CN-117298016-B - Composition with effects of relieving inflammation, resisting wrinkle and tightening and preparation method thereof

Abstract

The invention discloses a composition with the effects of relieving inflammation, resisting wrinkle and tightening and a preparation method thereof, wherein the composition comprises a TRPV1 inhibitor, a licorice root extract, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. The four raw materials play a synergistic role through compounding, reduce the release of pro-inflammatory mediators and inhibit the high reactivity of nerve fibers to relieve inflammation and resist stimulation, promote the generation of self collagen and sodium hyaluronate, reduce the oxidative stress reaction of organisms to achieve the effects of resisting wrinkles and tightening, and delay skin aging. The composition disclosed by the invention has comprehensive effects in various aspects such as relieving, anti-inflammatory, anti-irritation, antioxidation, anti-wrinkle and tightening, reduces inflammation generation, delays skin aging, relieves burning sensation and tingling sensation of skin, and meets the requirements of sensitive muscle groups on pursuing safety, high efficiency and the like.

Inventors

• Tou Weijian
• PU JUE
• ZHANG ZHIYU
• ZHAO WEIBO
• LIAN MING

Assignees

• 乐普睿康(北京)科技有限公司

Dates

Publication Date

20260508

Application Date

20231103

Claims (3)

1. 1. A composition with anti-inflammatory, anti-wrinkle and tightening effects is characterized by comprising 0.1-5 parts of TRPV1 inhibitor, 0.1-5 parts of licorice root extract, 0.01-5 parts of palmitoyl tripeptide-1, 0.01-5 parts of palmitoyl tetrapeptide-7, 0.01-3 parts of small molecule acid, 1-10 parts of 1, 2-pentanediol, 1-20 parts of phenoxyethanol and 60-90 parts of C12-15 alcohol benzoate; The TRPV1 inhibitor is acetyl dipeptide-1 cetyl ester; the small molecule acid is glycolic acid.
2. 2. A method for preparing the composition with anti-inflammatory and anti-wrinkle tightening effects of claim 1, comprising the steps of: step one, mixing the licorice root extract, palmitoyl tripeptide-1, 2-pentanediol and phenoxyethanol, heating and then keeping the temperature constant to obtain a first solution; Step two, mixing small molecular acid, palmitoyl tetrapeptide-7 and C12-15 alcohol benzoate, heating, keeping the temperature, and adding the mixture into the first solution to obtain a second solution; Step three, cooling the solution obtained in the step two, adding the TRPV1 inhibitor into the second solution, and stirring; and step four, performing ultrasonic filtration to obtain the composition.
3. 3. The preparation method according to claim 2, wherein the temperature is raised to 70-80 ℃ in the first step, the temperature is kept for 20-30 min, the temperature is raised to 70-80 ℃ in the second step, the temperature is kept for 20-30 min, and the temperature is lowered to 35-40 ℃ in the third step.

Description

Composition with effects of relieving inflammation, resisting wrinkle and tightening and preparation method thereof Technical Field The invention belongs to the field of cosmetics, and particularly relates to a composition with effects of relieving inflammation, resisting wrinkle and tightening and a preparation method thereof. Background Sensitive skin is a skin that is more responsive to external stimuli, caused by a variety of factors, including genetic factors, climate change, environmental pollution, allergens, and the use of irritating cosmetics or skin care products. The clinical manifestations of sensitive skin are subjective symptoms such as stinging, burning, tightening or itching, and often accompanied by objective signs such as inflammation and erythema, when stimulated by physical, chemical, mental and other factors. The mechanism of occurrence of sensitive skin is mainly related to the high reactivity of skin sensory neurons on the one hand and the impaired skin barrier function on the other hand. Sensitive skin is often accompanied by an excessive response to peripheral nerve sensory neurons, particularly painful skin reactions such as burning and itching caused by stimulation of the transient receptor potential vanilloid subtype 1 receptor (TRPV 1). On the other hand, impaired barrier of sensitive skin results in reduced protection of cutaneous nerve endings, TRPV1 receptors are more susceptible to activation by changes in the external environment, when TRPV1 receptors are activated, calcium influx, depolarization occurs, action potentials are generated, neurotransmitter transmission thus mediating sensory afferents of pain, itch, thermal sensation and chemical stimuli. The skin barrier of sensitive skin is impaired and is therefore more susceptible to irritation to trigger an inflammatory response than normal skin. After tissue damage caused by inflammation, inflammatory cells (e.g., macrophages and neutrophils) release certain enzymes called Matrix Metalloproteinases (MMPs). These MMPs can be directed to the site of damaged tissue and degrade collagen, further exacerbating inflammation. At the same time, collagen degradation can cause skin elasticity to disappear, and skin aging symptoms such as wrinkles, color spots, slackening and the like appear. In addition, chronic inflammation can trigger excessive free radical production, cause damage to cellular structures and DNA, and damage collagen and elastin in the skin. These lesions lead to signs of wrinkling, sagging and loss of elasticity of the skin, which accelerate the skin aging process. Chronic inflammation also affects the production and elimination of natural moisturizing factors of the skin, resulting in increased rates of skin moisture loss, and skin lacking sufficient moisture appears dry, rough and dull, increasing the risk of appearance of fine lines and wrinkles. At present, most of cosmetics aiming at sensitive skin on the market have single efficacy and often cause symptoms such as sensitive muscle users allergic itching, pain and the like. Based on the above problems and the increasing demand of aging resistance of sensitive muscle groups, it is now required in the market to develop a product which can simultaneously achieve relaxation, anti-inflammation, antioxidation, wrinkle removal, tightening and aging resistance. Disclosure of Invention In order to solve the technical problems, the invention provides the composition with the effects of relieving inflammation, resisting wrinkles and tightening, which has very important significance for application of sensitive muscle groups in anti-inflammation and anti-aging by inhibiting release of pro-inflammatory factors, counteracting nerve fiber hyperreactivity, promoting collagen secretion, inhibiting collagen degradation and reducing organism oxidative stress reaction. The invention provides a composition with anti-inflammatory, anti-wrinkle and tightening effects, which comprises 0.1-5 parts of TRPV1 inhibitor, 0.1-5 parts of licorice root extract, 0.01-5 parts of palmitoyl tripeptide-1 and 0.01-5 parts of palmitoyl tetrapeptide-7. The composition for relieving inflammation, resisting wrinkle and tightening provided by the invention combines and uses the four components of the TRPV1 inhibitor, the licorice root extract, the palmitoyl tripeptide-1 and the palmitoyl tetrapeptide-7, and realizes the multidimensional relief of skin inflammation and aging phenomena by synergistically exerting the respective effects from a plurality of action targets. Preferably, the TRPV1 inhibitor is one or more of acetyl dipeptide-1 cetyl ester, pentapeptide-1 and hydrolyzed algae extract. Preferably, the composition further comprises 0.01-3 parts of small molecule acid, wherein the small molecule acid comprises one or more of lactic acid, glycolic acid and mandelic acid. Preferably, the composition further comprises 1-10 parts of 1, 2-pentanediol. Preferably, the composition further comprises 60