CN-117244095-B - Preparation method of hydrocolloid dressing for oral cavity

CN117244095BCN 117244095 BCN117244095 BCN 117244095BCN-117244095-B

Abstract

The invention discloses a preparation method of an oral hydrocolloid patch, and relates to the technical field of medical supplies. Mixing baicalin extract with polyvinylpyrrolidone solution to obtain baicalin extract solution, mixing chitosan fiber, hydroxymethyl cellulose and baicalin extract solution to obtain mixed solution, vacuum defoaming, vacuumizing, maintaining pressure, primarily defoaming, ultrasonic defoaming, sealing the ultrasonic-finished solution with preservative film, standing, secondarily defoaming, fixing PU film in film-laying frame, pouring the defoamed mixed solution into film-laying frame, placing into blast drying oven, solidifying, and covering protective layer to obtain hydrocolloid application. The hydrocolloid dressing prepared by the invention has better adhesive force, can act on a wound for a long time, and effectively promotes the repair of damaged cells and wounds, thereby promoting the healing of the wounds in the oral cavity.

Inventors

XU LIXIN
SUN HUI
Yin Manqi
CAI FEIXIANG
ZHANG WENHAO
GU YING

Assignees

西岭(镇江)医疗科技有限公司

Dates

Publication Date: 20260512
Application Date: 20230807

Claims (2)

1. A method for preparing an oral hydrocolloid dressing, which is characterized by comprising the following steps: s1, mixing polyvinylpyrrolidone and purified water to obtain a polyvinylpyrrolidone solution; S2, mixing the baicalin extract with a polyvinylpyrrolidone solution to obtain a baicalin extract solution; S3, mixing chitosan fiber, hydroxymethyl cellulose and baicalin extract solution to obtain a mixed solution; s4, vacuum defoaming, namely vacuumizing the prepared mixed solution, maintaining pressure and primarily defoaming; s5, ultrasonic defoaming, namely performing ultrasonic defoaming on the mixed solution subjected to preliminary defoaming; S6, standing and defoaming, namely sealing the solution subjected to ultrasonic treatment by using a preservative film, standing at room temperature, and secondarily defoaming; S7, fixing the PU film in a film laying frame, pouring the defoamed mixed liquid into the film laying frame, putting into a blast drying box, solidifying, and covering a protective layer to obtain the hydrocolloid application; step S3, the chitosan fibers are modified chitosan fibers; the preparation method of the modified chitosan fiber comprises the following steps: Mixing chitosan fiber and deionized water according to a mass ratio of 1:50-1:80, stirring and dissolving for 1-2h at a temperature of 80-100 ℃ and a rotating speed of 800-1000rpm, adding beta-cyclodextrin with a mass of 2-3 times of the chitosan fiber, stirring and mixing for 20-30min at a temperature of 30-50 ℃ and a rotating speed of 800-1000rpm, then dropwise adding acetic acid solution with a mass fraction of 2-3% with a mass fraction of 0.2-0.3 times of the chitosan fiber, continuously stirring until the solution is white and viscous at a rotating speed of 800-1000rpm, finally dropwise adding genipin with a mass fraction of 1-2% and self-made essential oil with a mass fraction of 0.02-0.03 times of the chitosan fiber, stirring for 3-5h, and then continuously placing in a constant-temperature water bath kettle at a temperature of 37 ℃ for standing and crosslinking for 12h to gel state, thus obtaining modified chitosan fiber; the oral hydrocolloid dressing is also added with pericarpium Granati extract; The preparation process of the pomegranate rind extract comprises the following steps: crushing dried pericarpium Granati, sieving with 600-800 mesh sieve, mixing the pericarpium Granati powder with ethanol solution according to a mass ratio of 1:20-1:30, soaking for 3-5h, vacuum filtering at 80-90deg.C to obtain supernatant, rotary evaporating and concentrating the supernatant, extracting with petroleum ether for 3-5 times, concentrating and lyophilizing to obtain pericarpium Granati extract; the preparation method of the self-made essential oil comprises the following steps: Placing the basil essential oil and an ethanol water solution of zein with the mass fraction of 5-8% in a mixing kettle according to the volume ratio of 8:1-12:1, adding deionized water with the volume of 3-5 times of the basil essential oil, stirring and mixing for 20-30min at the rotating speed of 1000-1200rpm, standing for 20-30min, taking an upper suspension, rotationally evaporating and concentrating the suspension to be one fifth of the original volume, and preserving at the low temperature of 1-4 ℃ to obtain the self-made essential oil.
2. The method for preparing an oral hydrocolloid dressing according to claim 1, wherein the specific preparation steps of the hydrocolloid dressing are as follows: s1, placing polyvinylpyrrolidone and purified water in a beaker according to a mass ratio of 1:20-1:30, and stirring for 20-30min at room temperature under the stirring condition that the rotating speed is 400-600rpm to obtain polyvinylpyrrolidone solution; S2, placing the baicalin extract and polyvinylpyrrolidone solution in a mixing kettle according to a mass ratio of 1:20-1:30, and stirring for 9-12min at room temperature under the stirring condition of the rotating speed of 300-600rpm to obtain baicalin extract solution; S3, taking 10-20 parts of chitosan fiber, 10-20 parts of hydroxymethyl cellulose and 30-50 parts of baicalin extract solution, placing the modified chitosan fiber, and the hydroxymethyl cellulose and the baicalin extract solution into a mixing kettle, and stirring for 80-120min at room temperature under the stirring condition of the rotating speed of 1000-1300rpm to obtain a mixed solution; s4, vacuum defoaming, namely placing the prepared mixed solution into a vacuum drying box, sealing a preservative film, vacuumizing to-0.095 MPa, maintaining the pressure for 8-20min, and primarily defoaming; S5, ultrasonic defoaming, namely taking out the mixed solution subjected to preliminary defoaming from a vacuum drying oven, and placing the sealed solution into an ultrasonic cleaner for 9-15 min; S6, standing and defoaming, namely sealing the solution subjected to ultrasonic treatment by using a preservative film, standing for 20-30h at room temperature, and secondarily defoaming; and S7, fixing the PU film in a film laying frame, pouring the defoamed mixed solution into the film laying frame, putting into a blast drying box, keeping the liquid level at 5-8mm and 75-90 ℃ for 10-20 hours, curing, and covering a protective layer to obtain the hydrocolloid application.

Description

Preparation method of hydrocolloid dressing for oral cavity Technical Field The invention relates to the technical field of medical supplies, in particular to a preparation method of an oral hydrocolloid patch. Background The hydrocolloid dressing is made of natural hydrocolloid (sodium carboxymethylcellulose, pectin and animal gelatin), is made of hydrophilic material, is soft and moist, and has effects of releasing growth factors, accelerating granulation and neovascular proliferation, promoting collagen synthesis, and forming acidic moist environment, absorption, fixing function and wound hydration. Most hydrocolloid applications are affected by poor mucoadhesive properties and saliva and cannot be applied in the mouth. Disclosure of Invention The invention aims to provide a preparation method of an oral hydrocolloid dressing, which aims to solve the problems in the background technology. In order to achieve the above purpose, the present invention provides the following technical solutions: a method for preparing an oral hydrocolloid dressing, comprising the following steps: s1, mixing polyvinylpyrrolidone and purified water to obtain a polyvinylpyrrolidone solution; S2, mixing the baicalin extract with a polyvinylpyrrolidone solution to obtain a baicalin extract solution; S3, mixing chitosan fiber, hydroxymethyl cellulose and baicalin extract solution to obtain a mixed solution; s4, vacuum defoaming, namely vacuumizing the prepared mixed solution, maintaining pressure and primarily defoaming; s5, ultrasonic defoaming, namely performing ultrasonic defoaming on the mixed solution subjected to preliminary defoaming; S6, standing and defoaming, namely sealing the solution subjected to ultrasonic treatment by using a preservative film, standing at room temperature, and secondarily defoaming; And S7, fixing the PU film in a film laying frame, pouring the defoamed mixed liquid into the film laying frame, putting into a blast drying box, solidifying, and covering a protective layer to obtain the hydrocolloid application. Preferably, the specific preparation steps of the hydrocolloid dressing are as follows: s1, placing polyvinylpyrrolidone and purified water in a beaker according to a mass ratio of 1:20-1:30, and stirring for 20-30min at room temperature under the stirring condition that the rotating speed is 400-600rpm to obtain polyvinylpyrrolidone solution; S2, placing the baicalin extract and polyvinylpyrrolidone solution in a mixing kettle according to a mass ratio of 1:20-1:30, and stirring for 9-12min at room temperature under the stirring condition of the rotating speed of 300-600rpm to obtain baicalin extract solution; S3, taking 10-20 parts of chitosan fiber, 10-20 parts of hydroxymethyl cellulose and 30-50 parts of baicalin extract solution, placing the modified chitosan fiber, and the hydroxymethyl cellulose and the baicalin extract solution into a mixing kettle, and stirring for 80-120min at room temperature under the stirring condition of the rotating speed of 1000-1300rpm to obtain a mixed solution; s4, vacuum defoaming, namely placing the prepared mixed solution into a vacuum drying box, sealing a preservative film, vacuumizing to-0.095 MPa, maintaining the pressure for 8-20min, and primarily defoaming; S5, ultrasonic defoaming, namely taking out the mixed solution subjected to preliminary defoaming from a vacuum drying oven, and placing the sealed solution into an ultrasonic cleaner for 9-15min; S6, standing and defoaming, namely sealing the solution subjected to ultrasonic treatment by using a preservative film, standing for 20-30h at room temperature, and secondarily defoaming; and S7, fixing the PU film in a film laying frame, pouring the defoamed mixed solution into the film laying frame, putting into a blast drying box, keeping the liquid level at 5-8mm and 75-90 ℃ for 10-20 hours, curing, and covering a protective layer to obtain the hydrocolloid application. Preferably, the chitosan fiber in the step S3 may be a modified chitosan fiber. Preferably, the preparation method of the modified chitosan fiber comprises the following steps: Mixing chitosan fiber and deionized water according to a mass ratio of 1:50-1:80, stirring and dissolving for 1-2h at a temperature of 80-100 ℃ and a rotating speed of 800-1000rpm, adding beta-cyclodextrin with a mass of 2-3 times of the chitosan fiber, stirring and mixing for 20-30min at a temperature of 30-50 ℃ and a rotating speed of 800-1000rpm, then dropwise adding acetic acid solution with a mass fraction of 2-3% with a mass fraction of 0.2-0.3 times of the chitosan fiber, continuously stirring until the solution is white and viscous at a rotating speed of 800-1000rpm, finally dropwise adding genipin with a mass fraction of 1-2% and self-made essential oil with a mass fraction of 0.02-0.03 times of the chitosan fiber, stirring for 3-5h, and then continuously placing in a constant-temperature water bath kettle at a temperature of 37 ℃ for standing and cr