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CN-117045537-B - Polysaccharide composition with effects of improving skin immunity and strengthening skin barrier function and application thereof

CN117045537BCN 117045537 BCN117045537 BCN 117045537BCN-117045537-B

Abstract

The invention belongs to the field of daily chemical products, and discloses a polysaccharide composition with the functions of improving skin immunity and strengthening skin barrier and application thereof. The polysaccharide composition comprises baical skullcap root polysaccharide, adenophora root polysaccharide and corious versicolor polysaccharide, through the synergistic effect of the three polysaccharides, not only can the number of mast cells be reduced, but also the antibacterial peptide can be increased, silk polymerization protein can be increased, monocyte chemotactic protein-1 and interleukin-6 can be reduced, so that the effects of improving skin immunity and resisting inflammation and whitening are achieved, the polysaccharide composition can also be used as information molecules to widely participate in physiological processes such as mutual identification of ligands and receptors among cells, signal transduction among cells and the like, the average relative expansion multiple of mRNA of interleukin-6 expression factors can be reduced, and the polysaccharide composition can well participate in the differentiation of epidermal cells and the formation of skin barriers, so that the skin barrier consolidating function can be realized, and the polysaccharide composition can be used for preparing cosmetics.

Inventors

  • LIU GUANGRONG
  • YANG KAIYE
  • DU ZHIYUN
  • LIN LI

Assignees

  • 无限极（中国）有限公司

Dates

Publication Date
20260505
Application Date
20211029

Claims (7)

  1. 1. The polysaccharide composition is characterized by comprising, by mass, 0.5-1.5 parts of baical skullcap root polysaccharide, 0.5-1.5 parts of radix adenophorae polysaccharide and 0.5-1.5 parts of corious versicolor polysaccharide; the radix adenophorae polysaccharide, coriolus versicolor polysaccharide and baical skullcap root polysaccharide are respectively extracted from radix adenophorae, coriolus versicolor and baical skullcap root; the preparation method of the radix adenophorae polysaccharide comprises 1) degreasing radix adenophorae, 2) extracting polysaccharide from the degreased radix adenophorae to obtain crude polysaccharide extract, 3) carrying out solid-liquid separation on the crude polysaccharide extract to obtain radix adenophorae polysaccharide water solution, and drying to obtain radix adenophorae polysaccharide; The preparation method of the baical skullcap root polysaccharide comprises 1) degreasing baical skullcap root, 2) extracting the defatted baical skullcap root to obtain crude polysaccharide extract, 3) carrying out solid-liquid separation on the crude polysaccharide extract to obtain baical skullcap root polysaccharide aqueous solution, and drying to obtain baical skullcap root polysaccharide; The preparation method of the coriolus versicolor polysaccharide comprises 1) degreasing coriolus versicolor, 2) extracting polysaccharide from the degreased coriolus versicolor to obtain crude polysaccharide extract, 3) carrying out solid-liquid separation on the crude polysaccharide extract to obtain coriolus versicolor polysaccharide aqueous solution, and drying to obtain coriolus versicolor polysaccharide.
  2. 2. The polysaccharide composition according to claim 1, wherein, The polysaccharide composition comprises, by mass, 1 part of baical skullcap root polysaccharide, 1 part of radix adenophorae polysaccharide and 1 part of coriolus versicolor polysaccharide.
  3. 3. Use of the polysaccharide composition of any one of claims 1-2 in the preparation of a cosmetic.
  4. 4. Use of the polysaccharide composition of any one of claims 1-2 in the manufacture of a product having the function of inhibiting atopic dermatitis and/or consolidating the skin barrier.
  5. 5. The use according to claim 4, wherein the product inhibits atopic dermatitis and/or consolidates the skin barrier by any one of (a 1) to (a 6); (a1) Reducing the thickness of the epidermis; (a2) The expression quantity of the antibacterial peptide is improved; (a3) Reducing monocyte chemotactic protein-1 expression level; (a4) Increasing the expression level of silk-polymerized protein; (a5) Reducing the interleukin-6 expression quantity; (a6) Reducing mast cell numbers.
  6. 6. A product comprising the polysaccharide composition of any one of claims 1-2.
  7. 7. A cosmetic comprising the polysaccharide composition of any one of claims 1-2 and an adjuvant; The auxiliary materials are at least one of preservative, chelating agent, essence, humectant, colorant, emulsifying agent, antioxidant and skin conditioner.

Description

Polysaccharide composition with effects of improving skin immunity and strengthening skin barrier function and application thereof The application relates to a polysaccharide composition with the function of improving skin immunity and consolidating skin barrier function and application thereof, which are classified in China application with the application number of 202111272768.0 and the application date of 2021, 10 and 29. Technical Field The invention belongs to the field of daily chemical products, and particularly relates to a polysaccharide composition with the functions of improving skin immunity and strengthening skin barrier and application thereof. Background At present, cosmetics on the market are various in variety and different in efficacy, including moisturizing cosmetics, whitening cosmetics, acne-removing cosmetics and the like, but have single effects, are insufficient in moisturizing degree, cannot prevent skin aging, improve skin immunity and consolidate skin barriers, and some whitening lotions are added with forbidden additives such as lead-containing compounds and hydroquinone, and can whiten skin in a short period of time, but can cause heavy metal accumulation, skin becomes sensitive, causes irritation to skin, causes local pigmentation of facial skin and dark yellow skin color in a long period of time. The quality of the skin moisture retention can reflect whether the skin barrier function is normal or not. The reduced skin moisturization results in reduced skin barrier function, which in turn further reduces skin moisturization resulting in a vicious circle. Moisture retention is therefore the basis and also critical for skin care. Therefore, based on the demands of cosmetic development market, developing a polysaccharide composition with the functions of improving skin immunity and strengthening skin barrier has very important significance for developing whitening and moisturizing products. Disclosure of Invention The object of the first aspect of the present invention is to provide a polysaccharide composition. The object of the second aspect of the present invention is to provide the use of the polysaccharide composition of the first aspect. The object of a third aspect of the invention is to provide a product. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: in a first aspect of the present invention, there is provided a polysaccharide composition comprising at least three of a matrimony vine polysaccharide, a rose polysaccharide, a coriolus versicolor polysaccharide, a baical skullcap root polysaccharide and a south sand ginseng polysaccharide. Preferably, the polysaccharide composition comprises three of Lycium barbarum polysaccharide, flos Rosae Rugosae polysaccharide, coriolus versicolor polysaccharide, scutellariae radix polysaccharide and radix Adenophorae polysaccharide. Preferably, the polysaccharide composition comprises any one of (1) - (5); (1) Matrimony vine polysaccharide, rose polysaccharide and coriolus versicolor polysaccharide; (2) Baical skullcap root polysaccharide, adenophora stricta polysaccharide and coriolus versicolor polysaccharide; (3) Polysaccharide of Adenophora root, polysaccharide of Lycium barbarum and polysaccharide of Rosa rugosa; (4) Baical skullcap root polysaccharide, coriolus versicolor polysaccharide and rose polysaccharide; (5) Baical skullcap root polysaccharide, medlar polysaccharide and radix adenophorae polysaccharide. Preferably, the polysaccharide composition comprises any one of (6) - (10) in parts by mass; (6) 0.5-1.5 parts of matrimony vine polysaccharide, 0.5-1.5 parts of rose polysaccharide and 0.5-1.5 parts of coriolus versicolor polysaccharide; (7) 0.5-1.5 parts of baical skullcap root polysaccharide, 0.5-1.5 parts of radix adenophorae polysaccharide and 0.5-1.5 parts of coriolus versicolor polysaccharide; (8) 0.5-1.5 parts of adenophora stricta polysaccharide, 0.5-1.5 parts of lycium barbarum polysaccharide and 0.5-1.5 parts of rose polysaccharide; (9) 0.5-1.5 parts of baical skullcap root polysaccharide, 0.5-1.5 parts of coriolus versicolor polysaccharide and 0.5-1.5 parts of rose polysaccharide; (10) 0.5-1.5 parts of baical skullcap root polysaccharide, 0.5-1.5 parts of medlar polysaccharide and 0.5-1.5 parts of radix adenophorae polysaccharide. Preferably, the polysaccharide composition comprises any one of (11) - (15) in parts by mass; (11) 1 part of matrimony vine polysaccharide, 1 part of rose polysaccharide and 1 part of coriolus versicolor polysaccharide; (12) 1 part of baical skullcap root polysaccharide, 1 part of radix adenophorae polysaccharide and 1 part of coriolus versicolor polysaccharide; (13) 1 part of adenophora root polysaccharide, 1 part of matrimony vine polysaccharide and 1 part of rose polysaccharide; (14) 1 part of baical skullcap root polysaccharide, 1 part of coriolus versicolor polysaccharide and 1 part of rose polysaccharide; (15) 1 part of baica