CN-117482125-B - Application of Yun Weiling volatile oil in preparing digestion-promoting and appetite-improving medicine

CN117482125BCN 117482125 BCN117482125 BCN 117482125BCN-117482125-B

Abstract

The invention discloses an application of Yun Weiling volatile oil in preparing a digestion-promoting and appetite-improving medicament. The preparation method of the Yunweiling volatile oil comprises the steps of crushing the Yunweiling medicinal materials, adding 8-10 times of water, carrying out reflux extraction for 3-5 hours at 90-100 ℃, collecting the volatile oil through a volatile oil extractor, adding anhydrous sodium sulfate for dehydration, centrifuging and filtering to obtain Yun Weiling volatile oil. The invention provides an application of Yun Weiling volatile oil in preparing digestion-promoting and appetite-improving medicines, and experiments prove that the Yunweiling volatile oil can promote intestinal peristalsis, promote the secretion of GAS and MTL, enhance pepsin activity, promote pepsin secretion and promote the function of food intake, and has a prospect of becoming digestion-promoting and appetite-improving medicines.

Inventors

TAN WENHONG
CHEN GONG
LIU LU
CHEN WENHUI
JIN QIONG
ZHU PEIFENG
YANG ZHUYA

Assignees

云南中医药大学
云南云中营养与健康研究院

Dates

Publication Date: 20260505
Application Date: 20231220

Claims (3)

1. The preparation of the digestion-promoting appetite-improving traditional Chinese medicine composition based on the cloud weiling volatile oil is characterized by comprising, by weight, 10-20 parts of cloud weiling, 10-20 parts of poria cocos, 5-15 parts of dried orange peel, 5-15 parts of scorched hawthorn fruit, 5-15 parts of roasted malt and 5-10 parts of fructus amomi, wherein the preparation method of the decoction comprises the following steps: 1) Pulverizing the Yunweiling, adding water with the weight being 8-10 times that of the Yunweiling, and carrying out reflux extraction for 3-5 hours at the temperature of 90-100 ℃, collecting volatile oil by a volatile oil extractor, adding anhydrous sodium sulfate for dehydration, centrifuging and filtering to obtain Yun Weiling volatile oil, wherein the refluxed Yunweiling residues and the refluxed Yun Weiling aqueous solution are reserved; 2) Mixing poria cocos, dried orange peel, fried hawthorn, fried malt and fructus amomi with the residues of the poria cocos and the radix et rhizoma polygoni multiflori distilled in the step 1), adding 6-8 times of water for decoction for 20-40 min, adding 4-8 times of water for decoction for 20-40 min, and mixing the two decoctions; 3) Mixing the aqueous solution of the rufigwort in the step 1) with the decoction obtained in the step 2), adding the rufigwort volatile oil obtained in the step 1), and fully and uniformly mixing to obtain the decoction.
2. The preparation of the digestion-promoting appetite-improving traditional Chinese medicine composition based on the cloud weiling volatile oil is characterized by comprising the following raw materials in parts by weight: 1) Pulverizing the Yunweiling, adding water with the weight being 8-10 times that of the Yunweiling, and carrying out reflux extraction for 3-5 hours at the temperature of 90-100 ℃, collecting volatile oil by a volatile oil extractor, adding anhydrous sodium sulfate for dehydration, centrifuging and filtering to obtain Yun Weiling volatile oil, wherein the refluxed Yunweiling residues and the refluxed Yun Weiling aqueous solution are reserved; 2) Mixing poria cocos, dried orange peel, fried hawthorn, fried malt and fructus amomi with the residues of the poria cocos and the radix et rhizoma polygoni multiflori distilled in the step 1), adding 6-8 times of water for decoction for 20-40 min, adding 4-8 times of water for decoction for 20-40 min, and mixing the two decoctions; 3) Mixing the aqueous solution of the runweiling in the step 1) with the decoction obtained in the step 2), concentrating to obtain an extract with the concentration of 1.5-2 g/mL, adding the runweiling volatile oil obtained in the step 1), adding a proper amount of auxiliary materials, fully and uniformly mixing, and making pills with water to obtain the pill.
3. The preparation of the digestion-promoting appetite-improving traditional Chinese medicine composition based on the cloud weiling volatile oil is characterized by comprising the following raw materials in parts by weight: 1) Pulverizing the Yunweiling, adding water with the weight being 8-10 times that of the Yunweiling, and carrying out reflux extraction for 3-5 hours at the temperature of 90-100 ℃, collecting volatile oil by a volatile oil extractor, adding anhydrous sodium sulfate for dehydration, centrifuging, filtering, and dehydrating to obtain Yun Weiling volatile oil, wherein the refluxed Yunweiling dregs and the refluxed Yun Weiling aqueous solution are reserved; 2) Weighing 10-20 g of beta-cyclodextrin, placing in a 50mL beaker, adding 10-25 mL of absolute ethyl alcohol at 45-65 ℃ for stirring and dissolving, then dropwise adding the volatile oil of the rufigwort obtained in the step 1), stirring at the speed of 300-900 r/min for 1.5-2.5 h at the temperature of 45-65 ℃, concentrating and drying at the temperature of 40 ℃ under reduced pressure, washing with petroleum ether for 3 times, and volatilizing to constant quality at room temperature to obtain the rufigwort volatile oil clathrate compound; 3) Mixing poria cocos, dried orange peel, fried hawthorn, fried malt and fructus amomi with the residues of the poria cocos and the radix et rhizoma polygoni multiflori distilled in the step 1), adding 6-8 times of water for decoction for 20-40 min, adding 4-8 times of water for decoction for 20-40 min, and mixing the two decoctions; 4) Mixing the aqueous solution of the rufigwort in the step 1) with the decoction obtained in the step 3), concentrating, drying to obtain powder, adding the rufigwort volatile oil clathrate obtained in the step 2), fully and uniformly mixing, sieving with a 100-mesh sieve to obtain a mixture, adding a proper amount of 70% -90% ethanol, granulating by a wet method, and drying to obtain granules.

Description

Application of Yun Weiling volatile oil in preparing digestion-promoting and appetite-improving medicine Technical Field The invention belongs to the technical field of traditional Chinese medicine extracts, and particularly relates to application of a cloud weiling volatile oil in preparation of digestion-promoting and appetite-improving medicines. Background In recent years, there are increasing cases of poor digestion due to stress, irregular diet, unhealthy diet, or inappetence due to sub-health. Therefore, it is extremely necessary to find a medicament for promoting digestion and stimulating appetite, which is high in efficiency, low in toxicity, and capable of treating both principal and secondary aspect of disease. "Yun Weiling" is the dried root and rhizome of Inula nervosa wall (Inula nervosa wall.) of Inula of Compositae, also known as "Mao Xiucai", "Xiao Hei Yao", "Hei Wei Ling", "Ma Kalie Prop. Is mainly distributed in Yunnan, sichuan, guizhou, guangxi and Hunan places. Yun Weiling has a long history of both medicine and food use in Yunnan folks. Inula flower (Yun Weiling) is approved as a new resource food in the Ministry of health in 2010, and is produced into common food (seasoning) by taking dried rhizome as a raw material through the steps of carefully selecting, cleaning, drying, mechanical crushing and the like. As a new resource food, the food processing form of the product is simple and the application form is single in the market. With the continuous upgrading of consumption demands, improvement of consumption awareness and pursuit of healthy diet are achieved, and Yun Weiling has great potential and market prospect as a new resource food. The invention aims to provide a Yunweiling extract which can promote digestion and promote appetite. Disclosure of Invention The invention aims to provide application of a cloud Weiling volatile oil in preparation of digestion-promoting and appetite-improving medicines. The invention aims at realizing the application of the volatile oil of the Yunweiling in preparing the digestion-promoting and appetite-improving medicine. The preparation method of the Yunweiling extract comprises pulverizing Yunweiling materials, adding 8-10 times of water, reflux extracting for 3-5 hr, collecting by volatile oil extractor, dehydrating with anhydrous sodium sulfate, centrifuging, and filtering to obtain Yun Weiling volatile oil. The invention has the beneficial effects that the invention provides the application of Yun Weiling volatile oil in preparing the digestion-promoting and appetite-improving medicine, and experiments prove that the volatile oil can promote intestinal peristalsis, promote the secretion of GAS and MTL, enhance pepsin activity and promote pepsin secretion and promote the functions of food intake, wherein the pepsin activity of the volatile oil is better than that of a positive medicine group, and has the prospect of becoming the digestion-promoting and appetite-improving medicine. Drawings FIG. 1 shows the small intestine propulsion rate of mice (left panel) with Yun Weiling volatile oil prepared in example 1 The effect graph (# # # for the conversion values (right) shows P <0.0001 compared to the normal group, # shows P <0.05 compared to the model group, # shows P <0.01 compared to the model group, # shows P <0.0001 compared to the model group,); Fig. 2 is a graph showing the effect of Yun Weiling volatile oil prepared in example 1 on GAS (left panel) and MTL (right panel) secretion in mouse serum (# # # for comparison with normal group P <0.0001,/for comparison with model group P <0.05,/for comparison with model group P <0.01,/for comparison with model group P < 0.0001.); fig. 3 is a graph of the effect of Yun Weiling of the essential oil prepared in example 1 on pepsin activity (left graph) and pepsin output (right graph) in rats (P <0.05 compared to the normal group; P <0.01 compared to the normal group; P <0.001 compared to the normal group; P <0.0001 compared to the normal group); FIG. 4 is a graph showing the effect of the pharmaceutical compositions prepared in example 5 and comparative example 1 on the small intestine propulsion rate (left graph) and small intestine propulsion rate conversion value (right graph) of mice (## P <0.01 compared to normal group; **P<0.01***P<0.001**** P <0.0001 compared to model group); FIG. 5 is a graph showing the effect of the pharmaceutical compositions prepared in example 5 and comparative example 1 on pepsin activity (left graph) and pepsin output (right graph) of rats (*P<0.05**P<0.01***P<0.001**** P <0.0001 compared to normal group). Detailed Description The invention is further described below without limiting it in any way, and any modifications based on the invention fall within the scope of protection of the invention. The invention provides an application of a Yunweiling volatile oil in preparing a medicament for promoting digestion and stimulating appetite. The preparation method of the Yunweil