CN-116782767-B - Package for storing wet tissue

Abstract

A packaging system (10 b) includes a package defining a cavity (14 b), and a seal (18 b) configured to be coupled to the package to fluidly seal the cavity. The packaging system may also include at least one tissue scaffold (16 b) configured to be disposed within the cavity. The cavity having a single size may be configured to accommodate tissue scaffolds having different sizes. In addition to the cavity, the packaging system may include one or more additional reservoirs configured to hold a quantity of liquid. Such packaging systems may be used to store human or animal tissue, either wet or dry. The invention also provides a packaged tissue sample and a method of packaging tissue.

Inventors

• Mindy E. Sadik

Assignees

• 阿克松根股份公司

Dates

Publication Date

20260512

Application Date

20211020

Priority Date

20211019

Claims (20)

1. 1. A packaging system, comprising: A package defining a cavity; A plurality of tissue scaffolds, each configured to be disposed within the cavity, wherein the plurality of tissue scaffolds have a plurality of different sizes, and A seal configured to be coupled to the package to fluidly seal the cavity, Wherein the cavity is configured to receive each of the plurality of tissue scaffolds having different sizes.
2. 2. The packaging system of claim 1, wherein the cavity comprises at least one slot configured to engage a corresponding tab of the tissue scaffold to maintain a position of the tissue scaffold within the cavity.
3. 3. The packaging system of claim 1, wherein the tissue scaffold is configured to support a tissue sample.
4. 4. The packaging system of claim 1, wherein the tissue scaffold is configured to support a tissue sample and fit within the cavity to at least partially immerse the tissue sample in a liquid disposed in the cavity.
5. 5. The packaging system of claim 4, wherein the tissue scaffold is configured to allow the liquid to drain from the tissue scaffold when removed from the cavity.
6. 6. The packaging system of claim 5, wherein the tissue scaffold comprises one or more openings to allow the liquid to drain from the tissue scaffold when the tissue scaffold is removed from the cavity.
7. 7. The packaging system of claim 1, wherein the tissue scaffold comprises one or more features configured to facilitate manipulation of the tissue scaffold.
8. 8. The packaging system of claim 1, wherein the plurality of tissue scaffolds are configured to support tissue samples having a plurality of sizes.
9. 9. The packaging system of claim 1, wherein each of the plurality of tissue scaffolds and the cavity comprise cooperating features to support any of the plurality of tissue scaffolds within the cavity.
10. 10. The packaging system of claim 1, wherein the seal comprises a plastic film.
11. 11. The packaging system of claim 1, wherein the seal comprises a foil seal.
12. 12. The packaging system of claim 1, wherein the seal is configured to be peelable from the package to allow access to the cavity.
13. 13. A packaged tissue sample, wherein the tissue sample is packaged in a tissue packaging system, the tissue packaging system comprising: A package defining a cavity; a plurality of tissue scaffolds configured to be disposed within the cavity, and A seal coupled to the package to fluidly seal the cavity, Wherein the plurality of tissue scaffolds comprises tissue scaffolds having different sizes, wherein the cavity is configured to accommodate each of the plurality of tissue scaffolds having different sizes, and wherein each of the plurality of tissue scaffolds is configured to support the tissue sample.
14. 14. The packaged tissue sample of claim 13, wherein the tissue sample comprises one or more of neural tissue, vascular tissue, urinary tissue, tendons, or muscle tissue.
15. 15. The packaged tissue sample according to claim 13, wherein the tissue scaffold of the tissue packaging system is configured to at least partially immerse the tissue sample within a liquid disposed in the cavity.
16. 16. The packaged tissue sample according to claim 15, wherein the tissue scaffold of the tissue packaging system is configured to allow the liquid to drain from the tissue scaffold when removed from the cavity.
17. 17. The packaged tissue sample according to claim 16, wherein the tissue scaffold of the tissue packaging system comprises one or more openings to allow the liquid to drain from the tissue scaffold when the tissue scaffold is removed from the cavity.
18. 18. The packaged tissue sample according to claim 13, wherein the tissue scaffold of the tissue packaging system comprises one or more features configured to facilitate manipulation of the tissue scaffold.
19. 19. The packaged tissue sample according to claim 13, wherein the tissue scaffold of the tissue packaging system is configured to support the dimensions of the tissue sample.
20. 20. The packaged tissue sample according to claim 13, wherein the seal of the tissue packaging system comprises a plastic film.

Description

Package for storing wet tissue Technical Field The present invention is generally a packaging system for tissue samples, and more particularly a packaging arrangement for storing tissue in a liquid medium. Background Biological tissue can generally provide improved functional performance when used for in vivo implantation, as compared to equivalent synthetic devices. However, availability and use of tissue grafts may be limited by inherent supply limitations and logistical issues of acquisition, transportation and storage. Various techniques have been developed that allow for the acquisition, transport and storage of tissue that may be suitable for surgical implantation. However, many of the developed techniques may require the use of specialized refrigeration equipment to store donor tissue at extremely low temperatures. Such requirements may often limit the facilities that can utilize the available tissue and may complicate the transport of the tissue to the end-use surgical facility. The packages and related methods described herein overcome some of these problems and may enable a more convenient method to transport, store, preoperatively prepare, and end use wet or dry preserved tissue. In some suitable storage methods, the tissue may be stored in a preservative solution that can extend the useful shelf life of the tissue. In some such storage methods, the tissue may remain in the preservative solution until the tissue is used in the surgical procedure. Disclosure of Invention According to one embodiment, a packaging system may include a package defining a cavity. The packaging system may also include a tissue scaffold configured to be disposed within the cavity. The packaging system may further include a seal configured to be coupled to the package to fluidly seal the cavity. One or more of the following features may be included. The cavity may be configured to accommodate tissue scaffolds of different sizes. The cavity may include at least one slot configured to engage a corresponding tab of the tissue scaffold to maintain the position of the tissue scaffold within the cavity. The tissue scaffold may be configured to support a tissue sample. The tissue scaffold may be configured to at least partially immerse the tissue sample in a fluid disposed in the cavity. The tissue scaffold may be configured to allow fluid to drain from the tissue scaffold when removed from the cavity. The tissue scaffold may include one or more openings to allow fluid to drain from the tissue scaffold when the tissue scaffold is removed from the cavity. The tissue scaffold may include one or more features configured to facilitate manipulation of the tissue scaffold. The tissue scaffold may be configured to support tissue samples having a variety of sizes. The tissue scaffold may comprise one of a plurality of tissue scaffolds. Each of the plurality of tissue scaffolds may be configured to support a different sized tissue sample. Each of the cavity and the plurality of tissue scaffolds may include cooperating features to support any of the plurality of tissue scaffolds within the cavity. The seal may comprise a plastic film. The seal may comprise a foil seal. The seal may be configured to be peelable from the package to allow access to the cavity. According to another embodiment, a packaged tissue sample is provided, wherein the tissue sample is packaged in a tissue packaging system. The tissue packaging system may include a package defining a cavity. The tissue packaging system may further include a tissue scaffold configured to be disposed within the cavity. The tissue packaging system may further comprise a seal configured to be coupled to the package to fluidly seal the cavity. The tissue sample may be supported by a tissue scaffold. One or more of the following features may be included. The cavity may be configured to accommodate tissue scaffolds of different sizes. The tissue sample may include one or more human tissues including, but not limited to, neural tissue, vascular tissue, urinary tissue, skin tissue, tendons, and muscle tissue. The tissue sample may include one or more animal tissues including, but not limited to, nerve tissue, vascular tissue, urinary tissue, skin tissue, tendons, and muscle tissue. The tissue scaffold may be configured to at least partially immerse the tissue sample in a fluid disposed in the cavity. The tissue scaffold may be configured to allow fluid to drain from the tissue scaffold when removed from the cavity. The tissue scaffold may include one or more openings to allow fluid to drain from the tissue scaffold when removed from the cavity. The tissue scaffold may include one or more features configured to facilitate manipulation of the tissue scaffold. The tissue scaffold may be configured to support a tissue sample having one of a plurality of dimensions. The tissue scaffold may comprise one of a plurality of tissue scaffolds. Each of the plurality of tissue scaffolds may be configured to