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CN-116550172-B - Special precise ultrafiltration membrane for protein separation and preparation method thereof

CN116550172BCN 116550172 BCN116550172 BCN 116550172BCN-116550172-B

Abstract

The invention relates to the technical field of composite materials and discloses a special precision ultrafiltration membrane for protein separation and a preparation method thereof, comprising the following steps of S1, adding polyethersulfone, zinc oxide, glycerol, acetone and a solvent into a reaction kettle to prepare a mixed solution, stirring and heating the mixed solution; the method comprises the steps of S2, uniformly stirring the mixed solution prepared in S1, carrying out vacuum defoaming treatment to obtain ultrafiltration membrane casting solution, S3, extruding the casting solution in S2 from a ring spinneret through a metering pump, introducing air with temperature and humidity into the inner cavity of the ring spinneret, entering a gel tank for split-phase solidification to form a hollow fiber membrane, carrying out traction and rolling to obtain a nascent polyether sulfone hollow fiber ultrafiltration membrane, S4, washing the nascent polyether sulfone hollow fiber ultrafiltration membrane in S3 with pure water, and placing the nascent polyether sulfone hollow fiber ultrafiltration membrane in a dehumidification room with certain temperature and humidity for hanging and airing to obtain the hollow fiber special ultrafiltration membrane.

Inventors

  • WU FUGEN
  • ZHANG WENJIE

Assignees

  • 湖北聚孚膜科技股份有限公司

Dates

Publication Date
20260508
Application Date
20230510

Claims (6)

  1. 1. A special precision ultrafiltration membrane for protein separation is characterized by comprising the following components in parts by weight 15-25 Parts of polyether sulfone 0.1 To 1 part of zinc oxide 10-25 Parts of glycerol 3-5 Parts of acetone 50-70 Parts of a solvent; the preparation of the special precision ultrafiltration membrane for protein separation comprises the following steps, S1, adding 15-25 parts of polyethersulfone, 0.1-1 part of zinc oxide, 10-25 parts of glycerol, 3-5 parts of acetone and 50-70 parts of solvent into a reaction kettle according to weight fractions to prepare a mixed solution, and stirring and heating the mixed solution; s2, uniformly stirring the mixed solution prepared in the step S1, and carrying out vacuum defoaming treatment to obtain ultrafiltration membrane casting solution; S3, extruding the casting solution in the step S2 from the annular spinneret through a metering pump, introducing air with a certain temperature and humidity into the inner cavity of the annular spinneret, entering a gel groove for split-phase solidification to form a hollow fiber membrane, and obtaining a nascent polyether sulfone hollow fiber ultrafiltration membrane through traction and rolling; S4, cleaning the nascent polyether sulfone hollow fiber ultrafiltration membrane in the S3 by pure water, and placing the nascent polyether sulfone hollow fiber ultrafiltration membrane in a dehumidification room with a certain temperature and humidity for hanging and airing to prepare the polyether sulfone hollow fiber special ultrafiltration membrane for concentrating whey protein; The temperature of the air introduced in the S3 is 50-60 ℃, the humidity is 80-90%, the height of the air section in the S3 is 5-7 cm, and the irradiation time of the ultraviolet light in the cleaning and airing process in the S4 is 8-24 h.
  2. 2. The special protein separation precision ultrafiltration membrane of claim 1, wherein the molecular weight of the polyethersulfone is 5-7 ten thousand.
  3. 3. The special protein separation precision ultrafiltration membrane of claim 1, wherein the zinc oxide is nano zinc oxide with a particle size of 1-10 nm.
  4. 4. The special precision ultrafiltration membrane for protein separation according to claim 1, wherein the solvent is one or more selected from dimethylformamide, dimethylacetamide and N-methylpyrrolidone.
  5. 5. The special precision ultrafiltration membrane for protein separation according to claim 1, wherein the heating temperature in S1 is 40-60 ℃.
  6. 6. The special precision ultrafiltration membrane for protein separation according to claim 1, wherein the stirring time in the step S1 is 4-8 hours.

Description

Special precise ultrafiltration membrane for protein separation and preparation method thereof Technical Field The invention relates to the technical field of composite materials, in particular to a special precision ultrafiltration membrane for protein separation and a preparation method thereof. Background Whey protein (whey protein) is called protein king, is a protein extracted from milk, has the characteristics of high nutritive value, easy digestion and absorption, various active ingredients and the like, and is one of the well-known high-quality protein supplements for human bodies. The proteins in milk are mainly composed of two major classes, 20% are whey proteins, the rest 80% are casein, the main components of the whey proteins are beta-lactoglobulin and alpha-lactalbumin, and the molecular weights of the whey proteins are 14400Da and 18400Da respectively. In the milk food processing process, a large amount of byproducts such as whey protein, lactose and the like are generated, so that the direct discharge can cause a great deal of waste, and the environment is polluted. Therefore, the membrane technology is adopted for concentration and separation, and then the membrane is recycled, so that the membrane has high economic and social values. The ultrafiltration technology is membrane filtration, and the specific pore diameter of 0.01-0.1 um of the ultrafiltration membrane can effectively intercept bacteria, viruses, colloids and the like, thereby achieving the purposes of separation, classification, purification and concentration. The ultrafiltration process has the characteristics of no phase change, simple operation and the like, and is widely applied to the fields of water treatment, food industry, biochemical industry and the like. As ultrafiltration technology advances, its contribution to human society will also increase. But the ultrafiltration membrane has the problems of quick pollution, low separation efficiency, poor separation effect, easy bacteria breeding, difficult cleaning and maintenance and the like in the concentration and separation process of the whey protein. Therefore, a hollow fiber ultrafiltration membrane with better hydrophilicity, higher pure water flux and more accurate separation effect and antibacterial property is required to be developed. The hollow fiber ultrafiltration membrane called as a coiled flat ultrafiltration membrane has the advantages of large filling density, easy control of the production process and low production cost, and becomes a main form of the ultrafiltration membrane, thereby being the main stream of the current market. The ultrafiltration membrane is mainly made of PVDF, PES, PS, PVC, PAN, PP. Among the materials, polyethersulfone has excellent performances of mechanical property, chemical stability, heat resistance, corrosion resistance, oxidation resistance, heat resistance and the like, and has excellent biocompatibility, thus being an ideal membrane material for concentrating food materials. The main problems existing in the polyethersulfone hollow fiber filtering membranes in the market are (1) that the polyethersulfone material has low surface energy and strong hydrophobicity, which results in poor water wettability and low water flux on the surface of the membrane, and organic matters such as proteins and the like in the materials are easy to adsorb during concentration and separation, so that the membrane pores are blocked, and the water flux is reduced. (2) The polyether sulfone hollow fiber ultrafiltration membrane has the conditions of wide pore size distribution and low retention rate, and causes the problems of poor separation effect, low product purity and large material waste in the material concentration process. (3) In the use process of the ultrafiltration membrane, bacteria in the material can grow and reproduce on the surface of the membrane and in the membrane holes, so that the membrane holes are blocked, the water flux is reduced, and meanwhile, the material is easy to deteriorate. (4) The ultrafiltration membrane wire itself contains a protective liquid or has a relatively high content of membrane wire bacteria, so that the membrane wire needs to be continuously washed in the using process, and the food safety is not facilitated. The composition of the core liquid in the process of preparing the membrane by the polyether sulfone hollow fiber internal pressure membrane is very important to the membrane structure and the membrane aperture, the common practice is to change the components of the core liquid to adjust the ultrafiltration membranes with different pore diameters and different membrane structures, and the ultrafiltration membranes exist in the form of liquid, and the freshness of the core liquid adopting a certain temperature and humidity gas is reported. An internal pressure hollow fiber ultrafiltration membrane, a preparation method and application thereof are disclosed in Chinese patent application No. CN2