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CN-117064634-B - System, method and material composition for correcting eye condition

CN117064634BCN 117064634 BCN117064634 BCN 117064634BCN-117064634-B

Abstract

Systems, techniques, and material compositions for modifying an ocular condition are disclosed. The system includes a processing apparatus and an etching apparatus. The processing device includes a corrected pattern module configured to provide a selected two-dimensional pattern based on visual non-permanent input data indicative of a user and configured to generate operating instructions to form the selected two-dimensional pattern on a surface of a cornea via the etching device. The etching apparatus is configured to etch the selected pattern on a surface of the cornea of a user. The material composition comprises an aqueous solution comprising a plurality of nanoparticles comprising maghemite nanoparticles surrounded by biocompatible protein chains. The material composition may be used as an eye drop, allowing the nanoparticles to occupy etched areas on the cornea, thereby maintaining correction of the ocular state.

Inventors

  • ZEEV ZALEVSKY
  • Restoration
  • DAEWOO
  • Yi Fate.haleier
  • Rifka ban Esha

Assignees

  • 巴伊兰大学

Dates

Publication Date
20260505
Application Date
20190227
Priority Date
20180301

Claims (16)

  1. 1. A kit for correcting a visual impairment of a user, the kit comprising: A patterning device configured and controllably operable to create a selected pattern in the form of a surface relief on the cornea of the user, wherein the selected pattern is configured as a vision correction pattern capable of providing an optical effect of targeted correction of refractive error without modifying the shape of the cornea in accordance with a vision disorder of the user, and An eye drop comprising an aqueous solution comprising a plurality of albumin protein based nanoparticles configured such that when the nanoparticles are dispersed within a plurality of cut out regions of the pattern, the pattern is stabilized and the optical effect of the pattern is enhanced such that the optical effect can be sustained for up to months.
  2. 2. The kit of claim 1, wherein the albumin protein based nanoparticle comprises human serum albumin based protein.
  3. 3. The kit of claim 1 or 2, wherein the nanoparticles are selected to have a refractive index different from the tear water surrounding the cornea and/or eye of the user.
  4. 4. The kit of claim 1 or 2, wherein the albumin protein based nanoparticles comprise metal nanoparticles surrounded by human serum albumin protein chains.
  5. 5. The kit of claim 1 or 2, wherein the albumin protein based nanoparticles comprise metal particles carried by an albumin shell such that the albumin protein folds around the metal particles.
  6. 6. The kit of claim 1 or 2, wherein the nanoparticle comprises a cerium ammonium nitrate Fe 2 O 3 nanoparticle.
  7. 7. The kit of claim 1 or 2, wherein the selected pattern is configured to cause a localized modification of the refractive index of the cornea of the user.
  8. 8. The kit of claim 1 or 2, wherein the patterning device has one of the following configurations: The patterning device is configured to transmit selected ultrasonic waves for etching the pattern on the cornea of the user; the patterning device is configured to mechanically etch the cornea; the patterning device includes at least one laser unit and a beam steering module and is configured to provide optical energy for creating the selected pattern.
  9. 9. The kit of claim 8, wherein the patterning device comprises at least one laser unit and a beam steering module, the laser unit configured to provide etching at a depth up to a single cell layer of the cornea.
  10. 10. The kit of claim 1 or 2, wherein the pattern comprises a diffraction pattern.
  11. 11. The kit of claim 1 or 2, wherein the pattern comprises a Fresnel ring pattern.
  12. 12. The kit of claim 1 or 2, wherein the pattern has at least one of the following configurations: The pattern comprises a phase-influencing interference pattern; The pattern comprises an extension of a depth of field pattern; The pattern enables optical correction below 0.25 diopters between optical power resolution of 0.1 and 0.3 diopters.
  13. 13. The kit of claim 1 or 2, wherein the nanoparticle is further configured to carry one or more selected drugs.
  14. 14. The kit of claim 1 or 2, wherein the aqueous solution is formed from a solution comprising at least one of the group consisting of water, bacteriostatic water, sodium chloride solution, dextrose solution, liquid surfactant, and pH buffered solution.
  15. 15. The kit of claim 1 or 2, wherein the kit is adapted for use in a home or in an ophthalmic care provider clinic.
  16. 16. The kit of claim 1 or 2, wherein the selected pattern is configured to correct at least one of myopia, myopia control, hyperopia, presbyopia, and astigmatism.

Description

System, method and material composition for correcting eye condition The application is a divisional application of application number CN 201980016190.7 (PCT application number PCT/IL 2019/050219), application date 2019, 02-27, and application name "System, method and Material composition for correcting eye condition". Technical Field The invention belongs to the technical field of vision correction, and particularly relates to correction of vision disorders such as myopia, hyperopia, presbyopia, astigmatism and other vision disorders. Background Various eye conditions are known to limit vision. Various techniques are known to provide correction of such eye conditions, including spectacles, contact lenses and intraocular lenses (intraocular lenses), the lenses being used having a selected one or more optical power and/or a selected pattern designed to increase the depth of focus (depth of focus) of the lens in accordance with the eye condition of the user, a manner commonly used to overcome various eye conditions, such as presbyopia symptoms, based on advanced intraocular lens technology, via an auto-focusing intraocular lens (accommodating IOLs), a multifocal intraocular lens (multifocal IOLs) or a newer near intraocular lens having an extended depth of focus. Optical power may be provided generally using refractive manipulation of the optical path. However, diffraction techniques for manipulating the optical path may also provide suitable optical power. Such techniques may include a fresnel zone plate (Fresnel zone plates), or a ring, that provides diffraction of light in a lens-like manner. Additional light manipulation techniques may employ optical interferometry for depth of focus extension. For example, U.S. patent 7,859,769 provides an imaging arrangement and method for extending depth of focus. The imaging arrangement includes an imaging lens having a particular effective aperture, and an optical element in communication with the imaging lens. The optical element is a non-diffractive optical element configured as a phase-influencing (phase-affecting) element, the element defining a spatially low-frequency phase transition. The optical element and the imaging lens define a predetermined pattern formed by a plurality of spatially separated, substantially optically transparent features of different optical properties. The position of at least one phase-conversion region of the optical element in the imaging lens plane is determined by at least one dimension of the effective aperture. Protein-based drug delivery systems make it possible to encapsulate selected drugs and provide stable, non-toxic and typically non-antigenic carriers. Human serum albumin is a highly abundant plasma protein and has a long half-life, and is of interest as a drug carrier compound. Disclosure of Invention The present invention provides a novel technique for correcting an eye condition that causes vision difficulties to a user. The technique is to apply a pattern to the cornea of the user and introduce a selected material composition providing a change in refractive index onto the applied pattern. The pattern is selected according to an eye state of the user. Typically, the selected material composition is in the form of an eye drop comprising synthetic nanoparticles that provide a localized modification of the refractive index of the cornea through an enhanced optical pattern imprinted onto the surface epithelium layer of the cornea. This optical pattern will provide a temporary and targeted correction of refractive errors without modifying the shape of the cornea. The selected material composition may generally be provided in the form of eye drops comprising maghemite nanoparticles typically carried by an albumin shell, e.g., human serum albumin (HAS). The material composition is a biocompatible non-toxic material composition selected to have high stability both upon shelf (on shell) and on the cornea of the user. The maghemite-albumin nanoparticle features a high refractive index for modifying refractive index and overall ocular refraction according to the selected pattern when confined into the corneal epithelium by applying the pattern thereto. Further, the present invention provides a system for modifying an ocular state associated with a visual state, such as myopia, hyperopia, or presbyopia. The system includes a processing device and an etching device and is configured to receive input data indicative of an eye state of the user. The processing device is configured to respond to the input data and is configured to determine a two-dimensional pattern for correcting the visual impairment based on the input data. The processing device may typically include a correction pattern module configured to determine a drawing of the selected two-dimensional pattern based on input data indicative of a visual impairment of a user. The processing apparatus is further configured to generate a plurality of operating instructions to fo