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CN-117643732-B - Vacuum concentration device for S-adenosylmethionine p-toluenesulfonic acid sulfate preparation

CN117643732BCN 117643732 BCN117643732 BCN 117643732BCN-117643732-B

Abstract

The invention relates to the technical field of vacuum concentration equipment, in particular to a vacuum concentration device for preparing S-adenosyl methionine p-toluenesulfonic acid sulfate, which comprises a vacuum pump, wherein an air outlet end of the vacuum pump is rotationally connected and communicated with a first air guide pipe, the other end of the first air guide pipe is fixedly connected and communicated with a condensing tank, one end of the vacuum pump is fixedly connected and communicated with a continuous device fixedly connected and communicated with an air inlet end of the vacuum pump, the other end of the continuous device is fixedly connected and communicated with a constant temperature heating tank in annular distribution, the continuous device comprises an electric turntable fixedly connected with one end of the vacuum pump, an operator can divide concentrated solution into a plurality of parts and respectively fill the parts into the corresponding constant temperature heating tanks through the continuous device, and the vacuum pump can rapidly extract air and steam in the constant temperature heating tank connected with the vacuum pump under lower load.

Inventors

  • ZHANG QIUHUA
  • TIAN QUNLIANG
  • WANG ZHENG
  • ZHOU ZHONGPING
  • SU HAIJIA

Assignees

  • 江西兄弟医药有限公司

Dates

Publication Date
20260512
Application Date
20231213

Claims (9)

  1. 1. The vacuum concentration device for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate comprises a vacuum pump (1) and is characterized in that an air outlet end of the vacuum pump (1) is rotationally connected and communicated with a first air guide pipe (2), the other end of the first air guide pipe (2) is fixedly connected and communicated with a condensing tank (3), one end of the vacuum pump (1) is fixedly connected with a continuous device (4) fixedly connected and communicated with an air inlet end of the vacuum pump (1), and the other end of the continuous device (4) is fixedly connected and communicated with a constant-temperature heating tank (5) which is annularly distributed; The continuous device (4) comprises an electric rotary table (6) fixedly connected to one end of a vacuum pump (1), an opening and closing adjusting mechanism (7) fixedly connected and communicated with the air inlet end of the vacuum pump (1) is sleeved on the surface of the vacuum pump (1), a second air duct (8) is fixedly connected and communicated with the surface of the opening and closing adjusting mechanism (7), a sealing cover (9) fixedly connected with the vacuum pump (1) is fixedly connected and communicated with the other end of the second air duct (8), the constant-temperature heating tank (5) is in threaded connection with the other end of the sealing cover (9), a pressure relief mechanism (10) which is annularly distributed is arranged in the opening and closing adjusting mechanism (7), the other end of the pressure relief mechanism (10) penetrates through the opening and closing adjusting mechanism (7) and extends to the inside of the sealing cover (9), and an anti-coking mechanism (11) which is clamped with the constant-temperature heating tank (5) is arranged in the sealing cover (9). The opening and closing adjusting mechanism (7) comprises a ring frame (701), the ring frame (701) is sleeved on the surface of the vacuum pump (1), a first circular arc groove (702) is formed in the other end of the ring frame (701), a second circular arc groove (703) communicated with the first circular arc groove (702) is formed in the other end of the ring frame (701), the first circular arc groove (702) and the second circular arc groove (703) form a circle together, the depth of the first circular arc groove (702) is larger than that of the second circular arc groove (703), guide balls (704) which are uniformly distributed are in sliding connection with the inner walls of the first circular arc groove (702) and the second circular arc groove (703), one end of each guide ball (704) is fixedly connected with a guide rod (705), the other end of each guide rod (705) sequentially penetrates through the first circular arc groove (702) or the second circular arc groove (703) and the sealing cover (9) and extends to the outside of the sealing cover (9), the other end of each guide rod (705) is fixedly connected with a mounting frame (706), the depth of each first circular arc groove (702) is larger than that of the second circular arc groove (703) is in depth, the first circular arc groove (702) is fixedly connected with the inner wall (706) of one vertical rack (706), the top rack (708) is in contact with the top wall (707) of the vertical rack (708), the bottom of straight gear (708) and the interior bottom contact of installing frame (706) that set up in same vertical line with second circular arc groove (703), rack (707) can drive the rotatory effective angle of straight gear (708) and be ninety degrees, the one end fixedly connected with transmission shaft (709) of straight gear (708), the surface rotation of transmission shaft (709) is connected with spherical box (710), the inlet end of vacuum pump (1) and the one end of second air duct (8) all with be adjacent spherical box (710) fixed connection and intercommunication, the inlet end of vacuum pump (1) and the one end symmetric distribution of second air duct (8) are in the both sides of spherical box (710) central point, the surface fixedly connected with seal circular plate (711) of transmission shaft (709), with first circular arc groove (702) set up in same vertical line seal circular plate (711) are on a parallel with the horizontal plane, with second circular arc groove (703) set up in same vertical line seal circular plate (711) are perpendicular to the horizontal plane.
  2. 2. The vacuum concentration device for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 1, wherein the other end of the ring frame (701) is rotatably connected with a sealing ring cover (712), guide holes (713) distributed in a ring shape are formed in the top of the sealing ring cover (712), and the other end of the guide rod (705) penetrates to the outside of the guide holes (713).
  3. 3. The vacuum concentration device for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 2, wherein a rubber corrugated pipe (714) is fixedly connected to the surface of the guide rod (705), the other end of the rubber corrugated pipe (714) is fixedly connected with a sealing ring cover (712), and the guide hole (713) is arranged in the adjacent rubber corrugated pipe (714).
  4. 4. The vacuum concentration device for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 1, wherein guide channels (715) which are mutually communicated are formed in the surfaces of the guide ball (704) and the guide rod (705), a pressure release hole (901) which is communicated with a constant temperature heating tank (5) is formed in one end of the sealing cover (9), the pressure release mechanism (10) comprises a T-shaped sealing plug (1001), the T-shaped sealing plug (1001) is inserted into the pressure release hole (901), an n-shaped strip (1002) is fixedly connected to the other end of the T-shaped sealing plug (1001), the other end of the n-shaped strip (1002) penetrates into the interior of the adjacent guide channel (715), an adjusting piece (1003) is fixedly connected to the other end of the n-shaped strip (1002), and the other end of the adjusting piece (1003) sequentially penetrates through one guide channel (715) and the other guide channel (715) and contacts with the inner bottom wall of the first circular arc groove (702) or the second circular arc groove (703).
  5. 5. The vacuum concentration device for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 4, wherein the regulating member (1003) comprises an arc strip (10031) and a connecting rod (10032), the arc strip (10031) is fixedly connected to the inner bottom wall of the second arc groove (703), the length ratio of the arc strip (10031) to the second arc groove (703) is two to three, the arc strip (10031) is arranged at one side of the adjacent guide ball (704) far away from the adjacent guide rod (705), the connecting rod (10032) is fixedly connected to the other end of the n-shaped strip (1002), the surface of the connecting rod (10032) is connected with an adjusting rod (10033) which is connected with the adjacent guide channel (715) in a sliding manner, the other end of the adjusting rod (10033) sequentially penetrates through one guide channel (715) and the other guide channel (715) and contacts with the inner bottom wall of the first arc groove (702) or the other end of the arc strip (10031), the depth of the second arc strip (10033) is the same as the depth of the first arc groove (702) which is staggered with the other end of the arc strip (1002), the other end of the n-shaped bar (1002) arranged on the same vertical line as the circular arc bar (10031) is in contact with one end of the adjacent adjusting bar (10033).
  6. 6. The vacuum concentration device for S-adenosylmethionine p-toluenesulfonic acid sulfate preparation according to claim 5, wherein the adjusting member (1003) further comprises a mounting frame (10034) and a spring (10035), the mounting frame (10034) is slidably connected to the surface of the n-shaped strip (1002), the T-shaped sealing plug (1001) is arranged in the mounting frame (10034), the spring (10035) is sleeved on the surface of the n-shaped strip (1002), the top of the spring (10035) is arranged between the mounting frame (10034) and the T-shaped sealing plug (1001), and the spring (10035) is always in a compressed state.
  7. 7. The vacuum concentration device for S-adenosylmethionine p-toluenesulfonic acid sulfate preparation according to claim 6, wherein a filter screen (10036) is embedded and installed on the surface of the installation frame (10034), and the T-shaped sealing plug (1001) and the spring (10035) are both arranged on the inner side of the filter screen (10036).
  8. 8. The vacuum concentration device for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 1, wherein two mounting grooves (501) are formed in the vertical inner wall of the constant temperature heating tank (5), the anti-coking mechanism (11) comprises mounting strips (1101), the mounting strips (1101) are arranged in the constant temperature heating tank (5), two ends of the mounting strips (1101) penetrate through the inside of the mounting grooves (501) and are spliced with the mounting grooves (501) respectively, two rotating seats (1102) are rotatably connected to the surface of the mounting strips (1101), fan impellers (1103) are rotatably connected between the two rotating seats (1102), two ends of each fan impeller (1103) penetrate through the outside of the corresponding rotating seat (1102), two ends of each fan impeller (1103) are fixedly connected with driving bevel gears (1104), the other ends of the driving bevel gears (1104) are in meshed connection with driven bevel gears (1105), the other ends of the driven bevel gears (1101) are fixedly connected with shafts (1106) rotatably connected with the mounting strips (501), and the other ends of the driven bevel gears (1104) penetrate through the inside of the corresponding stirring shafts (1106) and extend to the inside of the heating tank (1101).
  9. 9. The vacuum concentration device for preparing S-adenosylmethionine p-toluenesulfonic acid sulfate according to claim 8, wherein an arc-shaped guide cavity (902) communicated with a second air duct (8) is formed in the inner bottom wall of the sealing cover (9), the surface of the fan blade wheel (1103) penetrates into the arc-shaped guide cavity (902), and the communicating position of the second air duct (8) and the arc-shaped guide cavity (902) is staggered with the axial lead of the fan blade wheel (1103).

Description

Vacuum concentration device for S-adenosylmethionine p-toluenesulfonic acid sulfate preparation Technical Field The invention relates to the technical field of vacuum concentration equipment, in particular to a vacuum concentration device for preparing S-adenosyl methionine p-toluenesulfonic acid sulfate. Background S-adenosylmethionine p-toluenesulfonate, SAM-T for short, is a natural molecule that is present in all cells of the human body. The concentration is higher in the liver, adrenal gland and pineal gland, and the distribution is uniform in the brain. S-adenosylmethionine p-toluenesulfonate has multiple protection effects on liver cells through mechanisms such as oxidation free radical resistance, liver cell regeneration promotion and the like. In recent years, the research also finds that S-adenosylmethionine paratoluenesulfonic acid sulfate can increase the fluidity of neuron membranes in the brain of a patient, promote the generation of excitatory neurotransmitters, and has important dual functions of improving the emotion of a liver disease patient and treating depression. At present, manufacturers mostly adopt a vacuum concentration device to concentrate and purify S-adenosylmethionine paratoluenesulfonic acid sulfate solution. Because more solution is needed to be added when the S-adenosyl-methionine p-toluenesulfonic acid sulfate solution is concentrated and purified, the single extraction amount of the S-adenosyl-methionine p-toluenesulfonic acid sulfate can be increased, but the evaporation time is long and the evaporation is uneven due to the fact that the solution amount of the vacuum concentration device is more, S-adenosyl-methionine p-toluenesulfonic acid sulfate crystals are easy to coke on the inner wall of the vacuum concentration device along with the extension of the evaporation time, the quality of the S-adenosyl-methionine p-toluenesulfonic acid sulfate can be influenced, the subsequent cleaning burden of production staff is increased, and the shutdown maintenance time of the vacuum concentration device is prolonged. Disclosure of Invention The invention aims to solve the problems that the existing vacuum concentration device has longer concentration time and uneven evaporation and is easy to crystallize and coke the S-adenosyl methionine p-toluenesulfonic acid sulfate. The invention realizes the aim through the following technical scheme that the vacuum concentration device for preparing S-adenosyl methionine p-toluenesulfonic acid sulfate comprises a vacuum pump, wherein the air outlet end of the vacuum pump is rotationally connected and communicated with a first air guide pipe, the other end of the first air guide pipe is fixedly connected and communicated with a condensing tank, one end of the vacuum pump is fixedly connected with a continuous device which is fixedly connected and communicated with the air inlet end of the vacuum pump, and the other end of the continuous device is fixedly connected and communicated with a constant-temperature heating tank which is annularly distributed; the continuous device comprises an electric turntable fixedly connected to one end of a vacuum pump, an opening and closing regulating mechanism fixedly connected and communicated with the air inlet end of the vacuum pump is sleeved on the surface of the vacuum pump, a second air guide pipe is fixedly connected and communicated with the surface of the opening and closing regulating mechanism, the other end of the second air guide pipe is fixedly connected and communicated with a sealing cover fixedly connected with the vacuum pump, the constant temperature heating tank is in threaded connection with the other end of the sealing cover, a pressure release mechanism which is annularly distributed is arranged in the opening and closing regulating mechanism, the other end of the pressure release mechanism penetrates through the opening and closing regulating mechanism and extends to the inside of the sealing cover, an anti-coking mechanism which is clamped with the constant temperature heating tank is arranged in the sealing cover, an operator can divide concentrated solution into a plurality of parts and respectively fill the corresponding constant temperature heating tanks through the continuous device, the vacuum pump can rapidly extract air and steam in the constant temperature heating tanks connected with the constant temperature heating tanks under lower load at the moment, compared with the existing design that more solution is directly arranged in the vacuum concentration device, the volume of the single vacuum pump is reduced, the vacuum load of the vacuum pump can be reduced, the vacuum pump has the advantages that the vacuumizing efficiency and the quality of the vacuum pump are greatly improved, the depth of the solution which can be contained in a single container is reduced, the evaporation time of the solution can be reduced, substances reaching the boiling point inside the solution