CN-116750354-B - Biological sample storage library

CN116750354BCN 116750354 BCN116750354 BCN 116750354BCN-116750354-B

Abstract

The invention belongs to the technical field of biological sample storage, and particularly provides a biological sample storage library. The automatic storage device aims at solving the problem that the sample is easy to damage due to tube picking operation in the process of storing and taking the frozen storage tubes of the existing automatic storage device. The biological sample storage warehouse comprises a box body, a lifting and transferring device, a code scanning device, a tube picking device and a freezing box transferring device, wherein the box body is internally provided with a storage room, a tube picking room and a sample receiving room, the tube picking room is communicated with the storage room, the sample receiving room is communicated with the upper part of the tube picking room and is communicated with the tube picking room through a first inlet and a second inlet, the sample receiving room is communicated with the external environment of the box body through a second inlet and a second outlet, the lifting and transferring device is arranged in the sample receiving room, and the code scanning device, the tube picking device and the freezing box transferring device are arranged in the tube picking room. The tube picking and storing room is communicated, so that the temperatures of the tube picking and storing room are consistent, a sample cannot be deactivated in the tube picking operation process, and the sample deactivation risk is reduced.

Inventors

WANG JIE
LIU ZHANJIE
ZHAO HONGBIN
XIE YUGANG
LIU HUI

Assignees

青岛海尔生物医疗科技有限公司
青岛海尔生物医疗股份有限公司

Dates

Publication Date: 20260508
Application Date: 20230621

Claims (10)

1. A biological sample repository, the biological sample repository comprising: The box body is internally provided with a storage room, a picking pipe room and a sample receiving room, wherein the picking pipe room is communicated with the storage room and distributed along the Y-axis direction, the sample receiving room is positioned above the picking pipe room and is communicated with the picking pipe room through a first inlet and a second inlet, and the sample receiving room is communicated with the external environment of the box body through a second inlet and a second outlet; A lifting and transferring device arranged in the sample receiving room, wherein the lifting and transferring device is arranged to transfer the freezing box between the picking pipe room and the sample receiving room through the first inlet and outlet, and is also arranged to transfer the freezing box between the sample receiving room and the outside through the second inlet and outlet; The code scanning device is arranged in the tube picking room and is used for scanning a box code of the freezing box and a tube code of the freezing tube in the freezing box; the tube picking device is arranged in the tube picking room and is used for picking tubes; And The frozen box transferring equipment is arranged in the picking pipe, and is arranged to be capable of transferring frozen boxes among the lifting transferring device, the picking pipe equipment, the code scanning device and the storage room.
2. The biological sample storage library of claim 1, wherein the lifting and transporting device comprises a first fixture, a lifting mechanism, a transporting rack, and a first horizontal transfer mechanism, The first fixing piece is arranged in the sample receiving room, the lifting mechanism and the first horizontal transfer mechanism are arranged on the first fixing piece and positioned in the sample receiving room, The transfer frame is connected with the lifting mechanism and passes through the first inlet and outlet, the transfer frame can place the freezing boxes in batches, The lifting mechanism is arranged to drive the transfer frame to move along the Z axis so as to enable the transfer frame to move between a first transfer position and a second transfer position, the first transfer position is positioned in the sample receiving room, and the second transfer position is positioned in the picking room; The first horizontal transfer mechanism is arranged to be capable of receiving and transferring the frozen storage box along the X axis, wherein in the condition that the transfer frame is located at the first transfer position, the transfer frame and the second inlet and outlet are arranged opposite to each other, the first horizontal transfer mechanism is capable of receiving the frozen storage box located on the transfer frame and conveying the frozen storage box to the external environment through the second inlet and outlet, and receiving the frozen storage box in the external environment through the second inlet and outlet and placing the frozen storage box on the transfer frame.
3. The biological sample storage library of claim 2, wherein the transfer rack comprises a rack body, wherein a plurality of storage positions are arranged in the rack body in an array along the length direction and the height direction of the rack body and form a plurality of columns and layers, each storage position is provided with a first opening and a second opening for taking and placing a freezing storage box, and the first opening and the second opening are oppositely arranged.
4. A biological sample storage library according to claim 3, wherein the top and bottom of the transfer rack are provided with a first seal and a second seal, respectively, the lifting mechanism being connected to the first seal, The first seal seals the first access opening with the transfer frame in the second transfer position, The second seal seals the first access opening with the transfer shelf in the first transfer position.
5. The biological sample storage library of claim 1, further comprising a transfer rack guide positioned within the picking chamber, the transfer rack guide being coupled to the transfer rack and capable of guiding the transfer rack during up and down movement of the transfer rack to provide for linear movement of the transfer rack.
6. The biological sample storage library of claim 1, wherein the cryopreservation cassette transfer apparatus comprises a first cryopreservation cassette receiving transfer device and a second cryopreservation cassette receiving transfer device, The first freezing box receiving and transferring device is arranged to be capable of receiving and transferring freezing boxes along an X axis and a Y axis, and is capable of being respectively in butt joint with the lifting and transferring device, the pipe picking device, the code scanning device and the second freezing box receiving and transferring device so as to receive and transfer the freezing boxes; the second cryopreservation cassette receiving and transporting device is configured to enable transfer of a cryopreservation cassette between the first cryopreservation cassette receiving and transporting device and the storage compartment.
7. The biological sample storage library of claim 6, wherein the first cryopreservation cassette receiving and transporting device comprises a first mount and a first lifting mechanism, a second mount, a first horizontal sliding mechanism, a third mount, a rotating shovel disk mechanism, and a second horizontal transfer mechanism mounted on the first mount; The first mounting piece is connected with the box body, the second mounting piece is connected with the first lifting mechanism, the first horizontal sliding mechanism and the second horizontal transferring mechanism are mounted on the second mounting piece, the first horizontal sliding mechanism and the second horizontal transferring mechanism are distributed along the X-axis at intervals, the third mounting piece is connected with the first horizontal sliding mechanism, the rotary shovel disc mechanism is mounted on the third mounting piece, The first lifting mechanism is arranged to drive the second mounting piece, the first horizontal sliding mechanism, the second horizontal transfer mechanism, the third mounting piece and the rotary shovel disk mechanism to move along a Z axis; The first horizontal sliding mechanism is arranged to drive the third mounting piece and the rotary shovel disk mechanism to move along the Y axis, so that the rotary shovel disk mechanism can be in butt joint with the pipe picking device to transfer the freezing box; The rotary shovel disc mechanism is arranged to be capable of rotating circumferentially around the vertical shaft and moving telescopically along the length direction of the rotary shovel disc mechanism so as to receive and transfer the freezing box; The second horizontal transfer mechanism is arranged to be capable of receiving and transferring the cryopreservation box along the Y axis and transferring the cryopreservation box among the tube picking equipment, the code scanning device and the second cryopreservation box receiving and transferring device.
8. The biological sample storage library according to claim 7, wherein the code scanning device and the second horizontal transfer mechanism are distributed at intervals along the Y axis, and the first lifting mechanism drives the second horizontal transfer mechanism to move to be at the same height as the code scanning device, wherein the second horizontal transfer mechanism is opposite to the code scanning device.
9. The biological sample storage library of claim 7, wherein the second cryopreservation cassette receiving and transporting device comprises a first support and a second horizontal sliding mechanism mounted on the first support, a second support and a cassette carrier; the second support piece is arranged on the second horizontal sliding mechanism, the box carrying piece is arranged on the second support piece, and the box carrying piece can carry the freezing box; The second horizontal sliding mechanism is arranged to drive the second supporting piece and the box carrying piece to move along the Y axis so as to transfer the freezing box between the picking pipe and the storage room, The box carrying pieces and the second horizontal transfer mechanisms are distributed at intervals along the Y axis, and the first lifting mechanism is arranged opposite to the box carrying pieces under the condition that the second horizontal transfer mechanisms are driven to move to the same height as the box carrying pieces; and/or the number of the groups of groups, The tube picking device comprises a third horizontal sliding mechanism, a freezing box fixing mechanism and a tube picking device, wherein the first freezing box receiving and transferring device, the second horizontal sliding mechanism and the code scanning device are sequentially arranged along a Y axis, the tube picking device and the code scanning device are distributed at intervals along an X axis, and the freezing box fixing mechanism can fix two freezing boxes at the same time; the third horizontal sliding mechanism and the tube picking device are connected with the box body, and the freezing box fixing mechanism is arranged on the third horizontal sliding mechanism; The third horizontal sliding mechanism is arranged to drive the freezing box fixing mechanism to move along the X axis so as to enable the freezing box fixing mechanism to move among a first box receiving position, a second box receiving position and a tube picking position; The freezing box fixing mechanism can be in butt joint with the rotary shovel disc mechanism at the first box connecting position and can be in butt joint with the second horizontal transferring mechanism at the second box connecting position so as to receive and transfer the freezing box; the tube picking device is arranged to be capable of picking the frozen box on the frozen box fixing mechanism at the tube picking position.
10. The biological sample storage library of claim 9, wherein the tube picking apparatus further comprises a tube jacking device configured to eject a frozen tube in a frozen box on the frozen box fixing mechanism at the tube picking position so that the tube picking device picks a tube smoothly.

Description

Biological sample storage library Technical Field The invention belongs to the technical field of biological sample storage, and particularly provides a biological sample storage library. Background The development of life science research and the progress of disease analysis detection and treatment and health care technologies in the clinical medical field have promoted the increasingly wide demand for biological samples, and have also put higher demands on the storage technology and equipment of biological samples, including demands on the safety, reliability and stability of stored samples, and the accuracy, efficiency and scientificity of sample access processes and procedures. Long-term storage of biological samples generally requires the use of as low a temperature as possible to reduce the biochemical reactions within the sample and to increase the stability of the various components within the sample. The development and use of automated cryogenic or ultra-cryogenic biological sample access devices is a necessary development in order to achieve long-term, stable, reliable storage and sampling of large volumes of biological samples. The existing automated storage equipment for low-temperature storage generally comprises a cache area and a main library area, wherein the cache area is used for receiving the frozen storage boxes and picking and managing the frozen storage pipes into the corresponding frozen storage boxes through a pipe picking device. However, in the existing buffer area, since the sample is conveyed by being communicated with the external environment, in order to ensure smooth operation of the internal device and avoid the frosting phenomenon in the buffer area from being reduced in the process of transferring the freezing box by being communicated with the external environment, the temperature difference between the buffer area and the external environment area needs to be reduced, so that the temperature in the buffer area is generally set to be minus 20 ℃ or minus 30 ℃. However, when the tube picking operation is required, the time required for the tube picking operation is long, so that the storage time of the frozen tube in the buffer area can be prolonged, the frozen tube is retained in the buffer area at minus 30 ℃ or above for a long time, and the sample is easy to deteriorate, thereby causing loss. Accordingly, there is a need in the art for a new solution to the above-mentioned technical problems. Disclosure of Invention The invention aims to solve the technical problems, namely the problem that the sample is easy to damage due to tube picking operation in the process of storing and taking the frozen tube by the existing automatic storage equipment. The invention provides a biological sample storage warehouse, which comprises a box body, a picking pipe room and a sample receiving room, wherein the box body is internally provided with the storage room, the picking pipe room is communicated with the storage room and distributed along the Y-axis direction, the sample receiving room is positioned above the picking pipe room and communicated with the picking pipe room through a first inlet and a second inlet, the sample receiving room is communicated with the external environment of the box body through a second inlet and a second outlet, a lifting and transferring device is arranged in the sample receiving room and used for transferring a freezing box between the picking pipe room and the sample receiving room through the first inlet and the second inlet, the lifting and transferring device is also arranged for transferring the freezing box between the sample receiving room and the external environment through the second inlet and the second outlet, a code scanning device is arranged in the picking pipe room and used for scanning the box code of the freezing box and a pipe code of the freezing box, a picking pipe device is arranged in the picking pipe room and used for picking and transferring the freezing box, and a lifting and transferring device is arranged in the picking and transferring device. In the preferred technical scheme of the biological sample storage warehouse, the lifting and transferring device comprises a first fixing piece, a lifting mechanism, a transferring frame and a first horizontal transferring mechanism, wherein the first fixing piece is installed in the sample receiving room, the lifting mechanism and the first horizontal transferring mechanism are installed on the first fixing piece and located in the sample receiving room, the transferring frame is connected with the lifting mechanism and penetrates through the first inlet and outlet, the transferring frame can be used for placing frozen storage boxes in batches, the lifting mechanism is arranged to drive the transferring frame to move along a Z axis so that the transferring frame can move between a first transferring position and a second transferring position, the first transferring position is loca