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CN-117084972-B - Oral liquid for treating purpura

CN117084972BCN 117084972 BCN117084972 BCN 117084972BCN-117084972-B

Abstract

The invention discloses an oral liquid for treating purpura, which is prepared by extracting black tea with yellow wine at high temperature and clarifying the extract. The invention adopts black tea and yellow wine as raw materials to prepare the oral liquid, can effectively treat thrombocytopenic purpura, allergic purpura and capillary hemorrhage caused by thrombocytopenia due to primary diseases, uses food to replace medicines as raw materials, has small toxic and side effects and high efficiency, and is prepared into a stable oral liquid form, and convenient to take, carry and store.

Inventors

  • ZHANG LINGXUE
  • LIU YUAN
  • ZHANG QIANQIAN
  • ZHANG QUANYUE

Assignees

  • 平阳润德医院有限公司

Dates

Publication Date
20260508
Application Date
20230703

Claims (9)

  1. 1. A preparation method of an oral liquid for treating purpura is characterized by comprising the steps of extracting black tea with yellow wine at high temperature, filtering to obtain black tea residue and extract, adding clarifier into the extract, and clarifying; The preparation method of the clarifying agent comprises the following steps: (1) Adding the black tea residue and furfural into ethanol, stirring and dispersing, adding hydrochloric acid solution, heating and stirring for reaction, filtering, washing, drying, and dispersing in deionized water to obtain water phase; (2) Adding glycidyl methacrylate, allyl glycidyl ether, N-methylene bisacrylamide and azodiisobutyronitrile into liquid paraffin, and uniformly stirring to obtain an oil phase; (3) Dropwise adding the oil phase into the water phase in a stirring state, stirring and homogenizing to obtain emulsion, heating and reacting for 18-24 h at 60-80 ℃, and drying the product to obtain a carrier; (4) Adding tannase into phosphate buffer solution with pH of 4-6 to obtain tannase solution, adding carrier into the tannase solution, oscillating to react, filtering, washing and drying to obtain clarifier.
  2. 2. The method for preparing the oral liquid for treating purpura according to claim 1, wherein the high-temperature extraction method is that black tea is added into yellow wine, boiled and extracted for 1-3 hours, and the black tea residue and the extract are obtained after filtration.
  3. 3. The method for preparing the oral liquid for treating purpura according to claim 2, wherein the adding ratio of black tea to yellow wine is 1 g:20-30 mL.
  4. 4. The preparation method of the oral liquid for treating purpura according to claim 2, wherein the clarifying method of the extracting solution is that a clarifying agent is added into the extracting solution, the mixture is stirred and reacted for 2-4 hours at 40-50 ℃, and the oral liquid for treating purpura is obtained after filtration.
  5. 5. The method for preparing oral liquid for treating purpura according to claim 1, wherein the particle size of the black tea dreg powder in the step (1) is 0.5-3 μm.
  6. 6. The preparation method of the oral liquid for treating purpura, which is disclosed in claim 1, is characterized in that the mass ratio of the black tea dreg powder to the furfural in the step (1) is 10:0.5-1, the pH of a system after adding hydrochloric acid solution is 1-3, the heating temperature during stirring reaction is 60-70 ℃, and the reaction time is 2-3 hours.
  7. 7. The preparation method of the oral liquid for treating purpura, which is characterized in that the mass volume ratio of the furfural modified black tea leaves to the deionized water in the step (1) is 10-15 g:30-40 mL; In the step (2), the mass volume ratio of glycidyl methacrylate, allyl glycidyl ether, N-methylene bisacrylamide, azodiisobutyronitrile and liquid paraffin is 3-5 g to 0.1-0.3 g to 60-70 mL; In the step (3), the volume ratio of the oil phase to the water phase is 30-40:60-70.
  8. 8. The method for preparing the oral liquid for treating purpura according to claim 1, wherein the mass concentration of the tannase solution in the step (4) is 0.05-0.1%, the mass-volume ratio of the carrier to the tannase solution is 0.3-0.5 g/5 ml, the oscillation reaction temperature is 30-45 ℃, and the reaction time is 3-5 h.
  9. 9. The method for preparing the oral liquid for treating purpura according to claim 1, wherein the amount of the clarifying agent in the extracting solution is 5-10 g/L.

Description

Oral liquid for treating purpura Technical Field The invention relates to the technical field of oral liquid preparation, in particular to an oral liquid for treating purpura. Background Purpura is also called purpura, and is characterized in that blood overflows under skin and mucous membrane, and blood stasis spots appear, and the purpura is not discolored, so that the purpura is one of common hemorrhagic diseases of children. Purpura is generally classified into allergic purpura and thrombocytopenic purpura, which are generally treated with hormonal immune agents, antiallergic drugs, and thrombocytopenic purpura is generally treated with immunosuppressants such as corticosteroids. However, hormone therapy has great side effects, can cause immunosuppression after long-term administration, has toxic and side effects such as bone marrow suppression, liver and kidney function damage, femoral head necrosis, immune system disorder and the like, and is not beneficial to the health of patients. Currently, there are also some traditional Chinese medicine formulas for treating purpura, for example, "a traditional Chinese medicine preparation for treating thrombocytopenic purpura" disclosed in the Chinese patent literature, whose publication number is CN104547554B, including pokeberry root, hairyvein agrimonia herb and bud, natural indigo, lithospermum, radix sanguisorbae, rhubarb, pilose asiabell root, donkey-hide gelatin, safflower, chinese ilex seed, eclipta, rhizoma polygonati, madder, cortex lycii radicis, cimicifugae foetidae, periostracum cicada, fructus cnidii and stiff silkworm. However, the traditional Chinese medicine preparation is added with more medicine components, and the toxic and side effects on human bodies are still difficult to avoid. Disclosure of Invention The invention aims to overcome the problems of medicines for treating purpura in the prior art, provides an oral liquid for treating purpura, which is prepared from black tea and yellow wine as raw materials, can effectively treat thrombocytopenic purpura, allergic purpura and capillary hemorrhage caused by thrombocytopenia due to primary diseases, has small toxic and side effects and high effective rate by using foods as raw materials instead of medicines, is prepared into a stable oral liquid form, and is convenient to take, carry and store. In order to achieve the above purpose, the present invention adopts the following technical scheme: An oral liquid for treating purpura is prepared by extracting black tea with yellow wine at high temperature, and clarifying the extractive solution. The black tea is warm in nature, has the effects of promoting blood circulation to remove blood stasis, is rich in tannic acid and other components with the function of astringing and stopping bleeding of capillaries, and can be extracted by yellow wine, so that the yellow wine can help to promote blood circulation, promote the components to enter the blood, and is beneficial to the drug efficacy cloth powder. Therefore, the invention uses the yellow wine to extract the black tea at high temperature to prepare the oral liquid, can effectively treat thrombocytopenic purpura, allergic purpura and capillary hemorrhage caused by thrombocytopenia due to primary diseases, has the advantages of three-day effect, two-week cure and high effective rate, and simultaneously uses the black tea and the yellow wine as raw materials as food, uses the food to replace medicines as raw materials, and has small toxic and side effects. In addition, the invention is prepared into oral liquid by high-temperature extraction, has fast absorption, convenient carrying and administration and easy preservation. However, when the yellow wine is used for extracting the black tea, the yellow wine contains a plurality of unstable substances such as protein, polysaccharide, tannin, iron ions and the like, and the black tea extract is also rich in components such as polyphenol components, caffeine, protein, metal ions and the like, and the polyphenol components are easy to react with the components such as protein, polysaccharide, caffeine and the like to generate precipitation, so that the extract obtained after the extraction is cooled and is easy to generate precipitation along with the extension of time, the oral liquid is unstable and is easy to become turbid, and the drug effect and the storage life of the oral liquid are influenced. Therefore, the invention clarifies the extracting solution after high-temperature extraction, can avoid precipitation in the storage process after cooling, improves the quality stability of the oral liquid and prolongs the storage life of the oral liquid. Preferably, the high-temperature extraction method comprises the steps of adding black tea into yellow wine, boiling and extracting for 1-3 h, and filtering to obtain black tea residue and extract. Preferably, the addition ratio of the black tea to the yellow wine is 1 g:20-30 mL. Preferably, the clarify