CN-116687908-B - Application of pummelo peel element or SR1078 in preparation of medicines for improving salivary gland function

Abstract

The invention discloses application of Nobiletin (NOB) or SR1078 in preparing medicaments for improving salivary gland functions, in particular to improving biological rhythms of salivary glands damaged by ionizing radiation. Salivary gland function can be significantly promoted by oral administration of a dose of NOB or SR 1078. And can not conflict with other medicines with functions of anti-inflammation, regeneration promotion and the like. Can be administered once or continuously for multiple times, and can be administered after injury without affecting tumor radiotherapy process.

Inventors

• YUE ZHICAO

Assignees

• 深圳大学

Dates

Publication Date

20260505

Application Date

20230629

Claims (1)

1. 1. Application of exocarpium Citri Grandis or SR1078 in preparing medicine for improving salivary gland function due to ionizing radiation injury; The molecular structural formula of the nobiletin is The molecular structural formula of the SR1078 is 。

Description

Application of pummelo peel element or SR1078 in preparation of medicines for improving salivary gland function Technical Field The invention belongs to the technical field of small molecule medicines, and particularly relates to application of pummelo peel element or SR1078 in preparation of medicines for improving salivary gland functions damaged by ionizing radiation. Background The radioactive xerostomia is a common complication after the radiotherapy operation of head and neck tumor, and seriously affects the life quality of patients. Mainly, after patients with head and neck tumor receive radiotherapy, the salivary gland tissue is damaged due to ionizing radiation, so that the secretion speed and quantity of saliva are obviously reduced, and the composition is changed, and the oral cavity is mainly dry. Under the condition of insufficient saliva, the food cannot be fully fused, so that chewing and swallowing are difficult, oral infection is often combined, and symptoms such as burning sensation, hypogustation and ulcer are sometimes generated. Clinically, xerostomia caused by other complex factors, including age, climate change, medicament use and the like, may also cause hyposalivary gland function and hyposalivation. Wherein, the light and medium patients can use sugar-free chewing gum or buccal tablet for relieving dry mouth to stimulate salivary gland and make them secrete saliva. However, the severe patient needs to use artificial saliva, and the existing artificial saliva on the market can simulate and replace natural saliva of a human body to achieve the effect of relieving dry mouth, but the problem cannot be fundamentally solved. In addition, research on stem cell therapy and regenerative medicine is in the laboratory stage. Accordingly, there is still a need in the art for further improvements and enhancements. Disclosure of Invention Aiming at the problems, the invention aims to provide the application of the pummelo peel element or the SR1078 in preparing the medicine for improving the biological rhythm, and aims to solve the problems of obvious reduction of the secretion speed and quantity of saliva and component change and dryness of the oral cavity caused by the existing salivary gland tissue injury caused by ionizing radiation. Improving salivary secretion speed and relieving xerostomia. The technical scheme adopted by the invention for solving the technical problems is as follows: In a first aspect, the use of tangerines or SR1078 for the manufacture of a medicament for improving salivary gland function damaged by ionising radiation. The following is a preferred technical scheme of the present invention, but not a limitation of the technical scheme provided by the present invention, and the following preferred technical scheme can better achieve and achieve the objects and advantages of the present invention. In a second aspect, the use of a pharmaceutical formulation for the manufacture of a medicament for improving the function of an ionising radiation damaged salivary gland, wherein the pharmaceutical formulation is canthaxanthin or SR1078. As a preferable technical scheme, the pharmaceutical preparation is applied to the preparation of medicines for improving the salivary gland function damaged by ionizing radiation, wherein the dosage of the pharmaceutical preparation is 30-150mg/kg. As a preferred technical scheme, the pharmaceutical preparation is applied to the preparation of medicines for improving the salivary gland function damaged by ionizing radiation, wherein the administration is single administration or continuous multiple administration. Compared with the prior art, the invention has the beneficial effects that the vitamin E or SR1078 is used as the active ingredient for treating the salivary glands after radiation injury, so that the function of the salivary glands after radiation injury can be improved, the salivary glands after injury can be increased in salivary secretion, the salivation speed of saliva can be improved, and the xerostomia symptom can be relieved. Drawings FIG. 1A shows biological rhythm changes (indicated by arrows) for gene expression analysis, differential expression gene pathway analysis (RNA-seq; 6 hours) by collecting submaxillary glands from C57BL/6 mice irradiated with 5Gy X-rays; FIG. 1B shows the biological clock key gene expression change (qRT-PCR); FIG. 1C shows reduced expression of a key salivary gland functional gene (qRT-PCR). On the abscissa, the bright-dark time, ZT0-ZT12 are the illumination times, ZT12-ZT24 are the dark times. FIG. 2 is a schematic diagram of the rescue of salivary gland function by a small molecule drug regulating biological rhythm, wherein A.150mg/kg of tangerines (Nob) are orally administered to rescue salivary gland function, a significant difference (N=5) is shown on the third day, B.50mg/kg of Nob are orally administered for seven consecutive days to rescue salivary gland function, a significant difference