CN-117357622-B - Traditional Chinese medicine formula with lipid-lowering effect, qu Ling turbidity-eliminating particles and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine formula with lipid-lowering effect, qu Ling turbidity-relieving granules and a preparation method thereof, belonging to the technical field of Chinese patent medicines. The traditional Chinese medicine comprises, by weight, 5-10 parts of red rice, 10-30 parts of poria cocos, 5-15 parts of rhizoma atractylodis, 5-15 parts of dried ginger and 5-15 parts of elecampane. The atractylis ovata, poria cocos, elecampane and the like can dispel cold, invigorate spleen, warm middle-jiao and harmonize stomach, so that qi of spleen and stomach can run smoothly, and simultaneously, the poria cocos turbidity-resolving particles contain statin components, so that excessive cholesterol synthesis in a body can be inhibited, the synthesis of low-density protein receptors is increased, the blood cholesterol and low-density protein cholesterol level are reduced, further development of cardiovascular diseases is prevented, and meanwhile, the problems of liver and kidney function injury, gastrointestinal discomfort and the like are avoided.

Inventors

• LIAO XIANJUN
• FU CHUNMEI
• HE YUNAN

Assignees

• 宣汉县中医院
• 四川大学

Dates

Publication Date

20260512

Application Date

20231013

Claims (9)

1. 1. The traditional Chinese medicine with the lipid-lowering effect is characterized by being prepared from the following raw material medicines in parts by weight: 5-10 parts of red yeast rice, 10-30 parts of poria cocos, 5-15 parts of rhizoma atractylodis, 5-15 parts of dried ginger and 5-15 parts of elecampane.
2. 2. The traditional Chinese medicine according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 5-10 parts of red yeast rice, 10-20 parts of poria cocos, 10-15 parts of rhizoma atractylodis, 10-15 parts of dried ginger and 8-15 parts of elecampane.
3. 3. The traditional Chinese medicine according to claim 2, which is characterized by being prepared from the following raw materials in parts by weight: 6 parts of red yeast rice, 20 parts of poria cocos, 12 parts of rhizoma atractylodis, 10 parts of dried ginger and 12 parts of radix aucklandiae.
4. 4. A Chinese medicinal preparation with lipid-lowering effect, which is characterized in that the Chinese medicinal preparation is a granule, a tablet, a capsule or a powder prepared from the Chinese medicament according to any one of claims 1-3.
5. 5. A method for preparing a quling turbidity-resolving granule preparation by using the traditional Chinese medicine according to any one of claims 1-3, which is characterized by comprising the following steps: (1) Cleaning the raw materials, respectively crushing the raw materials into powder with the particle size of 100-200 meshes, and uniformly mixing the powder of the raw materials; (2) Adding a solvent with the weight of 6-10 times to the powder obtained in the step (1) at the temperature of 45-60 ℃, performing ultrasonic extraction at the power of 150W and the frequency of 40KHz for 45-90 min, and collecting and concentrating the extract to obtain an extract; (3) Mixing the extract with adjuvant, stirring, and regulating humidity with ethanol to obtain soft material; (4) And preparing the soft material into wet particles, and then drying at 60-80 ℃ to obtain the product.
6. 6. The method of claim 5, wherein the extraction solvent is methanol, 75-95% ethanol, or absolute ethanol.
7. 7. The method according to claim 5, wherein the auxiliary agent is dextrin and powdered sugar, and the weight ratio of the auxiliary agent to the extract is 1:3:1.
8. 8. The method of claim 7, wherein the sugar powder is sucrose powder and the dextrin is a soluble dextrin.
9. 9. The use of the traditional Chinese medicine according to any one of claims 1 to 3 or the traditional Chinese medicine preparation according to claim 4 in the preparation of a medicament for treating a disorder caused by hyperlipidemia.

Description

Traditional Chinese medicine formula with lipid-lowering effect, qu Ling turbidity-eliminating particles and preparation method thereof Technical Field The invention belongs to the technical field of Chinese patent medicines, and in particular relates to a traditional Chinese medicine formula with lipid-lowering efficacy, qu Ling turbidity-relieving granules and a preparation method thereof. Background With the improvement of the living standard, the change of the diet structure, the acceleration of the living rhythm and the increase of the pressure of people, the problem of 'three highs' is gradually serious. Hyperlipidemia is not only an independent disease, but also causes of various diseases such as hypertension, coronary heart disease, diabetes, cerebral apoplexy, etc. Hyperlipidemia is a metabolic disorder in which one or more lipids in plasma are higher than normal due to abnormal lipid metabolism, and is manifested by hypercholesterolemia, triglyceride or a mixed hyperlipidemia of both, and is a major cause of atherosclerosis, cardiovascular and cerebrovascular diseases and fatty liver. The current therapeutic drugs are mainly phenoxy aromatic acids, statins, polyene fatty acids, etc. The medicine has definite clinical lipid-lowering effect, but has limited application range, and can cause adverse reactions such as liver and kidney function injury, gastrointestinal tract reaction, myopathy and the like after long-term administration. In addition, the traditional Chinese medicine is also used for treating hyperlipidemia clinically, such as a lipid-lowering and vein-relaxing capsule, a lipid-lowering and vein-relaxing granule, a lipid-lowering and vein-relaxing capsule and the like, but compared with western medicines, the traditional Chinese medicine has the advantages of less clear pharmacological study, slower onset of action, certain gastrointestinal discomfort and injury of liver and kidney functions, and even can cause the reversible increase of serum aminotransferase and creatine phosphokinase. Therefore, searching for lipid-lowering drugs with obvious efficacy, clear pharmacological mechanism and protective effect on gastrointestinal tract is still a hot spot for developing new drugs. Disclosure of Invention Aiming at the defects in the prior art, the invention provides the traditional Chinese medicine formula with the lipid-lowering efficacy, qu Ling turbidity-relieving granules and the preparation method thereof, which can effectively lower the blood lipid, treat the hyperlipidemia without damaging the liver and kidney functions and causing gastrointestinal discomfort. In order to achieve the above purpose, the technical scheme adopted by the invention for solving the technical problems is as follows: A traditional Chinese medicine formula with lipid-lowering effect comprises the following components in parts by weight: 5-10 parts of red yeast rice, 10-30 parts of poria cocos, 5-15 parts of rhizoma atractylodis, 5-15 parts of dried ginger and 5-15 parts of elecampane. Further, the composition comprises the following components in parts by weight: 5-10 parts of red yeast rice, 10-20 parts of poria cocos, 10-15 parts of rhizoma atractylodis, 10-15 parts of dried ginger and 8-15 parts of elecampane. Further, the composition comprises the following components in parts by weight: 6 parts of red yeast rice, 20 parts of poria cocos, 12 parts of rhizoma atractylodis, 10 parts of dried ginger and 12 parts of radix aucklandiae. A Chinese medicinal preparation with blood lipid reducing effect is granule, tablet, capsule or powder prepared from the above Chinese medicinal composition. The method for preparing the poria cocos turbidity-eliminating granular preparation by utilizing the traditional Chinese medicine formula is characterized by comprising the following steps of: (1) Cleaning the components, respectively crushing the components into powder with the particle size of 100-200 meshes, and uniformly mixing the powder of the components; (2) Ultrasonically extracting the powder obtained in the step (1) by using a solvent with the weight which is 6-10 times that of the powder at the temperature of 45-60 ℃ for 45-90 min, and collecting and concentrating the extract to obtain an extract; (3) Mixing the extract with adjuvant, stirring, and regulating humidity with ethanol to obtain soft material; (4) And preparing the soft material into wet particles, and then drying at 60-80 ℃ to obtain the product. Further, the extraction solvent is methanol, 75-95% ethanol or absolute ethanol. Further, the auxiliary agent comprises dextrin and powdered sugar, and the weight ratio of the auxiliary agent to the extract is 1:3:1. Further, the sugar powder is sucrose powder, and the dextrin is soluble dextrin. The application of the traditional Chinese medicine composition or the traditional Chinese medicine preparation in preparing medicines for treating diseases caused by hyperlipidemia. The invention has the beneficia