition according to any one of claims 1 to 3, wherein the millettia speciosa extract is prepared by: weighing 1kg of millettia speciosa, ultrasonically extracting for 30-120min by using 75-95% ethanol with the mass of 8-15 times of the millettia speciosa, filtering to obtain primary filtrate and filter residues, adding the 75-95% ethanol with the mass of 3-8 times of the millettia speciosa into the filter residues, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to 300-500g to obtain concentrated solution; adding 3-5 kg of 95% ethanol water solution into the concentrated solution under stirring, precipitating with ethanol for at least 10 hours, and collecting supernatant; concentrating the supernatant under reduced pressure to dryness, dissolving with small amount of 0-30% ethanol, passing through macroporous resin, eluting with 75-95% ethanol, and collecting eluate; concentrating the eluent under reduced pressure, and freeze-drying or vacuum-drying to obtain powder.
5. The anti-fatigue pharmaceutical composition according to any one of claims 1-3, wherein the kudzuvine root extract is prepared by the following method: weighing 1kg of radix Puerariae, ultrasonically extracting with 75-95% ethanol with the mass of 8-15 times of that of the radix Puerariae for 30-120min, filtering to obtain primary filtrate and filter residue, adding the 75-95% ethanol with the mass of 3-8 times of that of the radix Puerariae into the filter residue, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, mixing the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to 300-500g to obtain concentrated solution; adding 3-5 kg of 95% ethanol water solution into the concentrated solution under stirring, precipitating with ethanol for at least 10 hours, and collecting supernatant; concentrating the supernatant to dryness, dissolving with a small amount of 0-30% ethanol, passing through macroporous resin, eluting with 20-40% ethanol and 75-95% ethanol sequentially, respectively collecting eluates, concentrating the eluates eluted with 75-95% ethanol under reduced pressure, and lyophilizing or vacuum drying to obtain powder.
6. The anti-fatigue pharmaceutical composition according to any one of claims 1-3, wherein the rhizoma polygonati extract is prepared by the following method: weighing 1kg of rhizoma polygonati pieces, ultrasonically extracting for 30-120min by using 65-85% ethanol with the mass of 8-15 times of the rhizoma polygonati pieces, filtering to obtain primary filtrate and filter residue, adding the 65-85% ethanol with the mass of 3-8 times of the rhizoma polygonati pieces into the filter residue, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to 300-500g to obtain concentrated solution; adding 3-5 kg of 95% ethanol water solution into the concentrated solution under stirring, precipitating with ethanol for at least 10 hours, and collecting supernatant; concentrating the supernatant under reduced pressure to dry, dissolving with small amount of 0-30% ethanol water, passing through macroporous resin, eluting with 70-90% ethanol, and collecting eluate; concentrating the eluent under reduced pressure, and freeze-drying or vacuum-drying to obtain powder.
7. The anti-fatigue pharmaceutical composition according to any one of claims 1 to 3, wherein the polygonatum extract, the ginseng extract, the American ginseng extract, the codonopsis pilosula extract, the cistanche extract, and the cornus officinalis extract are prepared by the following methods, respectively: weighing 1kg of active raw materials, wherein the active raw materials are rhizoma polygonati officinalis chips, ginseng, american ginseng, radix codonopsis pilosulae, cistanche deserticola or dogwood, ultrasonically extracting for 30-120min by using 65-85% ethanol with the mass of 8-15 times of the active raw materials, filtering to obtain primary filtrate and filter residues, adding the 65-85% ethanol with the mass of 3-8 times of the active raw materials into the filter residues, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to 500-800g to obtain concentrated solution; adding 3-5 kg of 95% ethanol water solution into the concentrated solution under stirring, precipitating with ethanol for at least 10 hours, and collecting supernatant; concentrating the supernatant under reduced pressure until no alcohol smell exists, and freeze drying or vacuum drying to obtain powder.
8. The anti-fatigue pharmaceutical composition according to any one of claims 1 to 3, wherein the licorice extract, the astragalus extract, the eucommia ulmoides leaf extract, the angelica sinensis extract, the dried ginger extract, the cinnamon extract are prepared by the following methods, respectively: weighing 1kg of active raw materials, wherein the active raw materials are licorice tablets, astragalus tablets, eucommia leaves, angelica sinensis, dried ginger or cinnamon, ultrasonically extracting for 30-120min by using 50-70% ethanol with the mass of 8-15 times of the active raw materials, filtering to obtain primary filtrate and filter residues, adding the 50-70% ethanol with the mass of 3-8 times of the active raw materials into the filter residues, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to 300-500g to obtain concentrated solution; adding 3-5 kg of 95% ethanol water solution into the concentrated solution under stirring, precipitating with ethanol for at least 10 hours, and collecting supernatant; concentrating the supernatant under reduced pressure until no alcohol smell exists, and freeze drying or vacuum drying to obtain powder.
9. An anti-fatigue pharmaceutical composition according to any one of claims 1 to 3, wherein the dried orange peel extract is prepared by the following method: weighing 1kg of dried orange peel, ultrasonically extracting with 40-60% ethanol with the weight being 8-15 times of that of the dried orange peel for 30-120min, filtering to obtain primary filtrate and filter residue, adding the 40-60% ethanol with the weight being 3-8 times of that of the dried orange peel into the filter residue, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to 500-800g to obtain concentrated solution; adding 3-5 kg of 95% ethanol water solution into the concentrated solution under stirring, precipitating with ethanol for at least 10 hours, and collecting supernatant; concentrating the supernatant under reduced pressure until no alcohol smell exists, and freeze drying or vacuum drying to obtain powder.
10. The anti-fatigue pharmaceutical composition according to any one of claims 1 to 3, wherein the Cordyceps sinensis extract is prepared by: weighing 1kg of cordyceps sinensis, ultrasonically extracting for 30-120min by using 65-85% ethanol with the mass of 20-40 times of that of the cordyceps sinensis, filtering to obtain primary filtrate and filter residue, adding the 65-85% ethanol with the mass of 10-20 times of that of the cordyceps sinensis into the filter residue, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to 500-800g to obtain concentrated solution; adding 3-5 kg of 95% ethanol water solution into the concentrated solution under stirring, precipitating with ethanol for at least 10 hours, and collecting supernatant; concentrating the supernatant under reduced pressure until no alcohol smell exists, and freeze drying or vacuum drying to obtain Cordyceps extract.

Description

Nebulizable anti-fatigue pharmaceutical composition Technical Field The invention relates to the technical field of compositions, in particular to an atomized anti-fatigue pharmaceutical composition. Background The society pace of life is faster and faster, and work and study with high intensity is extremely easy to cause fatigue and even cause fatigue syndrome. Fatigue is not effectively relieved and can seriously affect physical health, resulting in the appearance of a series of symptoms. Nebulization is a rapid delivery route capable of delivering substances with anti-fatigue effects into the human body, but no nebulized product with anti-fatigue effects is currently available. Disclosure of Invention The present invention aims to solve at least one of the technical problems in the related art to some extent. To this end, an object of the present invention is to propose an nebulizable anti-fatigue pharmaceutical composition. In one aspect of the invention, the invention provides an nebulizable anti-fatigue pharmaceutical composition. According to an embodiment of the invention, it comprises: the active extract comprises at least one of a beautiful millettia root extract, an astragalus extract, a sealwort extract, a ginseng extract, an American ginseng extract, a pilose asiabell root extract, a cistanche extract, a cordyceps sinensis extract, a dogwood extract, a eucommia ulmoides leaf extract, a angelica sinensis extract, a liquorice extract, a dried orange peel extract, a dried ginger extract, a cinnamon extract, a fragrant solomonseal rhizome extract and a kudzuvine root extract. Therefore, the anti-fatigue pharmaceutical composition can be atomized, can be counted into a human body by adopting atomization inhalation, can greatly improve the absorption of the human body to the medicine, has quick absorption, quick effect and small dosage, further achieves better anti-fatigue efficacy, and is convenient to carry; moreover, the active extracts are all natural herbal extracts, so that the side effect on human bodies is small, and the efficacy is good. According to an embodiment of the present invention, based on the total weight of the anti-fatigue pharmaceutical composition, comprises: 0.1% -5% of the active extract; 0.01% -3% of sweetener; 0.1 to 5 percent of cooling agent; 0.01% -5% of essence; and the balance of solvent. According to an embodiment of the present invention, the cooling agent is at least one selected from menthol, menthone, isomenthone, l-menthyl lactate, WS-23, WS-3, WS-5, WS-12, neomenthol, isopulegol, menthyl acetate, isopulegol acetate, menthyl isovalerate, and menthone, the sweetener is at least one selected from sucralose, neotame, cyclamate, acesulfame, aspartame, neohesperidin dihydrochalcone, and hesperidin dihydrochalcone, the essence is at least one selected from limonene, benzyl alcohol, ethyl butyrate, vanillin, citronellal, isoamyl alcohol, ethyl maltol, isobutyl acetate, isopentyl acetate, benzyl benzoate, leaf alcohol, ethyl propionate, citral, gamma-decalactone, decanal, ethyl acetate, 2-methylbutyrate, 2-methylbutyl acetate, 2-methylbutyraldehyde, myrcene, ethyl caproate, aldehyde, isovalerate, leaf alcohol, leaf acetate, 2-methyl butyrate, and at least one selected from glycerol, and glycerin, and at least one selected from ethanol. According to an embodiment of the invention, the millettia speciosa champ extract is prepared by the following method: weighing 1kg of millettia speciosa, ultrasonically extracting for 30-120min by using 75-95% ethanol with the mass of 8-15 times of the millettia speciosa, filtering to obtain primary filtrate and filter residues, adding the 75-95% ethanol with the mass of 3-8 times of the millettia speciosa into the filter residues, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to 300-500g to obtain concentrated solution; adding 3-5 kg of 95% ethanol water solution into the concentrated solution under stirring, precipitating with ethanol for at least 10 hours, and collecting supernatant; concentrating the supernatant under reduced pressure to dryness, dissolving with small amount of 0-30% ethanol, passing through macroporous resin, eluting with 75-95% ethanol, and collecting eluate; concentrating the eluent under reduced pressure, and freeze-drying or vacuum-drying to obtain powder. According to an embodiment of the present invention, the kudzuvine root extract is prepared by the following method: weighing 1kg of radix Puerariae, ultrasonically extracting with 75-95% ethanol with the mass of 8-15 times of that of the radix Puerariae for 60min, filtering to obtain primary filtrate and filter residue, adding the 75-95% ethanol with the mass of 3-8 times of that of the radix Puerariae into the filter residue, ultrasonically extracting for 10-60min, filtering to obtain secondary filtrate, mixing the primary filt