CN-116785025-B - Eye implant and delivery system thereof

Abstract

The invention discloses an ocular implant and a delivery system thereof, which comprise a flexible substrate, a plurality of nanowire arrays arranged on the flexible substrate, an elastic ring arranged along the circumferential edge of the flexible substrate, wherein the elastic ring has elastic memory and can return to an inherent shape before deformation after deformation, and two opposite orifices arranged near the edge of the flexible substrate. The nanowire array of the ocular implant can be formed by splicing a plurality of materials, and can be spliced by selecting light-sensitive materials with different effects and different wave bands, so that the personalized ocular implant can be customized according to different conditions of a patient to achieve the aim of matching with the condition of the eyeground of the patient, and the design of folding and hole sites in the ocular implant and the characteristic of integral self-unfolding of the elastic ring can be realized, so that the ocular implant can be matched with a delivery system for positioning and minimally invasive implantation.

Inventors

• ZHENG HAO
• ZHANG JIAYI
• YAN BIAO
• JIANG CHUNHUI

Assignees

• 复旦大学

Dates

Publication Date

20260505

Application Date

20230525

Claims (17)

1. 1. An ocular implant, comprising: A flexible substrate; a plurality of nanowire arrays disposed on the flexible substrate, the plurality of nanowire arrays consisting of a plurality of nanowire arrays having different efficacy and/or different wavelength band light sensitivity; An elastic ring disposed along a peripheral edge of the flexible substrate, the elastic ring having an elastic memory capable of returning to a pre-deformation natural shape after deformation, and Two opposing apertures disposed near an edge of the flexible substrate for coupling with a delivery system to stretch the ocular implant.
2. 2. The ocular implant of claim 1, wherein the flexible substrate is selected from at least one of Polydimethylsiloxane (PDMS), polyvinyl alcohol (PVA), polyethylene terephthalate (PET), polyethylene naphthalate (PEN), and Polyimide (PI).
3. 3. The ocular implant of claim 2, wherein the flexible substrate is polydimethylsiloxane.
4. 4. The ocular implant of claim 1, wherein the size of the plurality of nanowire arrays is each independently selected from 0.01mm 2 to 2mm 2 and the spacing between adjacent two of the plurality of nanowire arrays is 0.01mm-1mm.
5. 5. The ocular implant of claim 4, wherein the size of the plurality of nanowire arrays is each independently selected from 0.1mm 2 to 1mm 2 .
6. 6. The ocular implant of claim 4, wherein the spacing between adjacent two of the plurality of nanowire arrays is 0.05mm-0.5mm.
7. 7. The ocular implant of claim 1, wherein the shape of the plurality of nanowire arrays are each independently polygonal, elliptical, or circular.
8. 8. The ocular implant of claim 7, wherein the polygon is a square, rectangle, diamond, triangle, or hexagon.
9. 9. The ocular implant of claim 1, wherein the elastic ring is selected from a metal alloy wire or an organic wire.
10. 10. The ocular implant of claim 9, wherein the metal alloy wire is at least one of a nichrome wire, a platinum iridium alloy wire, a inconel wire, an iron-chromium-aluminum alloy wire, an aluminum-platinum alloy wire, and a nickel-titanium alloy wire.
11. 11. The ocular implant of claim 10, wherein the metal alloy wire is a nichrome wire.
12. 12. A delivery system for implanting the ocular implant of any one of claims 1 to 11 into the eye of a subject, comprising: a cannula comprising a tubular portion and a head portion for receiving the ocular implant; a catheter which is capable of passing through the tubular portion of the sleeve and is movable along a length direction of the tubular portion and rotatable about the length direction as an axis, and A guide wire capable of passing through the catheter and movable along a length direction of the catheter and rotatable about the length direction, Wherein, one end of the catheter is provided with a first bending part, one end of the guide wire is provided with a second bending part, which are respectively used for coupling with the orifice of the ocular implant.
13. 13. The delivery system of claim 12, wherein the head of the cannula is configured to receive the ocular implant and hold the ocular implant in a collapsed state prior to delivery of the ocular implant.
14. 14. The delivery system of claim 12, wherein the catheter has a length longer than the tubular portion of the cannula and the guidewire has a length longer than the catheter.
15. 15. The delivery system of claim 12, wherein the first and second bends are configured to move the ocular implant into or out of the head of the cannula by relative movement of the catheter and guidewire with the cannula.
16. 16. The delivery system of claim 12, wherein the first and second bends are configured to stretch the ocular implant by relatively moving the catheter and the guidewire.
17. 17. An ocular implant kit comprising the ocular implant of any one of claims 1-11 and the delivery system of any one of claims 12-16.

Description

Eye implant and delivery system thereof Technical Field The present invention is in the field of ocular medical treatment, and more particularly, the present invention relates generally to an ocular implant and delivery system therefor. Background Artificial retina is a high-tech medical product implanted under the retina of a blind person to achieve a certain efficacy and tolerance. The principle of such an implanted device is to operate with miniature cameras, transmitters and miniature wireless computers on glasses. The external view is captured by a camera on the patient's glasses, and then the image is transmitted to the artificial retina on the surface of the patient's eyeball through a wireless transmitter and converted into an electric pulse signal. Electrodes on the artificial retina then stimulate the retinal optic nerve and continue to transmit signals along the optic nerve to the brain. The traditional technology adopts technical paths similar to artificial cochlea, cardiac pacemaker and brain pacemaker. Three types of small-sized active implantable medical instruments drive an electrode array implanted in fundus to achieve multipoint electrical stimulation. However, this technique has the drawbacks of limited clinical verification resolution and poor patient recovery and also has the risk of water short-circuiting due to the presence of the battery and chip on the intracorporal implant. In recent years, a split type artificial retina is developed abroad through a semiconductor MEMS technology, an in-vivo implant is a passive silicon photocell array, and energy and information are transmitted to the in-vivo implant through an in-vitro machine (glasses). While this technique circumvents the complex design of in vivo implants, currently there is a minimum volume limitation for a single silicon photocell due to MEMS technology limitations, and resolution cannot be improved to a satisfactory level. Meanwhile, the electrode array and the artificial retina of the MEMS process are not flexible enough, and can not be minimally invasive during implantation. Disclosure of Invention The invention aims to overcome the defects in the prior art and provide an eye implant which has enough flexibility and can be minimally invasive when implanted and a delivery system thereof. In a first aspect, the present invention provides an ocular implant comprising: A flexible substrate; A plurality of nanowire arrays disposed on the flexible substrate; An elastic ring disposed along a peripheral edge of the flexible substrate, the elastic ring having an elastic memory capable of returning to a pre-deformation natural shape after deformation, and Two opposing apertures disposed at the flexible substrate proximate the edge. In a preferred embodiment of the present invention, the flexible substrate may be selected from at least one of Polydimethylsiloxane (PDMS), polyvinyl alcohol (PVA), polyethylene terephthalate (PET), polyethylene naphthalate (PEN), and Polyimide (PI), preferably polydimethylsiloxane. In a preferred embodiment of the present invention, the size of the plurality of nanowire arrays may each be independently selected from 0.01mm 2 to 2mm 2, preferably 0.1mm 2 to 1mm 2, and the spacing between adjacent two of the plurality of nanowire arrays may be 0.01mm to 1mm, preferably 0.05mm to 0.5mm. In a preferred embodiment of the present invention, the shape of the plurality of nanowire arrays may each independently be polygonal, elliptical or circular, preferably square, rectangular, diamond, triangular or hexagonal. In a preferred embodiment of the present invention, the plurality of nanowire arrays may be composed of a plurality of nanowire arrays having different efficacy and/or different wavelength band light sensitivity. In a preferred embodiment of the present invention, the elastic ring may be selected from a metal alloy wire or an organic wire, wherein the metal alloy wire is preferably at least one of a nichrome wire, a platinum iridium wire, a inconel wire, an iron-chromium-aluminum alloy, an aluminum-platinum alloy wire, and a nickel-titanium alloy wire, preferably a nichrome wire. In a second aspect, the present invention also provides a delivery system for implanting an ocular implant according to the above in an eye of a subject, comprising: a cannula comprising a tubular portion and a head portion for receiving the ocular implant; a catheter which is capable of passing through the tubular portion of the sleeve and is movable along a length direction of the tubular portion and rotatable about the length direction as an axis, and A guide wire capable of passing through the catheter and movable along a length direction of the catheter and rotatable about the length direction, Wherein, one end of the catheter is provided with a first bending part, one end of the guide wire is provided with a second bending part, which are respectively used for coupling with the orifice of the ocular implant. In a preferr