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CN-117338965-B - Full-pipeline automatic sterilization process for traditional Chinese veterinary medicine extraction

CN117338965BCN 117338965 BCN117338965 BCN 117338965BCN-117338965-B

Abstract

The application belongs to the technical field of traditional Chinese medicine extraction equipment, in particular to a full-pipeline automatic sterilization process for traditional Chinese medicine extraction, which is characterized in that the full pipeline for traditional Chinese medicine extraction is modified to meet the requirements of high-temperature high-pressure steam sterilization, the full pipeline is sterilized by utilizing the high-temperature high-pressure steam before the traditional Chinese medicine extraction, then the extraction temperature in the extraction tank is controlled, and the sterilization of the extracting solution is ensured, so that the finally prepared oral liquid meets the sterilization requirement, the terminal sterilization process is saved, and the non-high temperature-resistant package can be directly adopted for filling, so that the manufacturing cost is greatly saved.

Inventors

  • LI HAIGUO

Assignees

  • 山东康普善生物技术有限公司

Dates

Publication Date
20260505
Application Date
20231027

Claims (8)

  1. 1. A full-pipeline automatic sterilization process for extracting traditional Chinese veterinary medicines is characterized in that a pneumatic control valve (100) is arranged at an inlet and an outlet of a tank body on a full pipeline, a pressure balance pipeline communicated with the outside is respectively arranged on the tank body on the full pipeline, a pneumatic valve (200) and a degerming breathing valve (300) are arranged on the pressure balance pipeline, the degerming breathing valve (300) is positioned at an outlet of the pressure balance pipeline, a temperature sensor and a pressure sensor are arranged on the tank body on the full pipeline, and the full-pipeline automatic sterilization process further comprises a controller (10), wherein the controller (10) is respectively connected with the temperature sensor, the pressure sensor, the pneumatic valve (200) and the pneumatic control valve (100); the full-pipeline automatic sterilization process comprises the following steps: S1, before the extraction and preparation of traditional Chinese veterinary medicines, the controller (10) is used for controlling the whole pipeline to be subjected to high-temperature high-pressure steam sterilization sequentially from one side of an extraction tank (1) by utilizing a steam system according to a preparation flow, wherein the temperature of the high-temperature high-pressure steam is more than 120 ℃ and the pressure of the high-temperature high-pressure steam is more than 2 atmospheres, the sterilization step comprises the steps of closing pneumatic valves (200) on each tank body, firstly opening the pneumatic control valve (100) at the inlet of the first tank body, opening the pneumatic control valve (100) at the outlet of the first tank body after the controller (10) reaches a set threshold value according to the temperature and the pressure in the first tank body, sequentially judging and sequentially sterilizing the follow-up pipeline and the tank body by the same threshold value, sequentially closing the pneumatic control valves (100) corresponding to the inlet and the outlet of each tank body along the opposite direction of the steam flow after the high-temperature high-pressure sterilization is completed, and closing the pneumatic valves (200) on each tank body after the pressure in each tank body reaches the normal pressure, and completing the sterilization; S2, after sterilization, heating and extracting the traditional Chinese veterinary medicine in an extraction tank (1), wherein the extraction temperature ensures that the extraction liquid meets the sterile requirement, and after extraction, carrying out subsequent separation and concentration to finally obtain cooled oral liquid; S3, conveying the cooled oral liquid into an aseptic filling workshop through an aseptic pipeline for aseptic filling, and filling by using non-high temperature resistant packaging.
  2. 2. The automatic sterilization process for veterinary medicine according to claim 1, wherein in the step S3, the aseptic treatment is performed before the non-high temperature-resistant package enters an aseptic filling workshop.
  3. 3. The automatic sterilization process for the traditional Chinese veterinary medicine extraction pipeline according to claim 2, wherein in the step S3, the aseptic treatment of the non-high temperature-resistant package is performed by adopting a fumigation method, a fumigation workshop connected with the aseptic filling workshop is arranged, and the non-high temperature-resistant package is directly sent into the aseptic filling workshop after the aseptic treatment of the fumigation workshop.
  4. 4. The full-pipeline automatic sterilization process for extracting veterinary drugs according to claim 1, wherein the full pipeline comprises an extracting tank (1), a filter (2), a centrifuge (3), a liquid storage tank (4) and a concentrator which are sequentially connected through pipelines (5) The concentrator (5) is connected with the paste collecting storage tank (6) or the sterile paste collecting room (7) through a pipeline, the paste collecting storage tank (6) or the sterile paste collecting room (7) is connected with the sterile filling room through a pipeline, and the concentrator (5) is a vacuum concentrator; An inlet of the extraction tank (1) is connected with a steam system, and pneumatic control valves (100) are arranged at an inlet and an outlet of the extraction tank (1), a liquid storage tank (4), a concentrator (5), a paste collecting storage tank (6) and a sterile paste collecting room (7); The extraction tank (1), the liquid storage tank (4), the concentrator (5) and the paste collecting storage tank (6) are respectively provided with a pressure balance pipeline communicated with the outside, the pressure balance pipeline is provided with a pneumatic valve (200) and a degerming breather valve (300), and the extraction tank (1), the liquid storage tank (4), the concentrator (5) and the paste collecting storage tank (6) are respectively provided with a temperature sensor and a pressure sensor; a circulating pump (8) is arranged between the filter (2) and the centrifugal machine (3), and a concentrated solution pumping pump (9) is arranged on a pipeline between the concentrator (5) and the paste collecting storage tank (6) or the sterile paste collecting room (7).
  5. 5. The full-pipeline automatic sterilization process for extracting veterinary drugs according to claim 4, wherein the pneumatic control valve (100) and the pneumatic valve (200) are connected with a compressed gas pipeline; the controller (10) is used for controlling the opening and closing of the pneumatic valve (200) and the pneumatic control valve (100).
  6. 6. The full-pipeline automatic sterilization process for extracting veterinary drugs according to claim 4, wherein the extraction tank (1), the liquid storage tank (4), the concentrator (5) and the ointment receiving storage tank (6) are respectively provided with a pressure one-way valve.
  7. 7. The full-pipeline automatic sterilization process for extracting veterinary drugs according to claim 1, wherein the steam system comprises a steam generator or a high-pressure boiler.
  8. 8. The full-pipeline automatic sterilization process for extracting veterinary drugs according to claim 3, wherein the fumigation workshop comprises a fumigation room (11) connected with a sterile filling workshop, an ultrasonic atomizer (12) arranged in the fumigation room (11), a circulating fan (13) and a temperature control module; An air inlet pipeline (1101) and an air exhaust pipeline (1102) are arranged on the fumigation chamber (11), a sterilizing filter (14) is arranged on the air inlet pipeline (1101), and an air exhaust fan (15) and a one-way air outlet valve (16) are arranged on the air exhaust pipeline (1102); A feeding sealing door (17) is arranged at one side of the fumigation chamber (11) far away from the sterile filling chamber, and a discharging sealing door (18) communicated with a clean area of the filling chamber is arranged at one side of the fumigation chamber (11) adjacent to the sterile filling chamber; The temperature control module is used for controlling the temperature of the fumigation chamber (11).

Description

Full-pipeline automatic sterilization process for traditional Chinese veterinary medicine extraction Technical Field The invention belongs to the technical field of traditional Chinese medicine extraction equipment, and particularly relates to a full-pipeline automatic sterilization process for traditional Chinese veterinary medicine extraction. Background The solution extracted from the veterinary drug is easy to be infected by bacteria, especially ubiquitous saccharomycetes, mould and bacillus subtilis, in the process of pipeline transportation, storage and canning, so that the produced finished product generates the losses of gas expansion, rancidity, shortened shelf life, unqualified product and the like, and the quality stability of the product is ensured, and the microorganism is killed by adopting a terminal sterilization mode in the existing production process. The prior art mainly applies a damp heat sterilization method to carry out terminal sterilization on traditional Chinese medicine oral liquid products, wherein the damp heat sterilization method comprises a hot press sterilization method, a circulating steam sterilization method and a boiling sterilization method, and is commonly used for terminal sterilization, namely, after the oral liquid is filled, the packaging material filled with the oral liquid is sterilized at high temperature. The method has remarkable sterilization effect, but the packaging material is required to be heat-resistant. For example, chinese patent document CN103550310A (CN201310524220. X) discloses a preparation method of polygonum capitatum hypoglycemic extract oral liquid, which comprises the following process steps of 1) polygonum capitatum hypoglycemic extract extraction, 2) configuration, 3) filling and 4) sterilization. The preparation method comprises placing the prepared medicinal liquid into a predetermined sterilized oral liquid bottle, sealing, boiling the oral liquid bottle in boiling water for 30 min, taking out, and standing. The terminal sterilization mode needs high temperature resistance of the packaging material, so that the cost of the packaging material is high, and a special procedure is needed in the oral liquid production process to sterilize the oral liquid product, so that the cost input of sterilization equipment is increased, and the production efficiency is influenced. Chinese patent document CN110101881A (201910353928.0) discloses a sterilization method in the production of veterinary Chinese medicinal oral liquid, which comprises the steps of extracting the veterinary Chinese medicinal oral liquid according to a formula, concentrating the extracting solution, filtering the concentrated solution to remove impurities, preparing the filtered solution, performing secondary terminal sterilization on the prepared solution, and filling the sterilized solution to a specified volume according to a process. The preparation method comprises the steps of adding purified water into the sterilized preparation solution to a specified volume, mixing uniformly, and filling to effectively kill microorganisms in production materials, so that the quality stability of the product is ensured. Compared with terminal sterilization, the secondary terminal sterilization is not limited by the requirements of product packaging materials in the sterilization mode selection, and the production applicability is wider. However, the secondary terminal sterilization mode directly utilizes steam to heat and sterilize the preparation liquid, the sterilization temperature can only be maintained below 100 ℃ because the existing equipment cannot maintain stable high pressure, the inactivation temperature and other conditions of different bacteria are quite different, the steam is directly introduced to sterilize in the production process, the aim of inactivating certain high-temperature resistant bacteria (such as bacillus subtilis) cannot be achieved, the corresponding sterilization standard cannot be achieved, and the preparation liquid is directly sterilized at high temperature by utilizing high-temperature steam, so that the drug effect, nutritional ingredients, color, aroma and taste of the oral liquid are easily influenced. Disclosure of Invention The invention aims to solve the problems and provide a full-pipeline automatic sterilization process for extracting traditional Chinese veterinary medicines, which is characterized in that the full pipeline for extracting the traditional Chinese veterinary medicines is modified to meet the requirements of high-temperature and high-pressure steam sterilization, the full pipeline is sterilized by utilizing the high-temperature and high-pressure steam before extracting the traditional Chinese veterinary medicines, and then the extraction temperature in an extraction tank is controlled to ensure the sterilization of an extracting solution, so that the finally prepared oral liquid meets the sterilization requirements, the terminal st