CN-116617240-B - New use of rutin or its hydrate, salt or derivative and injection thereof

Abstract

The invention relates to a new application of rutin or a hydrate, salt or derivative thereof and an injection thereof, belonging to the field of biological medicine. The invention provides an application of rutin or hydrate, salt or derivative thereof in preparing medicines for preventing or/and treating alcoholism, wherein the medicines are injection administration preparations, oral administration preparations and nasal administration preparations. The invention also provides a rutin injection, which is prepared by clathrating rutin with sulfobutyl-beta-cyclodextrin. The invention also provides the use of rutin or its hydrate, salt in preparing dietary supplements for preventing hangover symptoms or malfunctions after drinking alcoholic beverages. In addition, in the research process of rutin preparation, the invention discovers that the sulfobutyl-beta-cyclodextrin has good solubilization effect on rutin, and can obviously shorten the awake time and obviously reduce the death rate when treating alcoholism.

Inventors

• DENG CAIFENG
• ZHANG QUAN
• XU XIAOHONG
• ZHOU SHIYU
• CHEN YU
• LIU YUJIAO

Assignees

• 成都自然素生物科技有限公司

Dates

Publication Date

20260512

Application Date

20230504

Claims (2)

1. 1. The application of rutin injection in preparing medicines for preventing or/and treating alcoholism comprises sulfobutyl-beta-cyclodextrin and rutin, wherein the weight ratio of rutin to sulfobutyl-beta-cyclodextrin is as follows: rutin 1 part and sulfobutyl-beta-cyclodextrin 9-50 parts.
2. 2. The method according to claim 1, wherein the injection is prepared by the following steps: a. weighing raw and auxiliary materials rutin and sulfobutyl-beta-cyclodextrin, wherein the raw and auxiliary materials rutin and sulfobutyl-beta-cyclodextrin are prepared from the following components in parts by weight: Rutin 1 part, sulfobutyl-beta-cyclodextrin 9-50 parts; b. adding the raw and auxiliary materials in the step a into normal saline, heating to 70 ℃, stirring and maintaining for 15-25min, cooling to room temperature to obtain clear solution of rutin inclusion compound, adding pharmaceutically acceptable auxiliary materials, sterilizing to obtain injection, and further lyophilizing the injection to obtain lyophilized powder for injection.

Description

New use of rutin or its hydrate, salt or derivative and injection thereof Technical Field The invention relates to a new application of rutin or hydrate, salt or derivative thereof, in particular to an application in preparing a medicament for preventing or/and treating alcoholism, belonging to the field of biological medicine. Background According to the report of the World Health Organization (WHO) 2018, over 300 tens of thousands of people die from alcoholism each year, accounting for 5.3% of the total number of deaths worldwide, and the total number of alcohol drinks per year in people over 15 years old increases from 5.5 liters in 2005 to 6.4 liters in 2016, alcoholism has been one of the main factors in death of men 15-59 years old. For centuries, alcohol has been widely used as an entertainment drink worldwide as a substance that may develop a dependency, and as a hydroxy derivative, it is highly fat-soluble and rapidly absorbed, and most of alcohol is absorbed into the blood and excreted only in small amounts by urine, sweat and breath. Excessive drinking can cause abnormal functions of a plurality of organs or systems of the organism, often induce gastric and liver lesions, nervous and cardiovascular diseases and cancers, and even lead to paralysis of the respiratory center directly to die in serious cases. The heavy drinking has serious impact on the health, family and society of individuals, which is also a great challenge for the sanitation system of various countries. Excessive drinking can cause alcoholism, which is classified into chronic alcoholism and acute alcoholism according to the symptoms. Chronic alcoholism can lead to systemic multisystem multi-organ injury, brain tissue is an important target organ for alcohol, and is most vulnerable to injury, and brain injury is one of the more common and serious complications of chronic alcoholism. A series of mental and conscious disturbance syndromes, such as slow response, inattention, memory decline, spontaneous language decline, tremor delusions, hallucinations, amnesia, disorientation, ataxia, dyskinesia, etc., which are caused by chronic impairment of the brain frontal lobe and limbic system related memory and advanced mental functions due to long-term drinking are clinically defined as alcoholic encephalopathy, and chronic alcoholism also induces apoptosis of cerebral cortical nerve cells (Tang Fa soldiers, study of chronic alcoholism inducing apoptosis of mouse cerebral cortical nerve cells, university of chinese medicine science, 4 months 2010). For the treatment of chronic alcoholism, there are reports in the relevant literature such as the protection of garlic polysaccharide against brain injury in mice with chronic alcoholism (Wu Weiqing, the protection of garlic polysaccharide against brain injury in mice with chronic alcoholism, and the university of south-school's treatises, 4 th year 2012). Acute alcoholism (acute alcoholism AAI) refers to the condition that excessive alcohol or alcoholic beverage is consumed at one time and exceeds the oxidative metabolism of the liver to accumulate in the body, and causes the central nervous system to excite and inhibit at first, and the process of multi-system damage such as liver, cardiovascular and cerebrovascular diseases and the like is accompanied, and respiratory and circulatory failure can occur due to serious poisoning, and finally death is caused. The clinical manifestations of acute alcoholism vary from person to person and can be roughly divided into three phases, namely, excitation phase, ataxia phase and coma phase. The pathogenesis of acute alcoholism is not clear, and is related to the following aspects of direct action of the ingested alcohol on nerve cell membranes to influence cell functions, reduction of protein in brain, increase of water and dysmyelination due to fat-solubility of the alcohol. Ethanol is a neurotropic poison, can permeate blood brain barrier to promote anterior pituitary to release endorphin, the activity of endorphin system is enhanced, similar morphine-like biological effect can be generated, sleepiness, confusion and the like occur, the cerebral cortex of a central nervous system is directly inhibited in serious cases, the subcortical, medulla oblongata and spinal cord are further influenced, finally, the vital center is inhibited to cause respiratory function and circulatory failure, death is caused, the metabolism of the ethanol in liver is abnormal, for example, the occurrence of metabolic acidosis caused by lactic acid increase, ketone body accumulation and the like, the abnormal production of sugar is also caused, the absorption of vitamins can be influenced and inhibited by the ethanol, abnormal change of functions and structures of nervous tissues occurs after the sugar metabolism is generated, the ethanol enters the human body through the digestive tract, the mucous membrane necrosis can be caused, and gastric juice secretion is high, so that th